769 results about "CSF - Cerebrospinal fluid" patented technology

The invention relates to the technical field of medical treatment, and particularly discloses a minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system, which comprises a flexible probe, a data acquisition module, a data return module and a data analysis module, the flexible probe is embedded into the high-precision microarray electrode and the sensor to collect neural signals in real time; the data acquisition module is used for synchronously acquiring electroencephalogram signals and intracranial pressure of specific parts of the brain; the data return module manages the collected data; and the data analysis module analyzes the electroencephalogram signal and the intracranial pressure data. According to the minimally invasive implantable brain-computer interface intracranial multi-mode signal monitoring system provided by the invention, lumbar puncture enters a cerebrospinal fluid space and is sent to a target spot, so that the infection risk can be effectively reduced, the limitation on the action of a patient is reduced, and the system has the characteristics of real-time performance, directness and accuracy; the method has very important significance and value for evaluating brain injury and brain functional lesion of a patient, prognosis judgment and the like.

Aspects of the disclosure describe an implantable system for monitoring intracranial pressure (ICP) in a subject, the system comprising: a conduit for the flow of cerebrospinal fluid (CSF); a hermetically sealed compartment; a first pressure sensor configured to measure an absolute ICP and output a measurement, wherein the first pressure sensor is hermetically sealed in the compartment, and wherein the first pressure sensor comprises a surface exposed to the CSF in the conduit; a microcontroller disposed in the hermetically sealed compartment that receives multiple inputs including at least the output of the first pressure sensor; and an accelerometer disposed in the hermetically sealed compartment for monitoring a subject's positional status, and wherein the accelerometer communicates an output to the microcontroller.

A medical system includes a control unit that executes control of setting a first period in which cerebrospinal fluid is discharged from a body cavity while a fluid is injected into the body cavity and a second period in which the fluid is not injected into the body cavity and the cerebrospinal fluid is not discharged from the body cavity and alternately repeating the first period and the second period.

The present invention discloses a cerebrospinal fluid sampling and detection device for neurology, and relates to the detection technology field of auxiliary diagnosis of neurological diseases. The present invention comprises a device body, a sampling device is arranged on one side of the device body, a measuring component is arranged on the top of the device body, and a gas injection device is arranged inside the device body. The present invention, through the arrangement of the sampling device, allows the interior of the liquid storage tube to be filled with the required cerebrospinal fluid, and no gaps are left, thereby ensuring that the cerebrospinal fluid in the liquid storage tube is the expected amount, and at the same time, the hollow plug rod, the liquid storage tube, the connecting tube, and the device body cooperate, so that the hollow plug rod fits the inner wall of the liquid storage tube, and the hollow plug rod will inject all the cerebrospinal fluid into the device body, thereby avoiding the residue of cerebrospinal fluid, resulting in the actual amount of cerebrospinal fluid injected into the device body being lower than expected, resulting in insufficient concentration of the final sample, affecting the problem of test results.

The invention belongs to the technical field of nerve regulation and control engineering, and provides a cerebrospinal fluid rhythm-based Alzheimer's disease electrical stimulation system, which is characterized in that first frequency band range data and second frequency band range data in brain wave signals are coupled to obtain cerebrospinal fluid rhythm data; then, calculating the phase difference between the first frequency band range data and the cerebrospinal fluid rhythm data; finally, the stimulation frequency is dynamically controlled according to the phase difference, and the stimulation current is dynamically controlled according to the brain tissue water volume fraction. The problem that specific metabolism requirements of non-fast eye movement sleep and fast eye movement sleep cycles cannot be matched by adopting single-frequency-band stimulation is solved, dynamic changes of post-traumatic encephaledema and requirements and influences of cerebrospinal fluid rhythm on current control are considered, the real-time adaptive capacity to the dynamic changes of the post-traumatic encephaledema is improved, and the application prospect is wide. And the treatment effect of the Alzheimer's disease is ensured.

