36 results about "Lumbar puncture" patented technology

The invention provides an intelligent drug delivery method and system for pre-pump injection of m-hydroxylamine. The method comprises the following steps: determining an initial pumping rate, a target blood pressure range and a heart rate alarm threshold value of m-hydroxylamine according to initial information of a target patient; pre-pump injection of m-hydroxylamine is carried out according to the initial pump injection rate at a first preset time before lumbar anesthesia puncture operation; after the lumbar anesthesia puncture operation is completed, the current systolic pressure and the current heart rate of the target patient are collected based on the preset frequency; according to the current systolic pressure, the current heart rate, the target blood pressure range and the heart rate alarm threshold value, the initial pumping rate of m-hydroxylamine is adjusted; and carrying out pump injection of m-hydroxylamine based on the adjusted pump injection rate. By means of the method, pre-pumping injection is started before lumbar anesthesia puncture operation, occurrence of hypotension is preempted from the time dimension, the initial pumping injection rate is set based on information of a patient, the pumping injection rate is intelligently adjusted according to real-time feedback of the initial pumping injection rate, and therefore the occurrence rate of hypotension after cesarean section lumbar anesthesia is reduced.

The application discloses a lumbar puncture auxiliary mechanism and a use method thereof. The lumbar puncture auxiliary mechanism comprises a main body assembly, a supporting shell fixed to one side of a positioning disc, and a puncture needle penetrating through the positioning disc and the supporting shell. The main body assembly is provided with an adjusting assembly in the supporting shell. The adjusting assembly comprises a driving element arranged on one side of the positioning disc, a transmission element arranged on one side of the driving element, and an adjusting element arranged on one side of the transmission element. The adjusting element comprises a limiting shell fixed to the inner wall of the supporting shell, a rack sliding in the limiting shell, and a first spring fixed to the end of the rack. The adjusting assembly can intermittently supply the puncture needle, so that the puncture needle can smoothly break through the yellow ligament without improper force. The puncture process can be judged, so that the time when the puncture needle enters the epidural space and the subarachnoid space can be accurately grasped, and the accidental damage to the human body is reduced.

The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.

The utility model provides a restraint strap for a lumbar puncture patient. According to the restraint strap, elastic bands are symmetrically sewn on a chest strap, a son buckle and a mother buckle are arranged at the two ends of the chest strap respectively, two straps are sewn on the upper portion of the chest strap, the straps are connected with a chest strap connecting strap through buckles shaped like a Chinese character'ri ', upper Y-shaped straps are sewn on the tops of the straps, leg straps are sewn on the lower portions of lower Y-shaped straps, and the upper Y-shaped straps are connected with the lower Y-shaped straps through buckles shaped like a Chinese character'ri'. Velcro tapes are arranged at the two ends of the leg bridle, a son buckle and a buckle shaped like a Chinese character'ri 'are fixedly arranged at the two ends of the connecting band respectively, and the upper Y-shaped bridle is connected with the lower Y-shaped bridle through the connecting band. The restraint strap can stably fix the body of a patient, reduces unnecessary movement of the patient in the lumbar puncture process, helps the patient to keep a standard lumbar puncture body position, facilitates accurate positioning of a puncture point, shortens the lumbar puncture time, is reasonable in structural design, easy, convenient and practical to operate, reduces repeated operation caused by lumbar puncture failure, and improves the lumbar puncture success rate. And the efficiency of lumbar puncture is improved.

The utility model relates to the technical field of neonatal lumbar puncture fixing, in particular to a neonatal lumbar puncture fixing device which is characterized by comprising a flexible wrapping piece, exposure holes used for exposing the waist and the back of a neonatal are formed in the flexible wrapping piece, and bandages are arranged at the four corners of the flexible wrapping piece. The two groups of bandages located at the opposite angles are sequentially crossed and bound, so that the flexible wrapping pieces fixedly wrap the neck, the trunk and the four limbs of the newborn, and the body of the newborn is bent into a lumbar puncture position. The neonate lumbar puncture body position keeping effect is good, the neonate feels more comfortable, the body temperature of the neonate is not prone to losing, the neonate pacifying effect is better, the overall applicability is better, the whole putting-on and taking-off operation is easier and easier, putting-on and taking-off are convenient, and the overall working efficiency of medical staff is improved.

