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24 results about "Lumbar puncture needle" patented technology

Cerebrospinal fluid lumbar puncture needle pressure measuring device

The utility model discloses a cerebrospinal fluid lumbar puncture needle pressure measuring device, and relates to the technical field of medical instruments. The cerebrospinal fluid lumbar puncture needle pressure measuring device comprises an outer needle, an inner needle is arranged on the inner side of the outer needle in a penetrating mode, the outer needle comprises a pintle, a needle tube and a hollow needle, and the pintle, the needle tube and the hollow needle are communicated; the inner needle comprises a handle and a solid needle core; a flow guide opening is formed in the outer wall of the side, close to the needle tip, of the solid needle core, a flow channel is formed in the inner wall of the solid needle core and communicated with the flow guide opening, and a liquid outlet is formed in the outer wall of the side, close to the handle, of the solid needle core. By rotating the handle, the positions of the flow guide opening and the liquid outlet can be conveniently adjusted, it is ensured that cerebrospinal fluid can smoothly enter the flow channel after successful puncture and finally flow out into the pressure measuring tube and the liquid storage bag, leakage and waste of the cerebrospinal fluid are effectively avoided through the design, meanwhile, the pollution risk is reduced, and the safety of a patient is guaranteed.
Owner:PEOPLES HOSPITAL PEKING UNIV

Lumbar puncture needle with monitoring function

ActiveCN224461772USubarachnoid spaceSevere complication
This utility model discloses a lumbar puncture needle with monitoring function, comprising: a needle body, with a puncture needle main body internally connected to the needle body. The puncture needle main body is used to detect puncture depth and monitor cerebrospinal fluid pressure. The puncture needle main body includes an outer needle and an inner needle, with the inner needle located inside the outer needle. A gap is reserved between the outer and inner needles. A signal receiving mechanism is provided at the top of the outer needle. Both the outer and inner needles are electrically connected to the signal receiving mechanism via a point-to-line connection. This utility model provides a lumbar puncture needle with monitoring function, consisting of a system and a puncture needle main body. It can issue an alarm when the puncture needle tip contacts the cerebrospinal fluid in the subarachnoid space of the lumbar spine, and can monitor the cerebrospinal fluid pressure in real time during cerebrospinal fluid collection. Through precise puncture depth feedback and real-time cerebrospinal fluid pressure monitoring, doctors can more accurately locate the puncture point, reduce surgical errors, and improve the success rate of surgery. Real-time monitoring of cerebrospinal fluid pressure helps to detect abnormal intracranial pressure in a timely manner, prevent serious complications such as brain herniation, and ensure patient safety.
Owner:HUIZHOU CENT PEOPLES HOSPITAL

A lumbar puncture needle

This invention relates to a lumbar puncture needle, belonging to the field of medical device technology. It solves the problem in existing technologies where the lumbar puncture needle lacks a sealing measure before connecting to a pressure gauge, easily leading to needle contamination or fluid leakage during puncture. This invention includes a syringe and a needle body. The needle body is mounted on the syringe, which is used for drainage during puncture, while the needle body is used for spinal puncture. The first sleeve of this invention can be inserted into a valve-opening sleeve to connect the pressure gauge to the syringe. Simultaneously, the valve-opening lever can connect to the crimping end of the valve core and push the valve core towards the syringe, causing the sealing block to detach from the valve core's outer sleeve. This opens the valve module, allowing the liquid inside the syringe to enter the pressure gauge through the hollow part of the valve core's outer sleeve, the valve core's liquid transmission hole, the valve-opening sleeve, and the lever's liquid transmission hole. The pressure gauge can then measure pressure. The connection method is convenient and quick, and it ensures that the syringe does not leak when the pressure gauge is not connected.
Owner:PEKING UNIVERSITY THIRD HOSPITAL (THE THIRD CLINICAL MEDICAL SCHOOL OF PEKING UNIVERSITY) +1

