40 results about "Aqueous humour" patented technology

A device is disclosed for selectively improving and / or permanently ensuring the permeability for ocular aqueous humour through the trabecular formations into Schlemm's canal. A small tubular element is provided, whose wall material encloses a hollow duct that presents an open configuration on both ends along the longitudinal extension of the hollow duct, so that the size and the shape of the small tubular element correspond approximately to the internal contour of Schlemm's canal, and the wall material as well as the wall thickness are so selected that upon introduction into Schlemm's canal the small tubular element keeps the canal open and dilates adjacent trabecular formations.

Described herein is a device for glaucoma treatment and monitoring that comprises a combination of an intraocular pressure (IOP) sensor and a glaucoma drainage device. The device comprises an IOP sensor and an inductive antenna mounted within a porous biocompatible material that forms the drainage path. The IOP sensor is mounted in a footplate portion of the device and is mountable in the anterior chamber of an eye. The footplate portion is connected to a body portion that houses the spiral antenna by a neck portion which retains the footplate portion in a suitable position within the anterior chamber. Due to its size, the footplate portion housing the IOP sensor can readily be inserted into the anterior chamber with the body portion housing the spiral antenna located outside of the anterior chamber in a sub-scleral space to disperse the aqueous humour.

An apparatus for reducing intraocular pressure is provided. A tube extends from an inlet end in fluid communication with an anterior chamber of the eye, to direct an aqueous humor flow from the anterior chamber to an outlet end in fluid communication with a cavity, defined by a housing, for receiving the aqueous humor. A proximal end of an elongate tubular member defining a longitudinally-extending channel is engaged with the housing such that the channel is in fluid communication with the cavity and such that a distal end of the tubular member is spaced apart from the housing, wherein the channel is configured to receive the aqueous humor from the cavity and to direct the aqueous humor through the distal end to a drainage site disposed distally to the anterior chamber and to the housing. An associated method is also provided.

A drain valve (10) implantable surgically in the eye (O) of a patient for the treatment of glaucoma, comprising a main body (11), and a drainage tube (12), connected at one end with the main body (11) and provided to be implanted in the eye (O) so as to penetrate with its distal tip inside the anterior chamber (CA) of the eye globe (GO), so as to allow the drainage outwards of the aqueous humour (UA), wherein the valve (10) is characterised by a series of significant improvements, including: 1) an extractable configuration (12a, 12b) of the drainage tube (12), to allow the adaptation (f1) of the length of the drainage tube (12) during the surgical operation to implant the valve (10); 2) a flattened or flat shape in section (12′) of the drainage tube (12, 12a, 12b) suitable for reducing the dimensions in the radial direction (IR) of the drainage tube (12) with respect to the surface of the eye globe (GO); 3) a connection free from encumbrances between the tip portion (12f) of the drainage tube (12), provided to penetrate inside the eye globe (GO, CA), and the remaining part (12b′) of the drainage tube (12); 4) a series of retaining bags or compartments (11b), formed along the lower or soffit surface (S″) of the main body (11) in contact with the surface of the eye globe (GO), wherein these retaining bags (11b) are associated with respective through holes (11a) extended through the same main body (11) of the valve and are suitable for receiving and retaining the aqueous humour (UA), so as to improve lubrication of the eyeball in the zone of the valve, once implanted; 5) a divergent fan-shaped opening (11c) formed on the extrados (S′), not in contact with the eye globe, of the main body (11) of the valve, in order to convey the aqueous humour (UA) and improve the lubrication around the drain valve (10), once implanted; and 6. a modified configuration, with respect to conventional drain valves, such as to allow, during the surgical operation, an arrangement, closer to the iris, of the holes (11d) for the insertion of the yarn for fixing the valve to the surface of the eye globe. Thanks to these improvements the drain valve (10) ensures considerably improved and superior performances with respect to the currently known drain valves in use in the medical field for treating glaucoma.

