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Medicine for treating postoperative gastroenteropathy

A technology for gastrointestinal diseases and medicines, applied in the field of plant materials, can solve problems that affect breathing, circulatory function, gastrointestinal function cannot be restored, and no gastrointestinal diseases have been seen

Inactive Publication Date: 2009-07-08
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in some patients, the postoperative abdominal distension is getting worse, and the gastrointestinal function cannot be recovered for a long time. Severe abdominal distension can affect breathing, circulation function and incision healing, so it needs to be treated in time
[0003] After the patient's wound recovered and was discharged from the hospital, drugs and physical methods were used to restore the gastrointestinal function. The drugs mainly include Weifukang, Weishu Tablets, Cisapride Tablets (Prevox), Metoclopramide, and Neostigmine Methosulfate. (Neostigmine), currently there are no reports of drugs dedicated to postoperative and treatment of gastrointestinal diseases

Method used

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  • Medicine for treating postoperative gastroenteropathy
  • Medicine for treating postoperative gastroenteropathy
  • Medicine for treating postoperative gastroenteropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Taking the production of pharmaceutical granules of the present invention 1000g as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0038] Rhubarb 180g

[0039] Astragalus 375g

[0040] Hemp seeds 250g

[0041] Citrus citrus 156g

[0042] Magnolia officinalis 156g

[0043] Atractylodes macrocephala 188g

[0044] Woody incense 188g

[0045] Angelica 188g

[0046] 156g peach kernels

[0047] Radix Paeoniae Alba 156g

[0048] Add dextrin to 1000g

[0049] Its preparation method is as follows:

[0050] 1. Soak rhubarb, magnolia officinalis, and hemp seed in 10 times the amount of 80% ethanol for 14 hours, then reflux and extract 3 times, each time for 1 hour, filter, combine the extracts, recover ethanol under reduced pressure (0.05-0.07MPa), and concentrate To an extract with a relative density of 1.20-1.25 (60°C).

[0051] 2. Add astragalus, citrus aurantii, Atractylodes macrocephala, wood fragranc...

Embodiment 2

[0084] Taking the production of pharmaceutical granules of the present invention 1000g as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0085] Astragalus 518g

[0086] Hemp seeds 299g

[0087] Rhubarb 239g

[0088] Atractylodes macrocephala 179g

[0089] Woody incense 179g

[0090] Angelica 179g

[0091] Citrus citrus 100g

[0092] Magnolia officinalis 100g

[0093] peach kernel 100g

[0094] Radix Paeoniae Alba 100g

[0095] Add dextrin to 1000g

[0096] Its preparation process is carried out according to the preparation process of the granules of the present invention. Each bag weighs 5g, and each gram contains 1.993g of crude drug. Take it three times a day, one bag each time.

[0097] Taking the production of 1000 tablets of the pharmaceutical tablet product of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

...

Embodiment 3

[0127] Taking the production of pharmaceutical granules of the present invention 1000g as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0128] Astragalus 280g

[0129] Atractylodes macrocephala 239g

[0130] Woody incense 239g

[0131] Angelica 239g

[0132] Hemp seeds 200g

[0133] Citrus aurantium 169g

[0134] Magnolia officinalis 169g

[0135] 169g peach kernels

[0136] Radix Paeoniae Alba 169g

[0137] Rhubarb 120g

[0138] Add dextrin to 1000g

[0139] Its preparation process is carried out according to the preparation process of the granules of the present invention. Each bag weighs 5g, and each gram contains 1.993g of crude drug. Take it three times a day, one bag each time.

[0140] Taking the production of 1000 tablets of the pharmaceutical tablet product of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are...

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Abstract

A medicine for treating postoperative gastrointestinal diseases, which is composed of 6-12% of rhubarb, 14-26% of astragalus, 10-15% of hemp seed, 5-10% of Citrus aurantium, 5-10% of Magnolia officinalis, and 6% of Atractylodes Rhizoma ~12%, Muxiang 6~12%, Angelica 6~12%, Peach Kernel 5~10%, Paeonia suffruticosa 5~10%, the oral medicine prepared according to the conventional preparation method. The medicine of the present invention has been tested on the efficacy of the medicine, and the experimental results show that the medicine of the present invention can promote the defecation process of normal mice; Promoting effect; the medicine of the present invention also has obvious improvement effect on delayed gastric emptying and delayed intestinal propulsion in rats caused by abdominal surgery; the medicine of the present invention can resist the weakening of small intestine activity caused by compound diphenoxylate. The above results provide a reliable experimental basis for the drug of the present invention to be used for complications such as abdominal distension and constipation after abdominal surgery.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] After laparotomy, gastrointestinal function paralysis occurs due to reasons such as intestinal motor nerve dysfunction, causing intestinal dilatation and intestinal pneumatosis, often involving the entire intestinal tract. The patient cannot exhaust and defecate normally, which is called postoperative small intestine. Postoperative small bowel is a common complication after abdominal surgery. There is no consensus on the cause of its occurrence. Treatment measures include drug therapy and physical therapy. Generally, 24 to 72 hours after the operation, the gas will be exhausted through the anus, and the intestinal function will recover. However, in some patients, postoperative abdominal distension is getting worse day b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K36/73A61K36/71A61K36/708A61K36/575A61K36/481A61K36/60A61K36/285A61K36/284A61K36/232A61K9/16A61K9/20A61K9/00A61P1/14
Inventor 党正祥封卫毅魏友霞董亚玲张秋侠
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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