Lumbar puncture needle

The utility model relates to a lumbar puncture needle which comprises a puncture needle tube and a hard needle core. The puncture needle tube comprises a linear section needle tube and a bent section needle tube which is in angle connection with one end of the linear section needle tube; the needle tube seat is connected with the other end of the linear section needle tube, and the linear section needle tube, the bent section needle tube and the needle tube seat are hollow and are used for allowing the needle core to penetrate through; the hard needle core comprises a first fixed needle core body and a deformed needle core body connected with one end of the first fixed needle core body; the hard needle core seat is connected with the other end of the first fixed needle core body and is matched with the needle tube seat; the range of an angle formed by the linear section needle tube and the bent section needle tube is 120-170 degrees; when the deformable needle core body is inserted into the bent section needle tube, the deformable needle core body can be bent. After the puncture needle is punctured into human tissues, the puncture direction can still be adjusted, the puncture direction can be adjusted by rotating the puncture needle tube and the bending section needle tube, the puncture needle is ensured to be in a safe position, and complications are avoided.
Owner:THE FIRST PEOPLES HOSPITAL OF CHANGZHOU +1

Lumbar puncture needle

The utility model relates to a lumbar puncture needle which comprises a needle tube, a needle core, a connecting piece detachably connected with the needle tube, a pressure sensor arranged in the connecting piece and an end cover connected with the connecting piece, the connecting piece is arranged at one end of the needle tube and provided with a channel communicated with an inner cavity of the needle tube, and the needle core is inserted into the needle tube through the channel. The pressure sensor is used for detecting pressure of liquid in the channel, and the end cover is used for blocking the end of the channel and further blocking the liquid. The pressure sensor is arranged in the connecting piece, meanwhile, the end cover is arranged to block the channel, automatic pressure measurement of liquid in the needle tube is achieved, the measurement precision is higher, measurement is more convenient, meanwhile, the needle tube is detachably connected with the connecting piece, after use is finished, the needle tube can be detached, the connecting piece is cleaned and disinfected and then reused, the use cost is reduced, and the practicability is high. Meanwhile, needle tubes and needle cores of different specifications can be installed on the connecting piece, and more operation requirements are met.
Owner:THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV

A disposable closed-loop lumbar puncture pressure measurement and sampling integrated device and its pressure measurement method

PendingCN122320608AStopcockLumbar
This invention discloses a disposable closed-loop lumbar puncture pressure measurement and sampling integrated device and its pressure measurement method. The device includes: a first Luer interface connected to a lumbar puncture needle or lumbar drainage catheter, a second Luer interface connected to a sampling container, and a valve assembly disposed between the two interfaces. The valve assembly has a pressure measurement path, a sampling path, and a closing path, and can achieve multi-position switching through a stopcock or slide valve. The pressure measurement path is connected to a pressure indicator component, which transmits pressure through a diaphragm coupled to the cerebrospinal fluid (CSF) but is not directly connected to the CSF. The pressure indicator component can display the CSF pressure within a range of 0-60 cm H2O. The valve assembly preferably has a bubble trapping chamber and / or a flow limiting structure to reduce the influence of air bubbles on the reading and reduce the risk of rapid fluid release due to misoperation. This invention can achieve closed-loop pressure measurement without a long tubing column in the lateral decubitus position, and can complete CSF sampling within the same sterile closed loop, reducing the chance of external contamination, reducing sample waste, and simplifying the operation process.
Owner:杨守博

Lumbar puncture training simulator mixing magnetorheological damper and voice coil motor

The invention provides a lumbar puncture training simulator mixing a magnetorheological damper and a voice coil motor. The lumbar puncture training simulator is composed of the magnetorheological damper, the voice coil motor, a linear guide rail, a sliding block, a limiting block, a laser displacement sensor, a puncture holder, a cover plate and a laser displacement sensor support. The magnetorheological damper comprises a cylinder barrel, an end cover, a check ring, an MRD coil, a piston and a piston rod. And a liquid injection hole is formed in the damper cylinder barrel. The magneto-rheological damper and the voice coil motor are arranged in parallel, and under data feedback of the force sensor and the displacement sensor, a piston rod of the magneto-rheological damper and a rotor of the voice coil motor can output corresponding puncture force to the lumbar puncture needle and an operator. In the system, the MRD is responsible for generating passive force feedback, and the VCM generates active force feedback. The combined work of the two actuators forms a magnetoelectric hybrid driving system capable of providing accurate puncture force feedback. The lumbar puncture training device effectively simulates the change of puncture resistance in the lumbar puncture process and can be used as a lumbar puncture training device.
Owner:FUZHOU UNIV

