62 results about "Cerebro spinal fluid" patented technology

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The invention relates to a biological glue patch applied to non-invasive repair of dura mater, and relates to the technical field of medical biological materials. The biological glue patch comprises a patch base material, a biological membrane layer is arranged on one side of the patch base material, a hydrophobic membrane layer is arranged on the outer side of the biological membrane layer, a vacuum cavity is formed between the inner side of the biological membrane layer and the side portion of the patch base material, and biological glue is arranged in the vacuum cavity; one side, facing the biological membrane layer, of the patch base material is provided with a stabbing part for stabbing the biological membrane layer and the hydrophobic membrane layer. According to the biological glue patch, repairing of the dura mater is achieved in a glue adhesion mode, pinholes are avoided, the phenomenon of leakage of cerebrospinal fluid is avoided, meanwhile, the biological glue is protected through the biological film layer and the hydrophobic film layer, and the biological glue is prevented from being solidified and adhered in advance; the biological glue is released by arranging the stabbing part, the operation is simple, and the device can be applied to repairing the dural mater injury by a non-invasive single-side dual-channel spine endoscope technology.

The invention relates to the technical field of medical training, and discloses a lumbar puncture simulation teaching system based on an AR technology, and the system comprises an AR content generation module which collects a lumbar medical image and carries out the tissue segmentation and focus recognition; performing three-dimensional geometric modeling based on the tissue segmentation result and the focus recognition result to generate a lumbar vertebra 3D model; the AR display interaction module develops an interaction function of the lumbar vertebra 3D model by using a Unity platform and AR equipment; interactive operation of the user is monitored, and feedback is conducted in real time; and the operation evaluation module is used for evaluating the interaction operation of the user and assigning an improvement suggestion according to an evaluation result. A three-dimensional visual scene is constructed through the AR technology, a user can observe the needle inserting process from different angles according to the complex anatomical structure of the lumbar vertebra part, and dynamic effects such as cerebrospinal fluid pressure change are simulated; in the lumbar puncture simulation training, the AR system can feed back operation data in real time, such as the needle inserting angle, the puncture strength and the puncture depth, and the user is helped to accurately master operation skills.

The invention relates to the technical field of curative effect prediction, in particular to a curative effect prediction method and system for treating spinal cord injury by stem cells, and the method comprises the following steps: obtaining a multi-parameter metabolism sequence and constructing an activation rhythm map, recognizing a neural restoration synchronization section, extracting a metabolism dominant path and evaluating electrical signal response, generating a para-position map layer and predicting a curative effect trend. According to the method, through introduction of cross-time-sequence metabolism and trend synchronous identification of electrophysiological indexes, dynamic mapping of stem cell activation rhythms is realized, neural axon morphological changes and cerebrospinal fluid metabolism parameters are linked, and distribution positions of key response points in a treatment cycle are determined; the method comprises the following steps: establishing a causal path based on a sequence of metabolic mutation and neural restoration events, extracting an evolution stage dominated by a metabolic driving effect, marking a matching trend of a curative effect response and an intervention path on a time axis, identifying the number and positions of trend convergence, withdrawal and interruption areas, and realizing collaborative prediction of a restoration progress and a curative effect trend.

The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein components of inflammasomes in the cerebrospinal fluid that can be used to assess the severity of central nervous system injury in a patient are disclosed. Methods of using such protein biomarkers to determine a prognosis, direct treatment and rehabilitation efforts, and monitor response to treatment for a patient with a central nervous system injury are also described.

The present disclosure relates generally to a device and method for aiding in the repair of a dural tear. According to example embodiments, the device is placed substantially within a dural sac interior to a dural tear. The device provides a shield that prevents the underlying nerve roots (including rootlets) of the spinal cord from intruding into the torn area and prevents them from being injured during the repair procedure. The device also redirects cerebrospinal fluid from the area, which aids the surgeon in viewing the procedure site during suturing and / or repair.

