Chondroitin sulfate/dermatan sulfate extraction method

A technology of dermatan sulfate and chondroitin sulfate, which is applied in the direction of fermentation, etc., can solve problems such as affecting the use, limiting chondroitin sulfate/dermatan sulfate, and prone to endotoxin, and achieves stable molecular weight consistency, no endotoxin, and source wide range of effects

Inactive Publication Date: 2016-08-03
刘长国
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  • Abstract
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Problems solved by technology

However, there are obvious defects in these two sources: first, the production of the above-mentioned animal tissues is limited, thereby limiting the production of chondroitin sulfate / dermatan sulfate; second, the outbreak of mad cow disease and the unqualified treatment environment of tissues and organs after animal slaughter are serious Affect the use of human beings to animal-derived chondroitin sulfate / dermatan sulfate; third, the molecular weight (length) of chondroitin sulfate / dermatan sulfate produced by microbial fermentation is difficult to grasp, and most importantly, endotoxins are prone to exist, which directly limits its Next application

Method used

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Embodiment Construction

[0027] The present invention will be described in further detail below in conjunction with embodiment. It should be understood that the specific embodiments described here are only used to explain the present invention, but not to limit the present invention.

[0028] After poultry eggshells are processed by extraction technology (see patent application number 201510710364.3), three types of organic substrates can be obtained: acid-insoluble substrate (accounting for 70.4% of the total substrate), water-insoluble substrate (accounting for 20.6% of the total substrate), and water-soluble substrate (accounting for 20.6% of the total substrate). total matrix 9%). In this technical solution, these three organic matrices can be combined to extract chondroitin sulfate / dermatan sulfate, or can be used separately for extracting chondroitin sulfate / dermatan sulfate according to needs; the follow-up technical process is the same. The poultry eggshells of the present invention include, ...

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Abstract

The invention discloses a chondroitin sulfate/dermatan sulfate extraction method which comprises the following steps: drying the eggshell matrix and grinding to obtain eggshell matrix powder; separating and extracting total glycosaminoglycan from the eggshell matrix powder; and removing heparin/heparan sulfate, keratan sulfate and hyaluronic acid in the total glycosaminoglycan to obtain high-purity chondroitin sulfate/dermatan sulfate.

Description

technical field [0001] The invention relates to a method for extracting chondroitin sulfate / dermatan sulfate, in particular to an extraction method for obtaining chondroitin sulfate / dermatan sulfate from eggshells. Background technique [0002] Chondroitin Sulfate / Dermatan Sulfate is a straight-chain linear macromolecular polysaccharide rich in anions, which can combine with various cell growth factors, cytokines, cell receptors and biochemical enzymes in animals to induce signal transduction and regulate cell growth, differentiation and apoptosis. Chondroitin sulfate / dermatan sulfate are widely used as emulsifiers for condiments and salad dressings, or developed into drugs for herpes virus infectious arthritis, malaria, nerve tissue function repair, liver tissue regeneration, and tumor treatment, or because of its Biocompatibility and hydrophilicity are used as nano drug carriers. [0003] The commercial demand for chondroitin sulfate / dermatan sulfate is increasing, but t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/26
CPCC12P19/26
Inventor 刘长国赵红娟
Owner 刘长国
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