551 results about "CSF - Cerebrospinal fluid" patented technology

The invention relates to the technical field of medical treatment, and particularly discloses a minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system, which comprises a flexible probe, a data acquisition module, a data return module and a data analysis module, the flexible probe is embedded into the high-precision microarray electrode and the sensor to collect neural signals in real time; the data acquisition module is used for synchronously acquiring electroencephalogram signals and intracranial pressure of specific parts of the brain; the data return module manages the collected data; and the data analysis module analyzes the electroencephalogram signal and the intracranial pressure data. According to the minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system provided by the invention, lumbar puncture enters a cerebrospinal fluid space and is sent to a target spot, so that the infection risk can be effectively reduced, the limitation on the action of a patient is reduced, and the system has the characteristics of real-time performance, directness and accuracy; the method has very important significance and value for evaluating brain injury and brain functional lesion of a patient, prognosis judgment and the like.

Aspects of the disclosure describe an implantable system for monitoring intracranial pressure (ICP) in a subject, the system comprising: a conduit for the flow of cerebrospinal fluid (CSF); a hermetically sealed compartment; a first pressure sensor configured to measure an absolute ICP and output a measurement, wherein the first pressure sensor is hermetically sealed in the compartment, and wherein the first pressure sensor comprises a surface exposed to the CSF in the conduit; a microcontroller disposed in the hermetically sealed compartment that receives multiple inputs including at least the output of the first pressure sensor; and an accelerometer disposed in the hermetically sealed compartment for monitoring a subject's positional status, and wherein the accelerometer communicates an output to the microcontroller.

The invention belongs to the technical field of nerve regulation and control engineering, and provides a cerebrospinal fluid rhythm-based Alzheimer's disease electrical stimulation system, which is characterized in that first frequency band range data and second frequency band range data in brain wave signals are coupled to obtain cerebrospinal fluid rhythm data; then, calculating the phase difference between the first frequency band range data and the cerebrospinal fluid rhythm data; finally, the stimulation frequency is dynamically controlled according to the phase difference, and the stimulation current is dynamically controlled according to the brain tissue water volume fraction. The problem that specific metabolism requirements of non-fast eye movement sleep and fast eye movement sleep cycles cannot be matched by adopting single-frequency-band stimulation is solved, dynamic changes of post-traumatic encephaledema and requirements and influences of cerebrospinal fluid rhythm on current control are considered, the real-time adaptive capacity to the dynamic changes of the post-traumatic encephaledema is improved, and the application prospect is wide. And the treatment effect of the Alzheimer's disease is ensured.

The invention provides an implantable nerve probe integrated with a biological protection layer, a preparation method and a system. The nerve probe sequentially comprises a bottom biological protection layer, a bottom flexible substrate layer, a conductive layer, a top flexible substrate layer and a top biological protection layer from bottom to top, the bottom biological protection layer and the top biological protection layer form a biological protection layer located on the outermost periphery of the nerve probe and are used for avoiding erosion of a damp and hot cerebrospinal fluid environment in brain tissue. The integrated biological protection layer located on the outermost periphery of the flexible nerve probe is adopted, corrosion of cerebrospinal fluid to the nerve probe can be inhibited in in-vivo application, the long-term biocompatibility of the flexible nerve probe is effectively improved, the in-vivo long-term service life of the flexible nerve probe is effectively prolonged, and the nerve probe has the advantages of being high in integration level, high in stability and the like; and the requirement of in-vivo long-term effective service of the device can be met.

The invention discloses a recombinant protein and a detection reagent for detecting encephalitis of an anti-GABABR antibody, and belongs to the technical field of neuroimmunology diagnos.A GABABR1 partial sequence, a GABABR2 partial sequence and a transmembrane sequence (and a fluorescent label) are adopted to construct a cell strain for stably and highly expressing the recombinant protein by transfecting CHO cells or HEK293 cells, and the recombinant protein and the detection reagent are used for detecting the encephalitis of the anti-GABABR antibody. The sensitivity and the specificity of the kit in anti-GABABR antibody encephalitis detection can be remarkably improved, the aim of detecting the antibody by using a fixed CBA method or a living cell CBA method can be achieved, and the kit is suitable for auxiliary diagnosis of autoimmune encephalitis of cerebrospinal fluid / serum.

