67 results about "Cerebro spinal fluid" patented technology

Various embodiments provide an apparatus, system method for treating neurological conditions by delivering solid form medication to the ventricles or other areas of the brain. Particular embodiments provide an apparatus and method for treating epilepsy and other neurological conditions by delivering solid form medication to ventricles in the brain wherein the medication is contained in a diffusion chamber so as to allow the medication to dissolve in the cerebrospinal fluid of the brain and then diffuse out of the diffusion chamber to be delivered to the ventricles and brain tissue. In one or more embodiments, portions of apparatus have sufficient flexibility to conform to the shape of the ventricles of the brain when advanced into them and/or to not cause deformation of the ventricle sufficient to cause a significant physiologic effect.

The invention provides a preparation method of a duramater/spinal dural transplanting substitute which is obtained by repeated freezing and thawing of dural tissue, rolling and cracking of cells, crosslinking fixed protection, accellular antigen extraction, dense surface fibrosis modification, packaging and sterilization, and has the advantages of simple method, wide raw material sources, cheap raw materials, and low cost. The prepared dural substitute completely removes components of cells and other antigen components simultaneously when protecting dural tissue natural structure and properties, is good in biocompatibility, free of immune rejection, safe and reliable, good in mechanical performance, and easy in clinical operation, can meet the needs of defect repair, has the function of promoting tissue regeneration as a loose surface is beneficial to the tissue fluid adsorption, active factor enrichment, and growth of blood vessels and cells, and has the advantages of rapidness in fusion with a host, biodegradable absorption, and good repair effect. The animal test shows that the defect can be completely repaired without brain or spinal fluid leakage, or adhesion with brain tissue, and significant rejection is not found.

A device and method for delivering a treatment solution includes a bi-directional catheter comprising at least a first lumen and a second lumen, wherein the first lumen comprises a proximal end having an inflow portal and a distal end having an outflow portal, and the second lumen comprises a side wall having at least one inflow portal allowing for fluid communication from an outer surface of the side wall to an inner surface of the side wall and the second lumen further comprises a proximal end having an outflow portal. The device and method further include a pump having an input channel, a reservoir for receiving and containing the treatment solution, a cooling apparatus for cooling the treatment solution, and an output channel. The outflow portal of the second lumen of the catheter is in fluid communication with the input channel of the pump and the output channel of the pump is in fluid communication with the inflow portal of the first lumen.

A fully-automated method for segmentation of white matter, gray matter, and cerebral spinal fluid (CSF) and for calculating their respective volumes is disclosed. The technique preferably uses a T2-weighted scan and a proton-density scan. The T2-weighted scans are used to highlight those portion of the brain corresponding to CSF. Thereafter, the proton density images are separated in CSF-containing and CSF-free portions, in accordance with the T2-weighted images. The CSF-free portion is then segmented into white matter and gray matter portions. The CSF-containing portion is further segmented into pure CSF-regions, and regions containing a mixture of gray and white matter and CSF. After CSF is segmented from this mixture, the white and gray matter and again segmented, and the respective volumes of white matter, gray matter, and CSF are calculated. A technique for determining a threshold gray scale value for segmenting the white and gray matter to assist in the visual identification of such regions is also disclosed.

An implantable drainage device for draining the cerebro-spinal fluid of a patient, the device including:

• • a drainage valve including a valve member and a valve seat;
  • a control unit suitable for modifying an operating parameter of said valve, at least as a function of a measurement (D) of the fluid flow rate through said valve;
  • an actuator controlled by the control unit, suitable for modifying the operation of said valve as a function of said operating parameter as modified by the control unit; and
  • a mass flowmeter suitable for evaluating said flow rate of fluid through said valve.

