20 results about "Brain Ventricle" patented technology

The invention relates to a cerebrospinal fluid dynamic monitoring management method. Comprising the following steps: performing mode identification by using dynamic characteristics of cerebrospinal fluid pressure and flow velocity; by monitoring the flow velocity and pressure fluctuation of cerebrospinal fluid in real time, a comparison library of a normal mode and an abnormal mode is established; deep learning is carried out by using a fluid mechanics model and a neural network, and abnormal points of non-linear change are identified; through combination of a pressure sensor array and a flow velocity sensor, dynamic flow changes are captured in different areas of a cerebrospinal fluid system including a ventricle and a subarachnoid space, and abnormal fluctuations are identified through continuous analysis of time sequence data; by analyzing the interaction between the intracranial flow mode of cerebrospinal fluid and the compression expansion effect of brain tissues, an intelligent adjustment mechanism based on the flow pressure coupling effect is introduced; under the influence of cerebrospinal fluid pressure changes, deformation of brain tissue including ventricular expansion influences blood flow and tissue pressure in other intracranial areas.

The present invention operates to significantly reduce over or under drainage of cerebrospinal fluid (CSF) from the brain or spinal cord using an extraventricular drain (EVD) in the brain or lumbar drainage device (LDD) and automated intracranial pressure (ICP) monitoring. The present invention attaches the drainage catheter of the EVD to a flow controller or valve which controls the flow of CSF from the drainage catheter and is electronically controlled by a stepper motor communicating with a pressure transducer receiving pressure signals indicating an ICP without the need for constant manual re-leveling.

Ventricular catheters and their methods of use are disclosed. In some embodiments, the disclosed ventricular catheters may reduce, or substantially prevent, obstruction of the catheter by astrocytes or other brain tissue due to adhesion and / or growth within the catheter. For example, in some embodiments, the holes and internal lumen of a ventricular catheter may be constructed such that the wall shear stresses applied within the holes and internal lumen of the catheter are greater than a threshold shear stress to prevent cell adhesion and growth within the catheter.

The invention discloses a rotary irrigation type magnetic drive brain pressure monitoring drug delivery and liquid storage bag for intracranial infection. The rotary irrigation type magnetic drive brain pressure monitoring drug delivery and liquid storage bag comprises an Oma bag, a drug storage bag, a drainage tube, an intracranial pressure probe, a magnetic sensitive ball, a one-way tube and the like. According to the device, three independent one-way circulation channels of medicine injection, pressure measurement and drainage are constructed, an in-vitro magnetic field is utilized to drive a magnetic sensitive ball to stir to form eddy current, ventricular purulent moss is scoured in a targeted manner, and medicine is uniformly dosed; the memory metal baffle is automatically opened and closed under negative pressure, and dead space pollution is reduced; and the probe wirelessly monitors the ICP in real time and gives out an over-limit alarm. Compared with a traditional Ommaya capsule, the infection and blockage rate is remarkably reduced, the replacement period is prolonged to 3-6 months from 1 month, and long-term, safe and accurate intracranial pressure management and drug delivery are achieved.

The invention discloses a multi-parameter monitoring pressure-adjustable recoverable hydrocephalus shunting device and a treatment method, and belongs to the technical field of medical instruments. The device comprises a shunt pipe assembly and a recovery device. The shunt tube assembly forms a cerebrospinal fluid shunt passage from a ventricle to veins, a front-end brain pressure monitoring module, an automatic pressure regulation flow rate valve, a central processing and transmission module and a multi-parameter function monitoring module are integrated, and automatic regulation and control of intracranial pressure and real-time monitoring of multiple parameters of thrombus, blood pressure and blood oxygen are achieved. The flow velocity of cerebrospinal fluid is autonomously adjusted through the automatic pressure adjusting flow velocity valve according to dynamic changes of intracranial pressure, traditional manual adjustment is replaced, and adjustment and control accuracy and timeliness are improved; meanwhile, the shunt tube is safely and conveniently replaced through a magnetic recovery structure, and operation wounds and infection risks are reduced. The system is suitable for precise treatment and postoperative comprehensive monitoring of adult hydrocephalus.

The present invention provides a novel method to isolate and expand pure neural stem cells (NSCs) from cerebrospinal fluid (CSF) of premature babies with Intraventricular haemorrhage, which produces a population enriched in NSC-CSF cells free of contaminating fibroblasts and other cell types. The present invention also includes substantially pure populations of CSF-NSC cells, and their use to treat and prevent diseases and injuries, including Intraventricular haemorrhage and post- hemorrhage hydrocephalus / developmental deficits.

