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Trauma auxiliary material and preparation method thereof

An adjuvant and wound technology, which is applied to the field of wound adjuvant and its preparation, can solve the problems such as the flexibility and mechanical strength of the adjuvant, the short service life of the flexibility and the mechanical strength, the unfavorable drug utilization rate, etc. and protein loss, improve flexibility and mechanical strength, maintain the effect of wound blood supply and oxygen exchange

Inactive Publication Date: 2020-09-25
中国科学院大学深圳医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the method of the above application can improve the hygroscopicity and antibacterial properties of medical accessories, it does not take too much into consideration the flexibility and mechanical strength of the accessories. Replacement, and it is not conducive to the better combination of excipients and wounds, and it is also not conducive to improving the utilization rate of drugs

Method used

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  • Trauma auxiliary material and preparation method thereof
  • Trauma auxiliary material and preparation method thereof
  • Trauma auxiliary material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0047] The preparation method of wound auxiliary material of the present embodiment comprises the following steps:

[0048] 1) Preparation of spinning solution:

[0049] Configure a mixed solvent of N-N-methylpropylamine, acetone and chloroform, wherein the volume ratio of N-N-methylpropylamine, acetone and chloroform is 3:5:2;

[0050] Weigh 0.1-0.7g of polylactic acid-glycolic acid copolymer (PLGA) and 0.3-0.6g of polyethylene glycol (PEG) particles and add them to 100ml of N-N-methylpropylamine, acetone and chloroform mixed solvent, The sum of the mass concentrations of the polylactic acid-glycolic acid copolymer and polyethylene glycol particles in the mixed solvent is 26% to 30% (w / v), stirred at 37 to 45°C for 1.5 to 2 hours, and left to stand Degassing to prepare PEG / PLGA mixed precursor solution;

[0051] 2) Preparation process of silicone film:

[0052] Mix silicone resin, liquid paraffin, n-hexane and Span-80 uniformly in proportion (13-36 parts of silicone resin,...

Embodiment 2

[0072] In order to prove the high porosity and pore connectivity of the nanofiber membrane in the lower layer, the nanofiber membrane and the drug-loaded nanofiber membrane were characterized respectively.

[0073] The non-drug-loaded fibrous membrane was prepared as follows:

[0074] 1) Preparation of spinning solution:

[0075] Configure a mixed solvent of N-N-methylpropylamine, acetone and chloroform, wherein the volume ratio of N-N-methylpropylamine, acetone and chloroform is 3:5:2;

[0076] Weigh 0.1-0.7g of polylactic acid-glycolic acid copolymer and 0.3-0.6g of polyethylene glycol particles into 100ml of N-N-methylpropylamine, acetone and chloroform mixed solvent, the polylactic acid- The sum of the mass concentration of glycolic acid copolymer and polyethylene glycol particles in the mixed solvent is 26% to 30% w / v, stirred at 37-45°C for 1.5-2h, and left to defoam to obtain PEG / PLGA mixed precursor solution;

[0077] 2) Electrospinning the spinning solution in step...

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Abstract

The invention discloses a preparation method of a trauma auxiliary material, and belongs to the technical field of medical trauma auxiliary materials. The trauma auxiliary material is composed of twolayers, wherein the upper layer is a silicone membrane, and the lower layer is a PEG / PLGA composite nanofiber membrane. The preparation method of the PEG / PLGA composite nanofiber membrane comprises the following steps: 1) preparing a PEG / PLGA mixed spinning solution; 2) preparing a silicone membrane; 3) adhering the silicone membrane to an aluminum foil, fixing the aluminum foil on a roller receiver of an electric spinning machine, and performing electrostatic spinning on the mixed spinning solution obtained in the step 1); and 4) drying samples for a certain time after spinning. Through preparation of the double-layer membrane auxiliary material formed by combining the silicone membrane and the PEG / PLGA composite nanofiber membrane, the auxiliary material has moisturizing and antibacterial properties, the flexibility and mechanical properties of the auxiliary material can be remarkably improved, and the action time of drug properties of the auxiliary material is prolonged.

Description

technical field [0001] The invention belongs to the technical field of wound auxiliary materials, and more specifically relates to a wound auxiliary material and a preparation method thereof. Background technique [0002] Medical dressings are one of the most commonly used medical supplies in hospitals. Medical dressings are wound-wrapping supplies, medical materials used to cover wounds or other damaged parts, generally referring to gauze or non-woven fabrics or cotton, etc., which can protect wounds from mechanical damage. prevent traumatic injury, prevent wound infection, and promote wound healing as soon as possible. The preparation technology of medical auxiliary materials is in the stage of development and perfection in the world. Good biocompatibility, antibacterial activity and other aspects show bright development and application prospects. [0003] Regarding the research on medical accessories, relevant applications have been disclosed in the prior art, such as Ch...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/20A61L15/42A61L15/44A61L15/46D04H1/4382D04H1/728D01D5/00D01D1/06D01D1/02
CPCA61L15/20A61L15/26A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/404A61L2300/412A61L2400/12D01D1/02D01D1/065D01D5/003D01D5/0092D04H1/4382D04H1/728C08L71/02C08L67/04C08L83/04
Inventor 李茹冰丘海轶吴云赵月林海洋何丹丹梁瑶邹银萍毛勤荣
Owner 中国科学院大学深圳医院
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