An antibiotic-eluting article for implantation into a mammalian subject, produced by an additive manufacturing process wherein a polymeric material is concurrently deposited with a selected antibiotic. The additive manufacturing process may be a selective laser sintering process or a selective laser melting process or a selective heat sintering process or an electron beam melting process. The antibiotic-eluting article may be temporary or permanent orthopaedic skeletal component, an orthopaedic articulating joint replacement component, and/or an external hard-shell casing for an implantable device. One or more bone-growth-promoting compositions may be concurrently deposited with the polymeric material. The implantable device may be a cardiac pacemaker, a spinal cord stimulator, a neurostimulation system, an intrathecal drug pump for delivery of medicants into the spinal fluid, and infusion pump for delivery of chemotherapeutics and/or anti-spasmodics, an insulin pump, an osmotic pump, and a heparin pump.

The invention discloses a craniocerebral trauma model system under the action of bullet impact or shock waves. According to the adopted the technical scheme, the model used in the craniocerebral trauma model system comprises preparation of a craniocerebral model and is applied to analysis of craniocerebral trauma conditions under the action of bullet impact or shock waves. The craniocerebral modelcomprises basic structures of scalp, skull, brain tissue and cerebrospinal fluid, and meanwhile, a brain tissue acceleration sensor, an intracranial pressure sensor and a skull stress strain sensor are implanted in the model. The sensors are connected with a data acquisition module through data lines in sensor connecting bases and data is transmitted to a data evaluation module after being processed by a data processing module. The craniocerebral trauma model can be used in the field of effectiveness evaluation of protection equipment, quantifies the protection effectiveness of the protectionequipment, and can carry out research on the injury and protection of the human head from the view point of simulating human mechanical indexes. The defects of biological tests are overcome, and thecredibility of data approaching a real person is improved.

The invention relates to the technical field of cerebrospinal fluid extraction for hematologic tumor patients, and discloses a cerebrospinal fluid extraction device for hematologic tumor patients. Thedevice comprises a strap, a flexible strap is movably connected to the surface of the strap, a positioning block is movably connected to the surface of the flexible strap, a clamping box is movably connected to the end, away from the strap, of the flexible strap through a connecting rod, a clamping ring is movably connected to the interior of the clamping box, an air bag is fixedly connected to the interior of the clamping ring, and a vent pipe is fixedly connected to the surface of the air bag. The step of moving an exhaust plate to a placing table is perforation positioning coarse adjustment, and a corrugated pipe is extruded to generate gas. As the placing table is only fixedly connected to the fourth from last positioning block, only the gas generated by the corrugated pipe connectedto the placing table can enter the exhaust plate through a telescopic rod. The gas flows to a chute to push out a push rod to push the placing table to move. In addition, perforation positioning fineadjustment and two-step adjustment are combined, so that the effect of improving puncture positioning accuracy is achieved.

The invention discloses a multi-target brain region accurate electrical stimulation method based on a dense electrode array. The method comprises the following steps: collecting T1 weighted MRI head image data; performing tissue segmentation on the acquired MRI head influence data by using FSL software, and segmenting the data into five parts, namely scalp, skull, cerebrospinal fluid, gray matter and white matter; carrying out manual correction on the segmented five parts of tissues; tightly attaching n electrodes to the surface of the scalp, and taking the contact ends of all the electrodes and the scalp upwards by 1 mm to serve as conductive adhesive to obtain a head model with the electrodes; performing finite element triangular patch processing on the head model with the electrode; calculating an electric field distribution matrix at a finite element node of the brain when the unit current intensity is injected into each electrode; and calculating an optimization strategy. According to the multi-target brain region accurate electrical stimulation method, multiple kinds of stimulation of multi-target brain region accurate tDCS can be achieved without repeatedly moving the position of the electric electrode, and the flexibility is higher.

