Method for establishing spinal dura mater leakage arachnoid hernia type sacral canal cyst model

A technique of arachnoid and dura mater, which is applied in the establishment of dural leakage, arachnoid hernia type sacral cyst model, and achieves the effect of simple operation method, short modeling time and simple steps

Pending Publication Date: 2021-01-05
PEKING UNIV THIRD HOSPITAL
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Problems solved by technology

[0004] However, it is regrettable that the current research mainly focuses on the classification, diagnosis and treatment of sacral cysts, but there is no experimental animal model to simulate the dural leaky arachnoid hernia type sacral cysts, so it is difficult to use animal models A more comprehensive understanding of the formation process and existing pathogenesis of dural leakage arachnoid hernia type sacral canal cyst

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  • Method for establishing spinal dura mater leakage arachnoid hernia type sacral canal cyst model
  • Method for establishing spinal dura mater leakage arachnoid hernia type sacral canal cyst model
  • Method for establishing spinal dura mater leakage arachnoid hernia type sacral canal cyst model

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[0031] Some specific implementations of the present invention will be described below with reference to the drawings and examples. Those skilled in the art will understand that the purpose of providing these embodiments is only to illustrate how the solution of the present invention can be implemented, but not to limit the scope of the present invention in any way.

[0032] figure 1 Schematic showing the formation of a sacral cyst. Such as figure 1 It can be seen that the sacral canal consists of two layers, the adventitia, which is the outer layer of the dural sac, and the arachnoid layer located inside it. One possible mechanism involves that the cyst communicates with the subarachnoid space through a valve (valve) that allows only CSF to enter but not to exit, so that fluid accumulates into the cyst.

[0033] In a large number of surgical practices, the inventors found that, in some cases, if the end of the dura mater in the sacral canal or part of the dura mater or shea...

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Abstract

The invention relates to a method for establishing a spinal dura mater leakage arachnoid hernia type sacral canal cyst model. The method comprises the following steps: step 1) selecting a model animal; 2) exposing the tail end of the dural sac in the lumbosacral vertebrae of the model animal through an operation; 3) irregularly cutting the tail end of dural sac or thick nerve sleeve adventitia; and 4) completing modeling. By means of the method, the spinal dura mater leakage arachnoid hernia type sacral canal cyst animal model with the survival rate of 100%and the modeling success rate of 60%can be simulated and the cyst form is very similar to that in real cases.

Description

technical field [0001] The invention relates to the field of experimental animal models, in particular to a method for establishing a dural leakage arachnoid hernia type sacral cyst model. Background technique [0002] Sacral canal cyst is a type of meningeal cyst, which can be roughly divided into two types: 1) Nabors IB type: epidural meningeal cyst without spinal nerve root fibers (Nabors IB type), which is congenital dural diverticulum or congenital Arachnoid herniation caused by dural defects, mostly located at the S1-3 level of the sacral canal, is common in adults, and there is no significant difference between men and women; 2) Nabors type II: epidural meningeal cyst containing spinal nerve root fibers, Also known as Tarlov's perineurial cyst or spinal nerve root diverticulum (Nabors II type), it is a cyst formed by abnormal expansion of the distal end of the spinal nerve root sleeve, usually located at the S2-3 level of the spinal ganglion or its distal end, and is ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00A01K67/02
CPCA01K67/02A61D1/00
Inventor 孙建军杨军刘丽王涛
Owner PEKING UNIV THIRD HOSPITAL
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