The invention provides an implantable nerve probe integrated with a biological protection layer, a preparation method and a system. The nerve probe sequentially comprises a bottom biological protection layer, a bottom flexible substrate layer, a conductive layer, a top flexible substrate layer and a top biological protection layer from bottom to top, the bottom biological protection layer and the top biological protection layer form a biological protection layer located on the outermost periphery of the nerve probe and are used for avoiding erosion of a damp and hot cerebrospinal fluid environment in brain tissue. The integrated biological protection layer located on the outermost periphery of the flexible nerve probe is adopted, corrosion of cerebrospinal fluid to the nerve probe can be inhibited in in-vivo application, the long-term biocompatibility of the flexible nerve probe is effectively improved, the in-vivo long-term service life of the flexible nerve probe is effectively prolonged, and the nerve probe has the advantages of being high in integration level, high in stability and the like; and the requirement of in-vivo long-term effective service of the device can be met.

The invention discloses a recombinant protein and a detection reagent for detecting encephalitis of an anti-GABABR antibody, and belongs to the technical field of neuroimmunology diagnos.A GABABR1 partial sequence, a GABABR2 partial sequence and a transmembrane sequence (and a fluorescent label) are adopted to construct a cell strain for stably and highly expressing the recombinant protein by transfecting CHO cells or HEK293 cells, and the recombinant protein and the detection reagent are used for detecting the encephalitis of the anti-GABABR antibody. The sensitivity and the specificity of the kit in anti-GABABR antibody encephalitis detection can be remarkably improved, the aim of detecting the antibody by using a fixed CBA method or a living cell CBA method can be achieved, and the kit is suitable for auxiliary diagnosis of autoimmune encephalitis of cerebrospinal fluid / serum.

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The invention provides a cerebrospinal fluid peritoneal shunt peritoneal section endoscope assist device, and relates to the technical field of medical instruments, the endoscope assist device comprises a cerebrospinal fluid peritoneal shunt tube, the endoscope assist device comprises a puncture sheath shell, the periphery of the cerebrospinal fluid peritoneal shunt tube is wrapped with the puncture sheath shell, and a strip-shaped clamping groove is formed in the periphery of the puncture sheath shell; the strip-shaped insertion plate is connected with the strip-shaped clamping groove in a sliding mode, and the strip-shaped insertion plate is connected with the puncture sheath shell through a locking piece; an endoscope channel is arranged on the inner wall of the strip-shaped insertion plate and is used for mounting an endoscope; the puncture sheath shell is inserted into the abdominal cavity, a guiding effect is achieved when the cerebrospinal fluid peritoneal shunt tube enters the abdominal cavity, and due to the design that the puncture sheath shell and the strip-shaped inserting plate can be opened and closed, the puncture sheath shell can be conveniently separated from the cerebrospinal fluid peritoneal shunt tube through the strip-shaped clamping groove.

The invention relates to the technical field of drainage control, in particular to an intelligent cerebrospinal fluid drainage rate and pressure cooperative control system and method. The system comprises a drainage pipeline module, a positioning adjustment module, an intelligent pump control module, a monitoring sensing module, a cooperative control module and a man-machine interaction module, and can be used for establishing a cerebrospinal fluid drainage channel and being connected with a drainage bag; a laser positioning pen fixed on the infusion rod emits a laser beam which is horizontal to a preset drainage plane and adjusts the hanging height; an infusion pump and a pump body controller drive cerebrospinal fluid to flow according to set parameters and generate flow velocity, flow and drainage time control signals, meanwhile, real-time intracranial pressure data, real-time flow and flow velocity data and physical sign data are collected, and a drainage height adjusting instruction or a pump control parameter adjusting instruction is generated; cooperative control over the drainage rate and the intracranial pressure is achieved, and system operation parameters, patient monitoring data and the drainage state are displayed. The drainage device can accurately control the drainage amount of cerebrospinal fluid.

The invention discloses a construction method, a recognition method and a system for simulating lung cancer metastasis cells in cerebrospinal fluid based on diffraction imaging and a deep learning technology. The construction method comprises the following steps: culturing a plurality of lung cancer cell lines which are easy to cause brain metastasis, collecting whole blood of a healthy person and splitting red blood cells; the method comprises the following steps: respectively acquiring diffraction images of cultured cells through a polarization diffraction imaging flow cytometry with a TDI camera to obtain a pair of diffraction image pairs with S polarization and P polarization; performing image processing on the obtained diffraction cell image pair, and establishing a training image data set and a test image data set; and establishing a convolutional neural network, and training the convolutional neural network according to the training image data set to obtain a model for identifying the lung cancer metastatic cells in the cerebrospinal fluid. When in use, a cerebrospinal fluid sample of a patient is collected, S polarization and P polarization image pairs are obtained, and the trained model is input to respectively extract S polarization and P polarization image features of cells for feature recognition, so that whether the current sample contains lung cancer cells or not is predicted.

