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Application of chrysophanic acid in preparation of medicines for treating constipation

A rhein and drug technology, applied in the field of medicine, can solve problems such as increasing the risk of colorectal cancer and intestinal ecological balance imbalance

Inactive Publication Date: 2014-07-16
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Constipation will cause abdominal distension, belching, stomach acid and poisoning because harmful substances in the body cannot be eliminated in time, leading to intestinal ecological balance imbalance and increasing the risk of colorectal cancer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0008] 1. Materials and methods

[0009] (1) Materials Thirty healthy Kunming mice, weighing between 22g and 30g, were divided between male and female. Compound diphenoxylate tablets are products of Jiangsu Pingguang Pharmaceutical Co., Ltd. (batch number: 0805221, 2.5g / tablet), rhein is a product of Henan Dingguo Biotechnology Co., Ltd., and Eosin Y is a product of Shanghai Yongye Biotechnology Co., Ltd. (CAS No.: 17372-87-1), scale.

[0010] (2) Establishment of constipation model

[0011] Grouping 30 mice, both male and female, were randomly divided into 3 groups after weighing, control group, constipation group and rhein group, 10 mice in each group.

[0012] Preparation of medicament: Take 2 tablets of compound diphenoxylate tablets and add 5ml of distilled water to make a suspension. Accurately weigh 50 mg of rhein, add 10 ml of distilled water, mix well, and treat the mice in the rhein group by intragastric administration, the dosage is 0.1 ml / 10 g. Take 2g of eosin...

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PUM

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Abstract

The invention discloses application of chrysophanic acid in preparation of medicines for treating constipation. The key point of the technical scheme adopted by the invention is as follows: application of the chrysophanic acid in preparation of medicines for treating constipation caused by gastrointestinal motility dysfunction resulting from compound diphenoxylate medicines. The application disclosed by the invention is beneficial to finding of a new and effective medicine for preventing and treating constipation caused by gastrointestinal motility dysfunction resulting from compound diphenoxylate drugs, meanwhile, the application is used for further verifying the extensive pharmacological action of the chrysophanic acid, having important significance of promoting clinical application of traditional Chinese medicine chrysophanic acid to become a new clinical drug, and providing experimental evidence for illustration of the action mechanism of the chrysophanic acid and market promotion of the chrysophanic acid.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of rhein in the preparation of medicine for treating constipation. Background technique [0002] Constipation is a common clinical symptom with a high incidence. It is often characterized by prolonged defecation intervals, dry stools, and difficult stools. It seriously affects people's quality of life, is not conducive to the absorption of nutrients, and interferes with the normal metabolism of the body. Constipation will cause abdominal distension, belching, stomach acid and poisoning because harmful substances in the body cannot be eliminated in time, which will lead to the imbalance of intestinal ecological balance and increase the risk of colorectal cancer. Not only that, chronic constipation can also induce serious diseases such as Alzheimer's disease, cardiovascular and cerebrovascular diseases, cerebrovascular accidents and myocardial infarction. At the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P1/10
Inventor 杜爱林姜洪波高建辉白瑞樱孙莉莉郭珂一刘旭苏慧杰弓茹月吴雅倩李慧智解娜林瑞峰李天超冯素萍黄艳芬王乐男
Owner XINXIANG MEDICAL UNIV
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