Thermo-sensitive tri-block polymer as well as preparation method and use thereof

A technology of block copolymer and diblock copolymer, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, medical science, etc., can solve the problem of difficult to control degradation speed, non-degradable gel strength, and hydrogel strength. Low problems, to achieve the effect of adjustable gel strength, controllable properties, and good biocompatibility

Inactive Publication Date: 2008-09-03
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example: poloxamer is non-degradable and has low gel strength; chitosan / glycerophosphate hydrogel degrades quickly and is difficult to control; PEG-PLGA-PEG hydrogel has low strength and is expensive

Method used

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  • Thermo-sensitive tri-block polymer as well as preparation method and use thereof
  • Thermo-sensitive tri-block polymer as well as preparation method and use thereof
  • Thermo-sensitive tri-block polymer as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The synthesis of embodiment 1 present invention PEG-PCL-PEG copolymer

[0033]

[0034] According to the synthesis route of the above formula (wherein X and Y are respectively positive integers greater than 1), polyethylene glycol monomethyl ether (MPEG) and caprolactone (ε-CL) are added in a three-necked flask equipped with a stirrer, Use stannous octoate as catalyst, react at 130°C for 6 hours under nitrogen protection, cool down to 80°C, add cross-linking agent isophorone diisocyanate (IPDI) and react for another 6 hours to obtain the product, cool to room temperature and purify ,drying. In addition, suitable diisocyanate also includes: toluene diisocyanate, 1,6-hexamethylene diisocyanate, diphenylmethane-4,4'-diisocyanate and the like.

[0035] The obtained triblock copolymers are listed in Table 1.

[0036] The PEG-PCL-PEG copolymer that table 1 prepares

[0037] Numbering

Copolymer

PEG / PCL a

Total Mn a

PEG / PCL b

Total Mn ...

Embodiment 2

[0041]Embodiment two verification of PEG-PCL-PEG copolymer of the present invention

[0042] 1, the characterization method of PEG-PCL-PEG copolymer of the present invention

[0043] Using Fourier transform infrared spectrometer (FTIR) (200SXV, Nicolet), the copolymer was analyzed by KBr pellet method. 1 H-NMR is measured with nuclear magnetic resonance instrument (Varian 400, Varian), under 400MHZ, solvent is CDCl 3 , with tetramethylsilane as internal standard.

[0044] 2. Verification and characterization of PEG-PCL-PEG copolymer of the present invention

[0045] In this test, the PEG-PCL-PEG copolymer is expressed as E Y -C 2X -E Y , where 2X and Y represent the molecular weights of PCL and PEG in the copolymer, respectively. FTIR and 1H NMR were used to detect the structure and molecular weight of the copolymer.

[0046] figure 1 Yes to E 750 -C 750 diblock copolymer and E 750 - 1500 -E 750 Analytical comparison of infrared spectra of triblock copolymers. It...

Embodiment 3

[0051] The gel-sol transition characteristic of embodiment three PEG-PCL-PEG copolymers of the present invention

[0052] In the present invention, the test tube method is used to test the gel-sol transition temperature. When the system is in an immobile solid state, it is called a gel state (Gel); when the system is in a flowing liquid state, it is called a sol state (Sol); when the system is in a milky white suspension state, it is called a suspension State (Sus); when the water phase in the system is separated from the polymer phase, it is called the precipitation state (Prep).

[0053] 1, the preparation of PEG-PCL-PEG copolymer aqueous solution of the present invention

[0054] Weigh different PEG-PCL-PEG copolymers prepared in the above-mentioned Example 1, add them into double distilled water (ie double distilled water) according to different concentration requirements, fully and evenly dissolve, and set the volume to 4ml. Store at 4°C.

[0055] 2. Temperature respon...

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Abstract

The invention relates to medical polymers field, especially a temperature sensitive and biodegradable triblock copolymer with gel-sol transformation characteristics and preparation method thereof and usage. The triblock copolymer is PEG-PCL-PEG copolymer, the aqueous solution thereof performs Gel-Sol phase transformation along with the temperature rise and the phase transformation temperature is 40-55 degree. The PEG-PCL-PEG copolymer has a variety of excellent features to provide a new choice in field which is in need of temperature sensitive material.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to a temperature-sensitive tri-block copolymer and its preparation method and application. Background technique [0002] In recent years, biodegradable environmentally sensitive hydrogels have attracted extensive attention from scholars at home and abroad due to their good sensitivity, biodegradability and biocompatibility. Environment-sensitive hydrogel, also known as smart hydrogel, refers to the ability to sense changes or stimuli in the external environment (such as temperature, pH value, light, electricity, pressure, etc.), and to produce corresponding physical structures and chemical reactions. A class of polymer hydrogels with changing properties. Among them, temperature-sensitive physical hydrogels have attracted much attention due to their broad application prospects in the fields of controlled drug release systems, cell embedding, and tissue repair. [0003] At p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G63/08C08G63/85C08K5/29A61K47/34A61L31/06
Inventor 钱志勇魏于全赵霞
Owner SICHUAN UNIV
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