30 results about "Brain Ventricle" patented technology

The present invention relates to an improved cerebrospinal fluid shunt system comprising a coating covering at least part of the system and a flow restricting component exerting a passive and essentially constant resistance to flow. The present invention also relates to methods for implanting different catheters of a cerebrospinal fluid shunt system into a brain ventricle and the sinus system, respectively, of an individual. The present invention further relates to methods for shunting cerebrospinal fluid from a brain ventricle to the sinus system of an individual.

A cerebrospinal fluid shunt system comprises a brain ventricle catheter (15) to insert into the brain ventricle (21) so as to drain cerebrospinal fluid from the brain ventricle, a sinus catheter (18) to insert into the sinus sagittalis system (22) for feeding the cerebrospinal fluid into the sinus sagittalis system, a shunt body member (10) connected at one end thereof to said brain ventricle catheter and at another end thereof to said sinus catheter system to provide fluidic communication between said brain ventricle catheter (15) and said sinus catheter (18), and a flow restriction (16) defined within the shunt body member (10) to maintain a resistance to fluid flow of the shunt system of less than 8 mm Hg/ml/min, such as 2-7 or 4-6 and preferably about 5 mm Hg/ml/min. When the shunt system is implanted the shunt body member (10) is placed subcutaneously on top of the calvarium of a patient, behind the coronal suture on one of side of the sagittal suture. One end of each of the catheters (15, 18) is then connected to a respective end of the shunt body member (10), and a second end of each catheter is inserted in the right ventricle (21) and in the sinus sagittalis system (22), respectively, via holes bored in the scull (19).

An anti-siphon device limits the flow of a fluid from a first region of a patient's body to a second region. The device includes a housing having a spherical inner surface with a predetermined inner diameter. The housing has an inlet port for receiving fluid from the first region and an outlet port for directing fluid to the second region. The inlet port and the outlet port are disposed approximately diametrically opposite from each other. A spherical ball is disposed within the housing. The spherical ball has a ferromagnetic weight disposed off center therein. The spherical ball has an outer diameter that is less than the inner diameter of the housing so that the spherical ball is free to rotate within the housing and the fluid is free to flow between the inner surface of the housing and an outer surface of said spherical ball. The spherical ball has a circumferential recess extending through its center.

A therapeutic apparatus for treating intracranial disease by draining cerebrospinal fluid and monitoring injection pressure is composed of puncture needle, built-in tube for lower cavity of lumbar subarachnoid space or brain ventricle, pressure-measuring tube, pressure sensor, controller (YJR instrument), draining and lavation branches, and lavation pump. Its advantages are easy operation and high safety.

The present invention is directed to methods for controlled and optimized removal of cerebrospinal fluid (CSF) from the CSF space of a patient. The methods are particularly intended for the treatment of Alzheimer's disease and other conditions which are caused by, or otherwise related to, the retention and/or accumulation of toxic substances in the CSF. One aspect of the present invention provides a method for shunting toxic substances present in a brain ventricle to the sinus system of an individual suffering from, or at risk of developing, a condition related to the retention and/or accumulation of toxic substances in the CSF, such as Alzheimer's disease. In addition to Alzheimer's disease, the present invention will be useful for treating other conditions resulting from the accumulation of toxic substances and resulting lesions in the patient's brain, such as Down's Syndrome, hereditary cerebral hemorrhage with amyloidosis of the Dutch-Type (HCHWA-D), epilepsy, narcolepsy, Parkinson's disease, polyneuropathies, multiple sclerosis, amyotrophic lateral sclerosis (ALS), myasthenia gravis, muscular dystrophy, dystrophy myotonic, other myotonic syndromes, polymyositis, dermatomyositis, brain tumors, Guillain-Barre-Syndrome, and the like.

A system for analyzing a brain ventricle (8) is described. The system comprises an edge detector (52) for identifying an edge point (17) on an edge of the brain ventricle. Also, a length measurer (53) is provided for establishing a length measure of a path (10) starting from a central point (5) of the brain ventricle and terminating at the edge point (17). The edge detector (52) is arranged for detecting an edge point at an end of a lobe of the brain ventricle, the length measure corresponding to an extent of the lobe.

The invention provides an intravascular sub-hypothermia therapeutic instrument for an intensive care unit. The intravascular sub-hypothermia therapeutic instrument for the intensive care unit comprises a device in a human body and a device outside the human body, the device in the human body comprises a central temperature sensor probe and a central pressure sensor probe which are located on the forefoot position of the paracele of the human body and a three-cavity catheter located in a blood vessel of the human body, the device outside the human body comprises a control panel which conducts coordination treatment on the whole therapeutic instrument, a normal saline tank containing normal saline and a temperature regulating tank which contains cooling liquid and conducts regulation control on the temperature of the cooling liquid, and a complete circulation system is formed among the normal saline tank, the temperature regulating tank and the three-cavity catheter. The intravascular sub-hypothermia therapeutic instrument for the intensive care unit is simple in structure and convenient to use, the defects of an existing traditional cooling method are overcome, and the safety of a patient is improved by conducting heat exchange in the blood vessel; the temperature of a brain ventricle is measured, the temperature accuracy is guaranteed, and the safety is further improved; the temperature regulating chamber is arranged, rapid cooling and slow rewarming can be achieved, and the working difficulty of medical staff is reduced.