An implantable device for mechanically stimulating the trabecular meshwork is disclosed. The device is implanted in the eye adjacent the trabecular meshwork. The device imparts mechanical stimulating in the form of vibrations or movement to the trabecular meshwork. The imparted mechanical stimulation causes the trabecular meshwork to move in a manner that produces a pumping action to remove aqueous from the anterior chamber of the eye.

Method for the microbiological determination of traces of antibiotics in low volume biological samples, which comprises determining the minimum inhibitory concentration (MIC) of an antibiotic selected from among minocycline, ciprofloxacin, kanamycin, tetracycline and oxacillin against Staphylococcus aureus. The bacteria are grown in Mueller-Hinton broth (MHB) overnight, said cultures subsequently being diluted to 0.5 McFarland standard (1.5×108 cells / mL). Said antibiotics are subsequently added to 96-well plates in a final volume of 200 μL and incubated at 37° C. for 18 hours. Absorbency is determined and the results are expressed as the percentage of inhibition relative to the control containing the biological sample, in turn selected from urine, blood, synovial fluid, aqueous humour of the eye or cerebro spinal fluid (CSF), and the bacterial culture. The curve representing the percentage of inhibition of bacterial growth versus concentration of antibiotic is obtained, and is adjusted by the “Four Parameter Logistic Curve (4PL)”, yielding the concentration values of the antibiotics in the biological sample. The method determines amounts of antibiotic in the biological sample even at ng / mL level.

A drain valve (10) implantable surgically in the eye (O) of a patient for the treatment of glaucoma, comprising a main body (11), and a drainage tube (12), connected at one end with the main body (11) and provided to be implanted in the eye (O) so as to penetrate with its distal tip inside the anterior chamber (CA) of the eye globe (GO), so as to allow the drainage outwards of the aqueous humour (UA), wherein the valve (10) is characterized by a series of significant improvements, including:1) an extractable configuration (12a, 12b) of the drainage tube (12), to allow the adaptation (f1) of the length of the drainage tube (12) during the surgical operation to implant the valve (10);2) a flattened or flat shape in section (12′) of the drainage tube (12, 12a, 12b) suitable for reducing the dimensions in the radial direction (IR) of the drainage tube (12) with respect to the surface of the eye globe (GO);3) a connection free from encumbrances between the tip portion (12f) of the drainage tube (12), provided to penetrate inside the eye globe (GO, CA), and the remaining part (12b′) of the drainage tube (12);4) a series of retaining bags or compartments (11b), formed along the lower or soffit surface (S″) of the main body (11) in contact with the surface of the eye globe (GO), wherein these retaining bags (11b) are associated with respective through holes (11a) extended through the same main body (11) of the valve and are suitable for receiving and retaining the aqueous humour (UA), so as to improve lubrication of the eyeball in the zone of the valve, once implanted;5) a divergent fan-shaped opening (11c) formed on the extrados (S′), not in contact with the eye globe, of the main body (11) of the valve, in order to convey the aqueous humour (UA) and improve the lubrication around the drain valve (10), once implanted; and6. a modified configuration, with respect to conventional drain valves, such as to allow, during the surgical operation, an arrangement, closer to the iris, of the holes (11d) for the insertion of the yarn for fixing the valve to the surface of the eye globe.Thanks to these improvements the drain valve (10) ensures considerably improved and superior performances with respect to the currently known drain valves in use in the medical field for treating glaucoma.

Provided is an anterior segment aqueous fluid circulating flow simulation device. The organization of the simulation device comprises a cornea (1), a sclera (6), a crystalline lens (12), a vitreous chamber (14), an iris (11) and the like. A functional mechanism comprises a aqueous fluid circulating flow control system, a crystalline lens moving control system, a pupil retardation simulation system and an intraocular temperature adjusting system which work in a cooperative mode, so that normal and abnormal aqueous fluid circulating flow simulation is guaranteed. An auxiliary device comprises an aqueous fluid discharging groove (2), an aqueous fluid flow-in groove (5), a control panel (9), a crystalline lens inner cavity (13), pipelines (3, 4, 23 and 24), a water-leakage-preventing rubber mat (17), an external temperature control system and the like.

