Dermatan sulfate with low molecule and its preparing method

A dermatan sulfate, low-molecular technology, applied in the field of biomedicine, can solve the problems of low bioavailability, low bioavailability, complex process, etc., and achieve the goal of increasing the concentration of hydrogen peroxide, high bioavailability, and increasing the reaction temperature Effect
CN1445245AInactive Publication Date: 2003-10-01SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2003-10-01
Estimated Expiration
Not applicable Β· inactive patent
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Abstract

A low-molecular (3000-8000) dermatan sulfate is prepared from the dermatan sulfate through degradation by hydrogen peroxide, ultrafilter, and gel chromatography. Its advantages are sure thrombus-resistant and thrombolytic functions, easy absorption, long semi-life and high biologic utilization rate.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and in particular relates to a low-molecular dermatan sulfate and a preparation method thereof. Background technique

[0002] Dermatan sulfate is a kind of complex structure and sulfated glycosaminoglycans. The molecular weight of natural products is generally 15kD ~ 5kD, and it is widely found in animal tissues. Studies at home and abroad have shown that the anticoagulant activity of dermatan sulfate is lower than that of unfractionated heparin, but its antithrombotic activity is significantly higher than that of unfractionated heparin, and its bleeding side effects are significantly smaller than that of unfractionated heparin. . However, there are two major pharmacokinetic problems with dermatan sulfate: one is the short half-life, and the other is low bioavailability when administered by subcutaneous and intramuscular routes. As the molecular weight of dermatan sulfate increases, its bioavailabili...

Claims

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