The invention provides an intracranial pressure real-time monitoring and drainage adaptive control optimization system. The intracranial pressure real-time monitoring and drainage self-adaptive control optimization system comprises a hardware module, a software module and a mathematical model, the intracranial pressure is monitored in real time through a high-precision sensor, self-adaptive adjustment is carried out based on individual characteristics of a patient to optimize drainage control, and the hardware module comprises the high-precision pressure sensor used for monitoring the intracranial pressure in real time, and the software module is used for monitoring the intracranial pressure in real time; the drainage pipeline is connected into the patient valine and used for adjusting drainage of cerebrospinal fluid. By combining the high-precision pressure sensor, the artificial intelligence algorithm, the neural network and the fuzzy control strategy, the real-time response capability of the system to the intracranial pressure change is remarkably improved. The preferably adopted micro electro mechanical system sensor has the advantages of being high in precision and low in delay, intracranial pressure changes as small as 0.01 mmHg can be detected, and the drifting phenomenon of the sensor in long-term monitoring is reduced through the self-calibration function.

Provided herein are methods and immune biomarkers that identify progression and treatment options for multiple sclerosis (MS). Also provided are materials and methods for the prognosis, staging, and monitoring of MS in a sample and include methods of determining a subject as being at risk of developing MS. The methods include detecting at least one biomarker, such as CXCL13, CXCL10, CD27, NEFL, CCL4, and / or CCL3 in cerebrospinal fluid (CSF) in the subject; and administering a pharmaceutically effective amount of a treatment (e.g., tolebrutinib and potentially one or more additional therapies, such as an anti-CD20 therapy) to the subject.

The invention provides an analogue simulation method for accumulated craniocerebral injury under the action of multiple shock waves, and relates to the technical field of data processing. The method comprises the following steps: constructing an explosive shock wave model; constructing a head geometric model; the brain, the cerebellum and the brainstem in the solid area are represented through a Mooney Rivlin model; representing the skin, muscles and skull in the solid area through a linear elastic constitutive model; the cerebrospinal fluid in the fluid area is represented through the fluid dynamic model; coupling the fluid region and the solid region through an embedded boundary method; calculating the explosion impact pressure when the explosion impact waves of each turn are transmitted to the head through an explosion impact wave model; through a finite element analysis method, accumulated skull displacement, skull acceleration, skull stress, skull strain and intracranial pressure under the action of each turn of explosion shock waves are determined, and a brain accumulated injury value is calculated.

The invention provides a cooling system used in a ventricular, which is characterized by comprising a three-way joint, a drainage pipe, a cooling circulation pipeline, a cooling part, a drainage part and a semiconductor refrigerator, the cooling circulation pipeline comprises a cooling liquid input pipe and a cooling liquid output pipe, the cooling circulation pipeline extends to the cooling part and is connected with the inlet end and the outlet end of a cooling pipe in the cooling part, and the cooling pipe is of a double-helix structure. A plurality of open holes are formed in the end, away from the opening, of the drainage tube and used for cerebrospinal fluid infusion and drainage, and a plurality of pressure sensors and temperature sensors are distributed on the side wall of the drainage tube and used for monitoring the pressure and temperature in the ventricle; the ventricular drainage tube is modified, so that the ventricular drainage tube has the function of reducing the intracranial temperature, and the intracranial temperature and pressure can be monitored.

The invention relates to a heterogeneous human head model construction method and system oriented to multi-physics field simulation, based on real human head T1 weighted magnetic resonance image data, key tissues such as white matter, gray matter and cerebrospinal fluid are accurately segmented, and a three-dimensional geometric model used for generating carrying tissue identification information is researched and developed; converting the model data into a file format conforming to the NASTRAN standard by utilizing an independently developed format conversion program, and completely retaining organization classification information; finally, different tissue areas are automatically recognized through physical field simulation software, corresponding frequency dependent material attributes are distributed, and a finite element model capable of being directly used for simulation is formed. According to the method, seamless integration of the high-precision heterogeneous human head model and the simulation platform is achieved, tedious manual repairing and assignment operation is not needed, the method has the advantages of being high in precision, high in efficiency and good in compatibility, and the authenticity and reliability of biomedical simulation such as transcranial magnetic stimulation and radio frequency coil design can be remarkably improved.

