25 results about "Thiopyran" patented technology

The invention discloses a thiapyran molecule modified solar cell and a preparation method thereof. The cell sequentially comprises an ITO (Indium Tin Oxide) conductive glass layer, a 4-aminotetrahydro-2H-thiapyran-1, 1-dioxide hydrochloride modified [4-(3, 6-dimethoxy-9H-carbazole-9-yl) butyl] phosphonic acid hole transport layer, a Cs0.05 (FA < 0.77 > MA < 0.23 >) < 0.95 > Pb < (I < 0.77 > Br < 0.23 >) 3 wide-band gap perovskite thin film, a phenethyl ammonium iodide passivation layer, an electron transport layer of [6, 6]-phenyl-C61-butyric acid isomethyl ester, a 2, 9-dimethyl-4, 6, 7-tetrahydro-2H-thiapyran-1, 1-dioxide hydrochloride modified [4-(3, 6-dimethoxy-9H-carbazole-9-yl) butyl] the hole barrier layer is made of 1, 7-biphenyl-1, 10-phenanthroline; the electrode layer is made of metal Ag; according to the scheme, the hole transport layer is modified through thiapyran molecules, agglomeration of the hole transport layer is relieved, and a more compact and more uniform self-assembled single layer is generated by inducing favorable crystal orientation. A good bottom interface is obtained based on thiapyran molecule modification, and ordered growth of high-quality perovskite crystal grains is promoted. In addition, the energy level of the hole transport layer is effectively adjusted through thiapyran molecule treatment, and the extraction and transmission of carriers by the hole transport layer are enhanced.

The invention discloses an 8-bromine-5-substituted-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole derivative, and the 8-bromine-5-substituted-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole derivative is 8-bromine-5-(4-chlorophenethyl)-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole and / or 8-bromine-5-phenethyl-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole. The invention further discloses a preparation method of the 8-bromine-5-substituted-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole derivative. The 8-bromo-5-substituted-1, 3, 4, 5-tetrahydrothiapyran [4, 3-b] indole derivative provided by the invention has the effects of inhibiting rhizoctonia solani and promoting seed germination. The compound provided by the invention not only can be used for preventing and treating rice sheath blight disease through spraying treatment, but also can be used for preventing rice seeds from carrying bacteria in a seed soaking manner, so that the rice sheath blight disease is comprehensively prevented and controlled. Besides, rice seeds are soaked in a compound solution, germination of the rice seeds can be promoted, the root length, growth vigor and fresh weight indexes of the seeds are improved, and the compound has good application prospects and value in prevention and treatment of the rice sheath blight disease.

The invention relates to the technical field of thiapyran processing, in particular to a drying device for thiapyran processing, which comprises a supporting seat, a drying box is arranged at the top of the supporting seat, a discharging box is arranged on one side of the drying box, the bottom of the discharging box is communicated with a discharging pipe, the interior of the drying box is connected with a splitter plate through a mounting mechanism, and a driving mechanism is further arranged on the supporting seat. The other side of the drying box is movably connected with a supporting plate, the supporting plate communicates with a feeding hopper, heaters are installed on the discharging box and the supporting plate, a temperature sensor is arranged in the drying box, and a controller is further arranged on the supporting base. Air flow is optimized through the splitter plate, hot air can be evenly distributed, it is ensured that thiapyran materials make full contact in the drying process, the heat transfer efficiency is improved, the drying time is shortened, the production efficiency is improved, temperature changes are monitored in real time, the problem of uneven drying caused by temperature fluctuation is avoided, uneven drying is prevented, and manual intervention is reduced.

