Application of ethanolamine in preparation of composition for preventing, relieving or treating constipation

A technology for treating constipation and ethanolamine, applied in the field of biomedicine, can solve problems such as intestinal dysfunction, adverse reactions, irritation, etc., and achieve the effects of improving constipation, improving the propulsion rate of the small intestine and the number of defecation grains

Pending Publication Date: 2021-06-25
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all kinds of laxatives have a certain stimulating effect on the intestinal tract, and long-term use may lead to intestinal dysfunction and other adverse reactions

Method used

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  • Application of ethanolamine in preparation of composition for preventing, relieving or treating constipation
  • Application of ethanolamine in preparation of composition for preventing, relieving or treating constipation
  • Application of ethanolamine in preparation of composition for preventing, relieving or treating constipation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1——establish constipation mouse model

[0029] In this example, a constipation mouse model with slowed intestinal transit speed was established, and compound diphenoxylate was used as a modeling agent for the slowed intestinal motility model in mice.

[0030] Compound diphenoxylate consists of diphenoxylate hydrochloride and atropine sulfate. Diphenoxylate hydrochloride can act on the μ-type opioid receptor (μopioid receptor), inhibiting the release of ACh; atropine sulfate can act on mAChR, inhibiting the combination of ACh and mAChR, thereby inhibiting the activity of ACh. The above two substances jointly affect the intestinal ACh, and finally achieve the purpose of inhibiting the intestinal transit rate.

Embodiment 2

[0031] Embodiment 2——Measurement of small intestine propulsion rate

[0032] Forty 34-36g male KM mice (SPF grade, purchased from Weitong Lihua) were randomly divided into 5 groups, namely control group, model group and high, medium and low dose ethanolamine groups, 8 mice in each group. During the rearing period, the ambient temperature was kept at 22-24° C., the humidity was 50%-55%, a 12h / 12h day and night cycle was performed, and water and food were freely available. 16 hours before the start of the formal experiment, the five groups of mice were fasted without water.

[0033] The high-, medium-, and low-dose ethanolamine groups were given 1936, 387.20, and 77.44 mg / kg·BW ethanolamine aqueous solution (mixed with a vortex oscillator before use), respectively, and the model group and the control group were given an equal volume of normal saline solution; 30min Afterwards, the model group and the ethanolamine group were intragastrically administered compound diphenoxylate s...

Embodiment 3

[0037] Embodiment 3 - the impact of ethanolamine on the number of defecation grains

[0038] According to the results of small intestine propulsion rate in Example 2, the effective ethanolamine dose was obtained by screening, and the number of defecated particles and intestinal neurotransmitter content were evaluated with ethanolamine at this dose concentration (the effective ethanolamine dose was 1936 mg / kg·BW).

[0039] Twenty-four 34-36g male KM mice (SPF grade, purchased from Weitong Lihua) were randomly divided into 3 groups, namely control group, model group and ethanolamine group, with 8 mice in each group. During the rearing period, the ambient temperature was maintained at 22-24°C, the humidity was 50%-55%, a 12h / 12h day and night cycle was performed, and water and food were freely available. At the beginning of the experiment, the compound diphenoxylate solution (diphenoxylate hydrochloride 20mg / kg BW, atropine 0.2mg / kg BW; mixed with the previous vortex shaker) was ...

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PUM

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Abstract

The invention discloses application of ethanolamine in preparation of a composition for preventing, relieving or treating constipation. The composition comprises food, a health care product and a medicine. Ethanolamine promotes intestinal tract movement and prevents, relieves or treats constipation by increasing the content of serotonin in colon. Animal experiments prove that ethanolamine can significantly improve the small intestine propulsion rate and the defecation grain number of compound diphenoxylate modeling mice, and has the function of relieving constipation; Meanwhile, the ethanolamine promotes intestinal tract movement and prevents, relieves or treats constipation by increasing the content of serotonin in colon.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of ethanolamine in the preparation of a composition for preventing, alleviating or treating constipation. Background technique [0002] Constipation refers to a change in the normal defecation pattern, a decrease in the frequency of defecation, and at the same time difficulty in defecation and dry stool. It is a common clinical digestive system problem. Constipation can affect people of all ages, women more than men, the elderly more than young adults. Due to the high incidence of constipation, complex etiology, and repeated lingering course of disease, it will affect the quality of life of patients in severe cases. [0003] However, due to the unclear pathogenesis of constipation, there is a lack of effective treatment drugs. At present, the drugs for treating constipation are mainly divided into stimulant laxatives, bulky laxatives, osmotic laxatives, lub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/133A61P1/10A23L33/10
CPCA61K31/133A61P1/10A23L33/10A23V2002/00A23V2200/32
Inventor 赵亮弓佳卉欧扬雯姗陈善斌
Owner CHINA AGRI UNIV
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