Novel lumbar puncture needle

The utility model discloses a novel lumbar puncture needle, and relates to the technical field of lumbar puncture needles. The syringe comprises a needle tube used for puncture operation, and the tail end of the needle tube is connected with a first duckbilled silica gel one-way valve; the needle core can be inserted into the needle tube and is used for puncturing, a groove is formed in the surface of the needle core, and cerebrospinal fluid can flow out through the groove. Due to the design that the groove is formed in the surface of the needle core, cerebrospinal fluid can still flow out through the groove even if the needle core is completely inserted into the needle tube, so that a doctor can immediately judge whether the cerebrospinal fluid flows out or not and confirm whether the needle core correctly enters the subarachnoid space or not. By means of the design, operation is greatly simplified, the step of repeatedly pulling out the needle core is reduced, the efficiency and accuracy of the puncture process are improved, and discomfort of a patient is reduced.
Owner:SHANGHAI DONGLEI BRAIN HOSPITAL CO LTD

Children lumbar puncture needle auxiliary device

The invention provides a child lumbar puncture needle auxiliary device, and belongs to the technical field of lumbar puncture, the child lumbar puncture needle auxiliary device comprises a supporting component, a bearing base and a mounting seat arranged on the upper side of the bearing base, the mounting seat is rotatably connected with an auxiliary chair through a rotating shaft, and the upper end of the bearing base is provided with a driving assembly for driving the auxiliary chair to deflect; a penetrating auxiliary opening is formed in the surface of the auxiliary chair, a cross used for limiting a puncture needle is arranged on the outer side of the auxiliary opening through a strap, a guiding assembly used for guiding puncture is arranged on the cross, four strip-shaped openings are formed in the cross, strip-shaped blocks are arranged in the strip-shaped openings, and suction cups are arranged on the strip-shaped blocks. The device provided by the invention can assist a puncture needle, can conveniently collect cerebrospinal fluid, and also has better applicability and adjustability.
Owner:NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV

An intra-needle puncture device for ultrasound visualization enhanced minimally invasive lumbar puncture

The utility model discloses a kind of needle-in-needle puncture devices for ultrasound imaging enhanced minimally invasive lumbar puncture, the needle-in-needle puncture device includes guide needle, lumbar puncture needle and lumbar puncture auxiliary needle;The guide needle tube is hollow structure;The outer surface of one end of the guide needle tube is equipped with the first coating area of enhanced ultrasound imaging;The lumbar puncture needle includes lumbar puncture needle tube, and the lumbar puncture needle tube is located in the guide needle tube;The inside of the lumbar puncture needle tube is hollow structure;The outer surface of one end of the lumbar puncture needle tube is equipped with the second coating area of enhanced ultrasound imaging;The lumbar puncture auxiliary needle includes needle core, and the needle core is located in the lumbar puncture needle tube, and the needle core structure is compatible with the lumbar puncture needle tube structure.Compared with prior art, the needle-in-needle puncture device for ultrasound imaging enhanced minimally invasive lumbar puncture of the utility model improves the visual effect and operation accuracy under ultrasound guidance in puncture process.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Lumbar puncture needle

ActiveCN309669392SUlnar digital nerveSubarachnoid block
1. The name of the design product: lumbar puncture needle. 2. The use of the design product: for human epidural nerve block, subarachnoid block, nerve block puncture. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 combination state diagram. 5. Design 1 is designated as the basic design.
Owner:SHENZHEN YUANFA METAL CO LTD

Meniscus guide suturing device

PendingCN120814894ASuture equipmentsInternal osteosythesisBevel needleMeniscal suture
The invention provides a meniscus guiding suturing device, and belongs to the field of surgical instruments. The guider comprises a handle and a guide pipe fixed at the front end of the handle, and the tail end of the handle is provided with a channel communicated with the guide pipe; and the front end part of the guide needle is provided with a line carrying hole through which a suture line can pass, and the guide needle has the size that the line carrying hole can be exposed after passing through the channel and the guide tube at the same time. The device integrates the advantages of an existing stitching instrument, not only has the advantage of one-needle and one-thread stitching of a lumbar puncture needle and a bevel needle head, but also has the advantage of convenience in operation of instruments used by a Fast-Fix 360 meniscus stitching system and other total internal stitching technologies, and is low in price and capable of being reused after being disinfected.
Owner:GUANGXI INT ZHUANG MEDICINE HOSPITAL