This invention discloses a photosensitive supramolecular fluorescent polymer, its preparation method, and its anti-counterfeiting application in water, using trifluoroethyl methacrylate, hexafluorobutyl acrylate, 4-(acryloyloxy)butyl4-(2-methyl-3-(2-(2-methylbenzo[b]thiophen-3-yl)-4-oxo-5,6-2H-4H-thiaran[2,3-)b]thiaran-3-yl)benzo[b]thiophen-6-yl)-4-oxobutyrate, 4 This polymer was prepared by a simple one-step free radical copolymerization method using 1,1-(acryloyloxy)butyl3-(3,3,4,4,5,5-hexafluoro-2-(2-methyl-1,1-dioxide benzo[b]thiophene-3-yl)cyclopent-1-en-1-yl)-2-methylbenzo[b]thiophene-6-carboxylate 1,1-dioxide and phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (photoinitiator-819) as raw materials. The polymer exhibits excellent multicolor light-switching performance, high stretch ratio, high self-healing efficiency, strong substrate adhesion, and antifouling properties, especially demonstrating excellent stability under strong acid, strong alkali, and high salt environments. The synthetic route is simple, and it has great application potential in underwater anti-counterfeiting and encryption technologies.

The invention discloses a preparation method of a thiapyran-4-ketone compound, which comprises the following steps: taking an enaminone compound with a chemical structural formula as shown in a formula (I) and a sulfur source compound as raw materials, reacting for 12-24 hours in a solvent at 90-120 DEG C under the action of a catalyst to obtain a reaction product, and then purifying the reaction product to obtain the thiapyran-4-ketone compound. The structural formula of the thiapyran-4-ketone compound is shown as a formula (II). The preparation method disclosed by the invention has the characteristics of low raw material cost, mild reaction conditions, simplicity in operation, few reaction byproducts, environment friendliness and the like, thereby having a wide application prospect.

The present application provides a kind of singlet oxygen activated photo-cage chemiluminescence molecule, which has the structure shown in formula (I), wherein X is hydrogen or halogen, PC represents photo-cage group, R 1 It is an electron-withdrawing group containing oxygen and / or nitrogen, R 2 It is selected from adamantane, cyclobutane, methyl cyclobutyl formate and tetrahydrothiopyran-1,1-dioxide. The chemiluminescence molecule is activated by singlet oxygen and triggered by light of a specific wavelength, and through the processes of oxidation, photolysis, electron transfer, etc., an excited state benzoate structure is generated, which emits blue-green light when returning to the ground state. 2 Group, photo-cage group and R 1 Electron-withdrawing group synergistic effect, oxidation, photolysis, electron transfer, etc. process, generate excited state benzoate structure, it emits blue-green light when returning to the ground state.

The invention provides a triaryl onium salt as well as a preparation method and application thereof, and belongs to the field of photocatalysis and plastic degradation. According to the invention, the redox potential range of the triaryl onium salt is widened by regulating and controlling the structure of the photocatalyst (a substituent group on a conversion benzene ring), and the molar absorption rate, the quantum yield, the excited state life and the chemical stability in a visible spectrum are improved.

The invention discloses a preparation method of (3S, 4R)-4-amino tetrahydro-2H-thiapyran-3-ol hydrochloride and a preparation method thereof. According to the invention, tetrahydrothiapyran-4-ketone is used as a reaction starting material; the preparation method comprises the following steps: reacting (S)-3-((2-(trimethylsilyl) ethyoxyl) methoxyl) tetrahydro-4H-thiapyran-4-one with nitrosobenzene to prepare (S)-3-((2-(trimethylsilyl) ethyoxyl) methoxyl) tetrahydro-4H-thiapyran-4-one, removing aniline through catalysis of copper sulfate, protecting a hydroxyl functional group by using 2-(trimethylsilyl) ethoxymethyl chloride, and performing reductive amination reaction with (R)-(+)-tert-butylsulfinamide (compound 5) to obtain relatively stable imine. And carrying out hydrogenation reduction reaction on the imine, and removing tert-butylsulfinyl to obtain the target product. The whole preparation process is carried out at room temperature, the raw materials are easy to obtain, the operation is simple, the yield is relatively high, and a single-target configuration product can be prepared.

