55 results about "Aqueous humour" patented technology

A device is disclosed for selectively improving and / or permanently ensuring the permeability for ocular aqueous humour through the trabecular formations into Schlemm's canal. A small tubular element is provided, whose wall material encloses a hollow duct that presents an open configuration on both ends along the longitudinal extension of the hollow duct, so that the size and the shape of the small tubular element correspond approximately to the internal contour of Schlemm's canal, and the wall material as well as the wall thickness are so selected that upon introduction into Schlemm's canal the small tubular element keeps the canal open and dilates adjacent trabecular formations.

Described herein is a device for glaucoma treatment and monitoring that comprises a combination of an intraocular pressure (IOP) sensor and a glaucoma drainage device. The device comprises an IOP sensor and an inductive antenna mounted within a porous biocompatible material that forms the drainage path. The IOP sensor is mounted in a footplate portion of the device and is mountable in the anterior chamber of an eye. The footplate portion is connected to a body portion that houses the spiral antenna by a neck portion which retains the footplate portion in a suitable position within the anterior chamber. Due to its size, the footplate portion housing the IOP sensor can readily be inserted into the anterior chamber with the body portion housing the spiral antenna located outside of the anterior chamber in a sub-scleral space to disperse the aqueous humour.

An apparatus for reducing intraocular pressure is provided. A tube extends from an inlet end in fluid communication with an anterior chamber of the eye, to direct an aqueous humor flow from the anterior chamber to an outlet end in fluid communication with a cavity, defined by a housing, for receiving the aqueous humor. A proximal end of an elongate tubular member defining a longitudinally-extending channel is engaged with the housing such that the channel is in fluid communication with the cavity and such that a distal end of the tubular member is spaced apart from the housing, wherein the channel is configured to receive the aqueous humor from the cavity and to direct the aqueous humor through the distal end to a drainage site disposed distally to the anterior chamber and to the housing. An associated method is also provided.

A drain valve (10) implantable surgically in the eye (O) of a patient for the treatment of glaucoma, comprising a main body (11), and a drainage tube (12), connected at one end with the main body (11) and provided to be implanted in the eye (O) so as to penetrate with its distal tip inside the anterior chamber (CA) of the eye globe (GO), so as to allow the drainage outwards of the aqueous humour (UA), wherein the valve (10) is characterised by a series of significant improvements, including: 1) an extractable configuration (12a, 12b) of the drainage tube (12), to allow the adaptation (f1) of the length of the drainage tube (12) during the surgical operation to implant the valve (10); 2) a flattened or flat shape in section (12′) of the drainage tube (12, 12a, 12b) suitable for reducing the dimensions in the radial direction (IR) of the drainage tube (12) with respect to the surface of the eye globe (GO); 3) a connection free from encumbrances between the tip portion (12f) of the drainage tube (12), provided to penetrate inside the eye globe (GO, CA), and the remaining part (12b′) of the drainage tube (12); 4) a series of retaining bags or compartments (11b), formed along the lower or soffit surface (S″) of the main body (11) in contact with the surface of the eye globe (GO), wherein these retaining bags (11b) are associated with respective through holes (11a) extended through the same main body (11) of the valve and are suitable for receiving and retaining the aqueous humour (UA), so as to improve lubrication of the eyeball in the zone of the valve, once implanted; 5) a divergent fan-shaped opening (11c) formed on the extrados (S′), not in contact with the eye globe, of the main body (11) of the valve, in order to convey the aqueous humour (UA) and improve the lubrication around the drain valve (10), once implanted; and 6. a modified configuration, with respect to conventional drain valves, such as to allow, during the surgical operation, an arrangement, closer to the iris, of the holes (11d) for the insertion of the yarn for fixing the valve to the surface of the eye globe. Thanks to these improvements the drain valve (10) ensures considerably improved and superior performances with respect to the currently known drain valves in use in the medical field for treating glaucoma.

An implantable device for mechanically stimulating the trabecular meshwork is disclosed. The device is implanted in the eye adjacent the trabecular meshwork. The device imparts mechanical stimulating in the form of vibrations or movement to the trabecular meshwork. The imparted mechanical stimulation causes the trabecular meshwork to move in a manner that produces a pumping action to remove aqueous from the anterior chamber of the eye.