The invention relates to an infant positioning device for stabilizing and maintaining an infant in a fixed position for a lumbar puncture procedure. The device consists of a frame stand with openings for the infant's face and abdomen to support the infant in the proper position for the procedure and allow for unimpeded ventilation, a component of the frame to secure and stabilize the infant within the frame stand to prevent movement during the procedure, and an attachment stand to the frame that allows the frame to be free-standing. Vertically adjustable shoulder guards, tension-adjustable back strap, and tension adjustable head strap are provided for a custom fit.

The invention relates to the technical field of medical instruments, in particular to a lumbar puncture auxiliary device for blood clinic, which comprises a bed body, a base and a telescopic rod mounted on the base, a connecting plate is mounted at the top end of the telescopic rod, an air cylinder is mounted on the base, and the output end of the air cylinder is fixedly connected with the connecting plate; the moving part is installed on the connecting plate, a buffering part is installed on the moving part, and the moving part and the buffering part are used for positioning the back and the abdomen of the patient; the massage component is mounted on the moving component, and the massage component is used for massaging a patient; according to the scheme, through mutual cooperation of the moving part, the buffering part and other structures, accurate positioning of the back and the abdomen of the patient is facilitated, and therefore a doctor can conveniently conduct lumbar puncture operation; the requirements of different patients can be met.

The invention relates to the technical field of medical instruments, in particular to a head fixing device which comprises a bed body, a mounting seat arranged in a bed head mounting shell of the bed body and a forehead clamping mechanism arranged on the rear side of the top of the mounting seat and connected with the pillow through a traction piece, a clutch mechanism is arranged on the rear side of the forehead clamping mechanism and connected with the forehead clamping mechanism through three telescopic electromagnetic rods. The cheek clamping mechanisms are arranged on the left side and the right side of the pillow and connected with the clutch mechanism, and the problems that in the prior art, a head fixing device for traditional Chinese medicine is prone to being pressed too tightly or loosened in the actual use process, the head fixing adaptability and precision are insufficient, linkage is lacked, and the clinical operation efficiency is low are solved. The problems that in the prior art, vomiting complications of a patient after lumbar puncture are not considered, body position changes of the patient are easily caused, the illness state is aggravated, the convenient reset unlocking capacity is not achieved, and secondary injury is easily caused when fixation is removed are solved.

The application discloses a cell medicine protection liquid for injection and a preparation method and application thereof, and particularly relates to the technical field of biological medicine. The protection liquid comprises the following components: sodium chloride 5.5-6.5 mg / ml, potassium chloride 0.2-0.4 mg / ml, sodium lactate 2.5-3.5 mg / ml, calcium chloride 0.1-0.3 ug / ml, glucose 0.15-0.3 ug / ml, neurotrophic factor 0.5-2 ug / ml, and compound amino acid 4 ul / 100 ml. The protection liquid can be used for storing cell medicine for human lumbar puncture injection, and the medicine storage time is long, which helps to save valuable time for new fresh preparation detection and application of drug companies. The application uses a freeze storage tube, which is portable, convenient to transport and simple to operate, and does not need special treatment and direct application, thereby solving the limitation of no corresponding environment and equipment application, and greatly saving the cost.

The invention relates to the technical field of medical measurement, in particular to a lumbar puncture drainage device and method for continuously measuring cerebrospinal fluid pressure, and the lumbar puncture drainage device for continuously measuring cerebrospinal fluid comprises a puncture needle, a drainage cerebrospinal fluid container, an electronic pressure sensor, a drainage catheter, a shifting piece, an electronic element packaging tube and a signal transmission coil; the puncture needle and the cerebrospinal fluid drainage container are connected through the puncture needle and cerebrospinal fluid drainage container connector; the puncture needle and the cerebrospinal fluid drainage container joint are detachable; the cerebrospinal fluid drainage container is provided with a cerebrospinal fluid drainage channel, and the drainage catheter is connected with the cerebrospinal fluid drainage channel; the shifting piece is horizontally arranged in the cerebrospinal fluid drainage channel; the cerebrospinal fluid drainage channel is provided with a circular groove; the orifice of the drainage catheter is embedded in the circular groove; and the circular groove is tightly connected with the drainage catheter. The safety, reliability and maintenance convenience of the cerebrospinal fluid drainage device are improved.