The present invention provides an intracranial parameter detection device, including: a drainage tube body, a guide wire, a temperature-pressure detection device, and a biochemical parameter detection device, wherein the drainage tube body includes: a drainage cavity, the drainage cavity is provided with a drainage hole, so that after the drainage tube body is inserted into the cerebral ventricle, the cerebrospinal fluid flows into the drainage cavity through the drainage hole; a guide wire cavity, the guide wire cavity is arranged at the front end of the drainage tube body, and the guide wire is arranged in the guide wire cavity; a first detection cavity; a temperature-pressure detection device is arranged in the first detection cavity, and the temperature-pressure detection device is used to detect intracranial pressure ICP, cerebral perfusion pressure CPP, and intracranial temperature ICT; a biochemical parameter detection device is arranged in the drainage tube body, and the biochemical parameter detection device is used to detect the biochemical parameters of the cerebrospinal fluid drained into the drainage cavity. The device can realize cerebrospinal fluid drainage and realize real-time synchronous monitoring of multiple biochemical parameters of cerebrospinal fluid, intracranial pressure ICP, cerebral perfusion pressure CPP, and intracranial temperature ICT.

The invention provides a light-excited lateral flow immunosensor reagent strip, a detection analysis method and application of the light-excited lateral flow immunosensor reagent strip. The reagent strip comprises an electrode substrate, a combination pad, a sample pad layer, a chromatography membrane and a water absorption pad, and the sample pad layer, the combination pad, the chromatography membrane and the water absorption pad of the reagent strip are connected end to end and are sequentially overlapped and pasted on the electrode substrate. The light-excited lateral flow immunosensor reagent strip is applied to quantitative analysis of various disease markers in biological fluids such as blood, saliva, cerebrospinal fluid or urine.

The invention discloses a brain-computer interface signal enhancement and evaluation method fusing physical information. The method comprises the following steps: firstly, based on an individual structure magnetic resonance image, constructing a personalized six-layer brain tissue anatomical model comprising a cortex, a white matter, cerebrospinal fluid, a dura mater, a skull and a scalp, and endowing differentiated conductivity parameters; secondly, neuroelectrophysiology priori knowledge such as neurodynamics and white matter anisotropic conduction is converted into a representation rule which can be learned by a neural network; then, the rules are systematically embedded into a physical information neural network in a differentiable physical constraint form, including a cortical neurodynamic equation residual error, a volume conduction equation residual error of each layer and an interlayer interface continuity constraint; and finally, training a network by using the scalp electroencephalogram signals, and jointly outputting high-fidelity intracranial electroencephalogram signals and multi-modal neurophysiological information by minimizing a loss function containing reconstruction and physical constraints. According to the method, the fidelity, the physical rationality and the clinical interpretability of signal enhancement are effectively improved.

The invention provides a monoclonal antibody capable of specifically recognizing a specific metabolic fragment of human amyloid protein and application of the monoclonal antibody, and belongs to the technical field of genetic engineering. The invention provides a hybridoma cell strain AB5H, and the preservation number of the hybridoma cell strain AB5H is CCTCC (China Center For Type Culture Collection) NO: C201255. The hybridoma cell strain AB5H disclosed by the invention can secrete a monoclonal antibody which has relatively high activity and can specifically recognize human beta amyloid protein A beta 40; the monoclonal antibody is high in titer, can be used as a capture antibody, and is used for preparing a human Abeta40 protein quantitative detection kit and quantitatively detecting the content of Abeta40 in cerebrospinal fluid and blood, so that the detection result deviation caused by the fact that the content of Abeta40 in peripheral blood is easily influenced by metabolism, sample treatment conditions and methods and individual differences is overcome, and the detection accuracy is improved. The variation degree of a detection result is reduced, so that a judgment boundary value of a blood A beta detection result is conveniently obtained, and AD early diagnosis is realized.