Method for the microbiological determination of traces of antibiotics in low volume biological samples, which comprises determining the minimum inhibitory concentration (MIC) of an antibiotic selected from among minocycline, ciprofloxacin, kanamycin, tetracycline and oxacillin against Staphylococcus aureus. The bacteria are grown in Mueller-Hinton broth (MHB) overnight, said cultures subsequently being diluted to 0.5 McFarland standard (1.5×108 cells / mL). Said antibiotics are subsequently added to 96-well plates in a final volume of 200 μL and incubated at 37° C. for 18 hours. Absorbency is determined and the results are expressed as the percentage of inhibition relative to the control containing the biological sample, in turn selected from urine, blood, synovial fluid, aqueous humour of the eye or cerebro spinal fluid (CSF), and the bacterial culture. The curve representing the percentage of inhibition of bacterial growth versus concentration of antibiotic is obtained, and is adjusted by the “Four Parameter Logistic Curve (4PL)”, yielding the concentration values of the antibiotics in the biological sample. The method determines amounts of antibiotic in the biological sample even at ng / mL level.

A drain valve (10) implantable surgically in the eye (O) of a patient for the treatment of glaucoma, comprising a main body (11), and a drainage tube (12), connected at one end with the main body (11) and provided to be implanted in the eye (O) so as to penetrate with its distal tip inside the anterior chamber (CA) of the eye globe (GO), so as to allow the drainage outwards of the aqueous humour (UA), wherein the valve (10) is characterized by a series of significant improvements, including:1) an extractable configuration (12a, 12b) of the drainage tube (12), to allow the adaptation (f1) of the length of the drainage tube (12) during the surgical operation to implant the valve (10);2) a flattened or flat shape in section (12′) of the drainage tube (12, 12a, 12b) suitable for reducing the dimensions in the radial direction (IR) of the drainage tube (12) with respect to the surface of the eye globe (GO);3) a connection free from encumbrances between the tip portion (12f) of the drainage tube (12), provided to penetrate inside the eye globe (GO, CA), and the remaining part (12b′) of the drainage tube (12);4) a series of retaining bags or compartments (11b), formed along the lower or soffit surface (S″) of the main body (11) in contact with the surface of the eye globe (GO), wherein these retaining bags (11b) are associated with respective through holes (11a) extended through the same main body (11) of the valve and are suitable for receiving and retaining the aqueous humour (UA), so as to improve lubrication of the eyeball in the zone of the valve, once implanted;5) a divergent fan-shaped opening (11c) formed on the extrados (S′), not in contact with the eye globe, of the main body (11) of the valve, in order to convey the aqueous humour (UA) and improve the lubrication around the drain valve (10), once implanted; and6. a modified configuration, with respect to conventional drain valves, such as to allow, during the surgical operation, an arrangement, closer to the iris, of the holes (11d) for the insertion of the yarn for fixing the valve to the surface of the eye globe.Thanks to these improvements the drain valve (10) ensures considerably improved and superior performances with respect to the currently known drain valves in use in the medical field for treating glaucoma.

Provided is an anterior segment aqueous fluid circulating flow simulation device. The organization of the simulation device comprises a cornea (1), a sclera (6), a crystalline lens (12), a vitreous chamber (14), an iris (11) and the like. A functional mechanism comprises a aqueous fluid circulating flow control system, a crystalline lens moving control system, a pupil retardation simulation system and an intraocular temperature adjusting system which work in a cooperative mode, so that normal and abnormal aqueous fluid circulating flow simulation is guaranteed. An auxiliary device comprises an aqueous fluid discharging groove (2), an aqueous fluid flow-in groove (5), a control panel (9), a crystalline lens inner cavity (13), pipelines (3, 4, 23 and 24), a water-leakage-preventing rubber mat (17), an external temperature control system and the like.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention discloses a molecular marker lncRNAs NR_026887 for glaucoma diagnosis, a kit and application. The inventor finds that relative to the control group, expression of lncRNAs:NR_026887 in aqueous humour of glaucoma patients is up-regulated., thus hinting that NR_026887 is high expression lncRNAs (long noncoding RNA) of glaucoma and is a biomarker conducive to glaucoma diagnosis. The molecular marker provided by the invention provides a powerful molecular biological basis for diagnosis of glaucoma, and has far-reaching clinical significance and generalization performance.