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The invention provides a cerebrospinal fluid peritoneal shunt peritoneal section endoscope assist device, and relates to the technical field of medical instruments, the endoscope assist device comprises a cerebrospinal fluid peritoneal shunt tube, the endoscope assist device comprises a puncture sheath shell, the periphery of the cerebrospinal fluid peritoneal shunt tube is wrapped with the puncture sheath shell, and a strip-shaped clamping groove is formed in the periphery of the puncture sheath shell; the strip-shaped insertion plate is connected with the strip-shaped clamping groove in a sliding mode, and the strip-shaped insertion plate is connected with the puncture sheath shell through a locking piece; an endoscope channel is arranged on the inner wall of the strip-shaped insertion plate and is used for mounting an endoscope; the puncture sheath shell is inserted into the abdominal cavity, a guiding effect is achieved when the cerebrospinal fluid peritoneal shunt tube enters the abdominal cavity, and due to the design that the puncture sheath shell and the strip-shaped inserting plate can be opened and closed, the puncture sheath shell can be conveniently separated from the cerebrospinal fluid peritoneal shunt tube through the strip-shaped clamping groove.

The invention relates to the technical field of drainage control, in particular to an intelligent cerebrospinal fluid drainage rate and pressure cooperative control system and method. The system comprises a drainage pipeline module, a positioning adjustment module, an intelligent pump control module, a monitoring sensing module, a cooperative control module and a man-machine interaction module, and can be used for establishing a cerebrospinal fluid drainage channel and being connected with a drainage bag; a laser positioning pen fixed on the infusion rod emits a laser beam which is horizontal to a preset drainage plane and adjusts the hanging height; an infusion pump and a pump body controller drive cerebrospinal fluid to flow according to set parameters and generate flow velocity, flow and drainage time control signals, meanwhile, real-time intracranial pressure data, real-time flow and flow velocity data and physical sign data are collected, and a drainage height adjusting instruction or a pump control parameter adjusting instruction is generated; cooperative control over the drainage rate and the intracranial pressure is achieved, and system operation parameters, patient monitoring data and the drainage state are displayed. The drainage device can accurately control the drainage amount of cerebrospinal fluid.

Provided herein are methods and immune biomarkers that identify progression and treatment options for multiple sclerosis (MS). Also provided are materials and methods for the prognosis, staging, and monitoring of MS in a sample and include methods of determining a subject as being at risk of developing MS. The methods include detecting at least one biomarker, such as CXCL13, CXCL10, CD27, NEFL, CCL4, and / or CCL3 in cerebrospinal fluid (CSF) in the subject; and administering a pharmaceutically effective amount of a treatment (e.g., tolebrutinib and potentially one or more additional therapies, such as an anti-CD20 therapy) to the subject.

The invention provides an analogue simulation method for accumulated craniocerebral injury under the action of multiple shock waves, and relates to the technical field of data processing. The method comprises the following steps: constructing an explosive shock wave model; constructing a head geometric model; the brain, the cerebellum and the brainstem in the solid area are represented through a Mooney Rivlin model; representing the skin, muscles and skull in the solid area through a linear elastic constitutive model; the cerebrospinal fluid in the fluid area is represented through the fluid dynamic model; coupling the fluid region and the solid region through an embedded boundary method; calculating the explosion impact pressure when the explosion impact waves of each turn are transmitted to the head through an explosion impact wave model; through a finite element analysis method, accumulated skull displacement, skull acceleration, skull stress, skull strain and intracranial pressure under the action of each turn of explosion shock waves are determined, and a brain accumulated injury value is calculated.

The invention relates to a heterogeneous human head model construction method and system oriented to multi-physics field simulation, based on real human head T1 weighted magnetic resonance image data, key tissues such as white matter, gray matter and cerebrospinal fluid are accurately segmented, and a three-dimensional geometric model used for generating carrying tissue identification information is researched and developed; converting the model data into a file format conforming to the NASTRAN standard by utilizing an independently developed format conversion program, and completely retaining organization classification information; finally, different tissue areas are automatically recognized through physical field simulation software, corresponding frequency dependent material attributes are distributed, and a finite element model capable of being directly used for simulation is formed. According to the method, seamless integration of the high-precision heterogeneous human head model and the simulation platform is achieved, tedious manual repairing and assignment operation is not needed, the method has the advantages of being high in precision, high in efficiency and good in compatibility, and the authenticity and reliability of biomedical simulation such as transcranial magnetic stimulation and radio frequency coil design can be remarkably improved.