The present invention relates to a spinal needle that clearly identifies the presence of cerebrospinal fluid (CFS) to dispense a drug or anaesthetic in the correct direction and site of the meninges. The response of the sensor to the presence of CFS does not depend on environmental factors and is performed quickly to prevent excessive loss of CFS in the patient. The spinal needle comprises a hub having a proximal end and a distal end, said hub comprising a transparent tank arranged at the proximal end of the hub that is configured to receive CFS, an expandable CFS sensor arranged inside the transparent tank and a connection port arranged at the distal end of the hub configured to couple to a device for medical fluids, and a cannula comprising a tip fluidically connected to the proximal end of the hub.

Monitoring cardiopulmonary function of a patient based on cerebrospinal fluid (CSF) pressures involves fluidly communicating a first catheter with a first CSF access site of the patient; fluidly communicating a second catheter with a second CSF access site of the patient; providing, using a first pressure sensor in fluid communication with the first catheter, Erst pressure readings associated with the first CSF access site; providing, using a second pressure sensor in fluid communication with the second catheter, second pressure readings associated with the second CSF access site; and determining a cardiopulmonary function parameter associated with the patient based on first and second pressure signals derived from the first and second pressure readings. The first CSF access site may be associated with a brain ventricle of the patient and the second CSF access site may be associated with the patient's lumbar.

This invention discloses a vibration reduction and shock-resistant method and system for aerospace sensors in the field of aerospace equipment technology. The system includes a bracket and a sensor mounting base, which are fixedly connected by a first bolt. A vibration reduction and shock-resistant device is sleeved on the portion of the first bolt located between the bracket and the sensor mounting base. The vibration reduction and shock-resistant device includes a sleeve sleeved on the first bolt, with the inner wall of the sleeve threadedly connected to the first bolt. An end cap is threadedly connected to the middle of the outer wall of the sleeve, completely enclosing the lower part of the sleeve. A vibration reduction and shock-resistant space is left between the outer wall of the sleeve and the inner wall of the end cap. A multi-layered vibration reduction and shock-resistant structure resembling a woodpecker is provided within the vibration reduction and shock-resistant space. The multi-layered vibration reduction and shock-resistant structure resembling a woodpecker includes a beak layer, a hyoid bone layer, a cancellous layer, and a cranial cerebrospinal fluid layer arranged sequentially from the outer wall of the sleeve to the inner wall of the end cap. This solution, based on the vibration reduction mechanism of a woodpecker's head, can effectively disperse residual energy, allowing impact energy to be transmitted in multiple directions.

The application relates to the technical field of landing gears, in particular to a shock-absorbing landing gear imitating the head bone structure of a woodpecker and a preparation method, wherein the main body of the shock-absorbing landing gear is prepared from a TiAl alloy material, and the shock-absorbing landing gear comprises, from outside to inside, a strength layer, a buffer layer and a toughness layer; the strength layer imitates the hyoid layer of the head bone of a woodpecker; the buffer layer imitates the cancellous bone layer of the head bone of a woodpecker; and the toughness layer imitates the cerebrospinal fluid layer of the head bone of a woodpecker. The landing gear prepared by imitating the head bone structure of a woodpecker has excellent shock-absorbing and impact-resisting capacity; the landing gear is prepared by adopting a selective laser melting (SLM) technology, the number of connecting pieces in the landing gear is reduced, unnecessary assembly steps are saved, and assembly errors are reduced; the material and the part are integrally formed, and complicated preparation steps and machining processes are avoided.

