13 results about "Cerebrospinal fluid flow" patented technology

This invention discloses a wireless, passive, and visualized cerebrospinal fluid drainage tube flow monitoring sensor, system, and fabrication method, belonging to the field of biomedical sensing and microelectromechanical systems (MEMS) technology. It includes a flexible substrate, an interdigital capacitor-open resonant ring structure disposed on the substrate surface, and a microchannel pressure conversion structure bonded to it; the microchannel corresponds vertically to the position of the interdigital capacitor. The pressure generated by the cerebrospinal fluid flow drives the displacement of the liquid metal, modulating the equivalent dielectric constant of the interdigital capacitor and causing a resonant frequency shift. The frequency drift is wirelessly read by an external device, and the flow rate is calculated using an algorithm, achieving passive wireless continuous monitoring. This invention, employing the aforementioned sensor, system, and fabrication method, solves the problems of high infection risk, low accuracy, and inability to continuously monitor existing drainage monitoring methods that rely on manual observation or wired sensors. It has the advantages of high sensitivity, flexible integration, and good safety.

The embodiment of the invention provides a cerebrospinal fluid shunt monitoring system. The cerebrospinal fluid shunt monitoring system comprises a data acquisition unit and a data processing unit, the data acquisition unit is used for acquiring temperatures of upstream and downstream areas of a cerebrospinal fluid shunt tube, and the data transmission component is used for transmitting the temperatures acquired by the temperature detection component to the data processing unit; and the data processing unit is used for processing the temperature acquired by the data acquisition unit so as to determine the flow of cerebrospinal fluid. According to the cerebrospinal fluid shunt monitoring system disclosed by the embodiment of the invention, the quantitative precision can be improved, and the monitoring lower limit reaches 0.01 ml / min; meanwhile, the depth adaptability is achieved, measurement of the subcutaneous tissue thickness of 1-6 mm is supported, and the false detection rate is reduced to tilt; 5%.

This invention relates to the field of medical device technology, and more particularly to an implantable cerebrospinal fluid flow monitoring device and system based on wireless charging. The device includes a flat, elliptical housing with a fluid channel extending through its long axis. An upper interface is connected to one end of the fluid channel. A lower interface is fixedly connected to the other end of the housing, and this lower interface is connected to the other end of the fluid channel. A flow sensing module is fitted into the middle of the fluid channel. The square ceramic substrate of the flow sensing module is embedded in a groove in the inner wall of the channel, and its flush design with the inner wall avoids interference with fluid flow. A first temperature sensing chip and a second temperature sensing chip, symmetrically arranged on the upstream and downstream sides, work in conjunction with a micro-heating chip in the middle to ensure accurate flow detection. A wireless charging receiving coil is embedded inside the outer wall of one side of the housing to reduce internal module shielding interference. Combined with a solid-state lithium battery and a power management integrated circuit, this improves charging efficiency and battery life.

The invention discloses a multi-parameter monitoring pressure-adjustable recoverable hydrocephalus shunting device and a treatment method, and belongs to the technical field of medical instruments. The device comprises a shunt pipe assembly and a recovery device. The shunt tube assembly forms a cerebrospinal fluid shunt passage from a ventricle to veins, a front-end brain pressure monitoring module, an automatic pressure regulation flow rate valve, a central processing and transmission module and a multi-parameter function monitoring module are integrated, and automatic regulation and control of intracranial pressure and real-time monitoring of multiple parameters of thrombus, blood pressure and blood oxygen are achieved. The flow velocity of cerebrospinal fluid is autonomously adjusted through the automatic pressure adjusting flow velocity valve according to dynamic changes of intracranial pressure, traditional manual adjustment is replaced, and adjustment and control accuracy and timeliness are improved; meanwhile, the shunt tube is safely and conveniently replaced through a magnetic recovery structure, and operation wounds and infection risks are reduced. The system is suitable for precise treatment and postoperative comprehensive monitoring of adult hydrocephalus.

