Application of fulvic acid sodium in preparing drugs for treating diarrhea

A technology of sodium fulvic acid and fulvic acid, which is applied in the direction of drug combination, non-living material medical raw materials, digestive system, etc.

Inactive Publication Date: 2011-02-16
KUNMING UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far there is no specific animal experiment to prove that fulvic acid and its salts have the effect of treating diarrhea

Method used

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  • Application of fulvic acid sodium in preparing drugs for treating diarrhea
  • Application of fulvic acid sodium in preparing drugs for treating diarrhea
  • Application of fulvic acid sodium in preparing drugs for treating diarrhea

Examples

Experimental program
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Effect test

Embodiment 1

[0017] This experimental example is to use normal mice to test the effect of sodium fulvic acid of the present invention on the small intestine movement of mice. Under the dosage of sodium fulvic acid of 100-200mg / kg, the pharmacodynamic effect of continuous gavage for one week After observation, it was found that the drug reduced the propulsion rate of charcoal powder in the small intestine of normal mice, indicating that the drug has the effect of inhibiting gastrointestinal motility. The experimental materials used in this experiment are as follows:

[0018] (1) Sodium fulvic acid, provided by our laboratory.

[0019] (2) Sodium carboxymethyl cellulose 800-1200, Sinopharm Chemical Reagent Co., Ltd.

[0020] (3) Activated carbon, No. 3 branch of Tianjin No. 6 Chemical Reagent Factory.

[0021] (4) The experimental animals were clean Kunming mice, half male and half male, weighing (20±2) g, purchased from the Experimental Animal Center of Kunming Medical College. Observe f...

Embodiment 2

[0032] This experimental example adopts the mouse constipation model caused by compound diphenoxylate to test the effect of sodium fulvic acid of the present invention on the small intestine movement of mice. The pharmacodynamic effect of continuous gavage for one week was observed, and it was found that the drug had a synergistic effect on the inhibition of small intestine motility in mice caused by compound diphenoxylate, indicating that the drug had the effect of inhibiting gastrointestinal motility.

[0033] The experimental materials used in this experiment are as follows

[0034] (1) Sodium fulvic acid, provided by our laboratory.

[0035] (2) Compound diphenoxylate, produced by Changzhou Kangpu Pharmaceutical Co., Ltd., batch number 0906030, 2.5 mg / tablet, made into a suspension with a concentration of 0.1 mg / mL.

[0036] (3) Sodium carboxymethyl cellulose 800-1200: Sinopharm Chemical Reagent Co., Ltd.

[0037] (4) Activated carbon, No. 3 branch of Tianjin No. 6 Chemi...

Embodiment 3

[0051] This experimental example is the mouse spleen deficiency diarrhea model caused by rhubarb to test the effect of sodium fulvic acid of the present invention on small intestine movement in mice, and the pharmacodynamics at a dosage of 100-200 mg / kg of sodium fulvic acid The effect was observed, and it was found that the drug can significantly improve the signs of spleen-deficiency diarrhea mice caused by rhubarb, inhibit the gastrointestinal motility of spleen-deficiency mice, and resist diarrhea.

[0052] The experimental materials used in this experiment are as follows

[0053] (1) Sodium fulvic acid, provided by our laboratory.

[0054] (2) Raw rhubarb (Rheum officinale Raill), purchased from Yunnan Lvsheng Pharmaceutical Co., Ltd., the raw drug was crushed and passed through a 200-mesh sieve, and made into a 10% suspension before use.

[0055] (3) Ginseng Jianpi Pills, produced by Dongfanghong Pharmaceutical Co., Ltd., Tengchong County, Yunnan Province, batch number ...

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Abstract

The invention relates to an application of fulvic acid sodium in preparing drugs for treating diarrhea. Research discovers that the fulvic acid sodium in the invention has low toxicity, can restrain the gastrointestinal motility of a normal mice, can cooperate with reinforced compound diphenoxylate to restrain the gastrointestinal motility of the mice, can obviously improve the physical sign of a mice suffering splenasthenic diarrhea caused by rheum officinale, and restrain the gastrointestinal motility of the mice suffering diarrhea, thus treating the diarrhea; and the research shows that the fulvic acid sodium has obvious effect of treating the diarrhea.

Description

technical field [0001] The invention relates to the application of sodium fulvic acid, in particular to the application of sodium fulvic acid in the pharmaceutical field. Background technique [0002] Diarrhea is a common disease in my country, which seriously endangers people's health, especially the frequently-occurring disease of growth and development of children under 5 years old. It not only has a high incidence rate, but also is one of the main causes of death in this age group. According to incomplete statistics from the World Health Organization, 4.5 million children under the age of 5 die from diarrheal diseases in developing countries every year. [0003] Humic acid (HA) is a complex natural macromolecular organic weak acid, which is a product formed after the decomposition of plant residues in nature. It belongs to an aromatic compound, and its chemical structure has not yet been fully understood. Fulvic acid (FA) is the part of HA with the smallest molecular we...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/02A61P1/12
Inventor 李宝才李月梅梅展青张惠芬何静李鹏戴伟锋
Owner KUNMING UNIV OF SCI & TECH
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