The present application belongs to the field of organic chemical synthesis, and particularly relates to a thiepany spiroindolone compound and a synthesis method thereof. The present application takes MBH ester derived from oxidized indole and alpha-alkenol dithioester as starting materials, and prepares the target compound through a two-step one-pot reaction at room temperature in a specific base and solvent system. The synthesis strategy is novel, the reaction condition is mild, the operation is simple, efficient, and easy to operate, the raw materials and solvents are easy to obtain and controllable in cost, the reaction selectivity is high, the product yield is considerable, the substrate application range is wide, and the functional group tolerance is strong. The target product has clear in-vitro anti-tumor activity, definite application prospect, and outstanding industrialization potential, provides a new scheme for the preparation of thiepany spiroindolone compounds, and has strong popularization value.

The present invention relates to a pyrimido-thiopyrandione inhibitor for the KRAS G12C mutant protein and the use thereof. Specifically, the present invention provides compounds as shown in formula (I), the definition of each substituent in the formula being as described in the description. In addition, the present invention also relates to a composition of the inhibitor and the use thereof. The compounds provided by the present invention have good inhibitory activity on tumor growth and have good safety.

The invention relates to a KRAS G12C mutant protein pyrimido-thiapyran diketone inhibitor and application thereof, in particular to a compound shown in a formula (I), and the definition of each substitution in the formula is described in the specification. In addition, the invention also relates to a composition of the inhibitor and application thereof. The compound provided by the invention has good activity of inhibiting tumor growth. And the safety is good.

This invention discloses a chiral indothothiaran compound, its catalytic synthesis method, and its application as a HIF inhibitor, belonging to the field of biomedicine. The structure of the chiral indothothiaran compound is shown in general formula 3. Its catalytic synthesis method includes the following steps: using an alkynyl ketone compound 1 and an indole-2-thione compound 2 as reactants, adding a chiral primary amine catalyst and an acid additive, reacting in a substituted benzene solvent at 25-40°C for 24-48 hours to obtain the chiral indothothiaran compound shown in general formula 3. The chiral indothothiaran compound synthesized by this invention exhibits good inhibitory activity against hypoxia-inducible factor (HIF) and can be used to prepare drugs for the prevention or treatment of diseases related to HIF. The target product of this invention is directly obtained from commercially available raw materials through simple conversion, reducing the synthetic difficulty and making it suitable for large-scale preparation.

The present invention discloses a glyphosate compound formulation containing a thiopyran compound. The thiopyran compound is prepared by dissolving α-carbonylcyclopropamide and ethyl mercaptoacetate in acetonitrile as an organic solvent and reacting under the catalysis of an organic base. A preparation method for the glyphosate compound formulation and an application of the glyphosate compound formulation are also disclosed. The present invention compounds the thiopyran compound with glyphosate to obtain a glyphosate compound formulation for herbicidal use, thereby increasing the herbicidal effect on resistant weeds, accelerating the herbicidal rate of glyphosate, reducing the amount of glyphosate used, and effectively alleviating the risk of glyphosate resistance, thereby achieving the purpose of reducing costs and increasing efficiency. The invention has good application prospects in the field of pesticides.

The invention belongs to the field of chemical synthesis, and particularly relates to a tetrahydrothiapyran compound as well as a preparation method and application thereof. The chemical structural formula of the tetrahydrothiapyran compound is shown as a formula I. According to the invention, not only is a series of tetrahydrothiapyran compounds designed, but also a synthesis method is established, and structural identification is completed. In-vitro activity tests prove that the tetrahydrothiapyran compound has extremely high killing activity on pruritus inarus and is a mite killing drug with potential application value, and theoretical and technical data are provided for application and development of the compound. The acaricidal activity of the tetrahydrothiapyran compound disclosed by the invention is obviously higher than that of currently common clinically applied acaricidal drugs, and the tetrahydrothiapyran compound has the advantages of short synthesis route, mild conditions, low raw material price, simple post-treatment and the like, and is suitable for industrial large-scale production. # imgabs0 #

A crystal polymorphism form of CGRP antagonist (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(7-oxo-3,4,7,8-tetrahydro-2H-thiopyrano[2,3-b]pyridin-6-yl)piperidine-1-carboxamide, a preparation method therefor, a pharmaceutical composition containing the crystal form, and the use thereof in the treatment of related diseases.