In a method for measuring brain free water content, in response to an RF excitation field generated on the basis of a magnetic resonance fingerprinting sequence and applied to the brain, an equilibrium magnetization mixed term (M0) signal is acquired from radiation emitted by each excited voxel of the brain, to obtain an M0 value of each voxel of the brain; a receive coil sensitivity (RP) value of each voxel of the brain is acquired; the M0 value of each voxel of the brain is divided by the RP value of the corresponding voxel to obtain a proton density (PD) value of each voxel of the brain; a PD value of cerebrospinal fluid is taken to be a reference PD value; and the PD value of each voxel of the brain is divided by the reference PD value to obtain the free water content of each voxel of the brain. The method advantageously increases the speed and accuracy of measurement of brain free water content.

The present invention pertains to the anti-inflammatory therapeutic effect of xantohumol in spinal cord injury (SCI). The continuous administration of xanthohumol for 1-8 weeks to SCI rats resulted in improved results in 4 clinical tests used and in lowering and faster elimination of macrophages from the SCI lesion. Since the infiltration of the SCI lesion by numerous phagocytic macrophages indicates a severe destructive inflammation of extraordinary longevity, administration of xanthohumol is neuroprotective and resulted in a better and faster recovery of the locomotor function and the strength and sensory function in the hind limbs, in a shorter period of paralysis of the urinary bladder and in the recovery of the body weight lost due to the SCI surgery. Since the traumatic brain injury (TBI) involving the white matter, and stroke involving the white matter initiate the severe destructive inflammation as in the SCI, the administration of xanthohumol is expected to be anti-inflammatory and neuroprotective in both brain diseases. Since neurodegenerative diseases including Alzheimer's disease, frontotemporal dementia and Parkinson's disease, immune mediated neuroinflammation including multiple sclerosis and neuromyelitis optica and cerebrospinal infections have inflammatory pathogenesis involving microgliosis and infiltration by macrophages, the administration of xanthohumol is expected to result in therapeutic inhibition of progression of all above diseases as well as of related neurodegenerative, immune mediated and infectious diseases of the brain and of the spinal cord.

This utility model discloses a lumbar puncture needle with monitoring function, comprising: a needle body, with a puncture needle main body internally connected to the needle body. The puncture needle main body is used to detect puncture depth and monitor cerebrospinal fluid pressure. The puncture needle main body includes an outer needle and an inner needle, with the inner needle located inside the outer needle. A gap is reserved between the outer and inner needles. A signal receiving mechanism is provided at the top of the outer needle. Both the outer and inner needles are electrically connected to the signal receiving mechanism via a point-to-line connection. This utility model provides a lumbar puncture needle with monitoring function, consisting of a system and a puncture needle main body. It can issue an alarm when the puncture needle tip contacts the cerebrospinal fluid in the subarachnoid space of the lumbar spine, and can monitor the cerebrospinal fluid pressure in real time during cerebrospinal fluid collection. Through precise puncture depth feedback and real-time cerebrospinal fluid pressure monitoring, doctors can more accurately locate the puncture point, reduce surgical errors, and improve the success rate of surgery. Real-time monitoring of cerebrospinal fluid pressure helps to detect abnormal intracranial pressure in a timely manner, prevent serious complications such as brain herniation, and ensure patient safety.

The disclosed system provides an integrated neuroimaging analytics platform for comprehensive preoperative neurosurgical planning, intraoperative neurosurgical guidance and post-operative assessment by processing multimodal MRI (structural, diffusion, functional, and angiography) and CT data. The platform performs detailed anatomical characterization by delineating tumor subregions (peritumoral edema, enhancing tumor, and necrotic core), segmenting brain tissues (gray matter, white matter, and CSF), and executing lobe, cortical / subcortical parcellation. Advanced 3D rendering visualizes tumors alongside critical white matter fibre tracts derived from diffusion MRI, while MRA data is used to segment cerebrovascular structures, and functional MRI analysis identifies eloquent cortices associated with motor, speech, and visual functions. All results are integrated within a user-friendly GUI featuring advanced multiplanar slicing and a smart brush for interactive mask editing, complemented by a speech-to-text engine for streamlined analytical reporting. This comprehensive approach facilitates precise and efficient surgical planning, thereby enhancing patient safety and improving clinical outcomes.

