110 results about "Lumbar puncture" patented technology

The invention relates to the technical field of medical treatment, and particularly discloses a minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system, which comprises a flexible probe, a data acquisition module, a data return module and a data analysis module, the flexible probe is embedded into the high-precision microarray electrode and the sensor to collect neural signals in real time; the data acquisition module is used for synchronously acquiring electroencephalogram signals and intracranial pressure of specific parts of the brain; the data return module manages the collected data; and the data analysis module analyzes the electroencephalogram signal and the intracranial pressure data. According to the minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system provided by the invention, lumbar puncture enters a cerebrospinal fluid space and is sent to a target spot, so that the infection risk can be effectively reduced, the limitation on the action of a patient is reduced, and the system has the characteristics of real-time performance, directness and accuracy; the method has very important significance and value for evaluating brain injury and brain functional lesion of a patient, prognosis judgment and the like.

According to the modularized ultrasonic-guided lumbar puncture teaching model provided by the invention, on the basis of the detachable modularized ultrasonic-guided lumbar puncture teaching model, the pathological bony structure module for simulating the corresponding pathological conditions of the lumbar structure is introduced, so that the lumbar puncture process in different pathological states is simulated; therefore, trained medical staff can be helped to better understand the anatomical basis and operation key points of lumbar puncture, the understanding of different pathological changes is deepened, and an experimental platform is provided for studying the improvement of lumbar puncture operation, the occurrence mechanism of puncture-related complications and the like. Furthermore, better lumbar puncture operation in actual clinical work is promoted through a better teaching and training effect, and the medical service experience and personal safety of a patient are guaranteed.

The invention relates to the technical field of lumbar puncture devices, in particular to an optical fiber lumbar puncture pressure measuring injection gun. The device is characterized in that (1) an optical fiber is used for replacing an original needle core, and a grating is arranged at the position, close to a needle head, of the optical fiber, so that the device can play a role of the original needle core and can accurately position a puncture position by measuring the tissue refractive index; and (2) a novel fiber bragg grating bourdon tube pressure sensor is added, so that accurate real-time pressure measurement in the puncture process is realized. (3) a cerebrospinal fluid collecting and discharging operation trigger and a piston injector operation trigger are arranged on an operation gun, a piston injector and a one-way valve injector are arranged at the muzzle end of the operation gun, and a push rod of the one-way valve injector is fixedly connected with the cerebrospinal fluid collecting and discharging operation trigger through a first connecting rod; a collection one-way valve I is arranged at the inlet end of the one-way valve injector, a discharge one-way valve II is arranged at the outlet end of the one-way valve injector, and the inlet end is in airtight communication with the puncture needle through a three-way structure. A push rod of the piston injector is fixedly connected with the piston injector operation trigger through the second connecting rod, a discharging one-way valve III is arranged at the inlet end of the piston injector, and the inlet end of the piston injector is in airtight communication with a puncture needle through a three-way structure. The cerebrospinal fluid collecting and discharging trigger is pressed down so that negative pressure can be formed in the one-way valve injector, the cerebrospinal fluid discharging trigger is released so that positive pressure can be formed in the one-way valve injector, and the puncture process of a needle core in the puncture needle and the puncture process of a pressure measuring device are optimized through fiber bragg gratings. The pressure of cerebrospinal fluid is dynamically monitored at a time, a cerebrospinal fluid sample is reserved, a contrast agent and medicine are injected, and the lumbar puncture pressure measuring and liquid discharging injection process is optimized.

The invention relates to the technical field of medical training, and discloses a lumbar puncture simulation teaching system based on an AR technology, and the system comprises an AR content generation module which collects a lumbar medical image and carries out the tissue segmentation and focus recognition; performing three-dimensional geometric modeling based on the tissue segmentation result and the focus recognition result to generate a lumbar vertebra 3D model; the AR display interaction module develops an interaction function of the lumbar vertebra 3D model by using a Unity platform and AR equipment; interactive operation of the user is monitored, and feedback is conducted in real time; and the operation evaluation module is used for evaluating the interaction operation of the user and assigning an improvement suggestion according to an evaluation result. A three-dimensional visual scene is constructed through the AR technology, a user can observe the needle inserting process from different angles according to the complex anatomical structure of the lumbar vertebra part, and dynamic effects such as cerebrospinal fluid pressure change are simulated; in the lumbar puncture simulation training, the AR system can feed back operation data in real time, such as the needle inserting angle, the puncture strength and the puncture depth, and the user is helped to accurately master operation skills.