The present invention provides a high brain targeting, safe and noninvasive nasal-brain delivery preparation, which is characterized in that the nasal-brain delivery preparation comprises nimodipine, a good solvent, a diluent and an absorption enhancer, the good solvent is diethylene glycol monoethyl ether, and the absorption enhancer is phospholipid. The nasal-brain delivery preparation is prepared from a good solvent, a diluent, an absorption enhancer and the like according to a specific proportion. Nimodipine serving as an active ingredient is enriched in cerebrospinal fluid and brain tissues through a specific upper nasal meatus administration technology, so that the treatment effect of nimodipine is achieved; and meanwhile, the blood entering proportion is reduced, so that the cardiovascular toxicity and hepatotoxicity are reduced. In addition, the preparation formula has no irritation to local parts of the nasal cavity, and the compliance of a patient is improved.

The invention discloses a cerebrospinal fluid sampling and detecting device for the neurology department, and relates to the technical field of detection of auxiliary diagnosis of neurology department diseases. The device comprises a device body, a sampling device is arranged on one side of the device body, a measuring assembly is arranged at the top of the device body, and a gas injection device is arranged in the device body. Through the arrangement of the sampling device, the liquid storage pipe is filled with required cerebrospinal fluid, no gap is reserved, it is ensured that the cerebrospinal fluid in the liquid storage pipe is the expected amount, meanwhile, the hollow plug rod, the liquid storage pipe, the connecting pipe and the device body are matched, and the hollow plug rod is attached to the inner wall of the liquid storage pipe; the hollow plug rod can completely inject the cerebrospinal fluid into the device main body, so that the problems that the amount of the cerebrospinal fluid actually injected into the device main body is lower than the expectation due to the residual cerebrospinal fluid, the concentration of a final sample is insufficient, and the detection result is influenced are solved.

A method and device for reducing the damaging effects of a blast or concussive event includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during the incidence of the concussive event. Reducing blood out flow from the cranial cavity increases intracranial pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood out flow further increases the intracranial pressure, and thereby increases the pressure of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure reduces the likelihood of brain injury and any associated loss of olfactory function.

The invention relates to the technical field of biological medicines, in particular to FcRL2 as a serum marker or cerebrospinal fluid marker for early diagnosis, screening and typing detection of neurosyphilis patients. The FcRL2 protein is one of receptor superfamily members, Fc receptor-like glycoproteins, and is related to immune response regulation and immune cell functions. According to the invention, the concentration of the FcRL2 protein in serum or cerebrospinal fluid is used as an index for early diagnosis of neurosyphilis, typing detection of symptomatic neurosyphilis, asymptomatic neurosyphilis, neurosyphilis and recessive syphilis, evaluation of nerve injury degree and the like; the index can be independently used or used as a main reference index to be combined with other indexes to complete diagnosis screening, typing and nerve injury evaluation of the neurosyphilis. Compared with the prior art, the FcRL2 not only has high sensitivity, but also can diagnose the neurosyphilis through noninvasive serum detection, and is beneficial to diagnosis and management of the neurosyphilis in community hospitals and local hospitals.

The invention relates to an implantable selective spinal nerve root stimulation system, comprising a stimulator for generating an electrical stimulation signal having a frequency, pulse width and intensity, at least one stimulation electrode with stimulation contacts at the distal end, said stimulation electrodes extending towards the head end along the course of the horsetail nerve and penetrating out of the dural sac region at a midline, the device penetrates out of the skin from inside to outside through a spinous process gap or is directly connected with a stimulator along a subcutaneous tunnel. The stimulation contact of the stimulation electrode is elastically fixed in the free dorsal root nerve area in a surrounding mode, and the resistance from the stimulation contact to cerebrospinal fluid is larger than the resistance between the stimulation contact and the ectofascia which is elastically fixed to the dorsal root nerve. According to the invention, the problem that the function recovery of paraplegia lower limbs after high spinal cord injury cannot be effectively promoted due to the defects of poor reliability, great influence on the body position of a patient, high power consumption and the like caused by the existence of cerebrospinal fluids with different thicknesses between the existing stimulation electrode and the spinal cord and the dorsal nerve root can be solved.

