86 results about "Cerebro spinal fluid" patented technology

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The invention provides an analogue simulation method for accumulated craniocerebral injury under the action of multiple shock waves, and relates to the technical field of data processing. The method comprises the following steps: constructing an explosive shock wave model; constructing a head geometric model; the brain, the cerebellum and the brainstem in the solid area are represented through a Mooney Rivlin model; representing the skin, muscles and skull in the solid area through a linear elastic constitutive model; the cerebrospinal fluid in the fluid area is represented through the fluid dynamic model; coupling the fluid region and the solid region through an embedded boundary method; calculating the explosion impact pressure when the explosion impact waves of each turn are transmitted to the head through an explosion impact wave model; through a finite element analysis method, accumulated skull displacement, skull acceleration, skull stress, skull strain and intracranial pressure under the action of each turn of explosion shock waves are determined, and a brain accumulated injury value is calculated.

The invention relates to a biological glue patch applied to non-invasive repair of dura mater, and relates to the technical field of medical biological materials. The biological glue patch comprises a patch base material, a biological membrane layer is arranged on one side of the patch base material, a hydrophobic membrane layer is arranged on the outer side of the biological membrane layer, a vacuum cavity is formed between the inner side of the biological membrane layer and the side portion of the patch base material, and biological glue is arranged in the vacuum cavity; one side, facing the biological membrane layer, of the patch base material is provided with a stabbing part for stabbing the biological membrane layer and the hydrophobic membrane layer. According to the biological glue patch, repairing of the dura mater is achieved in a glue adhesion mode, pinholes are avoided, the phenomenon of leakage of cerebrospinal fluid is avoided, meanwhile, the biological glue is protected through the biological film layer and the hydrophobic film layer, and the biological glue is prevented from being solidified and adhered in advance; the biological glue is released by arranging the stabbing part, the operation is simple, and the device can be applied to repairing the dural mater injury by a non-invasive single-side dual-channel spine endoscope technology.

The invention relates to the technical field of lumbar puncture devices, in particular to an optical fiber lumbar puncture pressure measuring injection gun. The device is characterized in that (1) an optical fiber is used for replacing an original needle core, and a grating is arranged at the position, close to a needle head, of the optical fiber, so that the device can play a role of the original needle core and can accurately position a puncture position by measuring the tissue refractive index; and (2) a novel fiber bragg grating bourdon tube pressure sensor is added, so that accurate real-time pressure measurement in the puncture process is realized. (3) a cerebrospinal fluid collecting and discharging operation trigger and a piston injector operation trigger are arranged on an operation gun, a piston injector and a one-way valve injector are arranged at the muzzle end of the operation gun, and a push rod of the one-way valve injector is fixedly connected with the cerebrospinal fluid collecting and discharging operation trigger through a first connecting rod; a collection one-way valve I is arranged at the inlet end of the one-way valve injector, a discharge one-way valve II is arranged at the outlet end of the one-way valve injector, and the inlet end is in airtight communication with the puncture needle through a three-way structure. A push rod of the piston injector is fixedly connected with the piston injector operation trigger through the second connecting rod, a discharging one-way valve III is arranged at the inlet end of the piston injector, and the inlet end of the piston injector is in airtight communication with a puncture needle through a three-way structure. The cerebrospinal fluid collecting and discharging trigger is pressed down so that negative pressure can be formed in the one-way valve injector, the cerebrospinal fluid discharging trigger is released so that positive pressure can be formed in the one-way valve injector, and the puncture process of a needle core in the puncture needle and the puncture process of a pressure measuring device are optimized through fiber bragg gratings. The pressure of cerebrospinal fluid is dynamically monitored at a time, a cerebrospinal fluid sample is reserved, a contrast agent and medicine are injected, and the lumbar puncture pressure measuring and liquid discharging injection process is optimized.

A method and device for reducing the damaging effects of a blast or concussive event includes applying pressure to at least one jugular vein to reduce the egress of blood from the cranial cavity during the incidence of the concussive event. Reducing blood out flow from the cranial cavity increases intracranial pressure of the cerebrospinal fluid to reduce the risk of traumatic brain injury and injuries to the spinal column. Reducing blood out flow further increases the intracranial pressure, and thereby increases the pressure of the cochlear fluid, the vitreous humor and the cerebrospinal fluid to thereby reduce the risk of injury to the inner ear, internal structure of the eye and of the spinal column. In addition, increasing intracranial pressure reduces the likelihood of brain injury and any associated loss of olfactory function.

