88results about How to "Simple purification" patented technology

The invention discloses a water catalyst sterilizing and detoxifying device and a producing and using method thereof. The device comprises a water catalyst generator and a DC (direct current) power supply, wherein the water catalyst generator comprises an anode electrode and a cathode electrode which are both titanium electrodes; and the anode electrode is coated with a composite material coating. The producing method comprises the following steps of: (I) making electrodes; and (II) making the composite material coating: preparing composite material coating liquid, and brushing, drying and sintering the coating liquid in multiple times. The using method comprises the following steps of: a, placing the cleaned article and the water catalyst generator in the cleaning water; b, connecting the water catalyst generator with the DC power supply; and c, purifying the cleaned article with the water catalyst generator and the cleaning water. According to the invention, the design is reasonable, the producing and using processes are simple, and the purifying effect is good; and moreover, the problems of poor using effect, possible new pollution, easy damage to the nutrient components of thecleaned food and the like of the existing sterilizing and pesticide residue removing methods can be solved.

The invention discloses an esterifiable modification method of lignocelluloses and esterifiable modified lignocelluloses. The esterifiable modification method comprises the following steps: dissolving lignocelluloses in an ionic liquid; and carrying out esterification reaction on the lignocelluloses and an esterifying agent. The method disclosed by the invention has the characteristics that the prices of the used raw materials are low, the technologic process is simple, the reaction process has no pollution, a reaction system can be reused, the hydroxyl substitution degree of a prepared lignocellulose esterification material can be controlled, and the like; and the method is one of important methods for industrial transformation and utilization of renewable lignocellulose resources.

The invention relates to preparation and application of a cyclodextrin glycosyltransferase mutant, and belongs to the field of gene engineering and enzyme engineering. The amino acid of cyclodextrin glycosyltransferase is subjected to mutation; the enzyme activity of the obtained mutant can reach 2.5 times of that of wild enzyme; the purification of the obtained cyclodextrin glycosyltransferase mutant is simple; the industrial production can be realized.

The invention discloses a pulse potential preparation method for nitrogen-doped fluorescent carbon dots. The pulse potential preparation method is characterized in that a combination of organic matter 1 and organic matter 2 is used as a carbon source, mixed liquid formed by ultrasonically configurating water and the combination is used as electrolyte, the organic matter 1 is one of ethanol, citric acid and ascorbic acid, the organic matter 2 is one of o-phenylenediamine, m-phenylenediamine and p-phenylenediamine, and the ratio of the amount of matter of the organic matter 1, the organic matter 2 and water is 200-50:1:120-20; a two-electrode system is adopted, a working electrode and a counter electrode both are platinum electrodes, the pulse potential method parameters are set, the electrolyte is carbonized for 1-4 hours, and a reaction solution is obtained; after the reaction solution stands still for a period of time, supernatant is taken, the pH of the supernatant is adjusted to be neutral, centrifugal treatment is conducted, rotation, evaporation and concentration are conducted, and a concentrated solution is obtained; and the concentrated solution is subjected to dialysis treatment in deionized water, and then an aqueous solution of the nitrogen-doped fluorescent carbon dots is obtained. The method is simple, the fluorescence yield of the obtained fluorescent carbon dots is high, the water solubility is good, and the stability is good.

The invention relates to a synthesis method of a key raw material compound C of Elagolix. The synthesis method comprises the following steps: performing reaction of 3-flourine-trifluorotoluene, an organic lithium reagent and DMF in the presence of TMEDA and DIPA to obtain an intermediate A; performing oximation reaction of the intermediate A and alkoxamine hydrochloride or hydroxylamine hydrochloride to obtain an intermediate B; and reducing the intermediate B to obtain a target product compound C. The cheap commercialized basic chemical raw material 3-flourine-trifluorotoluene serving as a starting raw material is subjected to three-step chemical reaction to obtain the target product compound C, the starting raw material which has high cost and is not easily available is avoided, the synthesis cost of the target product compound C is greatly reduced, and the synthesis method has the advantages of being simple in purification, low in cost, high in efficiency, high in yield and suitablefor industrialized mass production.

