11 results about "Cerebro spinal fluid" patented technology

The present invention pertains to the anti-inflammatory therapeutic effect of xantohumol in spinal cord injury (SCI). The continuous administration of xanthohumol for 1-8 weeks to SCI rats resulted in improved results in 4 clinical tests used and in lowering and faster elimination of macrophages from the SCI lesion. Since the infiltration of the SCI lesion by numerous phagocytic macrophages indicates a severe destructive inflammation of extraordinary longevity, administration of xanthohumol is neuroprotective and resulted in a better and faster recovery of the locomotor function and the strength and sensory function in the hind limbs, in a shorter period of paralysis of the urinary bladder and in the recovery of the body weight lost due to the SCI surgery. Since the traumatic brain injury (TBI) involving the white matter, and stroke involving the white matter initiate the severe destructive inflammation as in the SCI, the administration of xanthohumol is expected to be anti-inflammatory and neuroprotective in both brain diseases. Since neurodegenerative diseases including Alzheimer's disease, frontotemporal dementia and Parkinson's disease, immune mediated neuroinflammation including multiple sclerosis and neuromyelitis optica and cerebrospinal infections have inflammatory pathogenesis involving microgliosis and infiltration by macrophages, the administration of xanthohumol is expected to result in therapeutic inhibition of progression of all above diseases as well as of related neurodegenerative, immune mediated and infectious diseases of the brain and of the spinal cord.

This utility model discloses a lumbar puncture needle with monitoring function, comprising: a needle body, with a puncture needle main body internally connected to the needle body. The puncture needle main body is used to detect puncture depth and monitor cerebrospinal fluid pressure. The puncture needle main body includes an outer needle and an inner needle, with the inner needle located inside the outer needle. A gap is reserved between the outer and inner needles. A signal receiving mechanism is provided at the top of the outer needle. Both the outer and inner needles are electrically connected to the signal receiving mechanism via a point-to-line connection. This utility model provides a lumbar puncture needle with monitoring function, consisting of a system and a puncture needle main body. It can issue an alarm when the puncture needle tip contacts the cerebrospinal fluid in the subarachnoid space of the lumbar spine, and can monitor the cerebrospinal fluid pressure in real time during cerebrospinal fluid collection. Through precise puncture depth feedback and real-time cerebrospinal fluid pressure monitoring, doctors can more accurately locate the puncture point, reduce surgical errors, and improve the success rate of surgery. Real-time monitoring of cerebrospinal fluid pressure helps to detect abnormal intracranial pressure in a timely manner, prevent serious complications such as brain herniation, and ensure patient safety.

The disclosed system provides an integrated neuroimaging analytics platform for comprehensive preoperative neurosurgical planning, intraoperative neurosurgical guidance and post-operative assessment by processing multimodal MRI (structural, diffusion, functional, and angiography) and CT data. The platform performs detailed anatomical characterization by delineating tumor subregions (peritumoral edema, enhancing tumor, and necrotic core), segmenting brain tissues (gray matter, white matter, and CSF), and executing lobe, cortical / subcortical parcellation. Advanced 3D rendering visualizes tumors alongside critical white matter fibre tracts derived from diffusion MRI, while MRA data is used to segment cerebrovascular structures, and functional MRI analysis identifies eloquent cortices associated with motor, speech, and visual functions. All results are integrated within a user-friendly GUI featuring advanced multiplanar slicing and a smart brush for interactive mask editing, complemented by a speech-to-text engine for streamlined analytical reporting. This comprehensive approach facilitates precise and efficient surgical planning, thereby enhancing patient safety and improving clinical outcomes.

The present disclosure provides systems and methods for detection of microbial DNA and RNA. In an aspect, a system or method for detection of microbial DNA or RNA comprises metagenomic next-generation sequencing of clinical samples (e.g., cerebral spinal fluid) to detect the microbial composition of the sample to diagnose a microbial infection (e.g., of the central nervous system).

The application discloses an intracranial hematoma ultrasonic crushing device and relates to the field of medical equipment, which comprises an ultrasonic vibration rod, an adhesion device and a reflux pipe, the reflux pipe is arranged at the end of the adhesion device far from the ultrasonic vibration rod, and a reflux pipe inner cavity is arranged in the reflux pipe; a drainage pipe and a suction pipe are arranged on the rod end cover. The application can realize ultrasonic crushing and discharge of intracranial hematoma, is clean and complete, avoids residue, enables blood clots to be fully adsorbed and discharged, and enables the cerebrospinal fluid pressure in the cranial cavity to be normal and not to be blocked. The trace suction and supply type purifies the cerebrospinal fluid, does not affect the intracranial pressure, and avoids the phenomenon of unstable intracranial pressure.

A device or system for delivering fluid to or removing fluid from a CSF-containing space of a brain and for recording electrical activity from white or grey matter in the brain includes a catheter including a proximal end, a distal end portion, a first lumen extending from the proximal end to the distal end portion, and one or more electrodes positioned relative to the catheter a distance from a distal end of the catheter, such that the one or more electrodes would be placed in contact with white or grey matter of the brain if the distal end of the catheter were positioned in the CSF-containing space. The catheter may include the electrodes or a lead adjacent the catheter may include the electrodes.

Device (1) for influencing intraocular pressure (IOP) with a controllable drainage device (2) which is suitable and intended for draining fluid from at least one area of ​​the eye (50), characterized in that the device (1) has a first sensor device (4) which detects at least one first value (W1) characteristic of the intraocular pressure (IOP), and a second sensor device (6) which detects at least one second value (W2) characteristic of a pressure acting on the eye, and a control device (8) which controls the drainage device (2) at least temporarily taking into account the first characteristic value (W1) and the second characteristic value (W2), wherein the second characteristic value (W2) is characteristic of an intracranial pressure and / or a cerebrospinal pressure.

A catheter, in particular an external ventricular drainage catheter, for placement in a ventricular system, in particular of a human, for drainage of liquid, in particular of cerebrospinal fluid, from a ventricle of the ventricular system, includes a tubular body having an internal drainage lumen running along the tubular body for the drainage of the liquid and a port, arranged in a distal region of the tubular body, the port connecting the drainage lumen with an outside of the tubular body and outside of the catheter for the drainage of the liquid from the ventricle into the drainage lumen. The catheter further includes an ultrasonic sensor, or transducer, for emitting frontal ultrasound waves and detecting the frontal ultrasound waves reflected back to the at least one frontal ultrasonic sensor, in particular for obtaining a sonogram. The frontal ultrasonic sensor is arranged at a distal tip of said tubular body.

The invention relates to a method and a device using said method that determine the time constant and thus the cerebrospinal fluid pressure in order to calculate, at high speed and with high accuracy, intracranial pressure (ICP) measurements performed with a spinal manometer of the cerebrospinal fluid (CSF) pressure value, without requiring the characteristics of the spinal needle used for lumbar puncture.