The invention provides a light-excited lateral flow immunosensor reagent strip, a detection analysis method and application of the light-excited lateral flow immunosensor reagent strip. The reagent strip comprises an electrode substrate, a combination pad, a sample pad layer, a chromatography membrane and a water absorption pad, and the sample pad layer, the combination pad, the chromatography membrane and the water absorption pad of the reagent strip are connected end to end and are sequentially overlapped and pasted on the electrode substrate. The light-excited lateral flow immunosensor reagent strip is applied to quantitative analysis of various disease markers in biological fluids such as blood, saliva, cerebrospinal fluid or urine.

The invention discloses a brain-computer interface signal enhancement and evaluation method fusing physical information. The method comprises the following steps: firstly, based on an individual structure magnetic resonance image, constructing a personalized six-layer brain tissue anatomical model comprising a cortex, a white matter, cerebrospinal fluid, a dura mater, a skull and a scalp, and endowing differentiated conductivity parameters; secondly, neuroelectrophysiology priori knowledge such as neurodynamics and white matter anisotropic conduction is converted into a representation rule which can be learned by a neural network; then, the rules are systematically embedded into a physical information neural network in a differentiable physical constraint form, including a cortical neurodynamic equation residual error, a volume conduction equation residual error of each layer and an interlayer interface continuity constraint; and finally, training a network by using the scalp electroencephalogram signals, and jointly outputting high-fidelity intracranial electroencephalogram signals and multi-modal neurophysiological information by minimizing a loss function containing reconstruction and physical constraints. According to the method, the fidelity, the physical rationality and the clinical interpretability of signal enhancement are effectively improved.

A method and device for reducing the damaging effects of a blast or concussive event includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during the incidence of the concussive event. Reducing blood out flow from the cranial cavity increases intracranial pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood out flow further increases the intracranial pressure, and thereby increases the pressure of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure reduces the likelihood of brain injury and any associated loss of olfactory function.

The invention discloses an Alzheimer's disease plasma diagnosis marker based on plasma pTau217 and application of the Alzheimer's disease plasma diagnosis marker. The plasma biomarker provided by the invention is pTau217, pTau217 / A beta 1-40 or pTau217 / A beta 1-42, and the detection of the plasma biomarker not only belongs to a reliable, simple and convenient non-invasive means, but also can efficiently evaluate the disease risk of the Alzheimer's disease. The method can replace the traditional Alzheimer disease detection method, such as cerebrospinal fluid amyloid protein detection and PET imaging, and is easy to clinically and widely apply. The method has an important application value.

In some embodiments, apparatus and related methods relate to a skeletal body adjustment device (SBAD) with telescopically connected bodies. For example, the SBAD may include control members configured to induce relative translation between the bodies. In some embodiments, apparatus and related methods relate to a body cavity conforming shunt. As an illustrative example, the shunt may, for example, include selectively deployable contact members. The contact members may, by way of example and not limitation, be configured as anchors, sensors, and / or therapy delivery devices. In some embodiments, apparatus and related methods relate to a multi-layer bladder (MLB) selectively deployable in a body cavity. The MLB may, for example, include sensing and / or delivery components. The MLB may, for example, include control member(s) and / or pressure control(s) configured to control shape, size, and / or pressure of the MLB. In some embodiments, apparatus and related methods relate to a dynamically controlled cerebrospinal fluid (CSF) shunt system.

The invention provides a device for assisting an Ommaya bag in extracting cerebrospinal fluid, and belongs to the technical field of medical instruments. Comprising an annular sterile positioning base and an injector, a through hole is formed in the middle of the annular sterile positioning base, a fixing cylinder concentric with the through hole is fixedly connected to the upper surface of the annular sterile positioning base, a stretching assembly is arranged on the right side of the fixing cylinder, and a tightening assembly is arranged in the fixing cylinder; elastic assemblies are arranged on the left side and the right side of the upper surface of the fixing cylinder. The operation sterile area is enlarged through the sterile adhesive layer and the transparent soft plate, the sterile adhesive layer composed of the nano-silver coating can achieve 72-hour continuous antibiosis, infection prevention and pathogen invasion risk reduction, the center position is located through concentric circle cross scales of the sterile semi-transparent film, guiding and visual positioning of the syringe needle are achieved, and the operation safety of the syringe needle is improved. The needle head can vertically penetrate into the center of a capsule cavity, and hematoma or capsule wall damage caused by puncture deviation is avoided.