The invention belongs to the technical field of drainage, and discloses an external ventricular drainage device for treating cryptococcus meningitis, which comprises a drainage bag and a drainage tube fixedly arranged on the drainage bag, and further comprises a mounting ring fixedly arranged at one end of the drainage tube, which is opposite to the drainage bag, a pressure sensor is fixedly arranged in the mounting ring, and the mounting ring penetrates through the dropping bottle; the adjusting mechanism is arranged on the drainage tube and used for adjusting the drainage speed of the drainage tube; through cooperation of the installation box, the placement groove, the abutting assembly and other structures, adjustment of the extrusion force of the drainage tube is facilitated, moderate adjustment of the drainage speed is achieved, and the problem that an existing device is not beneficial to intelligent regulation and control of the drainage speed of cerebrospinal fluid is solved. The intelligent detection of the brain condition of the patient is difficult to realize, and the accuracy and the safety of treatment are influenced.

A method of using alpha defensins as a biomarker to aid in the diagnosis and treatment of ventriculitis. This biomarker can help improve diagnostic accuracy and decrease unwarranted empirical broad spectrum antibiotic use in suspected external ventricular drains (EVD)-associated ventriculitis.

The utility model belongs to the field of cerebrospinal fluid drainage equipment, in particular to an adjustable constant-speed quantitative cerebrospinal fluid drainage device for neurosurgery, which comprises a peristaltic pump, a ventricle / brain pool drainage tube, a tee joint and a drainage bag, a hose is mounted on the peristaltic pump, one end of the hose is provided with a Luer lock convex surface, and the other end of the hose is provided with a Luer lock concave surface; the tee joint is located between the peristaltic pump and the ventricle / brain pool drainage tube, the end, close to the peristaltic pump, of the tee joint is provided with a Luer lock concave face, the end, close to the ventricle / brain pool drainage tube, of the tee joint is provided with a Luer lock concave face, the tee joint is connected with a Luer lock convex face of a hose on the peristaltic pump through the Luer lock concave face, and the side end of the tee joint is a blind end with a heparin cap. The drainage device is reasonable in design, full drainage pipeline Luer lock connection is achieved, safety and firmness of the drainage pipeline are guaranteed, drainage quantity and drainage speed can be monitored in real time through the peristaltic pump display panel, early warning can be carried out on abnormal conditions, and drainage safety is improved.

To provide a shunt system used to treat excess cerebrospinal fluid (CSF) accumulation.SOLUTION: In some embodiments, a system includes a cleaning mechanism designed to clean a portion of a shunting system. A ventricular catheter used in a CSF draining shunt system includes slits to facilitate CSF drainage, and biodegradable or bioresorbable material along one or more of these slits. A locking mechanism facilitating secure fitting between a catheter tubing and a shunt valve element is described. A mechanical valve to regulate CSF flow within a valve housing between a CSF inlet and a CSF outlet is described.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of medical instruments, and provides an automatic adjusting cerebrospinal fluid drainage device aiming at the problems that in traditional ventricular hydrops treatment, a catheter is prone to being blocked, drainage amount regulation and control are rough, and injection medicine is prone to retrograde infection and the like, the automatic adjusting cerebrospinal fluid drainage device comprises a drainage tube, and a fixing mechanism is arranged at the end, close to the human body, of the drainage tube; the end, away from the human body, of the drainage tube is provided with the flow control mechanism and connected with the liquid collecting bag. A flow monitoring mechanism and a peristaltic pump are arranged on the drainage tube, and the flow monitoring mechanism is connected with the peristaltic pump. By means of the combined design of the peristaltic pump, the flow pump and the independent feedback catheter, the drainage tube can be prevented from falling off in the drainage process, the drainage speed and the drainage amount can be automatically controlled, and the situation that the drainage tube is blocked due to excessive drainage or insufficient drainage when the drainage speed is too high is avoided; therefore, the problems of high cranial pressure, even cerebral hernia, low cranial pressure headache, even intracranial hemorrhage and the like are prevented.

