Lactobacillus rhamnosus CCFM1068 and application thereof

A technology of Lactobacillus rhamnosus and bacterial agents, applied in the field of microorganisms, can solve the problems of drug dependence, induced intestinal polyps, colonic lesions, etc., achieve strong adsorption capacity, increase the water content of feces, and have wide application prospects
CN110387342APending Publication Date: 2019-10-29JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2019-10-29

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Abstract

The invention discloses lactobacillus rhamnosus CCFM1068 and application thereof.Thelactobacillus rhamnosus CCFM1068 can rapidly colonize in an intestinal tract, the water content of feces issignificantly increased, the intestinal propulsive rate is increased, defecation time of a first black stool is shortened, the content of peptide YYin serum is down-regulated, the level of5-hydroxytryptamine in colon tissuesis up-regulated, the level of neurotrophin-3 in thecolon tissues is up-regulated, the level of brain-derived neurotrophic factorsin thecolon tissues is up-regulated, and the level of Aqp4 gene transcriptionin thecolon tissues is up-regulated. In addition, the lactobacillus rhamnosus CCFM1068has a strong adsorption capacity for perfluorooctanoic acid and the ability to alleviate thetoxicity of PFOA. The lactobacillus rhamnosus CCFM1068 can well tolerate simulated gastrointestinal fluid, be used for preparing pharmaceutical compositions and fermented foods for relieving constipation and PFOA toxicity, and has a very broad application prospect.
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Description

technical field

[0001] The invention belongs to the technical field of microorganisms, and in particular relates to Lactobacillus rhamnosus CCFM1068 and application thereof. Background technique

[0002] In recent years, with the continuous development of my country's social and economic level, the living standards of the public have continued to improve, the proportion of carbohydrates and fats in the diet structure has increased, and the proportion of crude fiber has gradually decreased. Changes in dietary structure have gradually changed people's intestinal flora. Studies have shown that there are significant differences in the intestinal flora of the constipated population and the normal population. At present, the intervention of probiotics on intestinal flora has become a research hotspot, so it can relieve constipation by mediating intestinal flora.

[0003] Constipation has many symptoms, the main manifestations are: defecation effort, hard stool, feeling of wantin...

Claims

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