The invention relates to a stainless steel device for permanent insertion into the sclerocorneal limbus, with different drainage and anchorage systems, enabling the aqueous humour to discharge through one or more virtual spaces from the anterior chamber to an intrascleral space in cases of simple glaucoma or to the equatorial episclera in cases of complex glaucoma, such as neovascular glaucoma. The space is virtual, not real, as in the case of the tubular device. It enables the aqueous humour to discharge slowly and continuously, minimizing the possibility of the chamber being flat or of germs penetrating through the device. Furthermore, the anchorage system is less aggressive, thus reducing the possibility of bleeding.

The invention provides a micro-fluidic cell culture device for simulating filter bubbles and application of the micro-fluidic cell culture device. The micro-fluidic cell culture device for simulating the filter bubbles comprises a cover plate, a cell culture main body and a notch groove bottom plate containing a micro-channel from top to bottom, the cell culture main body contains a semi-arc dome-shaped raised cell culture cavity with a flat bottom; and an inflow channel, an outflow channel and a gathering outflow channel are engraved on the grooving bottom plate. The invention also provides a use method of the micro-fluidic cell culture device for simulating the filtering bubble. The micro-fluidic cell culture device for simulating the filtering bubble simulates the biological form of the filtering bubble and the one-way and dynamic flowing process of aqueous humor in eyes, can be used for culturing cells in a state close to a natural physiological state and researching the functions of the cells, and has important significance on research of related diseases.

The present invention discloses a disposable negative-pressure anterior chamber Paracentesis syringe which belongs to the technical field of medical supplies. It comprises nine parts, including a needle cap, a Paracentesis syringe, a needle base, an internal needle, a protective cover of the internal needle, an airlock, a needle tube, a collection tube and a collection tube rack. The invention has the advantages that it fixes the Paracentesis syringe during puncture and limits the depth of the needle insertion, releases the aqueous humor slowly to prevent a sudden drop of the intraocular pressure, reduces the risk of the intraocular infection by separating the anterior chamber from outside and the collection tube can collect and store the aqueous humor directly.

Compositions, methods, and kits are provided for diagnosing vitreoretinal diseases and age-related pathologies. In particular, aqueous humor biomarkers have been identified that correlate with biological aging and age-related pathologies and morbidity. The use of such biomarkers may allow earlier intervention in treatment of aging-related diseases. In addition, methods of using aqueous humor biomarkers for prognosis, diagnosis, and monitoring treatment of vitreoretinal diseases are also provided.

Disclosed is a compound represented by general formula (I) (wherein the definition for each group is as described in the description) or a salt, solvate or prodrug thereof, which has a potent and long-lasting ocular hypotensive activity and has no adverse side effect on eyes such as irritation to eyes (congestion, corneal opacities, etc.) and increased aqueous protein level, and which is therefore highly safe and can be used as an excellent prophylactic and / or therapeutic agent for glaucoma or the like.

The present disclosure describes an optical probe for applying a laser light to at least the flat portion of the ciliary body and optionally other areas, such as the trabecular mesh, the ciliary crown and / or the ciliary sulcus of the eye, the present invention relates to methods, such as for treating glaucoma, reducing intraocular pressure (IOP), improving the outflow of aqueous humor from the eye, and / or reducing the accumulation of aqueous humor within the eye. The optical probe may be adapted for simultaneous treatment of a plurality of different regions, tissues, or eye bodies of the eye, or for sequential treatment of a plurality of different regions, tissues, or eye bodies of the eye.

The application selects highly conservative and excellent interspecies specificity UL49A gene as a target from multiple strains of HSV-1 and related herpes simplex virus (HSV-2, EBV, CMVh and VZV) coding sequences through bioinformatics whole genome alignment, designs and selects specific primer probe combination 124F / 124R / 124P, and establishes a HSV-1 probe method fluorescence quantitative PCR detection system targeting UL49A gene. Based on the primer probe group, the HSV-1 detection kit can be prepared, which is suitable for clinical biological samples such as lesion secretions, aqueous humor and blood, especially can provide a rapid, accurate and high-sensitivity etiological diagnosis scheme for HSV-1 related keratitis, and has good clinical application value.

