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Method for extracting sodium heparin and co-producing amino acid

An amino acid and heparin sodium technology, applied in the field of heparin sodium extraction, can solve the problems of complicated waste liquid treatment and environmental pollution, and achieve the effects of reducing waste liquid generation, improving economic benefits and reducing pollution

Inactive Publication Date: 2010-03-03
牛玉娥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned waste liquid treatment is very complicated and pollutes the environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] 1. Raw materials D254 resin, fresh intestinal mucosa, sodium chloride (refined salt), alcohol (industrial grade, content 95% by weight), lye (industrial grade, content 30--40%).

[0012] 2. Operation

[0013] 1. Pump 1,000 kg of scraped small intestinal mucosa into the enzymolysis tank, add 15 kg of refined salt, adjust the pH value of the solution to 9.0-9.2, add 6 kg of fresh pig pancreas when the temperature reaches 40°C-45°C, and continue Heat to 50°C-55°C, keep warm for enzymatic hydrolysis for 5 hours, then continue to heat to 80°C-85°C, keep warm for 15 minutes and then filter; add 45 kg of pretreated D254 resin to the filtrate, stir and absorb for 6 hours, extract Resin, the resin that collects is washed to neutrality in clear water; With 54 kilograms of 17--18% (weight) concentrated brine, resin is eluted 2 times, first time 6 hours, second time 2 hours, collect the washing of these two times Deliquification, mixing and filtering, to remove granular impurities...

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PUM

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Abstract

The invention discloses a method for extracting sodium heparin and co-producing amino acid, comprising the following steps: adding refined salt accounting for 1-1.8 weight percent of an intestinal mucosa into small intestinal mucosa; regulating the pH value of a solution to 9.0-9.2; adding fresh porcine pancreas to carry out zymolysis and filtering; carrying out resin absorption, elution and deposition; and drying to obtain the sodium heparin crude product; adding parenzyme into a filtering liquid, keeping the temperature to carry out the zymolysis and filtering to obtain an amino acid solution. The method for extracting sodium heparin and co-producing amino acid co-produces the amino acid solution on the basis of extracting the sodium heparin, thereby improving the economic effect, reducing the waste liquid and lightening the environment pollution.

Description

technical field [0001] The invention relates to a method for extracting heparin sodium from pig small intestine, in particular to a method for extracting heparin sodium and co-producing amino acids. Background technique [0002] The extraction of heparin sodium from pig small intestine mainly includes salt hydrolysis and enzymatic hydrolysis: the yield of enzymatic hydrolysis is relatively high, and an average of 1800 pig small intestines yield 1 kg of crude heparin sodium (potency is 100), but a large amount of waste liquid will be produced. Contains mainly peptides and proteins. The above-mentioned waste liquid treatment is very complicated and pollutes the environment. Contents of the invention [0003] The purpose of the present invention is to provide a method for extracting heparin sodium and co-producing amino acids, using the waste liquid extracted from heparin sodium to prepare amino acids, reducing the generation of waste liquid and reducing environmental pollut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/10C12P13/00C12S3/02
Inventor 石欣
Owner 牛玉娥
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