Adjustable lumbar puncture needle fixing frame

The invention relates to the technical field of lumbar puncture, and provides an adjustable lumbar puncture needle fixing frame which comprises a fixing seat detachably mounted on an operating bed body, and further comprises a moving seat, a lifting seat and a limiting seat, the moving seat is movably arranged on the fixing seat, the lifting seat is rotatably arranged on the moving seat in a liftable manner, and the limiting seat is arranged on the moving seat. A fixing assembly used for fixing the lifting seat is mounted on the moving seat, the limiting seat is movably and rotatably arranged on the lifting seat and used for allowing a puncture needle to penetrate through and limiting the puncture needle, and the auxiliary limiting assembly is mounted on the lifting seat and used for limiting the puncture needle. The auxiliary limiting assembly is tightly attached to the back of the patient to conduct auxiliary positioning on the positions of the lifting base and the puncture needle, the auxiliary limiting assembly comprises a backrest, the backrest is arranged on the limiting base through a telescopic structure, and the backrest is tightly attached to the back of the patient. By means of the technical scheme, the problems that in the prior art, after a needle core is pulled out, a puncture needle is suspended unstably, and the operation time is prolonged are solved.
Owner:LISHUI PEOPLES HOSPITAL

Lumbar puncture locator device

This disclosure provides a device and a method for combining a lumbar puncture needle and an ultrasonic density detection circuitry to provide an inexpensive and accurate lumbar puncture locator device. The disclosed device senses different tissue densities with different frequency tones and colored light indicators before needle insertion in the patient's lumbar vertebrae region. This invention allows a doctor, a nurse practitioner or a physician assistant to safely do a lumbar puncture in an office environment without the scheduling of the use of the radiology department. This device will allow a timelier diagnosis of infections (such as Lyme disease, bacterial and viral meningitis, herpes, West Nile virus, syphilis), multiple sclerosis, Alzheimer's dementia, tumors, idiopathic intracranial hypertension, subarachnoid hemorrhage, and others.
Owner:MITCHELL AMBER +1

Multifunctional controllable drip-proof lumbar puncture needle set capable of being used for intrathecal injection

The invention relates to the technical field of medical auxiliary instruments, in particular to a multifunctional controllable drip-proof lumbar puncture needle set capable of being used for intrathecal injection, which comprises a plastic transparent three-way tube, a closed overflow mechanism is arranged at the side opening end of the plastic transparent three-way tube, and a closed flow rate adjusting valve is arranged in the middle of an external multifunctional short tube. The liquid inlet end of the plastic transparent three-way pipe is in threaded connection with an external thread at one end of the lumbar puncture needle outer sleeve through an internal thread, a liquid leakage prevention mechanism is arranged in the liquid outlet end of the plastic transparent three-way pipe, and a reset spring in a protective shell can stretch out and draw back a guide rod through telescopic adjustment of the reset spring; when the cerebrospinal fluid is discharged, the anti-overflow disc is jacked into the annular open groove along with the pressure of the cerebrospinal fluid, and a gap is formed between the annular open groove and the anti-overflow disc, so that the cerebrospinal fluid can be conveniently discharged.
Owner:THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE

A syringe for intrathecal injection

This utility model relates to a medical device, disclosing a syringe for intrathecal injection, which includes a syringe barrel, a switching element, and a piston. The syringe barrel has at least two spaced-apart storage channels, allowing the syringe to simultaneously store at least two medications. The medication in one of the storage channels is pushed sequentially through a rotating groove, a second opening, an infusion channel, and a first opening to a connector under the action of the piston, and then injected into the patient through a lumbar puncture needle connected to the connector. When another medication is to be injected, the switching element is rotated to connect the second opening with the storage channel containing the other medication, pushing the piston to expel and inject the other medication. Thus, the syringe enables the storage and injection of at least two medications. Compared to syringes that can only store a single medication, this syringe only needs to be connected to the lumbar puncture needle once to complete the injection of at least two medications, improving work efficiency and reducing the possibility of lumbar puncture needle displacement.
Owner:GUANGZHOU FIRST PEOPLES HOSPITAL (GUANGZHOU DIGESTIVE DISEASE CENT GUANGZHOU FIRST PEOPLES HOSPITAL GUANGZHOU MEDICAL UNIV THE SECOND AFFILIATED HOSPITAL OF SOUTH CHINA UNIV OF TECH)