The invention relates to the technical field of medical teaching, and discloses a noninvasive intracranial pressure continuous monitoring teaching device and a fluctuation trend prediction method.The noninvasive intracranial pressure continuous monitoring teaching device comprises a protective shell and a closed-loop fluid system integrated in the protective shell, and the closed-loop fluid system is composed of a pump body, an intracranial simulation block, a first connecting pipe, a second connecting pipe, a third connecting pipe and a pressure regulating valve; the output end of the pump body is communicated with an input cavity of the intracranial simulation block through a first connecting pipe, the backflow end of the pump body forms a closed loop through a second connecting pipe, a pressure adjusting valve and a third connecting pipe, a detector used for collecting simulated intracranial pressure data in real time is arranged at the top end of the intracranial simulation block, and a display screen is arranged on the outer surface of the protective shell. A closed-loop fluid loop is constructed through a pump body, an intracranial simulation block and a pressure regulating valve regulated and controlled by PID, cerebrospinal fluid circulation is dynamically simulated, and the problem that traditional teaching lacks real pathological environment simulation and operation safety is effectively solved in combination with an embedded training lumbar puncture hole.

The invention discloses an early evaluation method, device and system for Alzheimer's disease. The method comprises the following steps: detecting whether a user completes a preset short-term task or not; when the user completes the preset short-term task, acquiring physiological data of the user; inputting the physiological data into an evaluation model to obtain a risk score, the evaluation model being an Alzheimer's disease early evaluation model; and generating an assessment report according to the risk score. According to the method, when the user completes the preset short-term task, the physiological data of the user are collected and input into the Alzheimer's disease early assessment model to obtain the risk score, so that the assessment report is obtained, the assessment report can be obtained without lumbar puncture, PET imaging detection and high-resolution MRI detection of the user, and the user experience is improved. The compliance is improved; the detection cost is reduced; and the detection timeliness is improved.

The present invention relates to an MRI-based method for predicting a degree of accumulation of a biomarker associated with Alzheimer's disease and a companion diagnosis method using same, wherein a degree of accumulation of a biomarker associated with Alzheimer's disease in each brain area of a subject can be accurately predicted using positron emission tomography (PET) or in cerebrospinal fluid (CSF) through a lumbar puncture without directly measuring an accumulated level of the biomarker associated with Alzheimer's disease, whereby the present invention can be used for diagnosis and companion diagnosis of various neurodegenerative diseases.

The invention provides an intelligent drug delivery method and system for pre-pump injection of m-hydroxylamine. The method comprises the following steps: determining an initial pumping rate, a target blood pressure range and a heart rate alarm threshold value of m-hydroxylamine according to initial information of a target patient; pre-pump injection of m-hydroxylamine is carried out according to the initial pump injection rate at a first preset time before lumbar anesthesia puncture operation; after the lumbar anesthesia puncture operation is completed, the current systolic pressure and the current heart rate of the target patient are collected based on the preset frequency; according to the current systolic pressure, the current heart rate, the target blood pressure range and the heart rate alarm threshold value, the initial pumping rate of m-hydroxylamine is adjusted; and carrying out pump injection of m-hydroxylamine based on the adjusted pump injection rate. By means of the method, pre-pumping injection is started before lumbar anesthesia puncture operation, occurrence of hypotension is preempted from the time dimension, the initial pumping injection rate is set based on information of a patient, the pumping injection rate is intelligently adjusted according to real-time feedback of the initial pumping injection rate, and therefore the occurrence rate of hypotension after cesarean section lumbar anesthesia is reduced.

The application discloses a lumbar puncture auxiliary mechanism and a use method thereof. The lumbar puncture auxiliary mechanism comprises a main body assembly, a supporting shell fixed to one side of a positioning disc, and a puncture needle penetrating through the positioning disc and the supporting shell. The main body assembly is provided with an adjusting assembly in the supporting shell. The adjusting assembly comprises a driving element arranged on one side of the positioning disc, a transmission element arranged on one side of the driving element, and an adjusting element arranged on one side of the transmission element. The adjusting element comprises a limiting shell fixed to the inner wall of the supporting shell, a rack sliding in the limiting shell, and a first spring fixed to the end of the rack. The adjusting assembly can intermittently supply the puncture needle, so that the puncture needle can smoothly break through the yellow ligament without improper force. The puncture process can be judged, so that the time when the puncture needle enters the epidural space and the subarachnoid space can be accurately grasped, and the accidental damage to the human body is reduced.

