41results about How to "Reduce adverse symptoms" patented technology

The invention discloses methods for identifying antibodies that reduce or prevent signaling by intact epidermal growth factor receptor (EGFR), or mutant EGFRs, such as EGFRvIII.

Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of their use for imaging senescent cells in vivo and for treating or preventing cancer, age-related disease, tobacco-related disease, or other diseases and disorders related to or caused by cellular senescence in a mammal. The methods include administering one or more of the agents of the invention to a mammal, e.g., a human. The agents, which specifically bind to senescent cells, can be labeled with a radioactive label or a therapeutic label, e.g., a cytotoxic agent.

The present invention is directed to conjugates that include a polypeptide capable of crossing the blood-brain barrier or entering one or more cell types attached to a transport vector, i.e., a composition capable of transporting an agent (e.g., a therapeutic agent). In certain cases, the polypeptides are directly conjugated to a lipid or polymeric vector to allow targeted application of a therapeutic agent to treat, for example, a cancer, a neurodegenerative disease, or a lysosomal storage disorder.

Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of their use for imaging senescent cells in vivo and for treating or preventing cancer, age-related disease, tobacco-related disease, or other diseases and disorders related to or caused by cellular senescence in a mammal. The methods include administering one or more of the agents of the invention to a mammal, e.g., a human. The agents, which specifically bind to senescent cells, can be labeled with a radioactive label or a therapeutic label, e.g., a cytotoxic agent.

The present inventions features methods for treating or preventing cancer (e.g., cancer of the central nervous system) by administering a compound that inhibits PAK kinase activity and / or merlin phosphorylation to a mammal (e.g., a human). The invention also provides screening methods for identifying additional inhibitors of PAK kinase activity and / or merlin phosphorylation.

This invention features methods and compositions for treating cancer and modulating signal transduction and metabolism pathways. For example, the methods and compositions of the invention can be used to kill or inhibit the growth or spread of cancer cells. The invention also features a method of identifying a compound that modulates a signal transduction or metabolic pathway.

The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.

The present inventions features methods for treating or preventing cancer (e.g., cancer of the central nervous system) by administering a compound that inhibits PAK kinase activity and / or merlin phosphorylation to a mammal (e.g., a human). The invention also provides screening methods for identifying additional inhibitors of PAK kinase activity and / or merlin phosphorylation.

The invention features a class of 2-nitroimidazole compounds with a secondary basic nitrogen atom and a linker bearing one or more therapeutic agents, cytotoxic agents, detectable labels, or chelating groups. In particular, the invention provides 2-nitroimidazole compounds containing a cluster of boron atoms for use in boron neutron capture therapy (BNCT). The 2-nitroimidazole compounds can be used to treat hypoxic conditions, including, e.g., cancer, inflammation, and ischemia. The weakly basic 2-nitroimidazole compounds target to hypoxic tissue and provide increased tissue concentration overall.

A flashing dot is alternately shown in the left image and right display of a binocular device at short intervals so as to allow a user to detect the misalignment in the displays. If misalignment occurs, the user sees a dot moving between two locations. The user uses a device or a software program to move the dot for minimizing the apparent movement until a single stationary dot is observed.

The invention provides methods for the administration of an anti-CD 1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, allergy, asthma, inflammatory condition, graft versus host disease, graft rejection, immunodeficiency disease, spontaneous abortion, pregnancy, and cancer.

The invention discloses a fertilizer for improving the stress resistance of corn. Raw materials of the fertilizer comprise pig manure, marsh mud, straw powder, fly ash, cake meal, urea formaldehyde, calcium nitrate, a calcium magnesium phosphate fertilizer, potassium dihydrogen phosphate, potassium chloride, agricultural rare earth, expanded perlite, borax, shell powder, animal bone meal, malic acid, tartaric acid, citric acid, humic acid, fulvic acid, a microbial agent, a microelement fertilizer, a plant growth regulator and a Chinese herbal medicine additive. The fertilizer for improving the stress resistance of corn has the advantages of reasonable formula, high fertilizer utilization efficiency, long fertilizer effect, realization of effective improvement of the soil environment and prevention of soil hardening after being applied, effective improvement of the stress resistance of the corn, promotion of the yield increase of the corn, effective improvement of the quality of the corn, good economic benefit, and promotion of the sustainable development of the agriculture in China.