The invention provides a preparation method of 2-hydroxy-4-cetyloxy-diphenyl ketone, which comprises the following steps: mixing 2,4-dihydroxy benzophenone, 1-bromohexadecane, mixed crystal solid alkali composite catalyst, potassium carbonate, benzyltriethylammonium chloride and nano silver iodide, introducing nitrogen, reacting at 130-155 DEG C under reflux for 8-10 hours, filtering out the solid, separating the water phase from the organic phase after reaction, extracting the organic phase with water, and distilling under reduced pressure to obtain the product. The method has the advantages of simple purifying treatment and no corrosion to equipment; and the prepared 2-hydroxy-4-cetyloxy-diphenyl ketone is mainly used for producing stone paper in the fields of outer wall paints, rubber and plastic industry, and is also suitable for producing specialty paper.

The invention discloses a method for preparing full acetylation cellulose. The method is as below: dispersing cellulose into dimethyl sulfoxide to obtain a cellulose suspension; then adding an acylation agent isopropenyl acetate and a catalyst 1,8-diazabicyclo [5,4,0] undec-7-ene in to the cellulosic suspension; conducting an esterification reaction in the conditions of isolation from air and stirring at the temperature of 60-130 DEG C for 2-15 h; and carrying out sedimentation treatment on the obtained solution, collecting precipitates, washing and drying the precipitates to obtain full acetylation cellulose. The method provided by the invention employs a polar solvent DMSO as a medium, and isopropenyl acetate as an acylation agent, and carries out acetylation of cellulose through the esterification reaction with mild conditions; and the catalyst 1,8-diazabicyclo [5,4,0] undec-7-ene effectively improves the transesterification efficiency. The method has simple operation, realizes high degree of acetylation and can effectively avoid the degradation of cellulose and equipment corrosion.

The invention provides a synthesis method of tolfenamic acid, and belongs to the field of medicament synthesis. According to the technical scheme, the synthesis method comprises the following steps of: adding o-chlorobenzoic acid and alkali metal hydroxide into methyl isobutyl ketone; heating and raising temperature for reaction; adding 3-chloro-2-methylaniline, an acid-binding agent and a catalyst into mixture; heating to react; performing extraction, acidification and filtration to obtain a tolfenamic acid rough product; and recrystalizing the rough product to obtain the tolfenamic acid refined product. The method has the advantages of easiness in operation, easiness in implementation of industrial production, high yield, low cost, safety and environmental friendliness.

The invention relates to a preparation method for a doxorubicin derivative, in particular to the preparation method for a doxorubicin13-position hydrazone derivative through fumaryl chloride and amino-alkyl-carboxylic acid.

The invention discloses a preparation method for paliperidone palmitate. The preparation method comprises the following steps: step 1, synthesis of 3-(2-hydroxyethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyltetrahydro-pyridino[1,2-alpha]pyrimidin-4-one; step 2, synthesis of 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyltetrahydro-pyridino[1,2-alpha]pyrimidin-4-one; step 3, synthesis of paliperidone; and step 4, synthesis of paliperidone palmitate. Compared with the prior art, the preparation method provided by the invention has the advantages of short reaction time, low cost, controllability of impurities, easiness in purification, high product purity and high yield.

The invention relates to the field of medical chemistry, particularly the field of pharmaceutical synthesis and more particularly a synthetic method for a pharmaceutical intermediate. The synthetic method comprises the steps: by taking 4-bromobiphenyl as an initial raw material, carrying out reaction with boride to obtain a compound II; and further synthesizing a target compound by directly taking a post-reaction solution as a raw material by treating or not treating a reaction liquid of the compound II. By adopting the synthetic route disclosed by the invention, the production process is simple, the product yield is high, the purification treatment is simple, the product purity is high after simple treatment, and the preparation cost is low, and the synthetic method is suitable for industrial production.