The invention relates to an implantable selective spinal nerve root stimulation system, comprising a stimulator for generating an electrical stimulation signal having a frequency, pulse width and intensity, at least one stimulation electrode with stimulation contacts at the distal end, said stimulation electrodes extending towards the head end along the course of the horsetail nerve and penetrating out of the dural sac region at a midline, the device penetrates out of the skin from inside to outside through a spinous process gap or is directly connected with a stimulator along a subcutaneous tunnel. The stimulation contact of the stimulation electrode is elastically fixed in the free dorsal root nerve area in a surrounding mode, and the resistance from the stimulation contact to cerebrospinal fluid is larger than the resistance between the stimulation contact and the ectofascia which is elastically fixed to the dorsal root nerve. According to the invention, the problem that the function recovery of paraplegia lower limbs after high spinal cord injury cannot be effectively promoted due to the defects of poor reliability, great influence on the body position of a patient, high power consumption and the like caused by the existence of cerebrospinal fluids with different thicknesses between the existing stimulation electrode and the spinal cord and the dorsal nerve root can be solved.

The invention relates to the technical field of medical training, and discloses a lumbar puncture simulation teaching system based on an AR technology, and the system comprises an AR content generation module which collects a lumbar medical image and carries out the tissue segmentation and focus recognition; performing three-dimensional geometric modeling based on the tissue segmentation result and the focus recognition result to generate a lumbar vertebra 3D model; the AR display interaction module develops an interaction function of the lumbar vertebra 3D model by using a Unity platform and AR equipment; interactive operation of the user is monitored, and feedback is conducted in real time; and the operation evaluation module is used for evaluating the interaction operation of the user and assigning an improvement suggestion according to an evaluation result. A three-dimensional visual scene is constructed through the AR technology, a user can observe the needle inserting process from different angles according to the complex anatomical structure of the lumbar vertebra part, and dynamic effects such as cerebrospinal fluid pressure change are simulated; in the lumbar puncture simulation training, the AR system can feed back operation data in real time, such as the needle inserting angle, the puncture strength and the puncture depth, and the user is helped to accurately master operation skills.

In some embodiments, apparatus and related methods relate to a skeletal body adjustment device (SBAD) with telescopically connected bodies. For example, the SBAD may include control members configured to induce relative translation between the bodies. In some embodiments, apparatus and related methods relate to a body cavity conforming shunt. As an illustrative example, the shunt may, for example, include selectively deployable contact members. The contact members may, by way of example and not limitation, be configured as anchors, sensors, and / or therapy delivery devices. In some embodiments, apparatus and related methods relate to a multi-layer bladder (MLB) selectively deployable in a body cavity. The MLB may, for example, include sensing and / or delivery components. The MLB may, for example, include control member(s) and / or pressure control(s) configured to control shape, size, and / or pressure of the MLB. In some embodiments, apparatus and related methods relate to a dynamically controlled cerebrospinal fluid (CSF) shunt system.

The invention relates to the technical field of curative effect prediction, in particular to a curative effect prediction method and system for treating spinal cord injury by stem cells, and the method comprises the following steps: obtaining a multi-parameter metabolism sequence and constructing an activation rhythm map, recognizing a neural restoration synchronization section, extracting a metabolism dominant path and evaluating electrical signal response, generating a para-position map layer and predicting a curative effect trend. According to the method, through introduction of cross-time-sequence metabolism and trend synchronous identification of electrophysiological indexes, dynamic mapping of stem cell activation rhythms is realized, neural axon morphological changes and cerebrospinal fluid metabolism parameters are linked, and distribution positions of key response points in a treatment cycle are determined; the method comprises the following steps: establishing a causal path based on a sequence of metabolic mutation and neural restoration events, extracting an evolution stage dominated by a metabolic driving effect, marking a matching trend of a curative effect response and an intervention path on a time axis, identifying the number and positions of trend convergence, withdrawal and interruption areas, and realizing collaborative prediction of a restoration progress and a curative effect trend.