The invention provides a modified combined spinal-epidural lumbar spinal needle, which comprises an operating handle, a needle insertion mechanism, a needle insertion controller and a drainage speed regulator, wherein the needle insertion controller cooperates with a fixing through hole of a grab handle; the fixation of an end of the needle insertion mechanism in the fixing through hole is realized; the drainage speed regulator cooperates with a drainage interface of the grab handle; the drainage control of cerebrospinal fluid is realized. A spiral fine tuning principle is utilized for the modified combined spinal-epidural lumbar spinal needle; through cooperatively designing the needle insertion mechanism and the needle insertion controller, the control of needle insertion precision in combined spinal-epidural puncturing operation is realized; meanwhile, through designing corresponding automatic pressure measuring and drainage speed regulating mechanisms, the corresponding pressure measuring and drainage operation is realized; the combined spinal-epidural lumbar spinal needle has the advantages that the needle insertion precision is high, the control operation is realized simply and conveniently, the automatic pressure measurement can be achieved, the drainage speed is flexibly controlled, and the like.

Method for the microbiological determination of traces of antibiotics in low volume biological samples, which comprises determining the minimum inhibitory concentration (MIC) of an antibiotic selected from among minocycline, ciprofloxacin, kanamycin, tetracycline and oxacillin against Staphylococcus aureus. The bacteria are grown in Mueller-Hinton broth (MHB) overnight, said cultures subsequently being diluted to 0.5 McFarland standard (1.5×108 cells/mL). Said antibiotics are subsequently added to 96-well plates in a final volume of 200 μL and incubated at 37° C. for 18 hours. Absorbency is determined and the results are expressed as the percentage of inhibition relative to the control containing the biological sample, in turn selected from urine, blood, synovial fluid, aqueous humour of the eye or cerebro spinal fluid (CSF), and the bacterial culture. The curve representing the percentage of inhibition of bacterial growth versus concentration of antibiotic is obtained, and is adjusted by the “Four Parameter Logistic Curve (4PL)”, yielding the concentration values of the antibiotics in the biological sample. The method determines amounts of antibiotic in the biological sample even at ng/mL level.

This invention relates to the field of internal quality control in diagnostic analysis, particularly in the analysis of microorganisms or other small particles, such as the detection of bacteria, protozoa, yeast, fungi, viruses, prions and the like, in water or other potable fluids, food, blood, urine, faeces, cerebro spinal fluid, and the like.

The invention relates to a novel lumbar puncture needle capable of realizing semi-automatic needle insertion, belongs to the technical field of medical instruments, solves the problems of needle head displacement and too deep needle insertion caused by manual needle pushing in the existing lumbar puncture, and enables the needle insertion process to be more accurate and stable. The novel lumbar puncture needle structurally comprises a needle head, an electromagnetic three-way valve, an optical fiber sensor, a pressure sensor, a sensor shell, a stepping motor, a needle inserting track and a puncture needle shell, wherein the needle head is connected with the electromagnetic three-way valve. After cerebrospinal fluid flows in, three functional states are realized along with reversing of a valve core; the optical fiber sensor can be used for directly measuring the pressure of the cerebrospinal fluid; the stepping motor drives the needle head to slowly advance along a needle inserting track at a constant speed, so that needle inserting errors caused by manual needle pushing are avoided; and the pressure sensor measures the needle insertion resistance and provides a judgment basis for the needle insertion depth. Through semi-automatic reversing of the electromagnetic three-way valve, measurement of the pressure of the cerebrospinal fluid by the optical fiber sensor, constant-speed slow needle insertion driven by the stepping motor, and real-time reflection of needle insertion resistance by the pressure sensor, accurate and efficient lumbar puncture operation is realized.