The invention discloses a molecular marker lncRNAs NR_026887 for glaucoma diagnosis, a kit and application. The inventor finds that relative to the control group, expression of lncRNAs:NR_026887 in aqueous humour of glaucoma patients is up-regulated., thus hinting that NR_026887 is high expression lncRNAs (long noncoding RNA) of glaucoma and is a biomarker conducive to glaucoma diagnosis. The molecular marker provided by the invention provides a powerful molecular biological basis for diagnosis of glaucoma, and has far-reaching clinical significance and generalization performance.

The invention relates to a stainless steel device for permanent insertion into the sclerocorneal limbus, with different drainage and anchorage systems, enabling the aqueous humour to discharge through one or more virtual spaces from the anterior chamber to an intrascleral space in cases of simple glaucoma or to the equatorial episclera in cases of complex glaucoma, such as neovascular glaucoma. The space is virtual, not real, as in the case of the tubular device. It enables the aqueous humour to discharge slowly and continuously, minimizing the possibility of the chamber being flat or of germs penetrating through the device. Furthermore, the anchorage system is less aggressive, thus reducing the possibility of bleeding.

The invention provides a micro-fluidic cell culture device for simulating filter bubbles and application of the micro-fluidic cell culture device. The micro-fluidic cell culture device for simulating the filter bubbles comprises a cover plate, a cell culture main body and a notch groove bottom plate containing a micro-channel from top to bottom, the cell culture main body contains a semi-arc dome-shaped raised cell culture cavity with a flat bottom; and an inflow channel, an outflow channel and a gathering outflow channel are engraved on the grooving bottom plate. The invention also provides a use method of the micro-fluidic cell culture device for simulating the filtering bubble. The micro-fluidic cell culture device for simulating the filtering bubble simulates the biological form of the filtering bubble and the one-way and dynamic flowing process of aqueous humor in eyes, can be used for culturing cells in a state close to a natural physiological state and researching the functions of the cells, and has important significance on research of related diseases.

The present invention discloses a disposable negative-pressure anterior chamber Paracentesis syringe which belongs to the technical field of medical supplies. It comprises nine parts, including a needle cap, a Paracentesis syringe, a needle base, an internal needle, a protective cover of the internal needle, an airlock, a needle tube, a collection tube and a collection tube rack. The invention has the advantages that it fixes the Paracentesis syringe during puncture and limits the depth of the needle insertion, releases the aqueous humor slowly to prevent a sudden drop of the intraocular pressure, reduces the risk of the intraocular infection by separating the anterior chamber from outside and the collection tube can collect and store the aqueous humor directly.

Disclosed is a compound represented by general formula (I) (wherein the definition for each group is as described in the description) or a salt, solvate or prodrug thereof, which has a potent and long-lasting ocular hypotensive activity and has no adverse side effect on eyes such as irritation to eyes (congestion, corneal opacities, etc.) and increased aqueous protein level, and which is therefore highly safe and can be used as an excellent prophylactic and / or therapeutic agent for glaucoma or the like.

The invention discloses a molecular marker lncRNAs NR_026887 for glaucoma diagnosis, a kit and application. The inventor finds that relative to the control group, expression of lncRNAs:NR_026887 in aqueous humour of glaucoma patients is up-regulated., thus hinting that NR_026887 is high expression lncRNAs (long noncoding RNA) of glaucoma and is a biomarker conducive to glaucoma diagnosis. The molecular marker provided by the invention provides a powerful molecular biological basis for diagnosis of glaucoma, and has far-reaching clinical significance and generalization performance.