The utility model relates to the technical field of postoperative rehabilitation, in particular to a bone lumbar puncture postoperative compression hemostasis device and a lumbar puncture postoperative compression hemostasis device.The bone lumbar puncture postoperative compression hemostasis device comprises a hemostasis unit which comprises a transparent patch, a hemostasis assembly arranged at the bottom of the transparent patch and a pressing assembly arranged on the upper portion of the transparent patch; the hemostasis assembly and the pressing assembly are matched with each other, and the hemostasis assembly comprises sponge arranged at the bottom of the transparent patch, antibacterial gel arranged on the sponge and a pasting part arranged on the transparent patch. The compression hemostasis device used after bone lumbar puncture has the advantages that the hemostasis assembly is matched with the pressing assembly, the operation that a third party needs to assist in pressing is omitted, manpower of clinical nursing staff is greatly saved, accuracy of the pressing position can be improved, a specially-assigned person is not needed for pressing, time of medical staff is saved, and the working efficiency of the medical staff is improved. The pressing time can be adjusted according to the actual condition of the patient.

The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.

The utility model provides a restraint strap for a lumbar puncture patient. According to the restraint strap, elastic bands are symmetrically sewn on a chest strap, a son buckle and a mother buckle are arranged at the two ends of the chest strap respectively, two straps are sewn on the upper portion of the chest strap, the straps are connected with a chest strap connecting strap through buckles shaped like a Chinese character'ri ', upper Y-shaped straps are sewn on the tops of the straps, leg straps are sewn on the lower portions of lower Y-shaped straps, and the upper Y-shaped straps are connected with the lower Y-shaped straps through buckles shaped like a Chinese character'ri'. Velcro tapes are arranged at the two ends of the leg bridle, a son buckle and a buckle shaped like a Chinese character'ri 'are fixedly arranged at the two ends of the connecting band respectively, and the upper Y-shaped bridle is connected with the lower Y-shaped bridle through the connecting band. The restraint strap can stably fix the body of a patient, reduces unnecessary movement of the patient in the lumbar puncture process, helps the patient to keep a standard lumbar puncture body position, facilitates accurate positioning of a puncture point, shortens the lumbar puncture time, is reasonable in structural design, easy, convenient and practical to operate, reduces repeated operation caused by lumbar puncture failure, and improves the lumbar puncture success rate. And the efficiency of lumbar puncture is improved.

The invention discloses a back puncture operation patient chair which comprises a chair back, the inclination of the chair back relative to the horizontal plane can be adjusted, a posture adjusting assembly is arranged on the face, making contact with a patient, of the chair back, and the supporting angle between the patient and the chair back is adjusted through the posture adjusting assembly; the seat cushion is hinged to the chair back, the seat cushion is used for supporting a patient, and a chair back inclination adjusting assembly is installed between the seat cushion and the chair back. Through the posture adjusting assembly arranged on the chair back, the posture angle, especially the thoracic cavity arching degree, of a patient can be accurately adjusted according to different operation requirements (such as thoracic cavity puncture and lumbar puncture), so that it is ensured that the patient can keep a proper posture in the operation process, discomfort caused by long-time operation is relieved, and meanwhile, the patient can be prevented from being injured. The inclination adjusting function of the seat cushion and the chair back enables the patients with different body types to be effectively supported, and the comfort is further improved.

This invention discloses a human fixation device suitable for lumbar puncture in children, comprising: a bed with an mounting surface; a thoracic restraint device disposed on the mounting surface, the thoracic restraint device including a first restraint surface and a first restraint strap, the first restraint strap binding the thoracic cavity of the human body to the first restraint surface; a lumbar guide assembly, the lumbar guide assembly being a guide plate for attaching to the lumbar region of the human body, the guide plate having guide perforations; and a leg restraint device rotatably connected to the mounting surface, the leg restraint device including a second restraint surface and a second restraint strap, the second restraint strap binding the human legs to the second restraint surface. The thoracic and leg restraint devices achieve restraint of the upper and lower body of the human body, and the restraint straps can simultaneously fix the patient's upper arm and forearm, thereby significantly reducing patient mobility and improving the restraint effect.