This invention provides a rat cerebrospinal fluid (CSF) metering and collection device with injection and pressure measurement functions. The device includes a glass tube and a catheter. A pressure probe is installed inside the glass tube. A three-way valve is installed at one end of the glass tube, and the other two ends of the three-way valve are connected to tubing. This device facilitates drug injection, facilitates CSF collection, measures CSF pressure, observes the relationship between CSF flow rate, flow velocity, and intracranial pressure, and simulates and studies the effects of ventricular drainage surgery. The rat CSF metering and collection device with injection and pressure measurement functions provided by this invention has the advantages of being easy to use, capable of collecting CSF, and accurately calculating the amount of CSF secreted.

A device that can be placed within or near the cranial vault that fluctuates in size in response to changes in CSF pressure is disclosed. The device diminishes in size when CSF pressures rise and increases in size as CSF pressures diminish. The device has the effect of reducing the flow of CSF occurring in the foramen magnum and provides an alternative to craniovertebral decompression in Chiari I patients. The device may have applications in other neurologic illnesses associated with abnormal CSF flow, such as Idiopathic Syringomyelia, Normal Pressure Hydrocephalus, and CSF dural leaks.

The invention relates to a local anesthesia dosage control system based on CFD (Computational Fluid Dynamics) and PC-MRI (Personal Computer-Magnetic Resonance Imaging) coupling and a working method thereof, and the system comprises an information collection unit which is used for collecting physical examination and medical evaluation information of a patient; the geometric unit is used for acquiring a T2 weighted MRI image sequence; the calculation model unit is used for determining the range of a lumbar, thoracic and vertebral segment calculation domain; a measurement unit for phase encoding using PC-MRI; the cerebrospinal fluid dynamic unit is used for acquiring an initial flow field of cerebrospinal fluid flow of the spinal canal of the patient; the dosage selection unit is used for selecting the injection dosage of the local anesthetic; the intrathecal administration calculation unit is used for establishing coupling analysis to obtain a local anesthetic concentration value of a blocking plane; and the dose evaluation unit is used for quantitatively evaluating the concentration value of the local anesthetic. The system is beneficial for improving the accuracy and safety of local anesthesia medication.

The utility model discloses a novel lumbar puncture needle, and relates to the technical field of lumbar puncture needles. The syringe comprises a needle tube used for puncture operation, and the tail end of the needle tube is connected with a first duckbilled silica gel one-way valve; the needle core can be inserted into the needle tube and is used for puncturing, a groove is formed in the surface of the needle core, and cerebrospinal fluid can flow out through the groove. Due to the design that the groove is formed in the surface of the needle core, cerebrospinal fluid can still flow out through the groove even if the needle core is completely inserted into the needle tube, so that a doctor can immediately judge whether the cerebrospinal fluid flows out or not and confirm whether the needle core correctly enters the subarachnoid space or not. By means of the design, operation is greatly simplified, the step of repeatedly pulling out the needle core is reduced, the efficiency and accuracy of the puncture process are improved, and discomfort of a patient is reduced.

The application belongs to the technical field of human brain electrical signal processing and brain regulation, and provides a multi-modal coupling type closed-loop electric stimulation sleep cooperative signal regulation device and system, which acquires multi-modal physiological signals including EEG slow wave power, cerebral blood flow and cerebrospinal fluid flow signals, filters and pre-processes the acquired multi-modal physiological signals to obtain pre-processed multi-modal signals, calculates the time domain correlation of the EEG slow wave power and the cerebral blood flow, and the frequency domain coherence of the cerebral blood flow and the cerebrospinal fluid flow signals, introduces the regulation factor of the time domain correlation of the EEG slow wave power and the cerebral blood flow and the frequency domain coherence of the cerebral blood flow and the cerebrospinal fluid flow signals to obtain a signal stimulation intensity calculation formula, and combines the signal stimulation intensity calculation formula and a constructed double-layer optimization architecture to optimize the signal stimulation intensity to obtain optimized signal stimulation intensity. A precise sleep regulation signal is generated.

