Degradable material capable of guiding the regeneration and renovation process of hard tissue and its preparation

A technology for degrading materials and hard tissue, applied in medical science, prosthesis, surgery, etc., can solve problems such as poor treatment effect, and achieve the effects of adjustable degradation speed, low cost, and wide application value

Inactive Publication Date: 2004-11-17
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to estimates in the United States, the number of surgical treatments involving bone replacement in the country has exceeded 1 million per year, and the treatment of osteoporosis and other symptoms is limited to taking calcium tablets, vitamins, hormones and other drugs, and the treatment effect is very poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Dissolve collagen and chitosan with a deacetylation degree of 70% and a molecular weight of 200,000 Daltons in 2% glacial acetic acid solution respectively to make a 1% collagen and chitosan solution, static defoaming, The two are mixed evenly in a ratio of 1:1. Add calcium phosphate powder to 2% glacial acetic acid solution to make a suspension with a concentration of 10%; then add the calcium phosphate suspension to the collagen / chitosan mixture at a volume ratio of 1%, and mix evenly. This gel-state mixture can be used sodium bicarbonate (NaHCO 3 ) to adjust the pH value to 5, Co 60 Ready to use after disinfection. The gel-like material can be injected directly into the site of repair with a needle.

Embodiment 2

[0026]Collagen and carboxymethyl chitosan with a deacetylation degree of 80% and a molecular weight of 100,000 Daltons were dissolved in lactic acid solution respectively to make a collagen and carboxymethyl chitosan solution with a concentration of 2%. Bubble, collagen and carboxymethyl chitosan solution are mixed evenly at a volume ratio of 100:1. Add hydroxyapatite powder to the lactic acid solution to make a suspension with a concentration of 100%; then add the hydroxyapatite suspension to the collagen / carboxymethyl chitosan mixture at a volume ratio of 10%, and mix uniform. Then add a 0.5% sodium hyaluronate acid solution at a volume ratio of 1%. Wherein the sodium hyaluronate solution is adjusted to a pH value of 1 with hydrochloric acid so as to fully mix with the collagen / carboxymethyl chitosan solution. Then sodium bicarbonate (NaHCO 3 ) to adjust the pH value to 8, disinfect with ozone, and set aside.

Embodiment 3

[0028] Dissolve collagen and chitosan with a deacetylation degree of 80% and a molecular weight of 100,000 Daltons in lactic acid solution to make a 2% collagen and chitosan solution, static defoaming, collagen and chitosan The sugar solution and the two are mixed evenly at a volume ratio of 100:1. The calcium hydrogen phosphate powder is dissolved in water to make a suspension with a concentration of 200%; then the calcium hydrogen phosphate suspension is added to the collagen / chitosan mixture according to the volume ratio of 10%, and mixed evenly. Then add the bone morphogenetic protein water suspension with a concentration of 1% according to the volume ratio of 1%. Then sodium bicarbonate (NaHCO 3 ) to adjust the pH to 6, sterilized by gamma-rays, and set aside.

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PUM

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Abstract

The invention discloses a degradable material for conducting hard tissue regeneration and renovation, and its preparation method which comprises, using degradable biomaterial collagen, chitosan or hydroxyl chitosan, tertiary calcium phosphate or hydroxyapatite as principal raw material, preparing acid solution and suspending liquid, mixing to prepare hard tissue filler, wherein the prepared biological material has good compatibility with the wound tissue.

Description

technical field [0001] The invention relates to a bioengineering material and a preparation method thereof, in particular to a degradable material for hard tissue repair and regeneration, and belongs to the technical field of bioengineering materials. Background technique [0002] Hard tissue (bone, tooth) restoration In the past few decades, although many repair approaches have been proposed, including the use of tissue engineering products [Langer R, et al.Science, 1993; 260:920-926], gene therapy [ Mulligan RC, et al. Science, 1993; 260-932] et al. However, 70% of clinical bone substitute materials still use autologous bone or allogeneic bone, which makes patients face high surgical syndrome and infection rate. However, various metals, ceramics or polymethyl methacrylate bone cements have their own shortcomings in terms of biocompatibility, bioactivity, biodegradability and mechanical compatibility with the host bone. [0003] In recent years, the application research o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/50A61L31/04A61L31/14
Inventor 王小红林峰颜永年熊卓吴任东张人佶卢清萍
Owner TSINGHUA UNIV
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