178 results about "IOP - Intraocular pressure" patented technology

Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.

RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; β1- and β2 adrenergic receptors; acetylcholinesterase; Na⁺/K⁺-ATPase; and Na—K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.

The present invention provides ocular implants adapted to reside in Schlemm's canal for reducing intraocular pressure of an eye and methods for using the same. In some embodiments the ocular implants comprise a thin rod adapted and configured to extend in a curved volume in Schlemm's canal. The thin rod comprises a plurality of wave-shaped segments such that a sufficient number and amount of wave-shaped segments extend to the inner wall of the trabecular meshwork and to the outer wall of Schlemm's canal thereby keeping Schlemm's canal open.

A viscoelastic medium is useful for the manufacture of a medicament, such as a medical device, for treatment of increased intraocular pressure in the eye of a human or animal. The medicament is administerable into at least one sclerally penetrating fistula of the eye such that the fistula is filled with the medicament. The medium is also useful in a method of treating increased intraocular pressure in the eye of a human or an animal in need thereof, comprising the step of injecting the viscoelastic medium into at least one sclerally penetrating fistula in the eye such that the fistula is filled with the medium.

Methods for the treatment of glaucoma are provided by the present invention. The compounds described cause a perturbation of the actin cytoskeleton in the trabecular meshwork or the modulation of its interactions with the underlying membrane. Perturbation of the cytoskeleton and the associated adhesions reduces the resistance of the trabecular meshwork to fluid flow and thereby reduces intraocular pressure.

The invention provides EP2 agonists, methods for their preparation, pharmaceutical compositions containing these compounds, and methods of using these compounds and compositions for lowering intraocular pressure and thereby treating glaucoma.

An implanted intraocular shunt can be manually manipulated, without surgical intervention, to modify the flow resistance of the shunt, thereby providing relief from high intraocular pressure while avoiding hypotony. For example, through the application of pressure along a surface of the eye, a portion of the shunt can be displaced or separated relative to the shunt, thereby decreasing the flow resistance of the shunt.

An apparatus and method for controlling fluid flow provided by an apparatus to a patient's eye during a surgical procedure. The method includes automatically adjusting an irrigation fluid source to a predetermined height during the surgical procedure using the apparatus, receiving a request either that the irrigation fluid source be moved to a different height from the predetermined height or that a manual adjustment mode be entered, and ceasing automatic adjusting and requiring manual adjustment of the height of the irrigation fluid source until the surgical procedure is completed or an indication received to resume automatic height adjustment of the irrigation fluid source. As an alternative, fluid flow rate or intraocular pressure may be maintained, and the design may include making adjustments to default values in other modes based on the adjustment made.

The invention belongs to the technical field of medical equipment and discloses a monitoring system and a method based on the linear relationship between intraocular pressure and intracranial pressure. The monitoring system comprises an information integration module, an intraocular pressure measurement module, a vital signs monitoring module, and a lumbar cistern pressure monitoring module. The intraocular pressure measuring module, the vital signs monitoring module, and the lumbar cistern pressure monitoring module are mutually independently connected with the information integrating moduleand do not affect each other. The vital sign monitoring module comprises an electrocardiogram monitoring unit, an invasive artery pressure monitoring unit and a dual-frequency electroencephalogram monitoring unit. The data are integrated through an information integration module for information display, information storage and integration with the information. Based on the linear relationship between intraocular pressure (IOP) and intracranial pressure (ICP), the system indirectly reflects the change of ICP by measuring IOP, and provides an effective non-invasive monitoring method for ICP during general anesthesia.

A tethered cannula having at least two curved sections for implantation into an eye and a method for implanting the cannula in the eye. The cannula can withstand ever present and changing rotational forces from eye movement and mechanical forces from the movement of the subject. The cannula can be connected to implantable or tetherable devices that are too large, heavy, or obstructive to attach directly to the eye, such as an intraocular pressure sensor or infusion pump.

The invention relates to the technical field of medical appliances and especially relates to a drainage-type flexible micro support and a medical appliance. A multi-cavity drainage pipe is disposed, wherein the multi-cavity drainage pipe passes according to the path of entering suprachoroidal space via a scleral process of an eye in an anterior chamber. The multi-cavity drainage pipe at least comprises a fluid access, multiple drug filling cavities and multiple drug filling cavities. The micro support passes according to the path of entering the suprachoroidal space via the scleral process of the eye in the anterior chamber; and the fluid access of the micro support guides chamber solution of the anterior chamber to flow into the suprachoroidal space, so that intra-ocular pressure is reduced. Meanwhile, the drug filling cavities can release drugs at fixed positions effectively and enduringly, so multiplication and inflammation of the fixed position can be greatly reduced.