The lumbar puncture system comprises a medical bed, a first mechanical arm, a second mechanical arm, a ray digital imaging system and a displayer, a ray detector is integrated on the medical bed, a ray generator is integrated at the tail end of the first mechanical arm, and the first mechanical arm adjusts the displacement and angle of the ray generator relative to the ray detector; the positioning grid is used for covering a puncture part of a patient and is positioned between the ray detector and the ray generator; the ray digital imaging system receives a signal of the ray detector and converts the signal into a digital image displayed by the display; a puncture module is integrated at the tail end of the second mechanical arm, and the second mechanical arm adjusts the puncture position and the puncture angle of the puncture module based on the digital image; the puncture angle and the puncture position before puncture are positioned, meanwhile, the puncture success rate is increased through imaging feedback in the puncture process, and it can be guaranteed that basic data support the success of secondary puncture even if a failure exists.

The lumbar puncture auxiliary mechanism comprises a main body assembly, the main body assembly comprises a positioning disc and a supporting shell fixed to one side of the positioning disc, and a puncture needle penetrates through the positioning disc and the supporting shell; the adjusting assembly is arranged in the supporting shell and comprises a driving piece arranged on one side of the positioning disc, a transmission piece is arranged on one side of the driving piece, an adjusting piece is arranged on one side of the transmission piece and comprises a limiting shell fixed to the inner wall of the supporting shell, a rack slides in the limiting shell, and a first spring is fixed to the end of the rack. By arranging the adjusting assembly, intermittent supply can be conducted on the puncture needle, so that the puncture needle can smoothly break through the ligamentum flavum, and the situation of improper force exertion is avoided; the puncture process can be judged, so that the opportunity that the puncture needle enters the epidural space and the subarachnoid space is accurately grasped, and accidental injuries to the human body are reduced.

The invention relates to a lumbar puncture training system which comprises a master control system, and the master control system is connected with a three-dimensional model management subsystem, a puncture training subsystem, a training management subsystem and AR glasses. A three-dimensional model is preset in the three-dimensional model management subsystem, the three-dimensional model management subsystem is used for forming a training model, and the main control system is used for transmitting the training model to the AR glasses for display; the puncture training subsystem is used for judging whether the puncture information of the user on the entity model is matched with the puncture image information on the three-dimensional model or not; and the training management subsystem is used for managing information of students and recording puncture records of the students. According to the application, the VR / MR technology and the entity model are combined and applied to clinical skill practical operation teaching and real-time feedback of the operation process, and a basis is provided for error correction of students in the teaching process for teachers, so that the lumbar puncture success rate of living training doctors is improved, and the overall operation ability of lumbar puncture is improved.

The invention discloses an early evaluation method, device and system for Alzheimer's disease. The method comprises the following steps: acquiring magnetic resonance imaging data and physiological data of a user; inputting the magnetic resonance imaging data and the physiological data into a cross-modal feature fusion model to obtain fusion features; inputting the fusion features into an expert model to obtain a prediction result; and generating an evaluation report according to the prediction result. According to the method, the magnetic resonance imaging data and the physiological data are processed through the cross-modal feature fusion model, so that the high-level fusion features are obtained, then the expert model is used for processing the fusion features, so that the prediction result is obtained, the evaluation report is obtained, a user can obtain the evaluation report without lumbar puncture and PET imaging detection, and the user experience is improved. The compliance is improved; and the detection cost is reduced.

The utility model relates to the technical field of neonatal lumbar puncture fixing, in particular to a neonatal lumbar puncture fixing device which is characterized by comprising a flexible wrapping piece, exposure holes used for exposing the waist and the back of a neonatal are formed in the flexible wrapping piece, and bandages are arranged at the four corners of the flexible wrapping piece. The two groups of bandages located at the opposite angles are sequentially crossed and bound, so that the flexible wrapping pieces fixedly wrap the neck, the trunk and the four limbs of the newborn, and the body of the newborn is bent into a lumbar puncture position. The neonate lumbar puncture body position keeping effect is good, the neonate feels more comfortable, the body temperature of the neonate is not prone to losing, the neonate pacifying effect is better, the overall applicability is better, the whole putting-on and taking-off operation is easier and easier, putting-on and taking-off are convenient, and the overall working efficiency of medical staff is improved.

The present invention relates to a support system or device for lumbar punctures; in particular, this invention comprises of a lumbar puncture support system / device for the positioning of the infant that maintains an optimal quality of immobilization of the infant during a lumbar puncture. The device comprises a seat base defining a leg support portion, a hip support portion and a back support portion. The hip support and the back support portion receives a hip of the infant. The leg support portion is positioned higher than the hip support position to cause thighs and knees of the infant to be close to or to touch an upper body of the infant to provide clear and exposed back of the infant for the lumbar puncture.