The application discloses a thietane molecule modified solar cell and a preparation method thereof. 0.05 (FA 0.77 MA 0.23 ) 0.95 Pb(I 0.77 Br 0.23 )3 wide band gap perovskite film, a phenylethylammonium iodide passivation layer, an electron transport layer of [6,6]-phenyl-C61-butyric acid methyl ester, a hole blocking layer of 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline and an electrode layer of metal Ag; the scheme modifies the hole transport layer by thietane molecules, relieves the agglomeration of the hole transport layer, induces favorable crystal orientation, and generates a denser and more uniform self-assembled monolayer. Based on the good bottom interface obtained after the modification of the thietane molecules, the ordered growth of high-quality perovskite grains is promoted. In addition, the thietane molecule treatment effectively adjusts the energy level of the hole transport layer, and enhances the extraction and transmission of the hole transport layer to the carriers.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a dihydrobenzothiapyran compound as well as a synthesis method and application thereof. The structure of the dihydrobenzothiapyran compound is shown as a formula III or a formula IV. The invention also provides a synthesis method of the dihydrobenzothiapyran compound, which does not need a metal catalyst, is mild in reaction condition and wide in substrate applicability, and realizes controllable derivatization of the product.

The invention discloses a preparation method and application of a supramolecular polymer with adjustable photoswitch fluorescence and 3D structure, and the supramolecular polymer is prepared from trifluoroethyl methacrylate, hexafluorobutyl acrylate, 2-(6-(dimethylamino)-1, 2, 4-trimethyl-1, 3-pentanediol monoisobutyrate, 1, 3-pentanediol monoisobutyrate, 1, 3-pentanediol monoisobutyrate, 1, 3- The preparation method comprises the following steps: preparing 2, 3-dioxo-1H-benzo [de] isoquinolin-2 (3H)-yl) ethyl acrylate (MNEA), 4-(acryloyloxy) butyl-4-(2-methyl-3-(2-(2-methylbenzo [b] thiophene-3-yl)-4-oxo-5, 6-2H-4H-thiapyran [2, 3-) b] thiapyran [3-yl) benzo [b] thiophene-6-yl)-4-oxobutyrate (BTBA), 1, 3-dioxo-1H-benzo [de] isoquinolin-2 (3H)-yl) ethyl acrylate (MNEA), 4-(acryloyloxy) butyl-4-(2-methyl-3-(2-methylbenzo [b] According to the invention, 2, 6-hexanediol diacrylate and phenyl bis (2, 4, 6-trimethylbenzoyl) phosphine oxide are used as raw materials, and the supramolecular polymer with the characteristics of photoswitch fluorescence and adjustable 3D structure is prepared in a photopolymerization manner. The supramolecular polymer obtained by the invention has the advantages of excellent fluorescence switch cycle performance, reversible and adjustable 3D structure, high tensile ratio, high anti-fouling performance and excellent stability in strong acid or strong alkali environment. In addition, the synthesis route of the supramolecular polymer is simple, and the supramolecular polymer has a huge application prospect in the anti-counterfeiting field.

The present invention relates to pyrimido[4,5-d]thiazine-2,4-dione inhibitors of KRAS G12C mutant protein and their uses. Specifically, the present invention provides a compound represented by formula (I), wherein the definitions of each substituent are as described in the specification. In addition, it also relates to compositions of the inhibitor and their applications. The compounds of the present invention have good activities in inhibiting tumor growth and have good safety profiles.

The invention discloses a dihydrobenzothiapyran-1, 1-dioxide compound as well as a preparation method and application of the dihydrobenzothiapyran-1, 1-dioxide compound. The preparation method comprises the following steps: carrying out a catalytic reaction on a compound 1, a compound 2 and a photocatalyst in an N2 atmosphere irradiated by visible light, and then purifying a reaction product to obtain a compound 3, wherein the compound 1 has a structure as shown in formula 1, the compound 2 has a structure as shown in formula 2, and the compound 3 has a structure as shown in formula 3: # imgabs0 #

The invention discloses a non-excitation small-molecule photosensitizer drug as well as a preparation method and application thereof, belongs to the technical field of clinical metastatic cancer treatment drugs, and solves the technical problems of low efficiency, weak targeting property and large side effect in deep tissue metastatic tumor treatment due to the defects of PDT in the prior art. According to the non-excitation small-molecule photosensitizer drug provided by the invention, an energy donor and an acceptor are connected into a single molecule through a photosensitizer molecule in a covalent coupling manner, the energy acceptor is a porphyrin photosensitizer, or a cyanine photosensitizer, or a thiapyranium salt photosensitizer, and the energy donor is a peroxyoxalate ester compound; a targeting group T, a photosensitizer P and a peroxyoxalate ester group C are connected through a covalent bond to form a (targeting group T)-photosensitizer P-peroxyoxalate ester group C; and effective photodynamic therapy on deep tissue metastatic tumors is realized.

The invention discloses a chiral indolothiapyran compound, a catalytic synthesis method thereof and application of the chiral indolothiapyran compound as an HIF inhibitor, and belongs to the field of biological medicine. The structure of the chiral indolothiapyran compound is shown as a general formula 3, and the catalytic synthesis method of the chiral indolothiapyran compound comprises the following steps: by taking an alkyne ketene compound 1 and an indole-2-thioketone compound 2 as reactants, adding a chiral primary amine catalyst and an acid additive, and reacting in a substituted benzene solvent at 25-40 DEG C for 24-48 hours to obtain the chiral indolothiapyran compound. The chiral indolothiapyran compound as shown in a general formula 3 is obtained. The synthesized chiral indolothiapyran compound has good hypoxia-inducible factor HIF inhibitory activity, and can be used for preparing drugs for preventing or treating diseases related to hypoxia-inducible factors (HIF). The target product is directly obtained from commercially available raw materials through simple conversion, the synthesis difficulty is reduced, and the method is suitable for large-scale preparation.

The invention relates to the field of synthesis of drug intermediates, and particularly discloses a one-step synthesis method of a drug intermediate 6-amino-2-thiocarbonyl-2H-thiapyran derivative, which comprises the following steps: taking mono-substituted acetophenone, malononitrile and carbon disulfide as reaction raw materials; under the catalytic action of heating and an alkaline functional deep eutectic solvent, the 6-amino-2-thiocarbonyl-2H-thiapyran derivative is directly synthesized through a one-step reaction. The whole synthesis process is simple and convenient in operation steps, high in target product and production efficiency, and good in economic benefit. Besides, the alkaline functional deep-eutectic solvent can be recycled, so that the utilization rate of the raw materials is increased, the environmental pollution is reduced, and the purpose of green synthesis of the 6-amino-2-thiocarbonyl-2H-thiapyran derivative is achieved.

The invention discloses a preparation method of 3-formyl-5,6-dihydro-2,6-dipropyl-2H-thiopyran, which belongs to the field of organic synthesis technology. The present invention uses 2-hexenal as raw material, first undergoes addition reaction with hydrogen chloride, and then replaces and prepares Bunte salt with sodium thiosulfate in the presence of a phase catalyst. The last pot method is hydrolyzed under acidic conditions and directly condensed with 2-hexenal to form a ring to obtain 3-formyl-5,6-dihydro-2,6-dipropyl-2H-thiopyran. The raw materials used in this route are cheap and easy to obtain, have high safety, are convenient for industrial production, have a high yield, can reach 89%, and are suitable for industrial large-scale production.