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The present invention provides a novel sequencing apparatus and the methods employed to determine the nucleotide sequence of many single nucleic acid molecules simultaneously, in parallel. The methods and apparatus of the present invention offer a rapid, cost effective, high through-put method by which nucleic acid molecules from any source can be readily sequenced without the need for prior amplification of the sample or prior knowledge of any sequence information.

Provided herein are compositions and methods related to purification of recombinant adeno-associated virus (rAAV) particles.

A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles. The peptide probes can be designed to bind to a desired peptide sequence or can even be based on dendrimer structure to control further aggregate propagation.

A method is for forming an oil-repellent film on a metallic part in a dynamic fluid pressure bearing mechanism used for a motor. The method includes applying a flowable oil-repellent agent on an application region of the metallic part; arranging an induction coil in the vicinity of the metallic part; and affixing the oil-repellent agent onto the metallic part by applying an induction heating to the metallic part by supplying an AC current with a frequency of about 5 to 100 kHz to the induction coil. Further, a motor includes a dynamic fluid pressure bearing mechanism including a metallic part on which an oil-repellent film is formed by the above method; a stator unit; and a rotor unit supported by the dynamic fluid pressure bearing mechanism in a manner rotatable with respect to the stator unit.

An insert for a helmet comprises a plurality of layers, each layer being of a Miura-Ori fold geometry.

The subject invention pertains to a method and apparatus for etching copper (Cu). The subject invention can involve passing a halide gas over an area of Cu such that CuX, or CuX and CuX2, are formed, where X is the halide. Examples of halides which can be utilized with the subject matter include, but are not necessarily limited to, Cl, Br, F, and I. Once the CuX, or CuX and CuX2, are formed the subject invention can then involve passing a reducing gas over the area of Cu for a sufficient time to etch away at least a portion of the CuX, or CuX2, respectively. With respect to a specific embodiment in which CuX and CuX2 are produced when the halide gas is passed over the area of Cu, the reducing gas can be passed until essentially all of the CUX2 is etched and at least a portion of the CuX is etched. Examples of reducing gases which can be utilized with the subject invention include, but are not necessarily limited to, hydrogen gas and hydrogen gas plasma. The subject invention can accomplish the etching of Cu by passing the reducing gas over the Cu so as to be on a CuX2—Cu3X2 metastable line when etching CuX2 and to be a CuY—CuX metastable line, where Y is the reducing gas element, when etching CuX. FIGS. 5, 6, and 8, show such metastable lines for Cu, with X being Cl, from temperatures ranging from 50° C. to 200° C. These can be extrapolated to other temperatures, for other halides, and / or other reducing gases. The subject invention can be used to, for example, etch partial into a layer of Cu, through a layer of Cu, or to smooth a Cu surface.

A plurality of piles is arranged in frame elements in an axially displaceable manner. Hammers are positioned on the piles. After driving of the piles into a seabed, the hammers are connected to the frame elements, wherein the frame elements together with the hammers are lifted to the surface of the water and to the seaborne vessel by a crane.

The invention relates to a method for producing a drywall. In the method, a panel made of a plurality of paneling boards (3) placed alongside one another is fixed to a frame structure (1). According to the invention, fixation elements (5) are first affixed to a substructure (2) in the edge area of a paneling board (3) and / or in the joint area (4) of two adjacent paneling boards (3). Then, by means of a clamping tool (7) for example, fastening elements (6) are set alongside the fixation elements (5), the respective paneling board (3) being simultaneously clamped between the substructure (2) and the fastening element (6).

The invention provides oligonucleotide(s) for simple, specific and / or sensitive test(s) for the presence of Mycobacterium tuberculosis. In particular, the present invention provides oligonucleotide(s) for test(s) for Mycobacterium tuberculosis. Kit(s) comprising the oligonucleotide(s) for use as probe(s) and / or primer(s) useful in the test(s) are also provided.

The invention relates to a method for producing a microwave filter (700), comprising making at least one through-cutout (750) in a first electrically conductive plate (740) shaped as a rectangle, with a short side and a long side, inserting the first plate (740) between a second (710) and a third (730) electrically conductive plate (710), the first plate being arranged parallel to the second and the third plate, making electrical connections (794, 795) between said three plates for interconnecting those edge surfaces on the plates which coincide with the direction of propagation of the electrical signals, as a result of which a space comprising one or more cavities is formed. The first plate (740) is arranged so that the extent of its short side coincides with the E-field of the microwave signals when they propagate in the filter (700), and the extent of its long side coincides with the direction of propagation of the electrical signals.