The application discloses a teaching simulative human eyeball aqueous humor circulation model in the technical field of eyeball aqueous humor circulation models, which comprises a model box, an eyeball model assembly arranged in the model box, a functional body arranged at the top of the model box and a pump assembly arranged in the functional body. The eyeball model assembly comprises an eyeball wall, an eyeball and an optic nerve, and the eyeball wall is provided with a cornea at the front end. An iris is arranged on the side of the cornea close to the eyeball, the space between the cornea and the iris is an anterior chamber, the included angle between the cornea and the iris is an anterior chamber angle, the center of the iris is provided with a pupil, the iris is provided with a lens on the side close to the eyeball, the lens is provided with a zonular ligament around the lens, and the other end of the zonular ligament is fixedly connected with a ciliary body. The space between the iris and the lens constitutes a posterior chamber. The application has the advantages of simple structure, simulation of the process that the aqueous humor is retained in the eye to press the optic nerve when the anterior chamber angle is closed or the aqueous humor outflow passage is blocked, and convenience for medical students to understand the process that the optic nerve is pressed by the increased intraocular pressure when the aqueous humor passage is blocked.

The invention discloses a molecular marker lncRNAs NR_026887 for glaucoma diagnosis, a kit and application. The inventor finds that relative to the control group, expression of lncRNAs:NR_026887 in aqueous humour of glaucoma patients is up-regulated., thus hinting that NR_026887 is high expression lncRNAs (long noncoding RNA) of glaucoma and is a biomarker conducive to glaucoma diagnosis. The molecular marker provided by the invention provides a powerful molecular biological basis for diagnosis of glaucoma, and has far-reaching clinical significance and generalization performance.

The invention relates to an ophthalmic puncture aqueous humor sampling device, which belongs to the technical field of body sample collection and comprises a linear support block, finger limiting parts are fixedly arranged on two sides of one end of the linear support block, a finger penetrating ring is fixedly arranged on the end face of the same side of the linear support block, and a rubber pad is arranged at the other end of the linear support block. A circular groove is formed in the upper end face of the linear supporting block, a rotatable circular rotating plate is mounted in the circular groove, a rotating block is fixedly arranged at the upper end of the circular rotating plate, a mounting block is mounted at the top end of the rotating block through a hinged connecting piece, a cylinder is fixedly arranged in the mounting block, and an injector is mounted in the cylinder. The linear supporting block is supported below the eyes of a patient, an operator holds the linear supporting block with one hand, the angle of the injector penetrating into the anterior chamber of the eyes is adjusted according to different actual conditions, aqueous humor in the anterior chamber is extracted, operation is convenient, and stability is good.

A posterior chamber intraocular lens with a function of reducing postoperative vaulting, the lens comprising an optical part and a support part: the optical part is provided with a through hole at the center and the edge of the optical area for maintaining aqueous humor circulation and balancing intraocular pressure; the support part adopts a four-foot haptic structure that is folded inward by 50-60 degrees, and the lower surface of the structure is configured with an array of microvilli that are 0.25 mm long, spaced 0.1 mm apart, and 0.5 mm x 0.5 mm in size; the through hole design ensures the efficiency of aqueous humor circulation, and the foot haptic shape and microvilli anchoring system are optimized in combination, which can effectively embed the ciliary groove tissue and realize a double fixation mechanism; the structure innovation can inhibit the axial displacement of the artificial lens after surgery, prevent excessive postoperative vaulting from falling, solve the problem of vaulting attenuation caused by the change of aqueous humor dynamics and insufficient mechanical fixation of the existing implant, and provide a long-term stable refractive solution for high myopia correction.

The invention discloses a multipurpose anterior chamber puncture device with a pressure monitoring function. The multipurpose anterior chamber puncture device comprises an aqueous humor collecting assembly, a pressure measuring and displaying module and a pressure / flow stepless inching adjusting module which are sequentially connected from front to back. Wherein the aqueous humor collecting assembly is used for puncturing the cornea of an eyeball and collecting aqueous humor; the aqueous humor collecting assembly is provided with scales for reading the release amount of the aqueous humor; the pressure measurement and display module is used for measuring and displaying anterior chamber intraocular pressure in real time when the aqueous humor collection assembly collects aqueous humor and guiding the pressure relief control process; the pressure / flow stepless inching adjusting module is used for adjusting intraocular pressure and the flow velocity of the aqueous humor when the aqueous humor collecting assembly collects the aqueous humor. According to the multi-purpose anterior chamber puncture device with the pressure monitoring function, quantitative collection of aqueous humor can be achieved, intraocular pressure can be monitored in real time, and the intraocular pressure release speed and the aqueous humor outflow speed can be controlled.