The invention provides a preparation method of a fuel cell catalyst. The method comprises the steps of (I) sequentially adding a carbon support and a platinum source into a mixed solution of ethyleneglycol and deionized water, dispersing evenly to form mixed slurry, and then adding an ethylene glycol solution of potassium hydroxide into the mixed slurry until the pH of the mixed slurry is adjusted to 9-11; (II) introducing nitrogen into the finally obtained mixed slurry until oxygen in the mixed slurry is completely discharged, injecting the mixed slurry into a spray reactor at 120-150 DEG Cfor carrying out spray reaction and cooling a reaction product to room temperature; (III) transferring the reaction product cooled to the room temperature into a positive pressure filter, filtering and purifying the reaction product through a continuous microporous membrane of the deionized water until the total ion concentration of filtrate is reduced to below 10ppm and obtaining catalyst filtrate; and (IV) injecting the catalyst filtrate into a spray dryer for carrying out spray drying and preparing a Pt / C catalyst. The method provided by the invention is simple in process, fast in reactionand high in product purity, and continuous production can be implemented.

The invention discloses a method for preparing sofosbuvir and belongs to the technical field of medicine synthesis. The method comprises the following steps: putting tertiary butyl magnesium halide into a tetrahydrofuran solution of a compound 2 with certain amount of water, further putting a compound 3, and performing reaction, thereby obtaining sofosbuvir. As a certain amount of water is added in a reaction system, the conversion rate of reaction is remarkably increased, the content of main byproducts is reduced, then the preparation cost of the sofosbuvir is lowered, and remarkable social and economic benefits are achieved.

The invention discloses a method for extracting astaxanthin from haematococcus pluvialis by a double-aqueous-phase coupled wall breaking technology. A double-aqueous-phase separating system is coupled with a freeze-thawing wall breaking technology through experiments, and the processes of wall breaking, extracting and separating are coupled through the introduction of the double-aqueous-phase system. The astaxanthin can be effectively separated from algae residues and various impurity components by a simple liquid separating method during wall breaking and extracting, and the purity and the extracting rate of the astaxanthin are effectively improved. The extracting and separating processes are reduced, and meanwhile, a freeze-thawing agent and an extractant are consistent with the phase forming substances of the double-aqueous-phase system. The types and the dosage of reagents are reduced, and the used reagents are environment-friendly and easy to recycle.

The invention relates to a preparation method of LiPF2 and a lithium ion battery non-aqueous electrolyte containing the LiPF2. The preparation of the LiPF2 comprises the following steps: introducing a SeOF2 gas in an organic solvent containing LiPF6 for reacting, and crystallizing, filtering and drying a product after completing the reaction, thus obtaining a LiPF2 product. The LiPF2 product prepared by the invention is high in purity, pollution of other metal ions does not exist, the product purity is 99.0 percent or more, the content of free acid (HF) is 70 ppm or less, and the content of an insoluble matter is 130 ppm or less. According to the preparation method disclosed by the invention, product purification is simple, and the high-purity LiPF2 product can be obtained through conventional steps of crystallizing, filtering and drying in the field; a lithium ion battery containing the lithium ion battery non-aqueous electrolyte has good low-temperature performance and good rate performance.

The invention discloses a method for extracting volatile oil and magnolol from mangnolia officinalis leaves. First, mangnolia officinalis leaf powder is placed in a distilling tank for steam distillation, the mangnolia officinalis volatile oil is extracted, then the magnolol is extracted by the following steps that 1. water and solid residues in the distilling tank are stirred, slaked lime is added, pH is adjusted to 9-10, stirring is carried out continuously for 30-40 min, and filtering is carried out; 2. filter residues are subjected to normal-temperature digestion by two times with lime water with pH of 9-10, the extracting liquid is combined, concentrated hydrochloric acid is used for adjusting pH of the extracting liquid to be 3-4, standing and settling are carried out, water is used for washing until neutral is achieved, constant temperature drying is carried out under the temperature of 45 DEG C, and crude extract is obtained; and 3. the crude extract and silica gel with four-time amount are mixed, petroleum ether is used for reflux extraction, extracting liquid is concentrated, cooling is carried out, after complete precipitation crystallization, filtering is carried out, and then an ethyl acetate and petroleum ether mixed solution is used for recrystallization. Comprehensive extracting of two effective components in the mangnolia officinalis leaves is achieved, the process is simple, cost is low, the extracting rate is high, and environment-protecting industrialized production can be achieved.