The invention belongs to the technical field of biological detection, and particularly relates to a monoclonal antibody combination for detecting apolipoprotein E4 and application of the monoclonal antibody combination. The combination comprises a monoclonal antibody 4E10 and a monoclonal antibody 3H7, and complementary determining region (CDR) sequences of the monoclonal antibody 4E10 and the monoclonal antibody 3H7 are shown as SEQ ID NO.1 to SEQ ID NO.12. In double-antibody sandwich ELISA, 4E10 is used as a coating antibody, 3H7 is used as a labeled antibody, APOE4 subtypes can be effectively recognized, high-specificity and high-sensitivity detection of APOE4 can be achieved, the detection limit reaches 100 pg / mL, and the kit is suitable for quantitative detection of APOE4 in samples such as serum and cerebrospinal fluid. The method provides a reliable immunological tool for early risk assessment of the Alzheimer's disease, and has important clinical application value.

The invention relates to an instrument for transferring cerebrospinal fluid in a ventricle into a body cavity of other parts of a human body, and particularly discloses an intraventricular hydrops drainage device which comprises a base used for being attached to a bone window of a skull, a confluence cavity and a liquid outlet connector communicated with the confluence cavity are arranged on the base, and the liquid outlet connector is provided with a liquid inlet and a liquid outlet. The flow guide hose is connected to the liquid outlet joint; a tip axially remote from the base; the drainage main body component is used for guiding cerebrospinal fluid in the ventricle to the confluence cavity; the drainage main body component comprises a plurality of micro-catheters; the near end and the far end of each micro catheter are attached to the base and the end respectively, and the near end of the micro central hole of each micro catheter is communicated with the confluence cavity; the micro-conduits are arranged in a plurality of circles in the circumferential direction and the radial direction; a micro drainage structure communicated with the micro central hole is arranged on the tube wall of each micro catheter, and the micro drainage structures are arranged in the circumferential direction and the axial direction of the tube wall of the micro catheter so as to allow cerebrospinal fluid to enter the micro central hole through the tube wall of the micro catheter.

The invention provides a nomeline nasal-brain delivery preparation for transnasal region mucosa administration, and an auxiliary material mixture of the nasal-brain delivery preparation comprises 1) phospholipid, and 2) any one of diluent ethyl oleate, isopropyl myristate, sesame oil or castor oil; optionally, the auxiliary material mixture can also comprise 3) a dissolving agent such as ethanol or diethylene glycol monoethyl ether, the auxiliary material mixture is a non-aqueous system, and a solution prepared from the mixture of the two or three auxiliary materials can be absorbed by the nasal meatus olfactory mucosa after being administrated through the nasal region mucosa, can be quickly conducted to the brain olfactory bulb region along olfactory nerves and cerebrospinal fluid, and can be used for treating the brain olfactory bulb. The problems that the peripheral side effect is high due to poor brain targeting of the medicine, the medicine takes effect slowly and the like are solved.

The invention relates to the technical field of medical data processing, in particular to an intelligent drainage method and system based on cerebrospinal fluid pressure, and the method comprises the steps: obtaining a pressure signal curve and a pulse period of a cerebrospinal fluid intelligent drainage system at each detection position; obtaining a synchronous conduction error value according to the signal change trend in the pulse period of the to-be-analyzed signal curves of each detection position and other detection positions in combination with the signal change trend between the historical signal curves; according to the signal delay condition between pulse periods in the signal curve to be analyzed of each detection position and other detection positions, combining the signal delay condition of the historical signal curve to obtain a signal delay characteristic value; according to the synchronous conduction error value, the signal delay characteristic value and the signal change trend, analyzing the signal artifacts of each pulse period in the signal curve to be analyzed to obtain an artifact-removed signal; the de-artifact signal is used for a drainage operation. According to the invention, the occurrence of misrecognition is reduced, and the reliability of intelligent drainage decision is ensured.

