Recombined human alkaline fibroblast growth factor gelling agent and process for preparing the same

Abstract

The invention relates to a recombinant human basic fibroblast growth factor gelling agent and the process for preparation, which comprises recombinant human basic fibroblast growth factor (rh-bFGF) stock solution 0.1-100% (W / W), medicinal auxiliary material 0-99.9% (W / W), the stock solution comprises effective treatment dose of recombinant human basic fibroblast growth factor (rh-bFGF) 0.01-1% (ug / g), NaCl 0.01-20% (W / W), phosphates cushioning liquid 2m Mol - 200m Mol, and right amount of water for injection, the medicinal auxiliary materials can be selected from: carbomer 940NF, sodium hyaluronate, trehalose, mannitol, dextran 40 and sodium heparin.

Description

Technical field:

[0001] The invention relates to a recombinant human basic fibroblast growth factor gel and a preparation method thereof. In particular, a recombinant human basic fibroblast growth factor gel suitable for treating burn wounds, fresh wounds and chronic wounds and a preparation method thereof. Background technique:

[0002] Wound healing is a complex and highly coordinated process, which can be basically divided into three distinct and interlaced stages: local inflammatory response, cell proliferation and differentiation, and tissue repair and reconstruction. This process involves the interaction and mutual influence of various growth factors and cytokines, and jointly regulates cell migration, proliferation, differentiation, angiogenesis, matrix deposition and tissue modeling.

[0003] In the traditional wound repair treatment, measures such as anti-infection, enhanced nutrition of the body and local protection of the wound are used to heal the wound naturall...