Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof

A technology for biodegrading polyester and magnesium oxide whiskers, which is applied in the fields of medical science and prostheses, can solve the problems of rapid degradation speed and strength attenuation, weak interfacial bonding force, slow degradation speed, etc., and achieve the reduction of non-infectious Sexual inflammatory response, improving mechanical strength and modulus, improving strength and toughness

Active Publication Date: 2013-09-25
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the results of clinical application over the years have also proved that biodegradable polyester absorbable orthopedic internal fixation materials still have the following shortcomings: (1) The mechanical strength of the material is not enough, the toughness is poor, and it is difficult to be used as a load-bearing bone repair; (2) ) The degradation rate and strength decay of the material are too fast in the early stage, and the degradation rate is too slow in the later stage. The weak acidity of the degradation product can easily lead to aseptic inflammatory reactions; (3) The material has poor hydrophilicity and the cell affinity is not ideal; (4) X-ray no development
However, the currentl

Method used

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  • Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof
  • Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof
  • Magnesium oxide whisker/biodegradable polyester composite material and its preparation method and application thereof

Examples

Experimental program
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Example Embodiment

[0056] Example 1: Preparation of magnesium oxide whiskers

[0057] Step (1): Add Na with a concentration of 0.5mol / L 2 CO 3 Under the condition of 800rpm stirring, the solution is dripped with 0.5mol / L MgCl at a rate of 2mL / min 2 In the solution; after the addition is complete, continue to stir for 15 minutes, leave to stand for 24 hours, filter with suction and wash with distilled water 4 times, and dry in a vacuum drying oven at 80°C to obtain magnesium carbonate whiskers;

[0058] Step (2): The magnesium carbonate whiskers obtained in step (1) are calcined in a muffle furnace. The calcining conditions are as follows: increase from room temperature to 800°C at a rate of 2°C / min and keep it for 2 hours, until it is cooled to 450°C Take out the crucible and quickly put it in a desiccator and cool it to room temperature to obtain magnesium oxide whiskers (MgO whiskers).

Example Embodiment

[0059] Example 2: Preparation of magnesium oxide whiskers

[0060] Step (1): The concentration of 0.5mol / L Na 2 CO 3 Under the condition of stirring at 1200rpm, MgCl with a concentration of 0.5mol / L was dropped into the solution at a rate of 3mL / min 2 In the solution; after the addition is complete, continue to stir for 30 minutes, leave to stand for 24 hours, filter with suction and wash with distilled water 5 times, and dry in a vacuum drying oven at 80°C to obtain magnesium carbonate whiskers;

[0061] Step (2): The magnesium carbonate whiskers obtained in step (1) are calcined in a muffle furnace. The calcination conditions are as follows: from room temperature to 380°C at a rate of 3°C / min and holding for 30 minutes, then at 5°C / min The rate is increased to 700°C and kept for 2h. When it is cooled to 400°C, the crucible is taken out and quickly placed in a desiccator to cool to room temperature, to obtain magnesium oxide whiskers (MgO whiskers).

[0062] Observe the morphology o...

Example Embodiment

[0063] Example 3: Preparation of magnesium oxide whiskers grafted with polylactic acid on the surface by direct dehydration polycondensation method

[0064] Step (1): In a three-necked flask, 10g of vacuum-dried MgO whiskers (prepared in Example 2) were dispersed in 200ml of toluene, and 1g of catalyst zinc oxide was added under stirring at 600rpm, and then slowly passed through a dropping funnel. Add 200g of L-lactic acid, after the addition is complete, azeotropic dehydration reaction at 110°C for 12h;

[0065] Step (2): After the above reaction, the product is separated by centrifugation at 800 rpm, the supernatant is removed, the lower solid product is removed, and then chloroform is added to dissolve, centrifuge, filter, and wash the solid product more than 5 times to remove the lactic acid adsorbed on the surface of the solid product Monomers and polylactic acid oligomers; finally, the solid product is collected by high-speed centrifugation and dried in vacuum to obtain MgO w...

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Abstract

The invention discloses a magnesium oxide whisker/biodegradable polyester composite material and its preparation method and an application thereof. The composite material contains 0.1-60 wt% of magnesium oxide whisker and 40-99.9 wt% of biodegradable polyester. The magnesium oxide whisker/biodegradable polyester composite material provided by the invention has excellent mechanical properties, good biocompatibility and bone healing-promoting capability. Alkalinity of the magnesium oxide whisker also can regulate and control degradation rate of the biodegradable polyester, neutralize its acidic degradation products and reduce inflammatory response. The magnesium oxide whisker/biodegradable polyester composite material is a novel bone tissue repair material with an excellent osteogenic activity. The preparation method is a solution blended process or a melt blending method by using the magnesium oxide whisker and the biodegradable polyester as raw materials, or an in situ polymerization method by using the magnesium oxide whisker and a cyclic ester monomer as raw materials. According to the invention, preparation cost of the composite material is low; the preparation method is simple; condition is mild; and the preparation method is easy for industrial production.

Description

technical field [0001] The invention belongs to the field of bone tissue repair materials, in particular to a magnesium oxide whisker / biodegradable polyester composite material and its preparation method and application. Background technique [0002] Bone trauma is one of the common diseases in clinical surgery. Lesions and damage of bone tissue directly affect people's quality of life. Therefore, the repair of bone tissue damage has always been a research topic that people pay close attention to. Biodegradable polyesters (such as polylactide, polyglycolide, etc.) are a class of polymer materials that have been approved by the US FDA (Food and Drug Administration, FDA) for the manufacture of biomedical materials. It has attracted much attention and is currently the most clinically used absorbable orthopedic internal fixation material. Biodegradable polyester absorbable orthopedic internal fixation materials have the characteristics of easy molding and processing, good initi...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08L69/00C08K7/08C08K3/22C08G63/08C08G63/78C08G64/30A61L27/44A61L27/50
Inventor 罗丙红文伟刘桦周长忍
Owner JINAN UNIVERSITY
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