The invention discloses a multipurpose anterior chamber puncture device with a pressure monitoring function. The multipurpose anterior chamber puncture device comprises an aqueous humor collecting assembly, a pressure measuring and displaying module and a pressure / flow stepless inching adjusting module which are sequentially connected from front to back. Wherein the aqueous humor collecting assembly is used for puncturing the cornea of an eyeball and collecting aqueous humor; the aqueous humor collecting assembly is provided with scales for reading the release amount of the aqueous humor; the pressure measurement and display module is used for measuring and displaying anterior chamber intraocular pressure in real time when the aqueous humor collection assembly collects aqueous humor and guiding the pressure relief control process; the pressure / flow stepless inching adjusting module is used for adjusting intraocular pressure and the flow velocity of the aqueous humor when the aqueous humor collecting assembly collects the aqueous humor. According to the multi-purpose anterior chamber puncture device with the pressure monitoring function, quantitative collection of aqueous humor can be achieved, intraocular pressure can be monitored in real time, and the intraocular pressure release speed and the aqueous humor outflow speed can be controlled.

Provided is an anterior segment aqueous fluid circulating flow simulation device. The organization of the simulation device comprises a cornea (1), a sclera (6), a crystalline lens (12), a vitreous chamber (14), an iris (11) and the like. A functional mechanism comprises a aqueous fluid circulating flow control system, a crystalline lens moving control system, a pupil retardation simulation system and an intraocular temperature adjusting system which work in a cooperative mode, so that normal and abnormal aqueous fluid circulating flow simulation is guaranteed. An auxiliary device comprises an aqueous fluid discharging groove (2), an aqueous fluid flow-in groove (5), a control panel (9), a crystalline lens inner cavity (13), pipelines (3, 4, 23 and 24), a water-leakage-preventing rubber mat (17), an external temperature control system and the like.

The invention belongs to the technical field of medical instruments and relates to a split type aqueous humor drainage device. The split type aqueous humor drainage device comprises a puncture needle, a drainage tube and a throttling structure; a needle head of the puncture needle penetrates through a tube cavity of the drainage tube, and the tip end of the puncture needle extends out of the drainage tube to be suitable for puncture; and the throttling structure and the drainage tube are arranged in a split mode. When an operation is carried out, a medical worker sleeves the drainage tube on the needle head of the puncture needle, then punctures at a preset position, then punctures the drainage tube into the preset position from one end of the drainage tube along the needle head, then pulls out the needle head, so that aqueous humor flows out from the preset position through the drainage tube, then immediately connects the throttling structure with the drainage tube, throttles the aqueous humor flowing out of the drainage tube through the throttling structure, and controlsthe flow speed of the aqueous humor. Throttling is carried out only through the throttling structure, the medical worker does not need to control the flow speed of aqueous humor, the number of human factors is small, the flow speed of the aqueous humor is relatively stable, operation of the medical worker is simplified, and the aqueous humor drainage operation is more efficient.

Disclosed are a low molecular polypeptide for preventing and treating inflammation, a preparation method and the use thereof and a pharmaceutical composition containing the polypeptide, wherein the polypeptide can penetrate the eye tissue barrier, can maintain a high concentration in neutral tears, aqueous humour and vitreous humour, and can be used to treat inflammation.

The invention provides an aqueous humor analysis method based on a titanium oxide nano-material matrix, which comprises the following specific steps: preparing a material dispersion solution from a titanium oxide nano-material and deionized water in a mass volume ratio range of 1-2 g / L, depositing 1-2 [mu] L of an aqueous humor sample on a target plate, drying the sample, and carrying out vacuum drying on the sample to obtain the titanium oxide nano-material matrix based aqueous humor analysis method based on the titanium oxide nano-material matrix. And applying 1-2 [mu] L of a material dispersion solution on the substrate, carrying out MALDI-TOF-MS mass spectrometry to obtain a metabolic fingerprint spectrum, and distinguishing cataract patients related to different diseases through a machine learning method. According to the method, the metabolic fingerprint spectrum of the aqueous humor sample is acquired by preparing the efficiently ionized binary laser / desorption ionization matrix, and the senile related cataract, the diabetes related cataract and the high myopia related cataract can be quickly distinguished by combining with a machine learning means; the method has a wide application prospect for distinguishing cataract related to different diseases and exploring a cataract molecular mechanism.