The invention discloses a pediatric lumbar puncture protection device and an operation method thereof, which is characterized in that a calf sleeve connecting belt is provided between two calf sleeves, a thigh sleeve connecting belt is provided between two thigh sleeves, a front arm sleeve connecting belt is provided between two forearm sleeves, a rear arm sleeve connecting belt is provided between two rear arm sleeves, a large and small calf sleeve connecting belt connection point is provided between the calf sleeve connecting belt and the thigh sleeve connecting belt, and a front and rear arm sleeve connecting belt connection point is provided between the forearm sleeve connecting belt and the rear arm sleeve connecting belt. The waist pad has a waist pad strap wrapped around the waist behind the human body, and a notch is provided behind the waist pad, and the notch is located outside the lumbar spine, and the notch is exposed for the lumbar puncture site. The advantages are: cotton cloth pieces are used to make sleeves for various parts, and the tightening sleeve can be adjusted to make the child obediently operated by the doctor without giving medicine, and the child cooperates well, the structure is reasonable, the production is easy, the materials are small, the raw materials are easy to obtain, and the operation and use are safe and reliable.

The invention relates to the technical field of lumbar puncture, in particular to a lumbar puncture developing positioning device which comprises a mechanical arm, a positioning grid and a supporting seat are fixedly connected to the mechanical arm, the positioning grid is used for emitting positioning longitude lines and positioning latitude lines, and a positioning assembly and a puncture assembly are fixedly connected to the supporting seat; the positioning assembly comprises a first telescopic rod and a suction cup, one end of the first telescopic rod is fixedly connected with the supporting seat, and the other end of the first telescopic rod is fixedly connected with the suction cup; the puncture assembly comprises a fixed pipe, a first square rod, a first lead screw, a second lead screw, a movable block, a first gear, an inner threaded pipe, a second square rod and a puncture pipe. The puncture position can be accurately aimed and positioned through the positioning grid, the probability of puncture failure easily caused by blind puncture under the condition that the spine structure is abnormal or varied or a patient is obese is reduced, blind puncture is prevented from being judged completely depending on experience of a doctor, and the success rate of puncture is increased.

The invention belongs to the technical field of medical instruments, and particularly relates to a lumbar puncture auxiliary positioning device which comprises a backrest plate, the lower end of the backrest plate is rotationally connected with a hip supporting plate, a pillow plate is fixedly mounted at the upper end of the backrest plate, an open groove is formed in the backrest plate, and a sliding groove is formed in the inner wall of one side of the open groove; a through groove is formed in the inner wall of the other side of the backrest plate in a penetrating mode, a first sliding plate is arranged in the sliding groove in a sliding mode, a second sliding plate is arranged in the through groove in a sliding mode, and the end of the second sliding plate is fixedly connected with a circular ring located on the outer side of the backrest plate. The hip joints, knee joints, the head and the neck of a patient are bent through the arrangement of the backrest plate and the hip supporting plate, then puncture points are conveniently found, adjustment of the puncture angle and depth is achieved through rotation of the rotating block and the threaded pipe, then a needle head can penetrate through the intervertebral space and enter the epidural space or the subarachnoid space, and a cerebrospinal fluid sample is rapidly obtained.

The invention relates to an infant positioning device for stabilizing and maintaining an infant in a fixed position for a lumbar puncture procedure. The device consists of a frame stand with openings for the infant's face and abdomen to support the infant in the proper position for the procedure and allow for unimpeded ventilation, a component of the frame to secure and stabilize the infant within the frame stand to prevent movement during the procedure, and an attachment stand to the frame that allows the frame to be free-standing. Vertically adjustable shoulder guards, tension-adjustable back strap, and tension adjustable head strap are provided for a custom fit.

The utility model relates to the technical field of medical instruments, and discloses a lumbar puncture body position fixing device which comprises a carrier plate, first air cylinders are fixedly connected to the edges of the two sides of the bottom wall, close to a first mounting groove, of the carrier plate, and a first rotating pin is rotationally connected to the middle of the bottom wall, close to the first mounting groove, of the carrier plate. A rotating plate is fixedly connected to the outer wall of the first rotating pin, connecting rods are rotatably connected to the two sides of the surface of the upper end of the rotating plate, first moving plates are rotatably connected to the ends, away from the first rotating pin, of the connecting rods, and two first connecting plates are fixedly connected to the surfaces of the upper ends of the two first moving plates; and the upper end surfaces of two adjacent first connecting plates are fixedly connected with the same positioning seat. According to the utility model, through the matching arrangement of the positioning seat and the arc-shaped plate, the activity space of a patient can be compressed, the patient is forced to keep a fixed body position, and the assistance of another medical personnel is not needed in the operation process.