Provided is an anterior segment aqueous fluid circulating flow simulation device. The organization of the simulation device comprises a cornea (1), a sclera (6), a crystalline lens (12), a vitreous chamber (14), an iris (11) and the like. A functional mechanism comprises a aqueous fluid circulating flow control system, a crystalline lens moving control system, a pupil retardation simulation system and an intraocular temperature adjusting system which work in a cooperative mode, so that normal and abnormal aqueous fluid circulating flow simulation is guaranteed. An auxiliary device comprises an aqueous fluid discharging groove (2), an aqueous fluid flow-in groove (5), a control panel (9), a crystalline lens inner cavity (13), pipelines (3, 4, 23 and 24), a water-leakage-preventing rubber mat (17), an external temperature control system and the like.

The invention belongs to the technical field of medical instruments and relates to a split type aqueous humor drainage device. The split type aqueous humor drainage device comprises a puncture needle, a drainage tube and a throttling structure; a needle head of the puncture needle penetrates through a tube cavity of the drainage tube, and the tip end of the puncture needle extends out of the drainage tube to be suitable for puncture; and the throttling structure and the drainage tube are arranged in a split mode. When an operation is carried out, a medical worker sleeves the drainage tube on the needle head of the puncture needle, then punctures at a preset position, then punctures the drainage tube into the preset position from one end of the drainage tube along the needle head, then pulls out the needle head, so that aqueous humor flows out from the preset position through the drainage tube, then immediately connects the throttling structure with the drainage tube, throttles the aqueous humor flowing out of the drainage tube through the throttling structure, and controlsthe flow speed of the aqueous humor. Throttling is carried out only through the throttling structure, the medical worker does not need to control the flow speed of aqueous humor, the number of human factors is small, the flow speed of the aqueous humor is relatively stable, operation of the medical worker is simplified, and the aqueous humor drainage operation is more efficient.

Disclosed are a low molecular polypeptide for preventing and treating inflammation, a preparation method and the use thereof and a pharmaceutical composition containing the polypeptide, wherein the polypeptide can penetrate the eye tissue barrier, can maintain a high concentration in neutral tears, aqueous humour and vitreous humour, and can be used to treat inflammation.

The invention provides an aqueous humor analysis method based on a titanium oxide nano-material matrix, which comprises the following specific steps: preparing a material dispersion solution from a titanium oxide nano-material and deionized water in a mass volume ratio range of 1-2 g / L, depositing 1-2 [mu] L of an aqueous humor sample on a target plate, drying the sample, and carrying out vacuum drying on the sample to obtain the titanium oxide nano-material matrix based aqueous humor analysis method based on the titanium oxide nano-material matrix. And applying 1-2 [mu] L of a material dispersion solution on the substrate, carrying out MALDI-TOF-MS mass spectrometry to obtain a metabolic fingerprint spectrum, and distinguishing cataract patients related to different diseases through a machine learning method. According to the method, the metabolic fingerprint spectrum of the aqueous humor sample is acquired by preparing the efficiently ionized binary laser / desorption ionization matrix, and the senile related cataract, the diabetes related cataract and the high myopia related cataract can be quickly distinguished by combining with a machine learning means; the method has a wide application prospect for distinguishing cataract related to different diseases and exploring a cataract molecular mechanism.

An ocular implants, kits and deployment methods are disclosed. In one arrangement, an ocular implant has an elongate body configured to be deployable at a deployment position at which the body extends from the anterior chamber of an eye to the subconjunctival space of the eye. The body comprises a conduit structure defining a conduit for promoting flow of aqueous humour through the conduit from the anterior chamber to the subconjunctival space. The body comprises an anchoring structure configured to expand from a radially contracted state to a radially expanded state.