An implantable shunt system 10 and method include a ventricle catheter 12 for insertion into the brain ventricle, a distal catheter 14 for insertion into a selected terminus in the patient, and a regulating valve 16 for controlling flow through the distal catheter. An implantable pump 24 delivers a liquid thrombolytic solution upstream from the regulating valve, and a check valve 18 prohibits flow through the check valve in the direction toward the brain ventricle. A storage reservoir or chamber 26 is provided for containing the thrombolytic agent.

Volume changes in a brain, brain ventricle, or hippocampus are quantitatively extracted from a comparison of 3D before and after images using an algorithm that distorts a triangulated surface of the before image to produce the surface of the after image and calculates the volume change from the area change.

A method to characterize shape variations in brain ventricles during embryonic growth in mammals, the method including extracting a brain ventricle skeleton from one or more images, calculating a volume profile for the skeleton using the extracted images, partitioning the brain ventricle based on the volume profile along the skeleton, the brain ventricle being partitioned into two lateral ventricles and a main ventricle, the main ventricle being further partitioned into three sub regions, determining volume vectors of the two lateral ventricles and the three sub regions, computing a means square error between the determined computed volume vectors and a pretrained mean volume vector of embryos during different gestational stages, and classifying the embryo to the gestational stage having the lowest mean square error. A method to characterize mutant detection in mammals, the method including acquiring one or more images, computing a volume profile directly along a path of the detected skeleton from the one or more images, aligning the volume profile against a standard profile, and evaluating the volume profile against the standard profile to detect a mutation.

The invention provides methods and uses for delivering progranulin to the central nervous system (CNS) of a mammal. Methods and uses include, for example, administering to a mammal a vector comprising a nucleic acid encoding progranulin, variant, derivative or functional fragment thereof to the mammal's brain ventricle to transduce CNS cells and/or cells that contact the cerebrospinal fluid (CSF) of the mammal such that the cells express the progranulin, variant, derivative or functional fragment thereof.

The present invention provides a novel method to isolate and expand pure neural stem cells (NSCs) from cerebrospinal fluid (CSF) of premature babies with Intraventricular haemorrhage, which produces a population enriched in NSC-CSF cells free of contaminating fibroblasts and other cell types. The present invention also includes substantially pure populations of CSF-NSC cells, and their use to treat and prevent diseases and injuries, including Intraventricular haemorrhage and post-hemorrhage hydrocephalus/developmental deficits.

A puncture drainage needle for intracranial ommaya sac, including a puncture needle, a pressure sensor, a flow sensor and a drainage connection tube, the puncture needle is connected to the drainage tube, and two lumen channels are arranged inside the puncture needle, one of which is a pressure probe and a drainage tube. The pressure sensor is connected to the channel through the conduction line channel, and the other lumen is the fluid drainage channel; the flow sensor is placed on the drainage tube with an adjustment knob; the puncture needle is divided into an intracranial section and an extracranial section, and the two sections are connected by an arc corner; There is a needle tip side hole in the needle tip of the segment, and a double needle wing structure is installed on the extracranial segment. The needle tube of the extracranial segment is connected with a drainage tube, and a pressure sensor, a flow sensor, and a medical three-way tube are installed on the drainage tube. The present invention can efficiently puncture the intracranial ommaya sac, adjust the drainage velocity of hemorrhage or cerebrospinal fluid, monitor intracranial pressure, ensure the smoothness of the pipeline, and provide dynamic monitoring for the treatment of patients with hemorrhage or hydrocephalus, which is beneficial to the prognosis of patients and treatment.

The invention relates to a drainage tube. The drainage tube is used for solving the problem that drainage tubes are prone to falling off from a brain ventricle. The drainage tube comprises an expandable elastic bladder (3), a catheter (2) and a drainage tube body (1). The elastic bladder (3) is provided with a hollow cavity; the ventricle end (5) of the drainage tube body is a closed end, and a drainage port (4) is formed close to the closed end; the elastic bladder (3) is arranged on the circumference of the drainage tube; the catheter (2) is communicated with the elastic bladder (3) and used for filling fluid into the cavity to expand the elastic bladder (3); the elastic bladder is not communicated with the drainage tube body. According to the drainage tube, the expandable elastic bladder formed in the drainage tube can limit the drainage tube inside the brain ventricle to prevent the drainage tube from falling off from the ventricle, thereby effectively avoiding accidents during a drainage process.