The utility model discloses a spinal nerve postoperative prone position pillow which comprises a bottom plate, a supporting block is fixedly connected to the top of the bottom plate, a hip placing platform is formed at the top of the supporting block, and a plurality of first clamping grooves are formed in the two sides of the top of the bottom plate; and the number of the placing plates is two, the two placing plates are arranged on the two sides of the supporting block respectively, and the placing plates are hinged to the supporting block. The hip of a patient is placed through the supporting block, the back and the legs of the patient are placed on the two placement plates with the adjustable inclination angles respectively, when the patient lies on the device prostrate, the hip of the patient is raised, the head of the patient is lower than the hip, cerebrospinal fluid backflow of the patient is increased, the tension of an operation wound is relieved, and the patient is more comfortable. In the recovery process of the patient, the height difference between the head and the hip of the patient can be continuously adjusted by adjusting the position of the supporting plate according to the condition of the patient, and postoperative nursing and recovery of the spinal nerve are facilitated.

The invention relates to the technical field of anesthetic injection, and discloses a puncture kit for preventing cerebrospinal fluid from leaking outwards for combined spinal-epidural anesthesia in the biomedical obstetrics department, the puncture kit comprises a kit box, the outer wall of the kit box is rotatably connected with a kit cover, the inner wall of the kit box is fixedly connected with a storage rack, the interior of the kit box is provided with an opening mechanism, and the opening mechanism is connected with the storage rack. A liquid guide mechanism is arranged in the sleeve box, a detection injection mechanism is arranged in the sleeve box, the opening mechanism comprises a skin breaking needle, an anesthetic cabin, a grasping handle, a finger ring and a resistance ring, and the skin breaking needle is connected to the inner wall of the storage frame in a sliding mode. Therefore, subcutaneous infiltration, skin breaking and anesthetic injection of a patient are carried out at the same time, the surgical operation process is simplified, the psychological burden of the patient is relieved, and meanwhile the dosing accuracy and effectiveness can be improved.

The utility model relates to the technical field of medical experiments, in particular to an auxiliary device for subarachnoid space injection or sampling, which comprises a spine clamping component and an indwelling hose detachably connected with the spine clamping component. The pipe penetrating through hole is used for allowing the indwelling hose to penetrate through. The device overcomes the defects that in the prior art, when cerebrospinal fluid is extracted from the subarachnoid space of a mouse or medicine is injected, mouse tissue needs to be cut open for multiple times, so that the experiment time and cost are increased, and the mouse is injured, and the device is arranged above the exposed spinal cord of the mouse, so that tissue adhesion can be effectively prevented; besides, injection or sampling operation can be directly performed through the indwelling hose, tissue does not need to be cut open again to expose the spinal cord, the experiment efficiency can be improved, and further damage to the mouse caused by multiple times of cutting open of the damaged part can be avoided.

The invention relates to the technical field of medical apparatus and instruments, and discloses a puncture indwelling device suitable for an Ommaya sac, which comprises a puncture needle body and a fixing assembly, the fixing assembly comprises a base. The base comprises a shell, an outlet formed in the bottom of the shell and a puncture diaphragm arranged above the shell. The inner side of the shell is an arc-shaped curved surface matched with the outer surface of the Omaya bag, a guide pipe is arranged at the bottom of the base, and the two ends of the guide pipe are connected with the Omaya bag and the outlet respectively; the puncture needle body comprises a needle tip, a needle tube, a needle wing and an extension tube which are connected with one another, the needle tip is inclined, an opening is formed in the side face of the needle tube, and the length of the needle tube is 2-3 cm. An annular rib is arranged on the inner side of the shell, and a medical silicone pressure-sensitive adhesive layer is arranged on the outer side of the annular rib. One end of the extension tube far away from the needle wing is provided with a liquid injection drainage joint. By means of the device, repeated puncture of a patient with the Ommaya bag can be avoided every day, the medical workload and scalp stimulation of a child patient are reduced, the infection risk is reduced, and needle head disengagement and ectopic and cerebrospinal fluid leakage are prevented.