The invention provides a lumbar puncture robot control method based on finite element simulation and fuzzy control, and relates to the field of lumbar puncture control, and the method specifically comprises the following steps: building a finite element puncture model covering a multi-layer soft tissue structure; analyzing an influence rule of different needle inserting speeds and angles on puncture force change, and extracting tissue interlayer breakthrough feeling characteristics; a three-input single-output fuzzy controller is designed, and a fuzzy rule table is constructed by taking the puncture force, the force sudden change value and the puncture depth as input and taking the needle inserting speed as output. According to the technical scheme, the problems that in the prior art, a lumbar puncture control strategy is low in precision and safety and poor in adaptability are solved.

A lumbar puncture restraint frame, comprising a bed plate, a popliteal fossa limiting block is slidably arranged on the lower part of the bed plate, and a limiting block positioning mechanism is arranged between the popliteal fossa limiting block and the bed plate; a back block is slidably arranged on the upper part of the middle part of the bed plate, and a block positioning mechanism is arranged between the back block and the bed plate; a chest and abdomen block is further arranged on the bed plate between the popliteal fossa limiting block and the back block. The lumbar puncture restraint frame solves the problem of lacking of body position restraining equipment in the prior art, is suitable for people who are difficult to maintain body position under forced body position, and is especially suitable for young patients. The equipment has simple structure, low cost and easy maintenance.

1. Name of the product in this design: Lumbar puncture device. 2. Purpose of this design: For use in lumbar puncture. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a child lumbar puncture fixing and restraining device and a fixing and restraining method, belongs to the field of surgical operation related instruments, is used for solving the problems that during child lumbar puncture, body position fixing is difficult, and fear resistance is likely to be generated, and is suitable for child lumbar puncture diagnosis and treatment scenes. The device comprises a base, a seat barrel, a backrest plate, an air pump, an air bag cushion, a shaking mechanism, a locking mechanism and an exhaust assembly. A holding rod is arranged on the inner wall of the seat barrel; the shaking mechanism comprises a first permanent magnet, a second permanent magnet, a second spring and a lifting column, the locking mechanism comprises an air bag pipe, a clamping pin column and a fixing cylinder, and the exhaust assembly comprises a pressing column, an air blocking plate and an exhaust box. During use, a child is guided to curl to sit, the air pump is started to inflate the airbag cushion to restrain the body position, and meanwhile the shaking mechanism is triggered to drive the seat barrel to shake up and down; after the movable plate covers the air delivery pipe connector, the air drives the locking mechanism to lock the seat barrel, the device has the fixing safety and the child pacifying effect, and operation is convenient and fast.

The present disclosure relates to an improved spinal needle apparatus 10 comprising a stylet assembly 12 including a stylet hub 14 and a stylet 16; a needle assembly 18 including a needle hub 20, a housing 22 and a hollow needle 24. The apparatus is configured to enhance precision and safety during spinal procedures, with features such as an ergonomic stylet hub 14, a secure pressure fit connection between the stylet hub 14 and needle hub 20, and a tube insert 48 accommodating various needle gauges. The apparatus facilitates accurate needle placement and verification of cerebrospinal fluid return, improving outcomes in lumbar punctures and spinal anesthesia.