The invention discloses a 3D gradient spin echo diffusion imaging method for inversion recovery preparation, a medium and equipment. The method comprises the following steps of firstly, in an inversion recovery preparation module, applying 180-degree inversion radio frequency pulse, and setting corresponding inversion recovery time to inhibit cerebrospinal fluid and free water signals; secondly, embedding a pair of trapezoidal cosine oscillation gradients or pulse gradients into 90-degree x-180-degree y-90-degree-x radio frequency pulses through a diffusion coding module, and separating diffusion coding from signal acquisition; then, inhibiting a fat signal by using a fat saturation module; and finally, collecting signals by adopting a 3D gradient spin echo reading mode. The time and the signal-to-noise ratio of magnetic resonance diffusion imaging are improved, accurate measurement of brain tissue diffusion magnetic resonance signal time dependence is facilitated, the effect is especially obvious for a brain area which is near a ventricle and is influenced by the cerebrospinal fluid due to a partial volume effect, and the clinical transformation of a time-dependent diffusion magnetic resonance technology is effectively promoted.

The invention discloses a device capable of effectively preventing infection of ventricular drainage patients. The device comprises a glass bottle, wherein a first rubber plug is arranged at the bottom of the bottleneck of the glass bottle, a first rubber hose is arranged at the bottom end of the glass bottle, a tree-way part is arranged on one side of the bottom end of the first rubber hose, anda second rubber hose is arranged at the side end of the three-way part. A silicone hose is arranged at the side end of the second rubber hose, a double-layer rubber pad is connected onto the siliconehose, and a screw fastener is arranged at the side end of the double-layer rubber pad. A connecting pipe is arranged at the bottom end of the three-way part, a second rubber plug in sealing fit with the inner wall of the three-way part is arranged in the connecting pipe, a wooden plug in sealing fit with the connecting pipe is arranged below the second rubber plug, and the three-way part is effectively sealed to prevent infection; and meanwhile, the double-layer rubber pad is closely attached to scalp of a patient by tightening the screw fastener, then, the double-layer rubber pad is adhered to the scalp of the patient by adhesive tapes, the sealing performance is increased, cerebrospinal fluid leakage is prevented, and infection is prevented.

The invention relates to the technical field of medical apparatus and instruments, and discloses a precise positioning brain retraction device which comprises a brain retraction mechanism and a precise positioning guide mechanism, and the brain retraction mechanism is used for blocking soft tissues around a surgical field; and the precise positioning guide mechanism is used for assisting the brain retraction mechanism in precisely entering a surgical target position. According to the invention, the hard catheter can be sleeved on the navigation pen of the IGS (the navigation is influenced by neurosurgery), the hard catheter is accurately inserted into the required operation position through the D mode planning of the IGS, the whole operation process is relatively convenient, the action of repeatedly sucking effusion is not needed, the insertion accuracy is high, and the operation is convenient. After the navigation pen is pulled out and the brain retraction mechanism is inserted in place, when the pressure in the ventricle or brain tissue rises, cerebrospinal fluid or hematocele can flow out of the hard catheter, so that the brain injury caused by high pressure to the brain of a patient is avoided, and the brain retraction mechanism can be directly and successfully inserted into the ventricle or hematoma cavity at a time along the hard catheter. And contusion to surrounding brain tissues in a repeated attempt process is avoided.

The invention discloses a ventricular drainage tube clamping device for neurosurgery, and relates to the technical field of medical instruments, the ventricular drainage tube clamping device comprises a mounting rack, a sleeve and a motor are fixedly arranged on the mounting rack, a heat-conducting medium is arranged in the sleeve, a drainage tube axially penetrates through the sleeve and is located in the heat-conducting medium, two ends of the sleeve are plugged by plugging pieces, and the motor is arranged on the motor. A heater and a circulating mechanism are arranged on the mounting frame, the sleeve, the heater and the circulating mechanism are connected in series through a guide pipe to form a backflow circulating structure, a heat-conducting medium circularly flows to heat the drainage pipe in a water bath, and an oscillating mechanism for improving the circulation of the drainage pipe is arranged on the sleeve. And the circulating mechanism and the oscillating mechanism are driven by a motor. The drainage tube is continuously heated in a water bath through the heat-conducting medium, so that cerebrospinal fluid in the drainage tube is not easy to cool and cake during circulation, and the liquidity of the drainage tube is improved.

The invention discloses an application of deoxyribonuclease I to preparation of a medicine for treating and preventing traffic hydrocephalus. The application is characterized in that the deoxyribonuclease I is used as an effective component and is used for degrading free DNA (deoxyribonucleic acid) in cerebrospinal fluid after intracranial hemorrhage or intracranial infectious diseases, so that the traffic hydrocephalus is treated and prevented; and the neurocognitive function is improved by relieving ventricular dilation caused by traffic hydrocephalus. Animal experiments prove that a kaolin-induced rat traffic hydrocephalus model is used as a research carrier. The level of the free DNA in cerebrospinal fluid can be remarkably reduced by injecting the deoxyribonuclease I into the lateral ventricle, and the nuclear magnetic resonance result shows that the deoxyribonuclease I can remarkably reduce the degree of ventricle expansion after 28 days. Through further application of a water morris maze experiment, it is found that the deoxyribonuclease I can obviously improve the neurocognitive function of an experimental animal.