The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein components of inflammasomes in the cerebrospinal fluid that can be used to assess the severity of central nervous system injury in a patient are disclosed. Methods of using such protein biomarkers to determine a prognosis, direct treatment and rehabilitation efforts, and monitor response to treatment for a patient with a central nervous system injury are also described.

The present disclosure relates generally to a device and method for aiding in the repair of a dural tear. According to example embodiments, the device is placed substantially within a dural sac interior to a dural tear. The device provides a shield that prevents the underlying nerve roots (including rootlets) of the spinal cord from intruding into the torn area and prevents them from being injured during the repair procedure. The device also redirects cerebrospinal fluid from the area, which aids the surgeon in viewing the procedure site during suturing and / or repair.

The present invention relates to a spinal needle that clearly identifies the presence of cerebrospinal fluid (CFS) to dispense a drug or anaesthetic in the correct direction and site of the meninges. The response of the sensor to the presence of CFS does not depend on environmental factors and is performed quickly to prevent excessive loss of CFS in the patient. The spinal needle comprises a hub having a proximal end and a distal end, said hub comprising a transparent tank arranged at the proximal end of the hub that is configured to receive CFS, an expandable CFS sensor arranged inside the transparent tank and a connection port arranged at the distal end of the hub configured to couple to a device for medical fluids, and a cannula comprising a tip fluidically connected to the proximal end of the hub.

Monitoring cardiopulmonary function of a patient based on cerebrospinal fluid (CSF) pressures involves fluidly communicating a first catheter with a first CSF access site of the patient; fluidly communicating a second catheter with a second CSF access site of the patient; providing, using a first pressure sensor in fluid communication with the first catheter, Erst pressure readings associated with the first CSF access site; providing, using a second pressure sensor in fluid communication with the second catheter, second pressure readings associated with the second CSF access site; and determining a cardiopulmonary function parameter associated with the patient based on first and second pressure signals derived from the first and second pressure readings. The first CSF access site may be associated with a brain ventricle of the patient and the second CSF access site may be associated with the patient's lumbar.

This invention discloses a vibration reduction and shock-resistant method and system for aerospace sensors in the field of aerospace equipment technology. The system includes a bracket and a sensor mounting base, which are fixedly connected by a first bolt. A vibration reduction and shock-resistant device is sleeved on the portion of the first bolt located between the bracket and the sensor mounting base. The vibration reduction and shock-resistant device includes a sleeve sleeved on the first bolt, with the inner wall of the sleeve threadedly connected to the first bolt. An end cap is threadedly connected to the middle of the outer wall of the sleeve, completely enclosing the lower part of the sleeve. A vibration reduction and shock-resistant space is left between the outer wall of the sleeve and the inner wall of the end cap. A multi-layered vibration reduction and shock-resistant structure resembling a woodpecker is provided within the vibration reduction and shock-resistant space. The multi-layered vibration reduction and shock-resistant structure resembling a woodpecker includes a beak layer, a hyoid bone layer, a cancellous layer, and a cranial cerebrospinal fluid layer arranged sequentially from the outer wall of the sleeve to the inner wall of the end cap. This solution, based on the vibration reduction mechanism of a woodpecker's head, can effectively disperse residual energy, allowing impact energy to be transmitted in multiple directions.

The application relates to the technical field of landing gears, in particular to a shock-absorbing landing gear imitating the head bone structure of a woodpecker and a preparation method, wherein the main body of the shock-absorbing landing gear is prepared from a TiAl alloy material, and the shock-absorbing landing gear comprises, from outside to inside, a strength layer, a buffer layer and a toughness layer; the strength layer imitates the hyoid layer of the head bone of a woodpecker; the buffer layer imitates the cancellous bone layer of the head bone of a woodpecker; and the toughness layer imitates the cerebrospinal fluid layer of the head bone of a woodpecker. The landing gear prepared by imitating the head bone structure of a woodpecker has excellent shock-absorbing and impact-resisting capacity; the landing gear is prepared by adopting a selective laser melting (SLM) technology, the number of connecting pieces in the landing gear is reduced, unnecessary assembly steps are saved, and assembly errors are reduced; the material and the part are integrally formed, and complicated preparation steps and machining processes are avoided.