The utility model relates to the technical field of body position fixing, and discloses a body position fixing device for a lumbar puncture patient, which comprises a bed board, a mattress is placed on the outer wall of the bed board, a human body groove is arranged on the outer wall of the mattress, a hinge structure is movably connected to the outer wall of the bed board, a folding board is connected to the outer wall of the hinge structure, and the folding board is provided with a folding groove. A movable groove is formed in the outer wall of the folding plate, the inner wall of the movable groove is connected with a lead screw, the outer wall of the lead screw is connected with a manual operation rod, the outer wall of the lead screw is sleeved with a sliding block, the outer wall of the sliding block is connected with a connector, and the inner wall of the connector is in threaded connection with a screw. By arranging the sliding block, the hand-operated rod, the pedal plate, the mattress and other structures, the patient can bend the legs without exerting force, under the condition that the hand-operated rod is manually rotated, the sliding block can carry the pedal plate to slide along the outer wall of the lead screw, and then the pedal plate can be adjusted to be in the length fit with the legs of the human body.

The application belongs to the field of biological medicine, and particularly relates to a drug for treating EGFR mutant non-small cell lung cancer meningeal metastasis, application, a medicine box and a preparation method of the drug, the drug is a lyophilized powder preparation or injection solution for subarachnoid injection of EGFR-TKIs, the amount of EGFR-TKIs in the drug is 0.01-5 mg per person, and the injection method comprises any one of lumbar puncture, injection through a catheter indwelled in the pre-bridge pool and Ommaya capsule injection. The prepared EGFR-TKIs injection solution can be directly injected into the subarachnoid space, greatly improving the drug concentration in the cerebrospinal fluid of the patient, the cerebrospinal fluid / plasma concentration ratio is increased from far less than 1 to more than 2 times, and even more than 10 times. The application can completely solve the problem of insufficient dose caused by the blood-brain barrier after oral administration of a targeted drug, and the drug has fast effect and can significantly improve the treatment effect of lung cancer meningeal metastasis.

The utility model discloses a lumbar puncture lateral position placing device which comprises a sickbed, two sets of transverse moving devices and height adjusting devices are arranged on the two sides of the sickbed, each height adjusting device comprises a supporting sleeve and a supporting rod, clamping grooves are formed in the supporting rods, clamping blocks are symmetrically arranged in the clamping grooves, clamping rods are arranged on the clamping blocks, and the clamping rods are arranged on the clamping blocks. Clamping holes matched with the clamping rods are formed in the supporting sleeves, adjusting blocks are arranged in the clamping grooves, adjusting rods are arranged on the two sides of the adjusting blocks, inclined grooves are formed in the clamping blocks, driving air cylinders are arranged on one sides of the supporting rods, hinge seats are arranged at the output ends of the driving air cylinders, hinge shafts are arranged on the hinge seats, and extrusion plates are arranged on the hinge shafts; the height of the squeezing plates is adjusted through the height adjusting device, the positions of the squeezing plates on a sickbed are conveniently adjusted through the transverse moving device, one squeezing plate is located on the upper portion of the back of a patient, the other squeezing plate is located on the curled shank of the patient, then the lateral position is conveniently fixed, and the patient is prevented from moving.

The utility model relates to an external auxiliary device for an Ommaya bag, which comprises a three-way cock, a puncture needle, a pressure measuring pipe joint and an injection joint, and three interfaces of the three-way cock are respectively connected with the puncture needle, the pressure measuring pipe joint and the injection joint. The utility model aims to provide the reliable device for measuring the pressure of the cerebrospinal fluid, extracting the cerebrospinal fluid and injecting the medicine, which is externally connected with the liquid storage bag, can be used for conveniently measuring the pressure of the cerebrospinal fluid, extracting the cerebrospinal fluid and injecting the medicine, is simple in structure and does not damage the bag wall. The liquid storage bag is externally connected with an auxiliary device, so that pains and risks caused by repeated lumbar puncture pressure measurement are avoided, and the medical workload is also relieved; the device is externally connected with an infusion apparatus, so that the infusion speed, time and quantity of medicines can be freely controlled.