This invention describes artificial expression constructs for regulating gene expression in target types of central nervous system cells. By using the artificial expression constructs of this disclosure, it is possible to express or modify the expression of synthetic genes in spinal motor neurons, including SpP1 spinal motor neurons, Parg spinal motor neurons, Ogdh1 spinal motor neurons, and ChAT spinal motor neurons; α motor neurons, including Chodl spinal motor neurons; γ motor neurons; spinal excitatory motor neurons, including Mafa excitatory neurons, Esrrg Trhr excitatory neurons, and Slc17a6 spinal excitatory neurons; spinal inhibitory neurons, including Slc6a5 spinal inhibitory neurons; whole spinal neurons, including Esrrg spinal motor neurons and types of neurons found throughout the spinal cord; cerebrospinal fluid contact neurons, including Poln spinal motor neurons; and non-neuronal cells of the spinal cord, including astrocytes and oligodendrocytes.

The invention discloses a pressure measuring tube for lumbar puncture and a puncture tool, and relates to the field of medical appliances, the pressure measuring tube comprises a tube body, one end of the tube body is a liquid inlet for cerebrospinal fluid to enter the tube body, and the other end of the tube body is a communication port for communicating the interior of the tube body with external air; an elastic film used for cutting off communication between the communication opening and the liquid inlet is arranged in the tube body, and the elastic film has elasticity; pressure scales are marked on the tube body from the position where the tube body is connected with the elastic film to the communication port, and the pressure value of the pressure scale closer to the communication port is larger; the puncture tool comprises a puncture sheath and a piezometric tube, and the piezometric tube is connected with the puncture sheath. According to the invention, the pressure intensity of cerebrospinal fluid can be accurately obtained only by keeping the piezometric tube upward without keeping the piezometric tube vertical, the structure is simple, and the production cost is low.

The application provides a terahertz wave-based intraoperative brain tissue drift real-time correction device and method, which can detect the position of the brain tissue of a patient in real time through terahertz waves during surgery, generate a three-dimensional fusion image in combination with a CT image, ensure that the position of the brain tissue during surgery is consistent with the position of the brain tissue in the three-dimensional fusion image, avoid brain tissue drift caused by loss of cerebrospinal fluid during surgery, cause differences between the shape and position of the brain tissue during surgery and preoperative images, solve the problem of deviation between surgical operation and preoperative planning caused by brain tissue drift, and thus ensure effective implementation of a surgical plan and improve the accuracy of surgical navigation.

The present invention relates to methods of treating diseases affecting motor function (e.g., motor function affected by diseases, brain and / or spinal cord injuries) using an adeno-associated virus (AAV) gene therapy vector comprising an adeno-associated virus 5 (AAV5) capsid protein and a gene product of interest flanked by an AAV ITR. In particular, the gene therapy vectors of the invention are administered by injection into cerebrospinal fluid (CSF), preferably by lumbar injection and / or injection into the cerebellar medullary pool.

The present disclosure provides systems and methods for clinical decision support of the diagnosis of infection. In an aspect, a system or method of clinical decision support (CDS) may comprise CDS of metagenomic next-generation sequencing results of clinical samples, (e.g., cerebral spinal fluid) to evaluate sample quality and microbial composition to diagnose a microbial infection (e.g., of the central nervous system).

Apparatus for the non-invasive in-vivo determination of changes in tissue, e.g. the myelination, of the optic nerve (ON) in a biological subject, said apparatus comprising: a laser source for generating an excitation laser beam; an optical system including a fundus camera operatively associated with the laser source for use in obtaining a fundus image for illuminating the optic nerve (ON) of a subject with the excitation laser beam; a detector (13) operatively associated with the optical system and configured to detect a Raman spectrum from the optic nerve (ON) and / or surrounding cerebral spinal fluid; and a processor provided with a computer program for comparing the detected Raman spectrum to at least one reference spectrum. The reference spectrum may correspond to the myelination of the optic nerve in a normal, healthy subject, for determining the changes in the myelination of the optic nerve of the subject based on the detecting and comparing steps from the Raman spectrum.

