The invention belongs to the field of micro-physiological systems, and discloses a
human body micro-physiological
system based on whole hPSC. Three-
dimensional modeling is carried out according to the relative positions and sizes of the organs in the
human body, partitioning is carried out according to different areas of the
human body, the brain chamber is located in the
cranial cavity area, the heart and double
lung chambers are located in the
thoracic cavity area, and the liver and double
kidney chambers are located in the
abdominal cavity area. The
lung chambers are arranged on the two sides of the heart, the liver is arranged on the right of the front upper portion of the
abdominal cavity area, and the
kidney chambers are arranged on the rear lower portion, the left portion and the right portion of the
abdominal cavity area and distributed in a splayed mode. Due to the fact that printing of a whole human body
chip cannot be achieved through an existing 3D printing technology, and openness of all cavities needs to be reserved to facilitate
cell loading, the strategy that 3D printing is conducted according to modules is adopted, and nine bionic modules including a head top module, a
cranial cavity module, a
thoracic cavity module, an abdominal cavity module, a hip-leg module, a
forearm module and a shank module are included. And by adopting a double-channel design, all organ chambers are connected together, so that the
information exchange of all organs is promoted.