The invention discloses a solid-phase multiplex row PCR detection kit and a detection method for infectious eye disease pathogens. The solid-phase multiplex row PCR detection kit comprises a PCR mixedsolution, immobilized primer and probes, a positive control, a negative control and RNase-free water, wherein the immobilized primers and probes are eight herpes virus primers and probes subjected toimmobilization treatment and are separately arranged in triple row PCR tubes, and 2-3 herpes virus primers and different fluorescently labeled probes are arranged in each PCR tube to detect eight herpes viruses simultaneously. The scheme of the invention has high sensitivity and high specificity, primer dimers can be reduced, and the amplification efficiency can be improved; by collecting tear, cornea infected parts, tissues, aqueous humor or vitreous humor and other specimens from the eyes of a patient for detection, disease-associated viruses can be simply, quickly and accurately screened to form etiological diagnosis, and clinical targeted medication can be assisted.

The invention provides an oocyte in-vitro maturation culture method and an application thereof. The method of the invention comprises the step of applying aqueous humor from a non-human animal to in-vitro maturation of oocytes of a non-human mammal. Experiments prove that the oocytes matured by the maturation culture method has remarkably higher developmental rate of subsequent in-vitro fertilized embryos and nuclear transfer embryos than a control group, indicating that the method can effectively improve the maturing quality of the in-vitro oocytes. Aqueous humor is used as a basic culture solution for in-vitro maturation culture of the oocytes and has natural advantages as follows: the aqueous humor is rich in nutritional ingredients to meet various nutritional requirements required by in-vitro maturation of the oocytes firstly; various natural growth factors contained in the aqueous humor play important roles in promoting in-vitro maturation of oocytes and later-stage in-vitro embryonic development secondly; and aqueous humor is directly used for culture, thereby avoiding tedious preparation process of culture solution and facilitating large-scale popularization and application of in-vitro embryo culture thirdly.

Provided is an aqueous humour discharge apparatus for glaucoma prevention. The aqueous humour discharge apparatus for glaucoma prevention includes: an aqueous humour discharge tube including a contact portion provided on one side and contacting the cornea of an eyeball, an exposed portion exposed not to contact the sclera of the eyeball and provided on the other side, and a channel formed between the contact portion and the exposed portion, to enable aqueous humour to flow therethrough; and a cover member arranged to surround the cornea and the sclera, the cover member including a contact hole formed on one surface that contacts the cornea, and contacted by the aqueous humour discharge tube, a discharge hole formed on the other surface located on the opposite side to the one surface and exposed to the outside, to discharge the aqueous humour, and a flow channel provided between the contact hole and the discharge hole to provide a discharge path of the aqueous humour.

An embodiment of the present invention provides an aqueous humor drainage device and a manufacturing method thereof, belonging to the field of medical instruments. The aqueous humor drainage device comprises an aqueous humor dispersion disk, an intraocular drainage tube and an external drainage tube, the aqueous humor diffusing disk is located under the conjunctiva in the upper part of the eyeball, in the suprascleral region, both the intraocular drainage tube and the external drainage tube are connected with the aqueous humor diffusion disk, the input part of the intraocular drainage tube isused for communicating with the anterior chamber region or the posterior chamber region in the eye, the output part of the intraocular drainage tube is used for communicating with the input part of the external drainage tube, and the output part of the external drainage tube is used for communicating with the conjunctival region on the lower surface of the eye. The aqueous humor drainage device can improve the condition of fiber wrapping, meanwhile, the aqueous humor drainage device can still effectively drain the aqueous humor under the condition of fiber wrapping, the service life of the aqueous humor drainage device is prolonged, the structure design is reasonable, and the practicability is strong.