An analysis method that comprises a step for detecting, by mass spectrometry, at least one of lysophosphatidylcholine and lysophosphatidic acid in a biological sample and uses a lysophosphatidylcholine compound containing a stable isotope element in a choline moiety as a standard sample can develop a technique capable of accurately analyzing lysophosphatidylcholine and lysophosphatidic acid in a spinal fluid.

In a method for measuring brain free water content, in response to an RF excitation field generated on the basis of a magnetic resonance fingerprinting sequence and applied to the brain, an equilibrium magnetization mixed term (M0) signal is acquired from radiation emitted by each excited voxel of the brain, to obtain an M0 value of each voxel of the brain; a receive coil sensitivity (RP) value of each voxel of the brain is acquired; the M0 value of each voxel of the brain is divided by the RP value of the corresponding voxel to obtain a proton density (PD) value of each voxel of the brain; a PD value of cerebrospinal fluid is taken to be a reference PD value; and the PD value of each voxel of the brain is divided by the reference PD value to obtain the free water content of each voxel of the brain. The method advantageously increases the speed and accuracy of measurement of brain free water content.

The present invention pertains to the anti-inflammatory therapeutic effect of xantohumol in spinal cord injury (SCI). The continuous administration of xanthohumol for 1-8 weeks to SCI rats resulted in improved results in 4 clinical tests used and in lowering and faster elimination of macrophages from the SCI lesion. Since the infiltration of the SCI lesion by numerous phagocytic macrophages indicates a severe destructive inflammation of extraordinary longevity, administration of xanthohumol is neuroprotective and resulted in a better and faster recovery of the locomotor function and the strength and sensory function in the hind limbs, in a shorter period of paralysis of the urinary bladder and in the recovery of the body weight lost due to the SCI surgery. Since the traumatic brain injury (TBI) involving the white matter, and stroke involving the white matter initiate the severe destructive inflammation as in the SCI, the administration of xanthohumol is expected to be anti-inflammatory and neuroprotective in both brain diseases. Since neurodegenerative diseases including Alzheimer's disease, frontotemporal dementia and Parkinson's disease, immune mediated neuroinflammation including multiple sclerosis and neuromyelitis optica and cerebrospinal infections have inflammatory pathogenesis involving microgliosis and infiltration by macrophages, the administration of xanthohumol is expected to result in therapeutic inhibition of progression of all above diseases as well as of related neurodegenerative, immune mediated and infectious diseases of the brain and of the spinal cord.

The utility model relates to the technical field of experimental extraction devices, in particular to a mouse cerebrospinal fluid extraction device, which comprises a supporting part, a connecting part and a connecting part, the supporting part consists of a vertical plate and a transverse plate, the vertical plate is fixedly connected to the upper surface of the transverse plate, so that the whole supporting part is L-shaped, and a groove for placing a mouse head is formed in the vertical plate; the mouse body fixing part is fixedly arranged on the upper surface of the transverse plate and comprises a supporting plate and a bandage; the hand placing part is movably arranged on the upper surface of the transverse plate and is used for placing the hand of a sampling person; the mouse head fixing part is arranged on the vertical plate and comprises two clamping plates which move relatively and a driving unit, the whole body of a mouse is fixed through the mouse body fixing part and the mouse head fixing part, the hand placing part is moved to the position above the mouse body, and the hand of a sampling person is placed through the hand placing part; the situation that the hand of a sampling person shakes when the spines of the mouse are extracted, and the extraction efficiency is affected is avoided.

This utility model discloses a lumbar puncture needle with monitoring function, comprising: a needle body, with a puncture needle main body internally connected to the needle body. The puncture needle main body is used to detect puncture depth and monitor cerebrospinal fluid pressure. The puncture needle main body includes an outer needle and an inner needle, with the inner needle located inside the outer needle. A gap is reserved between the outer and inner needles. A signal receiving mechanism is provided at the top of the outer needle. Both the outer and inner needles are electrically connected to the signal receiving mechanism via a point-to-line connection. This utility model provides a lumbar puncture needle with monitoring function, consisting of a system and a puncture needle main body. It can issue an alarm when the puncture needle tip contacts the cerebrospinal fluid in the subarachnoid space of the lumbar spine, and can monitor the cerebrospinal fluid pressure in real time during cerebrospinal fluid collection. Through precise puncture depth feedback and real-time cerebrospinal fluid pressure monitoring, doctors can more accurately locate the puncture point, reduce surgical errors, and improve the success rate of surgery. Real-time monitoring of cerebrospinal fluid pressure helps to detect abnormal intracranial pressure in a timely manner, prevent serious complications such as brain herniation, and ensure patient safety.