The invention discloses a body position auxiliary device for lumbar puncture, and belongs to the technical field of lumbar puncture, the body position auxiliary device comprises a main body module and an arc plate module, the main body module comprises a rotating cylinder, the outer surface of the rotating cylinder is rotatably sleeved with a central rotating sleeve, and the outer surface of the central rotating sleeve is fixedly connected with a binding assembly; the arc plate module comprises a plurality of steering assemblies, through arrangement of an external rotating sleeve, the steering assemblies, locking assemblies, linkage assemblies and first locking grooves, accurate adjustment and stable locking of the optimal bending radian of the waist of a patient are achieved, and through cooperation with sequential hinging of a plurality of steering units in the steering assemblies, the optimal bending radian of the waist of the patient is adjusted. The whole radian can be flexibly adjusted to adapt to body types and age differences of different patients, the problems that in the prior art, manual supporting is prone to fatigue, and bandage fixing is difficult to achieve accurately are solved, it is ensured that the patient stably maintains the individualized optimal waist bending radian in the whole puncture process, the accuracy of intervertebral space exposure is improved, and the puncture difficulty is reduced.

The utility model discloses a back puncture operation patient chair which comprises a chair back, the inclination of the chair back relative to the horizontal plane can be adjusted, a posture adjusting assembly is arranged on the face, making contact with a patient, of the chair back, and the supporting angle between the patient and the chair back is adjusted through the posture adjusting assembly. The seat cushion is hinged to the chair back, the seat cushion is used for supporting a patient, and a chair back inclination adjusting assembly is installed between the seat cushion and the chair back. By means of the posture adjusting assembly arranged on the chair back, the posture angle, especially the thoracic cavity arching degree, of a patient can be accurately adjusted according to different operation requirements (such as thoracocentesis and lumbar puncture), so that it is ensured that the patient can keep a proper posture in the operation process, discomfort caused by long-time operation is relieved, and meanwhile the patient can be prevented from being injured. The inclination adjusting function of the seat cushion and the chair back enables the patients with different body types to be effectively supported, and the comfort is further improved.

The invention belongs to the field of biological medicine, and particularly relates to a medicine for treating EGFR mutation non-small cell lung cancer meningeal metastasis, application, a medicine box and a preparation method of the medicine, the medicine is a freeze-dried powder preparation or injection of EGFR-TKIs for subarachnoid space injection, the amount of EGFR-TKIs per person in the medicine is 0.01-5 mg, and the amount of EGFR-TKIs in the medicine is 0.01-5 mg. The injection method comprises any one of lumbar puncture, bridge forebay indwelling catheter injection and Ommaya capsule injection. The prepared EGFR-TKIs injection can be directly injected into the subarachnoid space, the drug concentration in cerebrospinal fluid of a patient is greatly improved, the cerebrospinal fluid / plasma concentration ratio of the EGFR-TKIs injection is increased from far less than 1 to more than 2 times and even can reach more than 10 times, and the EGFR-TKIs injection can completely solve the problem of insufficient dosage caused by a blood-brain barrier after oral administration of a targeted drug and has a good application prospect. The medicine takes effect quickly, and the treatment effect on lung cancer meningeal metastasis can be remarkably improved.

The invention relates to the field of medical puncture, in particular to a child body position fixing structure and a puncture bed, the child body position fixing structure comprises a plate frame, a waist plate, a thigh plate, a shank plate and a head plate, the head plate is rotatably arranged at one end of the waist plate, and the thigh plate is rotatably arranged at the other end of the waist plate; the end part of the shank plate is rotationally connected with the end part, far away from the waist plate, of the thigh plate; leg binding belts are arranged on the thigh plate or the shank plate, shoulder binding belts are arranged on the head plate, and puncture holes and a waist binding belt are arranged on the waist plate; the waist plate, the thigh plate, the shank plate and the head plate are all mounted in the plate frame; the waist plate is fixedly connected with the plate frame, and a rotating shaft is arranged at the end of the plate frame. The supporting part is used for supporting the thigh plate or the shank plate and the head plate which are in a flat state, and the supporting part is fixedly arranged on the plate frame. The scheme is mainly used for fixing the body position of a child when the child is subjected to lumbar puncture, bone puncture, abdominal puncture and venipuncture.