The invention discloses an aqueous humor collection device, comprising: an outer cylinder body including a puncture needle installation end and a liquid collection tube installation end; a puncture needle fixedly installed on the puncture needle installation end and including the puncture needle inner end and the puncture needle outer end The liquid collection tube assembly includes a liquid collection tube and a pipe plug for sealing the mouth of the liquid collection tube; wherein, the outer peripheral wall of the liquid collection tube assembly is provided with an annular groove and an annular limiter set by the hoop annular groove, The radially outer end of the annular stopper abuts against the inner peripheral wall of the outer cylinder, the radially outer edge of the pipe plug forms a smooth contact with the inner peripheral wall of the outer cylinder and is provided with a pipe plug arranged along the extending direction of the outer cylinder cavity Exhaust channel, the barrel cavity of the outer cylinder is connected to the tube plug exhaust channel in the cavity area between the tube plug and the installation end of the puncture needle. By adopting the aqueous humor collection device of the present invention, the safety and reliability during anterior chamber puncture can be improved, and the accuracy of subsequent aqueous humor detection can be improved.

The invention discloses an aqueous humor collection device. The aqueous humor collection device comprises an outer cylinder, a puncture needle and a liquid collecting pipe assembly, wherein the outer cylinder is provided with a puncture needle mounting end and a liquid collecting pipe mounting end; the puncture needle is inserted in the puncture needle mounting end and comprises a puncture needle outer end and a puncture needle inner end; the liquid collecting pipe assembly is pluggably and movably inserted in an outer cylinder cavity and comprises a liquid collecting pipe and a pipe stopper; a ventilation structure is formed between the liquid collecting pipe assembly and the inner peripheral wall of the outer cylinder, and can be communicated with a cylinder cavity area, between the puncture needle inner end and the pipe stopper, of the outer cylinder cavity, and the aqueous humor collection device also comprises a limiting buffer structure used for limiting radial displacement of the liquid collecting pipe assembly and used for forming contact damping between the liquid collecting pipe assembly and the inner peripheral wall of the outer cylinder. The aqueous humor collection device can control the drainage speed of aqueous humor during puncture, avoid the contamination of the aqueous humor after collection is completed and the waste caused by transfer of the aqueous humor, and can ensure the insertion and pulling stability of the liquid collecting pipe assembly, thereby being conductive to improving the safety, reliability and detection accuracy.

The invention discloses a flushing needle for anterior chamber paracentesis. The flushing needle comprises a puncture needle head and a cylinder body. The flushing needle is characterized in that the puncture needle head is nested in a flat needle head with a smooth port, and a push rod is arranged on the outer surface of the cylinder body; a cavity is formed in the outer edge of the cylinder body, and a measuring valve body for measuring a pH value in the cylinder body and a pH adjusting valve body for adjusting the pH value in the cylinder body are arranged in the cavity; and the pH adjusting valve body is used for adjusting a pH value of liquid in the cylinder body according to feedback information of the measuring valve body. Firstly, the puncture needle head penetrates through the inner side of the limbus corneae of a patient to form a puncture opening, then, the push rod is used for enabling the flat needle head to slide and wrap the puncture needle head, and then, the flat needle head is used for flushing an anterior chamber; the pH value of the liquid in the cavity is obtained through the measuring valve body in the cavity, and the pH value of the liquid in the cavity is equal to that of the liquid in the anterior chamber; and the pH value in the cylinder body is adjusted by using the pH adjusting valve body, so that imbalance of the pH value of the anterior chamber caused by replacement of aqueous humor of the anterior chamber and the flushing liquid is avoided.

The invention relates to gene detection by using aqueous humor cfDNA to assist clinical diagnosis, and belongs to the technical field of gene detection. The cfDNA in aqueous humor is used for detection, obtained mutation information is compared with a reference genome, primary vitreoretinal lymphoma (PVRL) can be effectively diagnosed, the detection result is significantly better than the detection accuracy of the cfDNA in plasma, and early diagnosis can be achieved.