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4 results about "Beta sheet" patented technology
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The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins. Beta sheets consist of beta strands (also β-strand) connected laterally by at least two or three backbone hydrogen bonds, forming a generally twisted, pleated sheet. A β-strand is a stretch of polypeptide chain typically 3 to 10 amino acids long with backbone in an extended conformation. The supramolecular association of β-sheets has been implicated in formation of the protein aggregates and fibrils observed in many human diseases, notably the amyloidoses such as Alzheimer's disease.
De novo engineered polypeptides and methods of use thereof
The disclosure provides de novo designed and synthesized non-naturally occurring, beta strand reservoir polypeptides that can be processed into a beta sheet crystalline phase. The disclosure further provides compositions and beta sheet crystalline phases comprising the disclosed proteins, and methods of preparation and use thereof.
Owner:WL GORE & ASSOC INC +22
A ms2 virus-like particle based on site-directed mutation of coat protein and preparation method and application thereof
The application discloses a kind of MS2 virus-like particles based on capsid protein site-directed mutation and its preparation method and application, belong to molecular biological technique field.The amino acid of the beta sheet interface of capsid protein sequence, the amino acid of the interface when two capsid proteins molecules assemble, the carboxyl end site of capsid protein is subjected to site-directed mutation, obtain the mutant that can significantly improve the assembly efficiency and stability of capsid protein dimer.Utilize the mutant to construct MS2 virus-like particles, further by the design of mature enzyme and capsid protein expression element, control mature enzyme weak expression, capsid protein strong expression, to improve assembly efficiency.The application improves the assembly efficiency of MS2 virus by the above strategy, improves the proportion of wrapped RNA, enhances the stability of virus-like particle, greatly prolongs the stable storage time of RNA, improves the purity of wrapped RNA.
Owner:NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
De novo engineered polypeptides and methods of use thereof
The disclosure provides de novo designed and synthesized non-naturally occurring, beta strand reservoir polypeptides that can be processed into a beta sheet crystalline phase. The disclosure further provides compositions and beta sheet crystalline phases comprising the disclosed proteins, and methods of preparation and use thereof.
Anti-angiogenic agents and methods of using such agents
The anti-angiogenic agent or polypeptide has an amino acid segment substantially similar to domain 1 of CD2. The polypeptide has a beta fold formed by two segments. Methods of using such agents and polypeptides are also included. The agent or polypeptide has a terminal glycine.
Owner:GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC