Double hydrochloride vertebral gel spray for purifying nose and its use

A spray and nasal technology, which is applied in the field of hydrochloric acid Shishuangjing nasal gel spray, can solve problems such as nasal mucosa and cilia toxicity, and achieve the effects of less local irritation, good therapeutic effect, and not easy to be lost.

Inactive Publication Date: 2007-11-21
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

How to make trypansin hydrochloride nasal administration can be truly applicable to organisms, and the problem of making the dosage form suitable for nasal administration has not been solved, such as the combination and proportioning of trypansin hydrochloride and various auxiliary materials, and the preparation contains Penetration enhancers such as laurocaprazine, dimethyl-β-cyclodextrin, menthol, borneol, etc., have relatively high toxicity to nasal mucosa and cilia. truly practical

Method used

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  • Double hydrochloride vertebral gel spray for purifying nose and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～10

[0021] T-46(g): trypanazin hydrochloride; PEG: polyethylene glycol; the components of Examples 1-18 were made up to 1000 mL with water for injection. The commercial name of the junction angle of the present invention is Gelrite, which is purchased from Shanghai Zhongwei Biochemical Co., Ltd.

[0022] Examples 1-4, 18 preparation method: ① take the prescribed amount of isotonicity regulator, gelling agent and preservative in 850mL of water for injection, heat in a water bath at 90°C to dissolve completely. 2. hydrochloric acid dipyridine hydrochloride is used respectively [30ml 0.1mol / L (embodiment 1), 50mL 0.1mol / L (embodiment 2), 100mL 0.1mol / L (embodiment 3), 100mL 0.2mol / L (embodiment 4 ), 30ml 0.1mol / L (Example 18)] hydrochloric acid dissolved, added in the above solution under stirring, fully mixed. ③Examples 1 and 18 use 30% ethanolamine, and examples 2-4 use 30% trishydroxymethylaminomethane to adjust the pH to the required pH in Table 1, add water for injection...

Embodiment 17

[0024] Preparation method of Example 17: ① Take the prescribed amount of gelling agent in 680 mL of water for injection, and refrigerate overnight at 4°C to make the gelling agent fully swell and disperse evenly to obtain a clear solution. ②Tyrabiquinone hydrochloride was dissolved with water for injection, added into the above solution under stirring, and mixed well. 3. Add water for injection to a total amount of 1000mL, pack in white medical plastic bottles, and install a nasal cavity spray pump to obtain the nasal gel spray of Shishuangjing Hydrochloride of the present invention.

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Abstract

The invention is concerned with the Vertebral double net hydrochloride clean gelatin nebula pressurized spray for nose, which consists of Vertebral double net hydrochloride and gel substrate. It is uses for anti-trypanosomiasis. It is: stays in liquid form, in order to control to spray into nasal cavity easily and separates on the surface of Nasal evenly and forms gelatin by interdiffusing with nose grume. With its long lasting inside the nasal cavity, it can direct input the medicine to the brain that is 2-5 times over injection through vein.

Description

technical field [0001] The invention relates to a gel spray for nasal use, in particular to a nasal gel spray of Zhishuangjing hydrochloride and application thereof. Background technique [0002] Trybizine hydrochloride (T-46) is a triazine compound derivative with antimalarial and antitrypanosomal effects, chemical name: O, O'-bis-(4,6-diamino-1 , 2-dihydro-2,2-tetramethylene-1,3,5-triazin-1-yl)-1,6-hexanediol dihydrochloride, or O, O'-bis-( 7,9-diamino-6,8,10-triazaspiro[4.5]dec-7,9-dien-6-yl)-1,6-hexanediol dihydrochloride, now named hydrochloric acid Trybizine hydrochloride, chemical name 10,10'-[1,6-Hexanediylbis(oxy)]bis(6,8,10-triazaspiro[4.5]deca-6,8-diene-7,9- diamine)dihydrochloride, the structural formula is as follows: [0003] [0004] The trypanosin hydrochloride is a new type of anti-trypanosomal drug firstly developed by the applicant. The Chinese patent CN93112460.3 discloses its preparation method and application. Literature (Zhou Weicheng, Zhang Xiu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/12A61K31/53A61P33/06A61P33/02
Inventor 周晓通陶涛相小强周伟澄
Owner SHANGHAI INST OF PHARMA IND CO LTD
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