Medicated wine for treating rheumatism comprises the compositions: 15 g of angelica sinensis, 10 g of radix rehmanniae praeparata, 15 g of rhizoma ligustici wallichii, 15 g of taxillus sutchuenensis, 10 g of radix paeoniae alba, 10 g of rhizoma gastrodiae, 10 g of radix rehmanniae, 10 g of poria cocos, 10 g of radix gentianae macrophyllae, 10 g of radix aucklandiae, 10 g of radix astragali preparata, 10 g of polygala tenuifolia, 15 g of Chinese wolfberry, 15 g of charred white atractylodes rhizome, 15 g of radix dipsaci asperoidis, 15 g of eucommia ulmoides, 10 g of cassia twig, 15 g of homalomena occulta, 10 g of illicium difengpi, 20 g of safflower, 15 g of radix saposhnikoviae, 7.5 g of radix achyranthis bidentatae, 10 g of herba schizonepetae, 10 g of pericarpium citri reticulatae, 10 g of semen brassicae, 10 g of apricot kernel, 15 g of papaya, 10 g of notopterygium root, 15 g of cortex acanthopanacis, 15 g of rhizoma cibotii, 1000 g of rock sugar, and 1500 mL of pure grain Baijiu. Through long-term clinical trials, the medicated wine overcomes the shortages of traditional medicated wine, has the health-care effects of adjusting the balance of yin and yang, clearing heat and detoxifying, promoting blood circulation to remove blood stasis, inducing diuresis for replenishing blood, tonifying qi, nourishing yin, strengthening spleen and stomach, tonifying liver and kidney, and regulating menstruation and relieving pain, and especially has relatively good therapeutic effects on rheumatism palsy, low back aching pain, muscles and bones pain and joint swelling and pain.