The invention relates to a cerebrospinal fluid dynamic monitoring management method. Comprising the following steps: performing mode identification by using dynamic characteristics of cerebrospinal fluid pressure and flow velocity; by monitoring the flow velocity and pressure fluctuation of cerebrospinal fluid in real time, a comparison library of a normal mode and an abnormal mode is established; deep learning is carried out by using a fluid mechanics model and a neural network, and abnormal points of non-linear change are identified; through combination of a pressure sensor array and a flow velocity sensor, dynamic flow changes are captured in different areas of a cerebrospinal fluid system including a ventricle and a subarachnoid space, and abnormal fluctuations are identified through continuous analysis of time sequence data; by analyzing the interaction between the intracranial flow mode of cerebrospinal fluid and the compression expansion effect of brain tissues, an intelligent adjustment mechanism based on the flow pressure coupling effect is introduced; under the influence of cerebrospinal fluid pressure changes, deformation of brain tissue including ventricular expansion influences blood flow and tissue pressure in other intracranial areas.

The invention relates to the technical field of medical instruments, and discloses an interventional drainage shunt tube with a slit valve. The catheter comprises a catheter body of a tubular structure, the catheter body comprises a far-end part provided with an inlet, a near-end part arranged as a blind end and an inner cavity communicating the far-end part and the near-end part, and a slit valve is arranged on the peripheral wall, close to the blind end, of the near-end part. The slit valve is opened through the pressure difference between the ventricular system and the venous system to discharge cerebrospinal fluid from the ventricular system to the venous system, and the distance 10 between the end, close to the blind end, of the slit valve and the blind end in the axial direction meets # imgabs0 #, so that the situation that excessive gas remains in the drainage shunt tube, and consequently the drainage shunt tube is completely blocked and fails is avoided. According to the drainage shunt tube, gas residues in the blind end of the shunt tube can be reduced, and stable drainage of the shunt tube can be ensured, so that the safety and the stability of the drainage shunt tube are improved.

The invention relates to the technical field of medical experimental instruments, and discloses a stereotactic experimental mouse cerebrospinal fluid automatic extraction device which comprises a supporting seat, a supporting frame is fixedly connected to the top of the supporting seat, a first air cylinder is fixedly connected to the outer wall of the supporting frame, and the output end of the first air cylinder penetrates through the outer wall of the supporting frame and is fixedly connected with an extraction pipe. A second air cylinder is fixedly connected to the inner wall of the supporting seat, a first sliding groove is formed in the outer wall of the supporting seat, an adjusting mechanism is arranged in the supporting seat, the positioning mechanism is arranged in the supporting seat and comprises a positioning block, and a first supporting rod is fixedly connected to the outer wall of the positioning block. The mouse is positioned through the positioning mechanism, and the head of the mouse is clamped, so that the head of the mouse is fixed, the stability of the cerebrospinal fluid extraction process is improved, the operation difficulty is reduced, and the extraction device can extract the cerebrospinal fluid of the mouse more stably.

Disclosed in the present invention are a preparation method for a brain-targeting agomelatine nasal spray micelle and use thereof, which belong to the technical field of pharmaceutical formulations. According to the present invention, an injectable pharmaceutical excipient polyethylene glycol (15)-hydroxystearate (HS15) is taken as a carrier material, HS15 and agomelatine are dissolved in an organic solvent, and the resulting solution is subjected to rotary evaporation under reduced pressure to form a uniform film, which, upon hydration, forms an agomelatine micelle solution capable of being sprayed nasally for treating depression and insomnia. According to the present invention, the problem of low oral bioavailability of agomelatine due to poor solubility, serious first pass effect of hepar, difficulty in penetrating a blood-brain barrier, etc., is solved. The micelle structure constructed in the present invention is quickly delivered into the brain after nasal administration, and it is stable in cerebrospinal fluid and can achieve slow release of the drug, thereby improving the intracerebral bioavailability of the drug and achieving high brain targeting property and low systemic toxic and side effects. The micelle structure has good clinical application value and market prospects.

