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Degradable stephanoporate stent material for inducting osseous tissue regeneration and repair and preparation thereof

A technology for bone tissue regeneration and porous scaffolds, which is used in medical science, prosthesis, etc. It can solve the problems of unfavorable cell adhesion and proliferation, high brittleness, and rapid degradation, and achieves the promotion and induction of bone tissue repair and high porosity. , the effect of simple preparation process

Inactive Publication Date: 2008-12-17
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, collagen has the problem of degrading too fast, so the cross-linking modification of collagen has improved the degradation performance of collagen, but there is still a problem of high brittleness.
Moreover, these scaffolds are formed by compaction, without forming a porous shape, which is not conducive to cell adhesion and proliferation

Method used

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  • Degradable stephanoporate stent material for inducting osseous tissue regeneration and repair and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Add 1wt% hydroxyapatite collagen composite powder to 0.01wt% ammonia solution and stir evenly, add 0.1wt% konjac glucomannan powder and stir evenly until a jelly is formed. Put the jelly in a 40°C water bath to mature for 72 hours, and then wash it with distilled water until neutral. Freeze at -10°C, and finally freeze-dry to obtain the desired scaffold.

Embodiment 2

[0023] Example 2 Add 1wt% hydroxyapatite collagen composite powder to 0.1wt% ammonia solution and stir evenly, add 5wt% konjac glucomannan powder and stir evenly until a jelly is formed. Put the jelly in a 40°C water bath to mature for 72 hours, and then wash it with distilled water until neutral. Freeze at -10°C, and finally freeze-dry to obtain the desired scaffold.

Embodiment 3

[0024] Example 3: 1 wt% hydroxyapatite collagen composite powder was added to 1 wt% ammonia solution and stirred evenly, 25 wt% konjac glucomannan powder was added and stirred evenly until a jelly was formed. Put the jelly in a 40°C water bath to mature for 72 hours, and then wash it with distilled water until neutral. Freeze at -20°C, and finally freeze-dry to obtain the desired scaffold.

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Abstract

The invention discloses a degradable support material which induces the regeneration and repair of bone tissues and a preparation method thereof, pertaining to the technical field of the preparation of biomaterials. Degradable biomaterials, such as konjac glucan-mannan and hydroxyapatite / collagen protein or calcium phosphate / collagen protein composite powder, or hydroxyapatite or calcium phosphate are adopted as raw materials in the invention. Konjac glucan-mannan powder and hydroxyapatite / collagen protein or calcium phosphate / collagen protein composite powder, or hydroxyapatite or calcium phosphate are added into aqueous solution of an alkaline gelata and fully heated to form gel, and then after freeze-drying, the degradable porous support material is prepared. Not only does the materialhave simple preparation technology and low cost, but also the biomaterial prepared has good biocompatibility. Cell tests show that the material can be universally applied to bone operation and is theantibacterial porous material with adjustable degradation rate in vivo and can promote and induce the repair of the bone tissues, thereby having the wide application value in surgical operation.

Description

technical field [0001] The invention relates to a bioengineering material and a preparation method thereof, in particular to a degradable material for bone tissue repair and regeneration, and belongs to the technical field of bioengineering materials. Background technique [0002] Today, the development direction of bone scaffolds is to study bone scaffold materials with three-dimensional porous shape, certain mechanical strength to support physiological pressure, degrade at a controllable speed, and good biocompatibility. [0003] Human natural bone is composed of hydroxyapatite (HAP) and collagen (Col). Therefore, a lot of research has been done on collagen, hydroxyapatite and their combination for bone scaffolds at home and abroad. It is proved that collagen, hydroxyapatite and their composite bone scaffolds have good biocompatibility and osteoconductivity, and are good bone repair materials. At present, the research on bone scaffolds at home and abroad is mainly focuse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/56
Inventor 陈庆华赵昆渝陈寰贝
Owner KUNMING UNIV OF SCI & TECH
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