Controlled degradable surgical suture thread and fabricating method thereof

Abstract

The invention discloses a controlled degradable surgical suture thread and a fabricating method thereof. The innermost part is chitosan fiber core, the middle part is collagen layer, and the outermost part is ethyloic-chitosan layer. From innermost to outermost, the thickness ratio of each layer is 2:X:(3-X), wherein X is larger than 1 and smaller than 3. The value of X is related to degradation velocity of the surgical suture thread: the larger the value, the faster the degradation velocity of the surgical suture thread, and the shorter the healing period of wound suitable to be sutured; andthe smaller the value, the slower the degradation velocity of the surgical suture thread, and the longer the healing period of wound suitable to be sutured. The fabricating method of the surgical suture thread comprises: (1) preparing chitosan fiber core and collagen; (2) covering a layer of collagen outside the chitosan fiber; (3) covering a layer of ethyloic-chitosan outside the collagen cover of the chitosan fiber; (4) processing and polishing the suture thread prepared in (3) by an automatic coreless grinder, connecting with suture needles of different models to prepare into a finish product of surgical suture thread. The technical scheme of the invention has plentiful advantages: controllable degradation velocity, high tension strength, improved biocompatibility and anti-infectious property, quick wound healing, no obvious scars, good biocompatibility, etc.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a controllable degradable surgical suture that can be absorbed by the human body and a manufacturing method thereof. Background technique [0002] Surgical sutures are one of the most basic and important materials in surgical operations. They are mainly used for suturing various tissues to stop bleeding, atresia of residual cavity and tissue apposition. Surgical sutures are mainly divided into two categories: non-absorbable sutures and absorbable sutures. Compared with non-absorbable sutures, the main advantages of absorbable sutures are: ①No antigenicity (only slight tissue staining occurs when absorbed) ② non-pyrogenicity; ③ complete wound healing; ④ no need to remove stitches, which reduces the pain of patients and the chance of inducing infection; thus absorbable sutures are the development trend of surgical sutures. In terms of raw materials, the clinically applie...

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Problems solved by technology

[0004] In summary, the existing collagen or chitosan absorbable surgical sutures have the following defects: (1) the rate of degradation and absorption is not synchronous with the wound healing rate, and the maximum of the existing collagen or chitosan absorbable surgical sutures is The difficulty is that the rate of degradation and absorption is difficult to synchronize with the rate of wound healing, resulting in a compromise in the effect of the suture. If the rate of degradation and absorption is much faster than the rate of wound healing, the effect of the suture will be weakened; if the rate of degradation and absorption is much slower than the rate of wound healing , it will cause the suture to remain in the human body after the wound has healed, which will induce tissue inflammation and pain; (2) The tension strength and knot strength are relatively insufficient. Due to the material itself, the collagen or chitosan suture Tensile strength and knot strength are relatively low (Zhao Jingna. Research and application status of medical surgical sutures. Foreign Silk. 2: 26-29, 2008; Yin Yan, He Xiaowei, Huang Qiang, Yu Shujuan. Chitosan in absorbable surgical sutures Application in threads. China Beet Sugar Industry, 4:28-31, 2006); (3) Chitosan surgical sutures have relatively poor antibacterial ability (Yin Yan, He Xiaowei, Huang Qiang, Yu Shujuan. Application of absorbable surgical sutures. China Beet Sugar Industry, 4: 28-31, 2006; Cuero R.G. Antimicrobial action of exogenous chitosan. EXS.87: 315-333, 1999)

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