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Biological adhesive and preparation method and application thereof

A bio-adhesive and mixture technology, applied in surgery, medical science and other directions, can solve the problems of ineffective suture, inability to use alone, poor repair effect, etc. capacitive effect

Active Publication Date: 2020-10-02
BEIJING NATON INST OF MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the existing artificial materials for dura mater repair generally have the problem of weak adhesion. They can only be used as auxiliary adhesives and cannot be used alone. They need to be covered on the surface of the dura mater after the dura mater is sutured to achieve watertight repair. Effect
In the actual application process, the location of the dura mater injury may be located in the front, side of the dura mater or the nerve root sleeve, etc. During the operation, it may not be possible to perform effective surgery due to the special injury site and poor dural suture technique. Even if artificial materials for dura mater repair are used, the repair effect is not good, and cerebrospinal fluid leakage still occurs from time to time after spinal surgery

Method used

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  • Biological adhesive and preparation method and application thereof
  • Biological adhesive and preparation method and application thereof

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Effect test

preparation example Construction

[0048] The preparation method of the bioadhesive of the present disclosure comprises the following steps:

[0049] Step (1): The four-arm polyethylene glycol amino group is prepared into the first solution. The molecular weight of the four-arm polyethylene glycol amino group may be 2000-20000 Daltons.

[0050] In order to facilitate the use of the bioadhesive, the mass concentration of the four-arm polyethylene glycol amino group in the first solution in step (1) is 50 mg / mL-500 mg / mL.

[0051] Further, the mass concentration of the four-arm polyethylene glycol amino group in the first solution in step (1) is 100 mg / mL-300 mg / mL.

[0052] During specific implementation, the solvent of the first solution in step (1) can be one of secondary water, ultrapure water, physiological saline or phosphate buffer with a pH of 7.4.

[0053] Step (2): Four-arm polyethylene glycol succinimide succinate is prepared into a second solution.

[0054] In order to facilitate the use of the bio...

Embodiment 1

[0072] Weigh 400 mg of four-arm polyethylene glycol amino (molecular weight: 20,000 Daltons) and dissolve in 2 mL of pure water to obtain the first solution. Weighed 300 mg of four-arm polyethylene glycol succinimide succinate (molecular weight: 20,000 Daltons) and 1.2 mg of genipin were dissolved in 2 mL of pure water to obtain a second solution. Draw the first solution and the second solution with a double-barrel syringe, inject the first solution and the second solution into the sample bottle at the same time, then invert the sample bottle, and record the gelation time. The time during which the gel does not flow back is the gelation time. Gel time was tested by inversion method. The experimental results show that the gelation time is 5-10 seconds, which meets the requirements of intraoperative operation.

Embodiment 2

[0074] Weigh 250 mg of four-arm polyethylene glycol amino (molecular weight: 10,000 Daltons) and dissolve in 1 mL of pure water to obtain the first solution. Weighed 120 mg of four-arm polyethylene glycol succinimide succinate (molecular weight: 5000 Daltons) and 0.3 mg of genipin were dissolved in 1 mL of pure water to obtain a second solution. Draw the first solution and the second solution with a double-barrel syringe, inject the first solution and the second solution into the sample bottle at the same time, then invert the sample bottle, and record the gelation time. The time during which the gel does not flow back is the gelation time. Gel time was tested by inversion method. The experimental results show that the gelation time is 5-20 seconds, which meets the requirements of intraoperative operation.

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Abstract

The invention discloses a biological adhesive and a preparation method and application thereof. The biological adhesive comprises 4-arm polyethylene glycol amine and 4-arm polyethylene glycol succinimide succinate according to the mass ratio of 1: (0.1-10). The biological adhesive disclosed by the invention has the advantages of good biocompatibility, degradability and relatively high adhesive capacity, and is enough to tolerate the pressure of cerebrospinal fluid after being adhered to the spinal dura mater. Moreover, the biological adhesive disclosed by the invention is convenient to operatein an operation, can be independently used and does not need to be sutured, so that the operation time is greatly shortened and the operation risk is reduced. The biological adhesive disclosed by theinvention can be used for dura mater injuries of a special part which cannot be effectively sutured by a conventional method, such as injuries in front of and on the side of the dura mater and injuries in the positions of nerve root sleeves, can effectively reduce complications of cerebrospinal fluid leakage after a spinal operation, and improves prognosis of a patient.

Description

technical field [0001] The invention relates to the field of medical adhesives, in particular to a biological adhesive and its preparation method and application. Background technique [0002] At present, the intraoperative repair methods of dura mater mainly include direct suture and suture of dura mater replacement material. Among them, the direct suture method can achieve the purpose of directly and effectively repairing the dura mater. However, for those with a defect in the dura mater during the operation, direct suture often has too much tension, which is easy to entrap the spinal cord nerves, and because the stitches in the suture process The resulting "needle holes" make it difficult to achieve absolute watertight sutures. Using autologous or allogeneic tissue (such as muscle, fat, fascia, or dura mater) as a dura mater substitute material combined with tension-reducing suture can repair the dura mater with a certain defect, but the dura mater substitute material su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14C08G81/00
CPCA61L31/041A61L31/14C08G81/00C08G2230/00C08L87/005
Inventor 祝腾蛟王星田耘
Owner BEIJING NATON INST OF MEDICAL TECH CO LTD
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