For manufacturing a component formed of a plurality of moldings, which are made of plastic, are welded together. A first molding is manufactured in a first mold that has a first mold part and is then transported with the first mold part into a welding station. Correspondingly, a second molding is manufactured in a second mold that has a second mold part and is transported with the second mold part into the welding station. The mold parts holding the moldings are moved towards one another in the welding station such that the moldings are welded together. Additional moldings are manufactured in the molds simultaneously with the welding of the moldings.

A fixture for recycling bottles made of plastics, which includes a base plate and means for anchoring the bottles arranged on the upper side of the base plate and engaging in indentations provided on the bottle bottoms, and a recycling bottle made of plastics to be used with such a fixture and including an indentation on its bottle bottom. In order to facilitate handling of the bottles for recycling purposes and to enable the automated determination of possible deposits for the bottles as well as the simple and rapid recyclability of the bottles, it is provided that the anchoring means, in a sense oriented away from the upper side of the base plate, have decreasing cross sections and barb-shaped formations. Thus, the optimum support of the bottles on the fixture is safeguarded. Preferably, the base plate is located within the projection of the bottles onto the base plate.

An accumulator for a cooling fluid is provided that includes a floor. The floor has an interface for connecting a chamber of the accumulator to at least one cooling tube. The floor also has an opening that extends at least over a partial area of the chamber. The accumulator furthermore has a lid that is embodied in such a way as to seal the opening of the floor in a fluid-tight manner. The lid is embodied as wire or extrusion profile.

The present invention provides the identification and use of EGTom1 and / or EGTom2, homologs of EGTom1 and / or EGTom2, orthologs of EGTom1 and / or EGTom2, paralogs of EGTom1 and / or EGTom2, and fragments and variations thereof for altering salt tolerance, drought tolerance and / or sugar content of fruit (sweetness) in plants. The invention relates to the identification and use of nucleic acid sequences for salt / drought tolerance and fruit sweetness in plants.

An accumulator for a cooling fluid is provided that includes a floor. The floor has an interface for connecting a chamber of the accumulator to at least one cooling tube. The floor also has an opening that extends at least over a partial area of the chamber. The accumulator furthermore has a lid that is embodied in such a way as to seal the opening of the floor in a fluid-tight manner. The lid is embodied as wire or extrusion profile.

Measuring of the binding of a transcription factor (using, for example, chromatin immunoprecipitation) according to the present invention is provides an improved marker for a disease. These markers can be used in diagnostics for diseases where a transcription factor binding event plays a role. Additionally, they can be used to adjust disease risk profiles for healthy individuals as with typical genetic variants.

An adapter (1) is described for connecting an electrical plug-in connector (4) of a fuel injector to a counterplug (6), whose first end (3) is pluggable into a plug-in connector (4) of the fuel injector and whose second end (5) is pluggable into counterplug (6) of the electrical line. A first seal (7) being positioned between the first end (3) of the adapter (1) and the plug-in connector (4) of the fuel injector and a second seal (8) being positioned between the second end (5) of the adapter (1) and the counterplug (6).

A method is for forming an oil-repellent film on a metallic part in a dynamic fluid pressure bearing mechanism used for a motor. The method includes applying a flowable oil-repellent agent on an application region of the metallic part; arranging an induction coil in the vicinity of the metallic part; and affixing the oil-repellent agent onto the metallic part by applying an induction heating to the metallic part by supplying an AC current with a frequency of about 5 to 100 kHz to the induction coil. Further, a motor includes a dynamic fluid pressure bearing mechanism including a metallic part on which an oil-repellent film is formed by the above method; a stator unit; and a rotor unit supported by the dynamic fluid pressure bearing mechanism in a manner rotatable with respect to the stator unit.

The present disclosure relates to a method for detecting a fibre misalignment in an elongated structure, such as a wind turbine blade component. The elongated structure has a length along a longitudinal direction and comprises a plurality of stacked reinforcing fibre layers. The plurality of fibre layers comprises fibres having an orientation aligned, unidirectionally, substantially in the longitudinal direction. The method comprises scanning a surface of the elongated structure for identifying one or more surface irregularities, selecting one or more regions of interest comprising said one or more surface irregularities, examining said region of interest using penetrating radiation, and determining a position and / or size of the fibre misalignment based on said examining step.