The invention discloses a Schiff base compound as a Sb(III) ion colorimetric probe as well as a preparation method and use thereof. The Sb(III) ion colorimetric probe is prepared by using 1, 2-phenylenediamine and 4-dimethylaminocinnamaldehyde as raw materials, and the synthesis is completed only in one step; furthermore, the synthesis conditions are mild, and the yield is high. The ion colorimetric probe has better selectivity and higher sensitivity to metal ions Sb(III). After the Sb(III) is added, an ion colorimetric probe solution rapidly becomes rose red from pale yellow, the absorbance of the solution has a better linear relationship with the ion concentration, but the addition of other common metal ions basically does not cause the change of the color and absorbance of the solution.The ion colorimetric probe can be used for performing special and rapid detection on the Sb(III), is strong in anti-interference ability, can be widely used in the content detection of the Sb (III) in an aqueous solution system as well as visual colorimetric detection, thus having a good application prospect in the fields of analysis and detection.

The invention provides a synthesis process of N-paraphthalyl(diethanol)amino-L-phenylalanine ethyl ester. The process includes the first step of amino protection reaction, the second step of esterification reaction, the third step of reduction reaction and the fourth step of substitution reaction. According to the synthesis process, amino is protected by phthalic anhydride, and then esterification, reduction and substitution are conducted obtain the product. The process has the advantages of being low in cost, mild in reaction condition, low in toxicity, convenient to operate, high in yield and suitable for industrial production.

The invention discloses a preparation method of minocycline. The minocycline is (4S,4aS,5aR,12aS)-4,7-dimethylamino-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-tetraphenyl-2-formamide. According to the method, sancyline is subjected to protection of a phenolic hydroxyl group via an acyl group, and then selective dimethylamination is conducted on position 6. After a protection strategy is adopted in the process route of the method, generation of 9-position dimethylamination by-products is avoided, and purification is simple. Usage of precious metal is avoided in a reaction, a production unit is simple to operate, safe and environment-friendly, and the method is very suitable for industrial production.

The invention belongs to the field of chemical synthesis, and particularly relates to a water-phase one-pot synthesis method of 3-flavonol and a 3-flavonol derivative. According to the method, 2-hydroxyacetophenone, 2-hydroxyacetophenone derivatives, benzaldehyde and benzaldehyde derivatives are used as reaction substrates, or 2-hydroxy-chalcone and hydroxy-chalcone derivatives are used as reaction substrates; water or ethanol water solution is used as a solvent; under the aerobic condition at 20 to 100 DEG C, reaction is performed to obtain the 3-flavonol and the 3-flavonol derivative. The invention provides a fire-new reaction mechanism, and develops a novel 3-flavonol synthesis method with the advantages of high efficiency, convenience, high speed and wide substrate adaptability. The invention also provides a fire-new 3-flavonol derivative synthesized by the novel method; important application values are realized in the field of medical care sanitation.

The invention relates to the technical field of kitchen waste treatment, in particular to a kitchen waste treatment system. The kitchen waste treatment system comprises preliminary separation equipment, wet material treating equipment, liquid phase treatment equipment and material fermenting equipment, wherein the preliminary separation equipment is used for receiving kitchen waste and separatingthe kitchen waste into percolate, solid waste and wet materials preliminarily, the wet material treating equipment is used for receiving the wet materials, carrying out squeezing and dewatering treatment on the wet materials, and obtaining wet material liquid phases and wet material solid phases, the liquid phase treatment equipment is used for receiving percolate and the wet material liquid phases and further separating mixed liquid of the percolate and the wet material liquid phases into grease, organic matter and liquid phase impurities, and the material fermenting equipment is used for receiving the wet material solid phases and the organic matter, mixing the wet material solid phases and the organic matter with auxiliary materials to form a fermenting raw material, and fermenting thefermenting raw material into biological yeast. The kitchen waste treatment system can treat the kitchen waste fast and efficiently, and solve the problem that when the kitchen waste is treated throughthe prior art, secondary pollution to the environment is caused.