Lumbar puncture needle provided with scales and convenient to fix

The utility model belongs to the technical field of lumbar puncture needles, and particularly relates to a graduated lumbar puncture needle convenient to fix, which comprises a trocar, a graduated groove is arranged at the lower end of the trocar, a needle cap is movably mounted at the top of the trocar, and a fixing device is arranged on the outer side of the trocar. The fixing device comprises a first plastic sliding block, a second plastic sliding block, a protruding block, a mounting block, a clamping rod, a latex pad, a side plate and a skin application. According to the lumbar puncture needle with the scales and convenient to fix, the needle inserting depth during lumbar puncture can be simply and conveniently determined, the puncture depth can be preset according to the positions of the first plastic sliding block and the second plastic sliding block, unnecessary tissue damage caused by too deep puncture is prevented, meanwhile, the puncture needle can be simply and conveniently fixed to the skin surface, and the puncture needle is convenient to use. Shaking and minimally invasive injury are reduced, and the problems that in the background technology, the exact depth of needle inserting cannot be determined, the lumbar puncture needle can swing due to the movement of a patient, and larger tissue damage and even cerebrospinal fluid leakage can be caused are solved.
Owner:SOUTHWEST UNIV

Lumbar cistern drainage puncture device and method

The invention discloses a lumbar cistern drainage puncture device and method, and relates to the technical field of medical instruments, and the lumbar cistern drainage puncture device comprises a lumbar puncture needle, an inner guide needle, an outer guide needle and a lumbar cistern needle sheath; the lumbar puncture needle comprises a needle sheath and a detachable needle core; the inner guide needle is a solid hard guide needle, and the outer diameter of the inner guide needle is equal to the outer diameter of a needle core of the lumbar puncture needle; the outer guide pin is a tubular hard guide pin, and the inner diameter of the outer guide pin is equal to the outer diameter of the inner guide pin; and the inner diameter of the lumbar cisterna needle sheath is equal to the outer diameter of the outer guide needle. Repeated puncture caused by instrument size mismatching or channel deviation is avoided, so that disposable puncture catheterization is achieved fundamentally, and operation difficulty and patient trauma are reduced remarkably.
Owner:GUIYANG SECOND PEOPLES HOSPITAL

Needles for anaesthesia (lumbar puncture needles)

ActiveCN309654353SHuman bodyMedicine
1. The name of the design product: needle for anesthesia (lumbar puncture needle). 2. The use of the design product: for human epidural nerve block (epidural anesthesia), subarachnoid block (lumbar anesthesia), epidural and lumbar combined anesthesia, nerve block local anesthesia. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: assembly state diagram.
Owner:SHENZHEN YUANFA METAL CO LTD

Device for guiding indwelling of lumbar cistern drainage tube in sneaking mode

The invention relates to the technical field of lumbar cistern drainage tube sneaking and indwelling, and discloses a device for guiding lumbar cistern drainage tube sneaking and indwelling, which comprises a guide cone, and the guide cone comprises a tail cone connecting section, a limiting part and a rod section which are sequentially arranged from the rear end to the front end; the tail cone connecting section is used for being inserted into the tail end of a drainage tube to achieve fixed connection, the limiting part is used for being matched with a twisting controller, and the twisting controller drives the guide cone to puncture to soft tissue above a spinous process from the puncture position of the lumbar puncture needle and poke out of the skin after transversely sneaking for a set distance along the soft tissue above the spinous process, so that the drainage tube is guided to penetrate out through a sneaking tunnel. The establishment of a sneaking tunnel and the sneaking indwelling of a drainage tube are synchronously realized while the one-time puncture of the guide cone is realized; the device is safe, effective and easy to operate, the built tunnel barrier effect is good, the sneaking indwelling drainage tube is easy to maintain, and the trauma and infection risks can be effectively reduced.
Owner:SHANDONG FIRST MEDICAL UNIVERSITY FIRST AFFILIATED HOSPITAL (QIANFO MOUNTAIN HOSPITAL OF SHANDONG PROVINCE)

