Method for the detection of diphenoxylate in biological samples using liquid chromatography-tandem mass spectrometry for forensic purposes

A liquid chromatography and biological sample technology, applied in the field of liquid chromatography-tandem mass spectrometry detection of diphenoxylate in biological samples, can solve the problems of complicated operation, increased detection difficulty, low detection sensitivity, etc., and achieves simple operation and improved detection. The effect of detection sensitivity and shortened detection time
CN103344710BActive Publication Date: 2015-08-05INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
Publication Date
2015-08-05

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Abstract

The invention relates to a method for detecting diphenoxylate in a biological sample by liquid chromatography-tandem mass spectrometry for criminal investigation. The method comprises the following steps: (I) extracting diphenoxylate from the biological sample; and (II) detecting diphenoxylate extracted in the step (I) by a liquid chromatography-tandem mass spectrometry instrument. The method provided by the invention improves the sensitivity of the detection of diphenoxylate in the biological sample to be detected, and reduces the degree of detection difficulty of diphenoxylate in the biological sample to be detected.
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Description

technical field

[0001] The invention belongs to the field of analysis and detection of chemical substances in criminal investigation, in particular to a method for detecting diphenoxylate in biological samples using liquid chromatography-tandem mass spectrometry for the purpose of criminal investigation. Background technique

[0002] Diphenoxylate is a common antidiarrheal drug in clinical practice. In recent years, it is often poisoned due to improper use of drugs, especially among children under 10 years old. In addition, diphenoxylate is often used by drug addicts as a substitute for heroin, causing abuse and poisoning. Therefore, the detection of diphenoxylate is very necessary. In the detection of diphenoxylate in the prior art, the detection sensitivity is low and the operation is more complicated, which makes the detection more difficult; while in the criminal investigation for the detection of urine samples or blood samples of drug suspects, high detection sensitivit...

Claims

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