The disclosed system provides an integrated neuroimaging analytics platform for comprehensive preoperative neurosurgical planning, intraoperative neurosurgical guidance and post-operative assessment by processing multimodal MRI (structural, diffusion, functional, and angiography) and CT data. The platform performs detailed anatomical characterization by delineating tumor subregions (peritumoral edema, enhancing tumor, and necrotic core), segmenting brain tissues (gray matter, white matter, and CSF), and executing lobe, cortical / subcortical parcellation. Advanced 3D rendering visualizes tumors alongside critical white matter fibre tracts derived from diffusion MRI, while MRA data is used to segment cerebrovascular structures, and functional MRI analysis identifies eloquent cortices associated with motor, speech, and visual functions. All results are integrated within a user-friendly GUI featuring advanced multiplanar slicing and a smart brush for interactive mask editing, complemented by a speech-to-text engine for streamlined analytical reporting. This comprehensive approach facilitates precise and efficient surgical planning, thereby enhancing patient safety and improving clinical outcomes.

The utility model discloses a spinal nerve postoperative prone position pillow which comprises a bottom plate, a supporting block is fixedly connected to the top of the bottom plate, a hip placing platform is formed at the top of the supporting block, and a plurality of first clamping grooves are formed in the two sides of the top of the bottom plate; and the number of the placing plates is two, the two placing plates are arranged on the two sides of the supporting block respectively, and the placing plates are hinged to the supporting block. The hip of a patient is placed through the supporting block, the back and the legs of the patient are placed on the two placement plates with the adjustable inclination angles respectively, when the patient lies on the device prostrate, the hip of the patient is raised, the head of the patient is lower than the hip, cerebrospinal fluid backflow of the patient is increased, the tension of an operation wound is relieved, and the patient is more comfortable. In the recovery process of the patient, the height difference between the head and the hip of the patient can be continuously adjusted by adjusting the position of the supporting plate according to the condition of the patient, and postoperative nursing and recovery of the spinal nerve are facilitated.

The invention relates to the technical field of anesthetic injection, and discloses a puncture kit for preventing cerebrospinal fluid from leaking outwards for combined spinal-epidural anesthesia in the biomedical obstetrics department, the puncture kit comprises a kit box, the outer wall of the kit box is rotatably connected with a kit cover, the inner wall of the kit box is fixedly connected with a storage rack, the interior of the kit box is provided with an opening mechanism, and the opening mechanism is connected with the storage rack. A liquid guide mechanism is arranged in the sleeve box, a detection injection mechanism is arranged in the sleeve box, the opening mechanism comprises a skin breaking needle, an anesthetic cabin, a grasping handle, a finger ring and a resistance ring, and the skin breaking needle is connected to the inner wall of the storage frame in a sliding mode. Therefore, subcutaneous infiltration, skin breaking and anesthetic injection of a patient are carried out at the same time, the surgical operation process is simplified, the psychological burden of the patient is relieved, and meanwhile the dosing accuracy and effectiveness can be improved.

The utility model relates to the technical field of medical experiments, in particular to an auxiliary device for subarachnoid space injection or sampling, which comprises a spine clamping component and an indwelling hose detachably connected with the spine clamping component. The pipe penetrating through hole is used for allowing the indwelling hose to penetrate through. The device overcomes the defects that in the prior art, when cerebrospinal fluid is extracted from the subarachnoid space of a mouse or medicine is injected, mouse tissue needs to be cut open for multiple times, so that the experiment time and cost are increased, and the mouse is injured, and the device is arranged above the exposed spinal cord of the mouse, so that tissue adhesion can be effectively prevented; besides, injection or sampling operation can be directly performed through the indwelling hose, tissue does not need to be cut open again to expose the spinal cord, the experiment efficiency can be improved, and further damage to the mouse caused by multiple times of cutting open of the damaged part can be avoided.