The invention discloses a preparation method for an embritabine isomer. The preparation method comprises the following steps: with Solketal as a starting material, allowing the Solketal to undergo a six-step reaction of esterification, hydrolysis, oxidation, condensation cyclization, acetylation and glycosylation condensation so as to synthesize four mixture intermediates of emtricitabine; and splitting the four isomer intermediates into a cis-isomer mixture and a trans-isomer mixture through a chiral reagent. According to the invention, by adoption of a simple starting material, a mixture forsplitting key intermediates of four optical isomers of the emtricitabine is synthesized through the six-step reaction, and chiral acid is utilized to split the four isomers into a mixture of cis andtrans isomers, so the preparation method provided by the invention has the advantages of simple and convenient operation, high yield and high isomer chiral purity.

The invention relates to a synthesis method of 1-propyl-[4-(4 '-butylphenylazo)] azobenzene. The synthesis method comprises the following steps: carrying out a reaction on potassium hydrogen persulfate and 4-nitroaniline to obtain 4-nitro-nitrosobenzene, carrying out a reaction on the 4-nitro-nitrosobenzene, 4-n-butylaniline and acetic acid, and carrying out post-treatment to obtain 4-n-butyl-4'-nitro azobenzene; the preparation method comprises the following steps: dissolving 4-n-butyl-4 '-nitroazobenzene in DMF (Dimethyl Formamide), and reducing by hydrazine hydrate to obtain 4-n-butyl-4'-aminoazobenzene; the preparation method comprises the following steps: stirring 4-n-butyl-4 '-aminoazobenzene, concentrated hydrochloric acid and water, dropwise adding a sodium nitrite solution, dropwise adding a propylaniline glacial acetic acid solution, reacting, and performing post-treatment to obtain the 1-propyl-[4-(4'-butylphenylazo)] azobenzene. The synthesis method of the 1-propyl-[4-(4 '-butylphenylazo)] azobenzene is reasonable in process design, low in raw material cost, easy in purification treatment, high in yield and suitable for small-batch production.

The invention discloses a method for preparing sodium gluconate with an enzymatic method and belongs to the technical field of biochemistry. The method comprises steps as follows: glucose has an oxidation reaction with oxygen and water under the catalytic action of a glucose oxidase to produce gluconic acid and hydrogen peroxide, the hydrogen peroxide is decomposed into water and oxygen under the action of a catalase, and the gluconic acid has a neutralization reaction with sodium hydroxide to produce the sodium gluconate; the finished product, namely, the sodium gluconate, is obtained through enzyme deactivation, decolorization, concentration, crystallization and drying. The method can be used for producing food-grade and medicine-grade sodium gluconate and has the advantages that the operation is simple, the reaction time is short, the sodium gluconate is high in purity, little waste is produced and the like.

The invention discloses an expression method of an earthworm antibacterial peptide. According to the expression method, an improved maltose manipulator promoter Pglv-M1 is constructed, a bacillus subtilis expression vector consisting of an anamylase signal peptide sequence SP amyQ, an SUMO (small ubiquitin-related modifier) sequence and an antibacterial peptide sequence is constructed, and maltoseis adopted as an inducer to express an earthworm antibacterial peptide; an obtained target protein is cut by using SUMO protease, and affinity chromatography purification is implemented to obtain theearthworm antibacterial peptide LumbricinI (6-34). The purification product has antibacterial functions on all of escherichia coli, staphylococcus aureus, saccharomyces cerevisiae and the like. According to the method, bacillus subtilis is adopted as an expression host, so that endotoxin is avoided, and convenience in purification can be achieved; the promoter Pglv-M1 is used, the maltose is adopted as the inducer, and the inhibition function of the maltose upon the promoter Pglv-M1 can be alleviated; sequences of different sections are optimized, and the expression yield can be increased; and a fusion protein can be secreted out of cells, so that purification steps can be reduced.