The invention provides a Parkinson's disease auxiliary diagnosis kit based on an RT-QuIC technology and application of the Parkinson's disease auxiliary diagnosis kit, and belongs to the technical field of detection kits. The kit provided by the invention has remarkable minimally invasive property and high patient compliance, detection can be completed only by collecting trace skin tissues, and risks and pains of lumbar puncture or brain tissue biopsy are avoided. The kit has excellent detection performance, can realize highly sensitive and specific identification of early pathology of Parkinson's disease, has a fast detection process, can complete batch sample analysis in a short time, and powerfully supports clinical rapid diagnosis and screening requirements. Meanwhile, the overall cost is remarkably lower than that of existing methods such as imaging, a convenient, reliable and economical molecular detection means is provided for early discovery, clinical auxiliary diagnosis and treatment effect observation of the Parkinson's disease, and positive significance is achieved for improving the overall diagnosis and treatment level of the neurodegenerative diseases.

The utility model relates to a lumbar puncture body position maintaining device which comprises a trunk upper end fixator used for being fixed to the upper end of a trunk. The trunk lower end fixer is fixed at the lower end of the trunk; the inhaul cable winder is used for winding the inhaul cable; the upper inhaul cable is used for connecting the trunk upper end fixer with the inhaul cable winder; the lower inhaul cable is used for connecting the trunk lower end fixer with the inhaul cable winder; a user can lie on the rack on the side, and the inhaul cable winder is arranged on the rack. The utility model aims to provide the lumbar puncture body position maintaining device which can enable a user to reliably maintain the lumbar puncture body position, and solves the problem that the lumbar puncture body position cannot be kept stable when the user automatically curls to maintain the lumbar puncture body position.

The invention discloses an auxiliary device for lumbar puncture of children. The auxiliary device comprises a base plate, a supporting assembly, a backup plate, an inflation bag, a reinforcing plate, an arm fixing structure, a suspension structure, a waste collecting frame and the like. The chassis is combined with hydraulic and pneumatic elements through an elastic structure to realize damping and height adjustment; the backup plate is provided with an inflatable bag and a strip-shaped operation notch, so that a stable support and operation channel can be provided for puncture; the reinforcing plate and the inflatable bulge are used for limiting the front-back shaking of the body of the child; the arm supporting structure is composed of an electric telescopic assembly and an elastic tying belt, and the two arms can be stably fixed. The suspension structure can be used for placing equipment such as a tablet personal computer and is used for diverting attention of children and relieving nervous mood; the waste collecting frame is arranged on the rear portion of the base, and medical waste after operation is completed can be collected conveniently. According to the device, through combination of mechanical shock absorption, inflation fitting supporting and attention distraction means, the accuracy of puncture positioning can be effectively improved, the child earning risk is reduced, and the medical work efficiency is improved.

The invention relates to a supporting system or device for lumbar puncture. Specifically, the present invention includes a lumbar puncture support system / device for positioning an infant that maintains the infant in an optimal fixation condition during a lumbar puncture. The apparatus includes a seat defining a leg support portion, a hip support portion, and a back support portion. The buttocks support portion and the back support portion receive the buttocks of the infant. The position of the leg supporting part is higher than that of the hip supporting part, so that the thighs and knees of the infant are close to or in contact with the upper body of the infant, and therefore the clear and exposed back of the infant is provided for lumbar puncture.

The utility model discloses a child lumbar puncture fixing device which comprises a columnar throw pillow body, the throw pillow body comprises a body clinging face, two side faces adjacent to the body clinging face are limb clinging faces, long and narrow groove sets are formed in the limb clinging faces on the two sides, each groove set is composed of an upper limb containing groove and a lower limb containing groove, and three faces of each upper limb containing groove and three faces of each lower limb containing groove are open. Limb fixing mechanisms are arranged in the upper limb placing groove and the lower limb placing groove; the throw pillow body is further provided with an anti-toppling mechanism which enables the user to be in a side-lying state all the time. According to the utility model, the bolster body which is highly accepted by children is adopted as a main structure, the limb placing groove is formed in the bolster body and is used for placing the limbs of the children, and the limb fixing mechanism is arranged in the placing groove and is used for simply and quickly fixing the limbs of the children, so that the situation that the limbs of the children move without automatic control during puncture and the puncture effect is influenced is avoided; the throw pillow body is further provided with an anti-toppling mechanism, so that lumbar puncture can be smoothly carried out, and the success rate of lumbar puncture is increased.