The invention relates to the technical field of medical apparatus and instruments, and discloses a puncture indwelling device suitable for an Ommaya sac, which comprises a puncture needle body and a fixing assembly, the fixing assembly comprises a base. The base comprises a shell, an outlet formed in the bottom of the shell and a puncture diaphragm arranged above the shell. The inner side of the shell is an arc-shaped curved surface matched with the outer surface of the Omaya bag, a guide pipe is arranged at the bottom of the base, and the two ends of the guide pipe are connected with the Omaya bag and the outlet respectively; the puncture needle body comprises a needle tip, a needle tube, a needle wing and an extension tube which are connected with one another, the needle tip is inclined, an opening is formed in the side face of the needle tube, and the length of the needle tube is 2-3 cm. An annular rib is arranged on the inner side of the shell, and a medical silicone pressure-sensitive adhesive layer is arranged on the outer side of the annular rib. One end of the extension tube far away from the needle wing is provided with a liquid injection drainage joint. By means of the device, repeated puncture of a patient with the Ommaya bag can be avoided every day, the medical workload and scalp stimulation of a child patient are reduced, the infection risk is reduced, and needle head disengagement and ectopic and cerebrospinal fluid leakage are prevented.

The invention discloses a nerve detacher, and relates to the field of surgical tools. The nerve detacher comprises a cutting base, and a ligamentum flavum cutting unit and a ligamentum flavum separating unit are arranged on the cutting base. According to the nerve detacher, through the arrangement of the ligamentum flavum separating unit and the ligamentum flavum cutting unit, when the ligamentum flavum is cut, the second driving mechanism is used for driving the multiple sets of arc-shaped hook needles to rotate and prick into the ligamentum flavum, the nerve detacher is directly lifted through external force, and then the ligamentum flavum can be stressed and separated from the dura mater; subsequently, the ligamentum flavum is cut through the cutting action of a cutting tool bit in the ligamentum flavum cutting unit to quickly form a target incision, the cutting mode does not cause dura mater injury and the conditions of subsequent dura mater damage, cerebrospinal fluid leakage and iatrogenic injury increase, and the nerve detacher is simple to operate and high in practicability. The stability of the post-operation spine of the patient is guaranteed, and the spine fixing device is suitable for being used and popularized.

The invention provides a liquid storage bag with a wireless pressure monitoring function. The liquid storage bag comprises a liquid storage bag shell, a ventricular catheter connector, a flexible film and a wireless pressure sensor. A liquid storage cavity used for storing cerebrospinal fluid is formed in the liquid storage bag shell, and a pumping and injecting window is formed in the top wall, facing the scalp of a patient, of the liquid storage bag shell. The ventricular catheter connector is arranged on the liquid storage bag shell and communicated with the liquid storage cavity. And the flexible film covers the pumping and injecting window in a sealing manner. The wireless pressure sensor comprises a sensor body and an antenna, and the wireless pressure sensor is arranged in the liquid storage bag shell and makes contact with the liquid storage cavity so as to collect intracranial pressure signals of a patient and transmit the intracranial pressure signals to an external receiver. Wherein the wireless pressure sensor is a sensor based on a surface acoustic wave resonator or a film acoustic bulk wave resonator.

The invention relates to the technical field of medical apparatus and instruments, in particular to a spinal anesthesia cerebrospinal fluid color-changing puncture needle for anesthesia, which at least comprises an input part used for rotatably regulating and controlling the angle of mounting an injector and forming two channels used for conveying anesthetics; the color developing part is used for assisting taking and arranged at the end of the input part, anesthetic flows into the color developing part through bidirectional impact of the input part, a puncture needle tube is arranged at the input end of the color developing part, a needle core is arranged in the puncture needle tube, and the color developing part is used for displaying when the puncture needle tube makes contact with cerebrospinal fluid. The purpose of rotationally regulating and controlling the angle of the injector is achieved by regulating and controlling the inclination angle of part of the structure through the input part, anesthetics collide with one another and are mixed doubly through other structures in the input part and the color developing part, the anesthesia effect is improved, and part of the structure of the color developing part makes contact with cerebrospinal fluid, so that the anesthetic effect is improved. And other structural colors in the color developing part are changed, so that puncture is facilitated, and pain of a patient is reduced.