The present invention discloses a teaching model and demonstration method for dynamically demonstrating the cerebrospinal fluid circulation pathway, relating to the field of demonstration models. The model comprises a brain shell having cavities including the lateral ventricles, the third ventricle, and the fourth ventricle, and the subarachnoid space; aqueducts are provided between the cavities and between the fourth cavity and the subarachnoid space; the interior of each cavity is connected to a water tank via a water inlet pipe and a water pump, and the water tank contains water simulating cerebrospinal fluid; a plurality of water outlets are provided on the subarachnoid space, and the water outlets are connected to the water tank via a drain pipe; elastic filler serving as brain tissue is provided between all cavities and between the cavity and the subarachnoid space; the outlet of each aqueduct is configured as a variable diameter section, and a float is placed in the aqueduct; a motor is provided outside each aqueduct, and the output shaft of the motor passes through the aqueduct and is connected to the float via a traction rope. The present invention enhances teaching effectiveness by dynamically simulating the normal circulation process of cerebrospinal fluid and the pathological and physiological changes after obstruction.

A shunt for treating hydrocephalus and a system thereof. The shunt (1) comprises a distal portion (13) provided with a cerebrospinal fluid inlet, a proximal portion (12) provided with a cerebrospinal fluid outlet, and a tube body (11) provided with a flow lumen (15). The distal portion (13) is provided with a limiting part (14) for contacting a dura mater. The maximum radial dimension of the limiting part (14) in a delivery state is greater than the minimum radial dimension of a puncture orifice and the tube body. The shunt system comprises the shunt (1) and a delivery system. The delivery system is used for delivering the shunt (1) to a designated position in a venous system and a ventricular system. In the delivery process, the shunt (1) is placed within the delivery system. By means of the distal portion (13) of the shunt (1), the dural puncture orifice is dilated, and the limiting part (14), whose dimension is larger than that of the puncture orifice, is pressed into a cistern. By utilizing the elastic recovery capability of the biological membrane itself, the limiting part (14) and the dura mater form a locking anchorage. The limiting part (14) is limited by its own dimensions. The structure and the operation are simple, thereby simplifying the delivery process and the delivery system.

The invention relates to a ventricular drainage tube fixing support device which comprises a main support and a drainage height adjuster and is characterized in that the drainage height adjuster comprises a zero-point adjusting support and a height adjusting scale, the zero-point adjusting support is installed on a vertical rod of the main support in a sliding mode, and the height adjusting scale is installed on the vertical rod of the main support. A locking knob for locking the vertical rod and a zero calibration mechanism for determining a zero point are mounted on the zero point adjusting support; the height adjusting scale is vertically installed on the zero-point adjusting support in a sliding mode, a scale lifting adjusting mechanism is arranged in the zero-point adjusting support, a transverse rod is fixedly connected to the side wall of the height adjusting scale, and a container hook is installed on the transverse rod. The drainage height adjuster is arranged on the main support, so that the ventricular drainage tube can be reliably fixed, the position of the ventricular drainage tube can be kept stable, the position of the highest point of the drainage tube can be accurately adjusted, cerebrospinal fluid drainage is uniform, and it is guaranteed that intracranial pressure is stable.

The present invention relates to the field of medical equipment technology, and discloses an interventional drainage shunt tube with a slit valve. The present invention includes a tube body of a tubular structure, the tube body including a distal portion provided with an inlet, a proximal portion provided as a blind end, and an inner cavity connecting the distal portion and the proximal portion. A slit valve is provided on the peripheral wall of the proximal portion near the blind end. The slit valve is opened by the pressure difference between the ventricular system and the venous system to discharge cerebrospinal fluid from the ventricular system to the venous system. The distance between the end of the slit valve close to the blind end and the blind end in the axial direction is 10°, thereby avoiding excessive gas remaining in the drainage shunt tube, causing it to be completely blocked and ineffective. The present invention can reduce the gas residue in the blind end of the shunt tube while ensuring that the shunt tube can perform stable drainage, thereby improving the safety and stability of the drainage shunt tube.

In the present invention, inventors demonstrate that prenatal excess of anti-Müllerian hormone triggers PCOS-like impairment in female sexual behavior in mice. Sexual dysfunction in PCOS-like mice is associated with decreased expression of neuronal nitric oxide synthase (nNOS) neurons in different hypothalamic regions known to be involved in female sexual behavior: rostral periventricular area of the third ventricle (RP3V), ventromedial nucleus of the hypothalamus (VMH), and arcuate nucleus (ARN) during estrus. Chemogenetic inhibition of nNOS neuronal activity in the ventromedial nucleus of the hypothalamus of control adult females recapitulates PCOS-like sexual dysfunction. Of clinical relevance, administration of nitric oxide (NO) donor rescues normal sexual behavior in PCOS-like mice. Accordingly, the present invention relates to invention relates to Nitric Oxyde (NO) agent for use in the prevention or the treatment of sexual dysfunction associated with Polycystic Ovary Syndrome (PCOS) or with Hypoactive Sexual Desire Disorder (HSDD) in a subject in need thereof.