Flow-adjustable lumbar puncture needle

The utility model discloses a flow-adjustable lumbar puncture needle. A flow-adjustable lumbar puncture needle comprises a needle head and a connecting tube and is characterized in that a sleeve is installed in the connecting tube in a threaded mode, the two ends of the sleeve are communicated, a plug is arranged at one end of the sleeve and matched with the needle head, a plurality of through holes are formed in the surface of the sleeve, and a connector is arranged at an opening of the other end of the sleeve. According to the flow-adjustable lumbar puncture needle, the sleeve is arranged to control outflow of cerebrospinal fluid, compared with the prior art, the flow-adjustable lumbar puncture needle can be opened when pressure is measured and samples are collected by controlling outflow of the cerebrospinal fluid, the flow-adjustable lumbar puncture needle is closed in other time, and waste of the cerebrospinal fluid and pain of a patient in treatment are reduced.
Owner:YANCHENG YASI MEDICAL TECH CO LTD

Safe and adjustable lumbar puncture needle

The utility model relates to the field of puncture medical instruments, in particular to a safe and adjustable lumbar puncture needle which comprises a handle, a device body with an inner cavity inside, a connecting rod at one end of the handle, a transmission block fixedly arranged on the periphery of the connecting rod and a blunt needle fixedly arranged at the other end, opposite to the handle, of the connecting rod. An inner cavity in the device body is divided into a large cavity on one side of the handle and a small cavity on the other side of the handle, the diameter of the large cavity corresponds to the outer edge of the limiting block, the diameter of the small cavity is smaller than that of the large cavity, a puncture needle penetrating out of the device body is fixedly arranged at the end, away from the handle, of the small cavity, and the blunt needle is arranged in the puncture needle after being assembled in the inner cavity of the device body. According to the puncture needle with the structure, the bending degree of the puncture needle head can be adjusted, the needle does not need to be replaced midway, the puncture position can be indicated through air pressure change in the device, the puncture success rate can be increased, pain of a patient is relieved, and operation of medical staff is facilitated.
Owner:SHANDONG YINUO MEDICAL TECH CO LTD

Multi-modal data acquisition and hydrocephalus diagnosis method based on cerebrospinal fluid circulation

A multi-modal data acquisition and hydrocephalus diagnosis method based on CSF circulation is provided. Firstly, after performing a lumbar puncture for the patient, the lumbar puncture needle is connected to a pressure sensor and a micro pump, and then, the intracranial pressure baseline of the patent is collected for 5 min, the micro pump is started, and the patient is infused with normal saline at a rate of 1 cc / min until the patient's intracranial pressure reaches the ICP plateau, during the period, multiple physiological parameters such as intracranial pressure and heart rate are monitored; finally, the collected parameters such as intracranial pressure are substituted into the established physical model of CSF circulation, and the CSF kinetic parameters such as CSF absorption resistance are calculated for auxiliary diagnosis.
Owner:HAIHE LABORATORY OF BRAIN-COMPUTER INTERACTION & HUMAN-MACHINE INTEGRATION

Lumbar anesthesia needle

ActiveCN223873995UAnaesthesiaSurgical needlesSpinal needlesApparatus instruments
The utility model relates to the technical field of medical instruments, in particular to a lumbar anesthesia needle. The outer tube is hollow and tubular, and the far end of the outer tube is provided with a dosing through hole; the inner core is arranged in the outer tube; a limiting module; a through hole is formed in the outer pipe, the inner pipe is installed on the outer pipe and comprises a first module and a second module, the first module and the second module are movably installed through a positioning column, and the friction force between the through hole and the outer pipe is adjusted through the installation gap between the first module and the second module; and a sharp puncture point is arranged on the inner core or the outer tube. The limiting module is arranged on the outer tube and is locked after puncture is in place, the needle body is prevented from further going deep, iatrogenic injury caused by misoperation is reduced, and operation safety is improved.
Owner:ANHUI BACKBONE BIOTECHNOLOGY CO LTD