The invention relates to the technical field of medical equipment, and discloses an intelligent lateral ventricle and abdominal cavity shunt tube which comprises an inner core drainage tube, the two ends of the inner core drainage tube are closed, the inner core drainage tube is divided into a ventricle section, a middle section and an abdominal cavity section, the ventricle section of the inner core drainage tube is arranged in the ventricle of a patient, and the middle section of the inner core drainage tube is connected with the abdominal cavity section. The abdominal cavity section of the inner core drainage tube is arranged in the abdominal cavity of a patient, and the pressure monitoring device is arranged on the middle section of the inner core drainage tube and used for monitoring the shunt volume of cerebrospinal fluid. The technical means that the pressure monitoring device and the flow adjusting device are matched is adopted, the pressure in the ventricle is monitored in real time through the pressure monitoring device, the flow dividing amount of cerebrospinal fluid is adjusted in cooperation with the flow adjusting device, the defects in the prior art are overcome, and then the practicability of the device is improved.

The invention belongs to the technical field of medical image analysis, and particularly relates to a cerebrospinal fluid cell intelligent analysis and diagnosis system and method based on deep learning. The method comprises the following steps: cutting an original image through a multi-scale segmentation model, and recording and storing position information of each cell image; segmenting all single cell and cell cluster images by a multi-scale segmentation model; training a cell classification model for endowing image category attributes to the single cells and the cell clusters; counting classification results output by the cell classification model to generate quantitative indexes; and generating a category visualization image and a diagnosis report through the positioning information of the single cell and cell cluster images. According to the method, a digital image processing technology and a deep learning algorithm are utilized, a traditional method is combined with an intelligent algorithm, effective image information is fully utilized, a detection result is visualized, checking by a doctor is facilitated, and finally the functions of automatic positioning, accurate classification and quantitative index of single cells and cell clusters in a cerebrospinal fluid sample are achieved.

The invention relates to the technical field of biology, in particular to an Alzheimer disease auxiliary detection kit based on a cerebrospinal fluid sample alpha-synuclein seed amplification technology and application of the Alzheimer disease auxiliary detection kit. The Alzheimer disease auxiliary detection kit based on the cerebrospinal fluid sample alpha-synuclein seed amplification technology comprises a substrate protein, a reaction reagent, a negative reference substance and a positive reference substance, and the sample is a to-be-detected cerebrospinal fluid sample. Cerebrospinal fluid of a subject is used as a detection sample for the first time, and clinical diagnosis research on the Alzheimer's disease by the RT-QuIC technology is carried out. The kit has obvious advantages in the aspects of high sensitivity, specificity, repeatability, practicability, rapidness, low cost and the like, the kit is simple in clinical sampling, the detection kit has the characteristics of simple operation process, low cost and the like, the detection time is short, the accuracy and the specificity are high, clinical popularization is easy, and the application prospect is wide. The kit can be clinically used for helping clinicians to diagnose the Alzheimer's disease in an auxiliary manner.

A use of a new highly toxic amyloid oligomer Apo*3F as a target for diagnosing Alzheimer's disease (AD) in the early stage and the middle-late stage and mild cognitive impairment (MCI) caused by AD. The Aβo*3F specifically binds to an antibody 3F and is present in cerebrospinal fluid (CSF), blood and / or brain tissue of AD patients and patients with MCI caused by AD, and the levels show highly significant differences in CSF, blood and / or brain tissue of AD patients, MCI patients and healthy elderly persons. In addition, the Apo*3F is an ultra-highly toxic oligomer, is the most important toxic component in an Aβ oligomer mixture, has a strong pathogenic effect, and plays a key role in the occurrence and development of AD.

Alzheimer's disease, the most common cause of dementia in older individuals, is a debilitating neurodegenerative disease for which there is currently no cure. In the past, AD could only be definitively diagnosed by brain biopsy or upon autopsy after a patient died. These methods, which demonstrate the presence of the characteristic plaque and tangle lesions in the brain, are still considered the gold standard for the pathological diagnoses of AD. However, in the clinical setting brain biopsy is rarely performed and diagnosis depends on a battery of neurological, psychometric and biochemical tests, including the measurement of biochemical markers such as the ApoE and tau proteins or the beta-amyloid peptide in cerebrospinal fluid and blood. The present invention discloses and describes panels of makers that are differentially expressed in the disease state relative to their expression in the normal state and, in particular, identifies and describes panels of makers associated with neurocognitive disorders. Such biomarker panel might have considerable value in triaging patients with early memory disorders to yet more specific but more invasive and costly approaches such as molecular markers in CSF and on PET imaging in clinical trials and possibly in clinical practice.