The present invention discloses a trimethyliodosilane preparation method comprising the steps of: 1) in the presence of a protective gas, anion exchange resin and water are added into a reaction vessel, then stirring is started, the reaction vessel is heated to 45 DEG C, trimethyl chlorosilane is added, after the trimethylchlorosilane is added, the reaction vessel is heated to 65-75 DEG C and stirred for 1.5-3 hours for reaction, atmospheric distillation is performed, 99-100 DEG C distillate is collected, dried with anhydrous sodium sulfate, and filtered to obtain hexamethyldisiloxane; 2) in the presence of a protective gas, the hexamethyldisiloxane and aluminum powder are added into another reaction vessel, stirring is started, the reaction vessel is heated to 55 DEG C, elemental iodine is added, after completion of the addition of the elemental iodine, the bath temperature is raised to 120-140 DEG C for reaction and refluxing for 2-3 hours, the device is changed into a distillation apparatus for atmospheric distillation, and 106-107 DEG C distillate is collected to obtain the trimethyliodosilane. The method can improve the yield of the trimethyliodosilane, and is simple in operation, mild in conditions, and suitable for mass production and marketing.

The invention belongs to the technical field of medicine, and mainly relates to a preparation method of a cefotiam hexetil process impurity of 2-(2-(2-(2-(2-(2-aminothiazole-4-yl)-acetamido) thiazole-4-yl)-acetamido) thiazole-4-yl) acetic acid. According to the method, 2-amino-4-thiazole acetic acid and 2-amino-4-thiazole acetyl chloride are used as raw materials to be dissolved into a solvent; microwaves are used for assisting the base catalysis reaction; the pH is regulated to an acid state; filtration and washing are performed to obtain the 2-(2-(2-(2-(2-(2-aminothiazole-4-yl)-acetamido) thiazole-4-yl)-acetamido) thiazole-4-yl) acetic acid, i.e., the cefotiam hexetil process impurity. The reaction equation is shown as the accompanying drawing. Therefore the method has the characteristics that the reaction time is short; the synthesis operation is simple and convenient; the purification operation is easy; the yield is high; the purity is high; the product can be used as a necessary product of cefotiam hexetil quality control or can be applied to the cefotiam hexetil impurity reference substance study, and the like.

The invention discloses a method for preparing high-content helional. The method comprises the following steps: adding benzodioxole and boron trifluoride into an enameled reaction kettle, and adding an oil-soluble antioxidant into the enameled reaction kettle; adding the benzodioxole into an agitating pan, adding 2-methylallyl diacetate to prepare and drip the mixture; dripping the mixture at the kettle temperature of less than 10 DEG C for 4-10 hours; transferring the reaction products into a distillation still, recovering the benzodioxole, and distilling the helional monoester; adding methanol, water and potassium hydroxide into the reaction kettle, adding the helional monoester, maintaining the temperature of 50-90 DEG C, carrying out a hydrolysis reaction, cooling within 3-5 hours, ending the reaction, transferring to a washing pot, standing for 30 minutes, and separating the lower water; and transferring the reaction products in the washing pot into a fractionation kettle, recovering the methanol at normal pressure, and performing fractionation on the crude helional to obtain the finished product with the high content of 98.5 weight percent. The method is mild in reaction conditions, convenient to operate, readily available in raw materials and low in cost.

The invention discloses a method for synthesizing a carbon nanotube based on an iron-cobalt-aluminum catalyst with a layered structure, and belongs to the technical field of chemistry. According to the method, vermiculite is subjected to expansion treatment, secondary intercalation expansion, crushing, separation and screening, demagnetization and water flotation, then the iron-cobalt-aluminum catalyst is uniformly precipitated and loaded in a reaction kettle, and the obtained catalyst is subjected to secondary crushing, secondary screening and secondary demagnetization to obtain the layered catalyst with low metal impurity content. After the catalyst is reduced, olefin is cracked in stages in a fluidized bed to synthesize the carbon nanotube. The microstructure of the carbon nanotube obtained by the method is in an array shape, the content of ferromagnetic metal impurities is low, the conductivity is good, and the purification treatment is relatively easy.

The invention relates to the technical field of biology, in particular to application of plants as a host in M7842 expression. Plants such as lettuce are used as an effective expression platform for recombination protein production, and the simple and efficient agrobacterium mediate vacuum infiltration method is adopted for expressing the M7842. The expression system determines that plant foreignproteins can be collected four days after infection of agrobacterium. The Western Blot protein hybridization method is adopted for determining successful expression of M7842, the AKTA protein purifying system is used for successfully separating out M7842. The activity testing result shows that the tumor growth restraining effect of M7842 on the mouse model is remarkable.