The invention discloses a spinal cord injury inflammation marker based on proteomics as well as a screening method and application thereof, creatively provides establishment of a relation chain between a cerebrospinal fluid sample and spinal cord injury, verifies the reference value of the relation chain for identifying grade differentiation of spinal cord injury, finds out a key point of the relation chain, namely a biomarker, and further provides a screening method for the spinal cord injury inflammation marker based on proteomics. The biomarker, namely the inflammation marker, specifically comprises five core proteins: interleukin 16 (IL-16), tumor necrosis factor (TNF-alpha), complement component 5a (C5a), matrix metalloproteinase 8 (MMP-8) and interleukin 3 (IL-3), and is beneficial to effectively, quickly and accurately understanding the pathogenesis of spinal cord injury.

The surgical suture with the changeable thickness comprises a needle head and a suture body, the needle head is arranged at one end of the suture body, the suture body comprises an inner-layer suture and an outer-layer sleeve wrapping the inner-layer suture, the outer-layer sleeve sequentially comprises a first wrapping section and a second wrapping section from front to back, a closing layer is arranged at the front end of the first wrapping section, and the closing layer is arranged at the rear end of the second wrapping section. The closing layer is connected with the needle head, and the tail end of the first wrapping section is connected with the second wrapping section through an easy-to-tear line. According to the use principle, a medical worker enables a needle head and a thread end to penetrate through a sewing area, then separates the first wrapping section from the second wrapping section, and pulls out the first wrapping section from the sewing area in sequence; the inner layer suture expands to a certain degree, so that the gap between the suture and the suture hole is reduced, and cerebrospinal fluid leakage or blood loss is reduced.

The utility model discloses a channel wire pusher, which comprises a rod part welded at one end of a handle part, claw-shaped pushing hand parts used for pushing wires are distributed at the top end of the rod part, an obtuse angle is formed between the rod part and the handle part, the included angle between every two claw-shaped pushing hand parts is 30 degrees, the included angle between the handle part and the rod part is 160 degrees, and the rod part is connected with the handle part. The number of the claw-shaped pushing hand parts is three, the length of each claw-shaped pushing hand part is 0.4 cm, the diameter of each claw-shaped pushing hand part is 0.2 cm, the length of each handle part is 4 cm, the diameter of each handle part is 1 cm, and the length of each rod part is 15 cm, and the diameter of each rod part is 0.3 cm. The device has the advantages of being small and exquisite, free of surgical view shielding, wide in application range, firm in knotting and the like, assists in dura mater suturing in the spinal microchannel surgery, reduces cerebrospinal fluid leakage after the surgery, and improves the working efficiency. And therefore, the novel medical infusion support disclosed by the utility model has a good use effect.

The application discloses a cerebrospinal fluid drainage device and a drainage system. The drainage device comprises a drainage component having a drainage cavity, a sink groove formed on the outer periphery of the drainage component and radially inwardly contracted, a drainage hole arranged on the groove bottom of the sink groove to make the drainage cavity communicate with the sink groove, a disturbance component comprising a disturbance rod and radially extending bristles arranged on the disturbance rod, the disturbance rod extending into the drainage cavity from the proximal end of the drainage component, the bristles corresponding to the drainage hole, and the distal end of the bristles being capable of extending to the radial outside of the groove bottom of the sink groove through the drainage hole, the bristles disturbing the drainage hole by being driven, and a converging component connected to the proximal end of the drainage component, the converging component having a converging cavity, the converging cavity communicating with the drainage cavity.