The invention discloses a teaching model and a demonstration method for dynamically demonstrating a cerebrospinal fluid circulation pathway, and relates to the field of demonstration models, and the teaching model comprises a cavity with a lateral ventricle, a third ventricle and a fourth ventricle, and a brain shell of a subarachnoid space; water guide pipes are arranged between the cavities and between the fourth cavity and the subarachnoid cavity, the interior of each cavity is communicated with a water tank through a water inlet pipe and a water pump, and water simulating cerebrospinal fluid is stored in the water tank; a plurality of water outlets are formed in the subarachnoid cavity and are communicated with the water tank through drainage pipes; elastic filling materials serving as brain tissues are arranged among all the cavities and between the cavities and the subarachnoid cavity; an outlet of each water guide pipe is arranged to be a variable-diameter section, and a floating ball is placed in each water guide pipe. A motor is arranged outside each water guide pipe, and an output shaft of each motor penetrates through the corresponding water guide pipe to be connected with the corresponding floating ball through a traction rope. According to the invention, the teaching effect is enhanced by dynamically simulating the normal circulation process of cerebrospinal fluid and the pathophysiological change after obstruction.

The invention belongs to the technical field of medical instruments, and particularly discloses an intracranial drainage intelligent management and safety early warning device which comprises a mounting frame, and an adjusting and collecting device is arranged on the mounting frame and used for collecting cerebrospinal fluid; the drainage tube is connected to the adjusting and collecting device, and an insertion tube is arranged at the bottom end of the drainage tube and used for being inserted into the ventricle for drainage; and the adjusting mechanism is arranged between the drainage tube and the intubation tube. Limiting of the limiting structure on the drainage tube is relieved by rotating the protective cover, the length between the drainage tube and the intubation tube is adjusted by moving the drainage tube, then the length of the whole structure is adjusted, body positions of different patients, the spatial layout of a bed head and the installation position of an intelligent device are conveniently adapted, the length adjusting efficiency of the drainage tube is conveniently improved, and the practicability is high. The structural continuity, the overall reliability and the connection sealing performance of the pipeline are improved conveniently, and then the drainage efficiency is improved.

The invention discloses an external ventricular drainage device for monitoring intracranial pressure in real time and a use method thereof. The device comprises a drainage module, a pressure measuring module, a pressure regulating module and a liquid collecting module, the drainage module is used for leading cerebrospinal fluid out of the ventricle; the pressure measuring module is communicated with the drainage module and is used for measuring the pressure of cerebrospinal fluid, converting a pressure signal into an electric signal and displaying an intracranial pressure value in real time; reference height registration is set between the pressure measuring module and the pressure regulating module, so that the detection plane of the pressure measuring module corresponds to the zero point of the graduated scale of the pressure regulating module; the pressure regulating module is communicated with the drainage module, and the flow of cerebrospinal fluid led out by the drainage module is controlled by regulating the height of the shunt bottle; the liquid collecting module is communicated with the drainage module and is used for collecting the led-out cerebrospinal fluid. According to the invention, the monitoring precision, the operation intuition and the clinical safety of bedside external ventricular drainage can be improved, and the portability and the clinical adaptability are considered at the same time.

A catheter, in particular an external ventricular drainage catheter, for placement in a ventricular system, in particular of a human, for drainage of liquid, in particular of cerebrospinal fluid, from a ventricle of the ventricular system, includes a tubular body having an internal drainage lumen running along the tubular body for the drainage of the liquid and a port, arranged in a distal region of the tubular body, the port connecting the drainage lumen with an outside of the tubular body and outside of the catheter for the drainage of the liquid from the ventricle into the drainage lumen. The catheter further includes an ultrasonic sensor, or transducer, for emitting frontal ultrasound waves and detecting the frontal ultrasound waves reflected back to the at least one frontal ultrasonic sensor, in particular for obtaining a sonogram. The frontal ultrasonic sensor is arranged at a distal tip of said tubular body.