Thermo-sensitive tri-block polymer as well as preparation method and use thereof
A technology of block copolymer and diblock copolymer, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, medical science, etc., can solve the problem of difficult to control degradation speed, non-degradable gel strength, and hydrogel strength. Low problems, to achieve the effect of adjustable gel strength, controllable properties, and good biocompatibility
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Embodiment 1
[0032] The synthesis of embodiment 1 present invention PEG-PCL-PEG copolymer
[0033]
[0034] According to the synthesis route of the above formula (wherein X and Y are respectively positive integers greater than 1), polyethylene glycol monomethyl ether (MPEG) and caprolactone (ε-CL) are added in a three-necked flask equipped with a stirrer, Use stannous octoate as catalyst, react at 130°C for 6 hours under nitrogen protection, cool down to 80°C, add cross-linking agent isophorone diisocyanate (IPDI) and react for another 6 hours to obtain the product, cool to room temperature and purify ,drying. In addition, suitable diisocyanate also includes: toluene diisocyanate, 1,6-hexamethylene diisocyanate, diphenylmethane-4,4'-diisocyanate and the like.
[0035] The obtained triblock copolymers are listed in Table 1.
[0036] The PEG-PCL-PEG copolymer that table 1 prepares
[0037] Numbering
PEG / PCL a
Total Mn a
PEG / PCL b
Total Mn ...
Embodiment 2
[0041]Embodiment two verification of PEG-PCL-PEG copolymer of the present invention
[0042] 1, the characterization method of PEG-PCL-PEG copolymer of the present invention
[0043] Using Fourier transform infrared spectrometer (FTIR) (200SXV, Nicolet), the copolymer was analyzed by KBr pellet method. 1 H-NMR is measured with nuclear magnetic resonance instrument (Varian 400, Varian), under 400MHZ, solvent is CDCl 3 , with tetramethylsilane as internal standard.
[0044] 2. Verification and characterization of PEG-PCL-PEG copolymer of the present invention
[0045] In this test, the PEG-PCL-PEG copolymer is expressed as E Y -C 2X -E Y , where 2X and Y represent the molecular weights of PCL and PEG in the copolymer, respectively. FTIR and 1H NMR were used to detect the structure and molecular weight of the copolymer.
[0046] figure 1 Yes to E 750 -C 750 diblock copolymer and E 750 - 1500 -E 750 Analytical comparison of infrared spectra of triblock copolymers. It...
Embodiment 3
[0051] The gel-sol transition characteristic of embodiment three PEG-PCL-PEG copolymers of the present invention
[0052] In the present invention, the test tube method is used to test the gel-sol transition temperature. When the system is in an immobile solid state, it is called a gel state (Gel); when the system is in a flowing liquid state, it is called a sol state (Sol); when the system is in a milky white suspension state, it is called a suspension State (Sus); when the water phase in the system is separated from the polymer phase, it is called the precipitation state (Prep).
[0053] 1, the preparation of PEG-PCL-PEG copolymer aqueous solution of the present invention
[0054] Weigh different PEG-PCL-PEG copolymers prepared in the above-mentioned Example 1, add them into double distilled water (ie double distilled water) according to different concentration requirements, fully and evenly dissolve, and set the volume to 4ml. Store at 4°C.
[0055] 2. Temperature respon...
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