Synthetic polymer and natural extracellular matrix composite material, artificial blood vessel and preparation method thereof

Abstract

The invention relates to a degradable synthetic polymer and natural extracellular matrix composite material, an artificial blood vessel and a preparation method thereof. Degradable synthetic polymer components during preparation can be selected from one or more materials to perform proportioning; support materials with different fiber diameters, different fiber arrangement, different apertures anddifferent pore structures can be prepared through various technologies such as electrospinning, wet spinning, melt spinning, 3D printing, pouring, phase separation and particle leaching; and naturalextracellular matrix components are wide in sources, can be selected from vascular tissues (such as the arteries and veins of pigs and cows) of different species of animal sources or the vascular tissues (such as umbilical cords) of human donors, and can flexibly adjust the components and content thereof according to needs. The composite material and the artificial blood vessel prepared by the preparation technology can have good mechanical properties, controllable space structures, appropriate degradation velocity and excellent biocompatibility and biological induction activity; and the composite material, the artificial blood vessel and the preparation method are simple in preparation technology, high in controllability, mild in condition and suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to a composite material of degradable synthetic macromolecule and natural extracellular matrix, an artificial blood vessel and a preparation method thereof. Background technique [0002] Vascular disease is the disease with the highest fatality rate in the world. The occurrence of this disease is often due to the narrowing or blockage of blood vessels, which leads to reduced blood flow and lack of nutrients, which damages tissues or organs. It usually manifests as coronary heart disease, cerebrovascular disease, peripheral artery disease, etc. disease and deep vein thrombosis. According to the prediction of the World Health Organization, by 2030, the number of people dying of cardiovascular-related diseases in the world will increase to 23.3 million each year. Vascular transplantation is still a routine method for the treatment of such diseases. The first choice for th...

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Problems solved by technology

The synthetic polymer components can choose one or more material ratios, and can be prepared by various technologies such as electrospinning, wet spinning, melt spinning, 3D printing, phase separation, particle leaching, etc. Scaffold materials with fiber diameters, different fiber arrangements, different pore diameters, and different pore structures can provide artificial blood vessels with good mechanical properties, controllable spatial structures, and suitable degradation speeds, thus solving the problem of pure ECM materials used as artificial blood vessels. Weak mechanical properties, compact structure, instability, etc.; the natural extracellular matrix components can choose different kinds of animal-derived vascular tissue (such as pig, bovine arteries, veins, etc.) or human donor vascular tissue (such as umbilical cord etc.), which have a wide range of sources, and can flexibly adjust the composition and content of ECM according to the needs, because ECM contains a large amount of glycosaminoglycans, collagen and exosomes (which contain a variety of micro RNAs related to tissue regeneration and development) and other natural Active ingredients, which can make the original inert synthetic degradable polymer materials have good biological activity, which can regulate the post-implantation inflammatory response (such as the polarization of macrophages to the pro-regenerative M2 type) and promote tissue cell proliferation Biological effects such as maturation, so that the artificial blood vessels implanted in the body can achieve good regeneration

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