The application relates to the field of interventional medical technology, in particular to a percutaneous interventional venous sinus puncture access device. The access device is formed by the mutual cooperation of a balloon catheter, a deflecting catheter and a puncture guide wire, can puncture into the subarachnoid cavity in the cranial cavity on the venous sinus without damaging the brain, break the dura mater and arachnoid, construct a stoma between the pontocerebellar angle pool and the inferior petrosal sinus, and make the cerebrospinal fluid flow from the subarachnoid cavity to the venous sinus, to the jugular vein and to the heart, and participate in blood circulation. The access device can also be used for delivering a shunt, so that the hydrocephalus which can only be effectively treated by operation in the past can be treated by a minimally invasive interventional method, the access device is not used for surgical open operation, the intraoperative trauma is reduced, the operation time is saved, and the possibility of postoperative infection is greatly reduced.

This invention belongs to the interdisciplinary field of neuroengineering and sleep medicine, and provides a closed-loop transcranial electrical stimulation system and method based on the resonance regulation of cerebrospinal fluid and blood vessels. First, data related to blood vessel diameter and cerebrospinal fluid flow velocity are collected. Then, based on these data, the phase difference between the blood vessels and cerebrospinal fluid is obtained using a maximum independent variable point set function. The electrical stimulation frequency is determined based on this phase difference and a preset relationship between the phase difference and the stimulation frequency. Finally, transcranial electrical stimulation is performed according to the determined frequency. This method not only considers cerebrospinal fluid flow and vascular factors, but also achieves real-time dynamic determination and adjustment of the electrical stimulation frequency through the determined phase difference between the blood vessels and cerebrospinal fluid, improving the effectiveness of electrical stimulation and ensuring sleep quality under electrical stimulation.

The invention discloses an external ventricular drainage device for monitoring intracranial pressure in real time and a use method thereof. The device comprises a drainage module, a pressure measuring module, a pressure regulating module and a liquid collecting module, the drainage module is used for leading cerebrospinal fluid out of the ventricle; the pressure measuring module is communicated with the drainage module and is used for measuring the pressure of cerebrospinal fluid, converting a pressure signal into an electric signal and displaying an intracranial pressure value in real time; reference height registration is set between the pressure measuring module and the pressure regulating module, so that the detection plane of the pressure measuring module corresponds to the zero point of the graduated scale of the pressure regulating module; the pressure regulating module is communicated with the drainage module, and the flow of cerebrospinal fluid led out by the drainage module is controlled by regulating the height of the shunt bottle; the liquid collecting module is communicated with the drainage module and is used for collecting the led-out cerebrospinal fluid. According to the invention, the monitoring precision, the operation intuition and the clinical safety of bedside external ventricular drainage can be improved, and the portability and the clinical adaptability are considered at the same time.

The present invention discloses a diffusion magnetic resonance (MR) method for measuring arterial pulsation dependence of perivascular cerebrospinal fluid flow in glymphatic system: DTI acquisition: Brain MRI images were acquired using dynamic diffusion tensor imaging (DTI); Cardiac signal synchronization: Simultaneously collect heart rate fluctuation time-series signals; Peak coordinate determination: Identify the peak timing of cardiac pulsation signals from the time-series data; Image realignment: Reorganize brain MR images according to their temporal positions within the cardiac cycle; Temporal interpolation: Perform uniform time-sampling reconstruction to generate equidistant diffusion MRI datasets across the cardiac cycle; Parameter calculation: Compute axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) at each voxel level; Mask-based analysis: Generate characteristic curves of AD / RD / MD and spin density(S) dynamics using region-specific masks in individual space. This method enables non-invasive measurement of: (1) Cerebrospinal fluid (CSF) flow velocity / direction in large perivascular spaces during heartbeats; (2) Microvascular perivascular CSF dynamics through diffusion parameter analysis.