The invention discloses an Alzheimer's disease plasma diagnosis marker based on plasma pTau217 and application of the Alzheimer's disease plasma diagnosis marker. The plasma biomarker provided by the invention is pTau217, pTau217 / A beta 1-40 or pTau217 / A beta 1-42, and the detection of the plasma biomarker not only belongs to a reliable, simple and convenient non-invasive means, but also can efficiently evaluate the disease risk of the Alzheimer's disease. The method can replace the traditional Alzheimer disease detection method, such as cerebrospinal fluid amyloid protein detection and PET imaging, and is easy to clinically and widely apply. The method has an important application value.

The invention relates to the technical field of biological medicines, in particular to a CLM-6 protein (CMRF35-l ike molle 6) as a serum marker or cerebrospinal fluid marker for early diagnosis, screening and typing detection of a neurosyphilis patient. According to the invention, the concentration of CLM-6 protein in cerebrospinal fluid or serum is used as an index for early diagnosis of neurosyphilis, typing detection of symptomatic neurosyphilis, asymptomatic neurosyphilis, neurosyphilis and recessive syphilis, nerve injury degree evaluation and the like; the index can be independently used or used as a main reference index to be combined with other indexes to finish the diagnosis screening and typing of the neurosyphilis and the evaluation of nerve injury. Compared with the prior art, the CLM-6 not only has higher sensitivity, but also can realize noninvasive serum detection on the neurosyphilis, is convenient to detect, and is more beneficial to early diagnosis and management of the neurosyphilis in community hospitals and local hospitals.

In some embodiments, apparatus and related methods relate to a skeletal body adjustment device (SBAD) with telescopically connected bodies. For example, the SBAD may include control members configured to induce relative translation between the bodies. In some embodiments, apparatus and related methods relate to a body cavity conforming shunt. As an illustrative example, the shunt may, for example, include selectively deployable contact members. The contact members may, by way of example and not limitation, be configured as anchors, sensors, and / or therapy delivery devices. In some embodiments, apparatus and related methods relate to a multi-layer bladder (MLB) selectively deployable in a body cavity. The MLB may, for example, include sensing and / or delivery components. The MLB may, for example, include control member(s) and / or pressure control(s) configured to control shape, size, and / or pressure of the MLB. In some embodiments, apparatus and related methods relate to a dynamically controlled cerebrospinal fluid (CSF) shunt system.

The invention provides a relaxation exchange magnetic resonance imaging REXI sequence. A filtering module is composed of a 90-degree excitation radio frequency pulse and a 180-degree refocusing radio frequency pulse; the switching module is composed of a 90-degree excitation radio frequency pulse and switching delay; the detection module is composed of a 90-degree excitation radio frequency pulse and a plurality of 180-degree refocusing radio frequency pulses; paired crushing gradient pulses are applied to the filtering module and the detection module; and applying a phase-disturbing gradient pulse to the switching module. The invention further discloses an acquisition and analysis method of the REXI sequence, in REXI acquisition, the echo time of the filter module is fixed, and only the exchange delay time of the exchange module and the echo time of the detection module are changed; and performing REXI analysis, and fitting data by adopting a double-chamber exchange model. The invention also discloses an application of the REXI sequence and the acquisition and analysis method thereof in magnetic resonance imaging measurement of cerebrospinal fluid transmembrane transport, and the REXI sequence is especially suitable for magnetic resonance imaging for rapidly measuring the molecular exchange speed between a short T2 component and a long T2 component in a two-component system.

The invention provides a device for assisting an Ommaya bag in extracting cerebrospinal fluid, and belongs to the technical field of medical instruments. Comprising an annular sterile positioning base and an injector, a through hole is formed in the middle of the annular sterile positioning base, a fixing cylinder concentric with the through hole is fixedly connected to the upper surface of the annular sterile positioning base, a stretching assembly is arranged on the right side of the fixing cylinder, and a tightening assembly is arranged in the fixing cylinder; elastic assemblies are arranged on the left side and the right side of the upper surface of the fixing cylinder. The operation sterile area is enlarged through the sterile adhesive layer and the transparent soft plate, the sterile adhesive layer composed of the nano-silver coating can achieve 72-hour continuous antibiosis, infection prevention and pathogen invasion risk reduction, the center position is located through concentric circle cross scales of the sterile semi-transparent film, guiding and visual positioning of the syringe needle are achieved, and the operation safety of the syringe needle is improved. The needle head can vertically penetrate into the center of a capsule cavity, and hematoma or capsule wall damage caused by puncture deviation is avoided.