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Long-acting slow-release oral ulcer film and preparation method thereof

An oral ulcer and film-sticking technology, which is applied in the field of long-acting sustained-release oral ulcer film and its preparation, achieves the effects of convenient access, easy self-operation, and wide drug-carrying range

Inactive Publication Date: 2016-11-16
佛山市高明绿化纳新材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the use of modified cellulose and polycaprolactone to prepare composite membranes and its application in the treatment of oral ulcers has not been reported

Method used

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  • Long-acting slow-release oral ulcer film and preparation method thereof
  • Long-acting slow-release oral ulcer film and preparation method thereof
  • Long-acting slow-release oral ulcer film and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0042] The preparation method of anhydrous DMSO: add 1 gram of calcium hydride to 500 mL of dimethyl sulfoxide and stir for 12 hours, then filter with a sand core funnel to obtain anhydrous dimethyl sulfoxide.

[0043] The preparation method of dry caprolactone monomer: add 1 gram of calcium hydride to 500 mL of caprolactone monomer and stir for 12 hours, then filter with a sand core funnel to obtain dry caprolactone monomer.

[0044] The drying method of the modified cellulose: place the modified cellulose in a vacuum oven and dry at 70° C. for 16 hours.

Embodiment 1

[0046] (1) Synthesis of hydroxyethyl cellulose grafted polycaprolactone copolymer:

[0047]Weigh 5 grams of dried hydroxyethyl cellulose and dissolve it in 30 mL of anhydrous dimethyl sulfoxide, raise the temperature to 40-60 °C until the hydroxyethyl cellulose dissolves; then add 0.1 gram of stannous octoate and 2 grams of dried The caprolactone monomer is raised to 80°C, filled with nitrogen in the reaction bottle for 15 minutes, then heated to 120°C, and reacted for 12 hours under a nitrogen atmosphere; after the reaction, the product is precipitated twice in 150 mL of n-hexane, and then heated Under the condition of vacuum drying for 24 hours, the hydroxyethyl cellulose grafted polycaprolactone copolymer was obtained.

[0048] (2) Preparation of oral ulcer patch:

[0049] a. Dissolving hydroxyethyl cellulose in 95% ethanol solution with a mass fraction of 4%, forming a film on a horizontally clean glass plate coated with a little liquid paraffin, and drying at 50°C to obt...

Embodiment 2

[0053] (1) Synthesis of hydroxypropyl methylcellulose grafted polycaprolactone copolymer:

[0054] Weigh 5 grams of dried hydroxypropylmethylcellulose and dissolve it in 30mL of anhydrous dimethyl sulfoxide, raise the temperature to 40-60°C until the hydroxypropylmethylcellulose is dissolved; then add 0.1g of stannous octoate and 2g After drying the caprolactone monomer, heat up to 80°C, fill the reaction bottle with nitrogen for 15 minutes, then heat up to 120°C, and react under nitrogen atmosphere for 12 hours; after the reaction, the product is precipitated twice in 150mL of n-hexane, and then in Vacuum drying at 60° C. for 24 hours to obtain a hydroxypropylmethylcellulose grafted polycaprolactone copolymer.

[0055] Weigh 3 mg of the obtained copolymer and dissolve it in 0.5 mL of deuterated dimethyl sulfoxide. The obtained sample was characterized by H NMR, and the results were as follows: figure 1 . figure 1 The peaks corresponding to the chemical shifts at 2.50 and 3...

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Abstract

The invention belongs to the technical field of biomedical materials and discloses a long-acting slow-release oral ulcer film and a preparation method thereof. The oral ulcer film is formed by three layers of composite membranes, wherein the innermost layer is of a modified cellulose membrane adhesion layer, the interlayer is of a modified cellulose grafted polycaprolactone copolymer membrane drug-containing layer, and the outermost layer is of a polycaprolactone membrane drainage layer. The oral ulcer film is easy to use, good in biological safety and degradable; the inner layer of material has the advantages of adhesion and waterproof outer layer by design of the three layers of the composite membranes, and the oral ulcer film can be ensured to be applied to the infected part for a long time; the amphiphilic design of the interlayer is fit for embedding of the majority of hydrophilic or hydrophobic drugs, the function that the inner hydrophilic layer and the hydrophobic layer are adhered is achieved, and the oral ulcer film is hopefully and widely applied in the field of oral ulcer treatment.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a long-acting slow-release oral ulcer patch and a preparation method thereof. Background technique [0002] Oral ulcers and other diseases have the characteristics of multiple, repeated, and periodic, which have seriously affected human health and daily life. At present, oral administration or spray administration is mostly used clinically for treatment. The oral administration method is easy to cause side effects and drug resistance, and because the number of administrations is large, it brings inconvenience to the life of the patient; although the spray administration method can directly apply the drug to the affected area, it will be affected by the secretion of saliva in the human mouth. And cause fast, a large amount of loss of medicine, the residence time of medicine is short, bioavailability is not high. [0003] In recent years, drug-loaded oral...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K47/34A61P1/02
CPCA61K9/7007A61K47/34A61K47/38
Inventor 马栋林倩明胡家彩
Owner 佛山市高明绿化纳新材料有限公司
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