The invention discloses a lumbar vertebral puncture needle assembly with positioning and color rendering functions, including mating guide needles, a lumbar puncture needle and a needle core, the needle core is separated from the inner wall of the lumbar puncture needle, the peripheral surface of the lumbar puncture needle is provided with a plurality of perforations, a lead pin is fixedly arranged in that position seat, the positioning seat is a transparent plastic seat, the bottom surface of the positioning seat is connected with a medical adhesive tape, the positioning seat is provided witha vertical through hole arranged coaxially with the guide needle, A lumbar vertebral puncture needle passes through a vertical through hole and is matched with a guide needle. The positioning seat comprises a color developing base and a drainage top seat, wherein the color developing base is provided with a color developing groove communicated with a vertical through hole, the color developing groove is filled with a color developing liquid for cerebrospinal fluid, a communication port is provided on the drainage top seat, and the drainage top seat is provided with a rotary switch matched with the communication port. The invention has the advantages of accurate and stable positioning, convenient drainage, convenient observation of the puncture effect through the color developing base, andno need of frequently pulling and inserting the needle core.

The invention discloses a biological adhesive and a preparation method and application thereof. The biological adhesive comprises 4-arm polyethylene glycol amine and 4-arm polyethylene glycol succinimide succinate according to the mass ratio of 1: (0.1-10). The biological adhesive disclosed by the invention has the advantages of good biocompatibility, degradability and relatively high adhesive capacity, and is enough to tolerate the pressure of cerebrospinal fluid after being adhered to the spinal dura mater. Moreover, the biological adhesive disclosed by the invention is convenient to operatein an operation, can be independently used and does not need to be sutured, so that the operation time is greatly shortened and the operation risk is reduced. The biological adhesive disclosed by theinvention can be used for dura mater injuries of a special part which cannot be effectively sutured by a conventional method, such as injuries in front of and on the side of the dura mater and injuries in the positions of nerve root sleeves, can effectively reduce complications of cerebrospinal fluid leakage after a spinal operation, and improves prognosis of a patient.

The present invention discloses indicator fluids, reference indicator fluid, and usage thereof, and systems and methods for assessing movement of molecular substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a human cranio-spinal cavity. Indicator fluid moving from the cerebrospinal fluid compartment enables measurements of levels of indicator fluid in blood or urine and assessment of the cranio-spinal cavity's ability to remove molecular substances. The indicator fluids may be contrast agents used for imaging, such as by computed tomography imaging, and magnetic resonance imaging, or imaging utilizing radioactive substances by positron emission tomography, single-photon emission computed tomography or scintigraphy. Using these imaging modalities, the invention describes indicator fluids, systems and methods enabling assessment of movement of substances within, to or from a cerebrospinal fluid, brain or spinal cord compartment of a cranio-spinal cavity, and from the human cranio-spinal cavity to lymphatic pathways or kidneys.

The invention provides an infarction region segmentation method and device based on a brain image, equipment and a medium. The method comprises the steps of determining a seed point region for infarction region segmentation based on a candidate ventricle region and a cerebral cortex region extracted from a brain image; determining an infarction segmentation point in the candidate ventricle region by using an optimal path from each pixel point in the seed point region to a central point in the brain image; and segmenting a corresponding infarction region from the candidate ventricle region by using the infarction segmentation point. According to the method, the ant colony algorithm is adopted to analyze the infarction segmentation points in the candidate ventricle region, so that the corresponding infarction region is segmented from the candidate ventricle region by using the infarction segmentation points, the infarction region adhered to cerebrospinal fluid in the candidate ventricle region is automatically and effectively segmented, and the universality and efficiency of infarction region segmentation are enhanced.

A puncture drainage needle for intracranial ommaya sac, including a puncture needle, a pressure sensor, a flow sensor and a drainage connection tube, the puncture needle is connected to the drainage tube, and two lumen channels are arranged inside the puncture needle, one of which is a pressure probe and a drainage tube. The pressure sensor is connected to the channel through the conduction line channel, and the other lumen is the fluid drainage channel; the flow sensor is placed on the drainage tube with an adjustment knob; the puncture needle is divided into an intracranial section and an extracranial section, and the two sections are connected by an arc corner; There is a needle tip side hole in the needle tip of the segment, and a double needle wing structure is installed on the extracranial segment. The needle tube of the extracranial segment is connected with a drainage tube, and a pressure sensor, a flow sensor, and a medical three-way tube are installed on the drainage tube. The present invention can efficiently puncture the intracranial ommaya sac, adjust the drainage velocity of hemorrhage or cerebrospinal fluid, monitor intracranial pressure, ensure the smoothness of the pipeline, and provide dynamic monitoring for the treatment of patients with hemorrhage or hydrocephalus, which is beneficial to the prognosis of patients and treatment.