An actively adjustable wheel suspension for the wheels of an axle of a motor vehicle, wherein each wheel is articulated on the body side of the motor vehicle via a plurality of wheel control elements, includes for each wheel on the axle a rotary actuator which is supported on the body side and includes a torsion bar. The two rotary actuators can be activated for active adjustment via a control unit, with the rotary actuators and the torsion bars of the rotary actuators being oriented in motor vehicle longitudinal direction. The rotary actuators include each at least one strut, which is oriented in motor vehicle transverse direction, for torque support.

The invention relates to a method for manufacturing a housing of a turbomachine, in particular a gas turbine. The method comprises at least the steps: providing a housing blank (10), manufacturing a housing element (14), producing an assembly opening (12) corresponding to the housing element (14) in the housing blank (10), arranging the housing element (14) in the assembly opening (12), and joining the housing element (14) to the housing blank (10) by means of a welding method. In addition, the invention relates to a turbomachine housing.

The present invention relates to particles comprising non-covalent complexes which comprise starch and an active agent and dry compositions containing such particles for the oral delivery of the active agents. Preferably the particles are degraded and release the active agent within the intestines, protecting the active agent from degradation in the stomach. The present invention further relates to methods for preparing suspensions of these particles having a uniform particle size in the range of several microns.

A plurality of piles is arranged in frame elements in an axially displaceable manner. Hammers are positioned on the piles. After driving of the piles into a seabed, the hammers are connected to the frame elements, wherein the frame elements together with the hammers are lifted to the surface of the water and to the seaborne vessel by a crane.

A viscoelastic medium is useful for the manufacture of a medicament, such as a medical device, for treatment of increased intraocular pressure in the eye of a human or animal. The medicament is administerable into at least one sclerally penetrating fistula of the eye such that the fistula is filled with the medicament. The medium is also useful in a method of treating increased intraocular pressure in the eye of a human or an animal in need thereof, comprising the step of injecting the viscoelastic medium into at least one sclerally penetrating fistula in the eye such that the fistula is filled with the medium.

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. In a specific embodiment, present inventors have developed and applied a new technology and associated computation methods enabling simultaneous genome-scale analysis of genetic (copy number) and epigenetic (total methylation (TM) and allele-specific methylation (ASM) alternation, This method, called MBD-SNP, features affinity enrichment or methylated genomic DNA fragments using a methyl-binding domain polypeptide.

Measuring of the binding of a transcription factor (using, for example, chromatin immunoprecipitation) according to the present invention is provides an improved marker for a disease. These markers can be used in diagnostics for diseases where a transcription factor binding event plays a role. Additionally, they can be used to adjust disease risk profiles for healthy individuals as with typical genetic variants.

The present disclosure relates to a method for detecting a fibre misalignment in an elongated structure, such as a wind turbine blade component. The elongated structure has a length along a longitudinal direction and comprises a plurality of stacked reinforcing fibre layers. The plurality of fibre layers comprises fibres having an orientation aligned, unidirectionally, substantially in the longitudinal direction. The method comprises scanning a surface of the elongated structure for identifying one or more surface irregularities, selecting one or more regions of interest comprising said one or more surface irregularities, examining said region of interest using penetrating radiation, and determining a position and / or size of the fibre misalignment based on said examining step.

The invention relates to a method for manufacturing a housing of a turbomachine, in particular a gas turbine. The method comprises at least the steps: providing a housing blank, manufacturing a housing element, producing an assembly opening corresponding to the housing element in the housing blank, arranging the housing element in the assembly opening, and joining the housing element to the housing blank by means of a welding method. In addition, the invention relates to a turbomachine housing.

The invention provides novel oligonucleotides and methods of using the same for detection or measurement of specific nucleic acid molecules. The invention also features nucleic acid arrays comprising the oligonucleotides of the invention. An oligonucleotide of the invention comprises (1) a reporter-binding sequence capable of hybridizing to a fluorrophore-labeled reporter sequence and (2) a hairpin-forming sequence capable of forming a stem-loop. Formation of the stem-loop modifies (e.g., quenching) the fluorescence signals of the reporter sequence when the reporter sequence is hybridized to the oligonucleotide. This can be achieved, for example, by bringing one or more guanine based in the oligonucleotide into close proximity to the fluorophore(s) of the reporter sequence by virtue of the formation of the stem-loop. Disruption of the stem-loop, such as by hybridization of a target sequence to at least part of the hairpin-forming sequence, produces a detectable change in the fluorescence signals.