This invention provides an interventional transvenous lumbar puncture and shunt kit, belonging to the field of interventional medical device technology. The kit includes a flexible inner tube, a flexible outer tube, and a drive unit. The flexible outer tube is fitted over the flexible inner tube. The drive unit includes a drive handle located proximal to the flexible inner tube and a drive ring located proximal to the flexible outer tube and cooperating with the drive handle. During puncture, the overlap between the distal ends of the flexible inner and outer tubes is adjusted by manipulating the drive handle and drive ring, thereby adjusting the distal flexibility of the interventional transvenous lumbar puncture and shunt kit. This invention primarily addresses the technical problem of the lack of a dedicated device in the prior art that can balance the passage of tortuous blood vessels with puncture support and is suitable for transvascular lumbar puncture.

This invention discloses an early diagnostic biomarker for Alzheimer's disease (AD) and its application, belonging to the field of medical and pharmaceutical technology. Specifically, it discovers that the PPP2R5C protein in plasma neuronal-derived exosomes is an early diagnostic biomarker for AD. Based on this discovery, it also provides an application of the biomarker: an early AD diagnostic kit containing a monoclonal antibody against the PPP2R5C protein. This invention overcomes the detection limitations of lumbar puncture and PET-CT methods used in the early diagnosis of AD. Experimental results show that PPP2R5C in plasma neuronal-derived exosomes is significantly downregulated in both AD patients and patients with amnestic mild cognitive impairment (aMCI), exhibiting a trend of normal cognitive function controls > aMCI > AD. This demonstrates that PPP2R5C in plasma neuronal-derived exosomes is an early diagnostic biomarker for AD, and provides the application of an early AD diagnostic kit based on this PPP2R5C biomarker.

The utility model discloses a portable lumbar puncture practice device which comprises a box body, a mounting rack, springs, human body-imitated lumbar vertebra bones and a lumbar vertebra bone bending regulator, and the mounting rack is mounted in the box body; the spring is mounted on the mounting frame; the imitated human body lumbar vertebra bone is bound on the spring; the lumbar vertebra bending adjuster comprises a first rotating hand disc, a second rotating hand disc, a first universal flexible shaft, a second universal flexible shaft, a first telescopic cylinder and a second telescopic cylinder, and the first rotating hand disc and the second rotating hand disc are installed on the top of the box body; the first telescopic cylinder is vertically mounted on the mounting frame, and a first telescopic rod of the first telescopic cylinder is connected with the spring; the first rotating hand disc is connected with a screw rod of the first telescopic cylinder through a first universal flexible shaft; the second telescopic cylinder is horizontally mounted on the mounting frame, and a second telescopic rod of the second telescopic cylinder is connected with the spring; and the second rotating hand disc is connected with a screw rod of the second telescopic cylinder through a second universal flexible shaft. The lumbar vertebra bending degree can be adjusted, so that the simulation authenticity is improved.

The utility model relates to medical education field especially, especially relates to a teaching lumbar puncture model, including spine component, contains a plurality of vertebra model and intervertebral piece, the intervertebral piece includes each other's connection nucleus pulposus model, annulus fibrosus model and yellow ligament model, bone component contains the sacrum model and ilium model connected, and is connected with spine component, ligament component contains interspinal ligament, muscle component is constituted by lower muscle model and upper muscle model, skin component covers on upper muscle model, and is equipped with the puncture hole of being able to penetrate in the target area corresponding position, the puncture hole penetrates upper muscle model, interspinal ligament and yellow ligament model in proper order, fixed component is used for supporting and fixed muscle component, the vertebra model, bone component adopts hard material to make, the intervertebral piece, ligament component, muscle component, skin component adopt flexible material to make. Its solved the technical problem that the simulation degree of existing lumbar puncture model is insufficient.