The invention relates to a lumbar spinal needle capable of preventing liquid leakage. The lumbar spinal needle comprises a needle tube and a needle core, wherein a notch connected with a piezometer tube or a collecting tube is formed in a needle tail part of the needle tube; a ''T''-shaped pore passage is formed in the needle tail part, comprises a main pore passage penetrated by the needle core and a branched pore passage communicating with the notch and is divided into a main pore passage front-side part, a main pore passage tail-side part and the branched pore passage by taking a junction of the main pore passage and the branched pore passage as a border; the pore diameter of the main pore passage tail-side part is larger than the outer diameter of the needle core, a one-way valve assembling slot is formed in the main pore passage tail-side part, and a silica gel one-way valve is fixedly mounted in the one-way valve assembling slot; and a switch type one-way valve is mounted in thebranched pore passage. According to the lumbar spinal needle, an opening in the tail of the needle tube can be relatively advantageously closed in a paracentesis operation process, and the loss of cerebrospinal fluid in a lumbar spinal paracentesis process can be effectively controlled.

The invention discloses a lumbar puncture teaching model for visualizing puncture points. The model comprises a simulation human body, a simulation lumbar vertebra module and a simulation pelvis module; the simulation lumbar vertebra module and the simulation pelvis module are connected and embedded into a simulation human body; the simulation lumbar vertebra module is at least provided with a simulation supraspinous ligament, a simulation interspinous ligament, a simulation ligamenta flava, a simulation hard spine module, a simulation vertebral canal, simulation cerebrospinal fluid, a fourthsimulation lumbar vertebra bone and a fifth simulation lumbar vertebra bone, wherein the fourth simulation lumbar vertebra bone and the fifth simulation lumbar vertebra bone are adjacently arranged; alumbar puncture marking ring right facing the intervertebral space between the fourth simulation lumbar vertebra bone and the fifth simulation lumbar vertebra bone is arranged on the symmetrical center line of the back of the simulation human body; the simulation human body comprises simulation skin and simulation subcutaneous muscle tissues; a view window is formed in the right waist of the simulation human body; a perspective soft rubber block which can be perspective to the simulated subcutaneous muscle tissue and the simulated lumbar vertebra module is embedded in the view window. The model has the advantages that lumbar puncture points are visualized, a puncture path is visualized, the practicability is high, and the lumbar puncture technical level of a practitioner can be effectively improved.

The invention discloses a method for manufacturing a human body transparent spinal canal cavity by applying a 3D printing technology, which comprises the following steps of: 1, measuring and acquiring data of the human body spinal canal cavity through computed tomography, namely CT (Computed Tomography); 2, using CATIA software to generate a 3D image according to the measured data; and 3, inputting the 3D printing data of the vertebral canal cavity into a 3D printer, and generating the bionic human body transparent vertebral canal cavity by applying a transparent polyester material through 3D printing. The method has the beneficial effects that when the bionic human body transparent spinal canal cavity is filled with bionic colorless cerebrospinal fluid, the pharmacokinetic law of anesthetics with obvious colors in the spinal canal cavity can be observed and researched under direct vision, and quantitative research data and technical training of anesthesia plane control are obtained. Quantitative research on subarachnoid space anesthesia level control factors can be carried out, and meanwhile, extremely favorable help can be provided for anesthesia department doctors and medical college school students to carry out anesthesia level control factor training.