The invention discloses a planting method of Trichosanthes kirilowii Maxim. The planting method includes: culturing seedlings, selecting land and preparing soil, transplanting the seedlings, performing field management and performing disease and pest control. The planting method has the advantages that a stress-resistance nutrient solution is injected into root tubers and then the leaves and the roots of the seedlings are sprayed with stress-resistance processing liquid, so that the survival rate of the root tubers developing into the seedlings is increased, the survival rate of the planted seedlings is increased, and the growth and development of the seedlings is promoted; high yield and high quality are achieved by applying fertilizer special for the Trichosanthes kirilowii Maxim and using green traditional Chinese medicine to perform the disease and pest control; the planting method is high in Trichosanthes kirilowii Maxim seedling transplanting survival rate, good in seedling growth and development and capable of increasing and stabilizing yield and increasing quality.

The present disclosure provides a method for alleviating or suppressing tobacco or nicotine associated withdrawal symptoms and ease smoking cessation in individuals who wish to quit or decrease smoking tobacco or nicotine comprising the use of probiotic microorganisms.

The invention discloses a health pig feed in summer. The health pig feed is characterized by comprising the following components in parts by weight: 40-45 parts of corn, 16-20 parts of wheat bran, 10-15 parts of sorghum rice, 20-22 parts of bean cake, 1-1.5 parts of bone meal, 4-4.5 parts of fish meal, 2-2.5 parts of edible salt, 5-6 parts of oyster shell, 0.1 part of cyrtomium fortunei, 0.3-0.5 part of Chinese yam, 0.2 part of poria cocos, 0.1 part of pericarpium citri reticulatae, 0.2 part of hawthorn, 0.1 part of sea-buckthorn, 0.1 part of radix isatidis, 0.2 part of abrus cantoniensis hance, 0.1 part of sophora fruit, 0.2 part of lophatherum gracile, 0.1 part of witloof, 0.5 part of poplar flower, 0.1 part of gynostemma pentaphylla, 0.1 pinellia ternate, 0.1 part of phellodendron chinense, 0.1 part of pomegranate bark, 0.2-0.5 part of muskmelon pedicel, 0.2-0.25 part of medulla stachyuri, 0.1-0.2 part of saussurea japonica, 0.1-0.2 part of cremanthodium reniforme and 0.1 part of pericarpium arecae. The pig feed disclosed by the invention is beneficial to normal growth and development of pigs, and is capable of ensuring a good immune system, and avoiding various problems of low immunity, weak resistance, inappetence, slow weight gain, diarrhea and the like of the pigs caused by the environmental influence in summer.

The invention relates to a huperzine osmotic-pump controlled release tablet, which is composed of tablet core containing huperzine and semipermeable film coating with small holes. The huperzine osmotic-pump controlled release preparation is characterized in that the preparation comprises the following components by the weight percent: 0.2-0.6 percent of huperzine in the tablet core, 85-95 percent of osmotic pressure accelerating agent, 1-10 percent of suspending agent and o.1-5 percent of other components. A coating film contains cellulose acetate, PEG (polyethyleneglycol) 4000 and a plasticizing agent, and the proportion of the cellulose acetate, the PEG4000 and the plasticizing agent is 1: (0.3-0.4) : (0.1-0.2). The weight of the coating is increased by 11-13 percent.

The invention discloses a porcupine breeding system. The porcupine breeding system is characterized in that a physical portion, a food portion and a feeding method are provided; the physical portion comprises a courtyard built with surrounding walls, and the courtyard is built in the open and is larger than 400m<2> in area; the courtyard is square or round; the surrounding walls are 1.3m high from the ground; the underground part of each surrounding wall is 0.5m; a plurality of pens are arranged at the center of the courtyard, and the edge of each pen is at least 4m away from the closest one of the surrounding walls; the pens are built on a platform at least 1.2m high from the ground; each pen is square or round and not smaller than 4m<2> in area; at most three porcupines are bred in each pen. The porcupine breeding system has the advantages that environmental conditions and a foot system are used together to form a disease control system and a temperament control system, the environmental conditions, the disease control system, temperament control measures and the food system in the porcupine breeding system collocate, act and balance with one another, porcupine behaviors and internal balance are improved, and immunity, behaviors, temperament and appetite of the porcupines are all under good control.

The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing cancer and other related diseases that result in dysregulation of malic enzyme 2. In particular, the methods and compositions include combination therapy, such as with a combination of two or more ME2 inhibitors or a combination of an ME2 inhibitor and an anticancer agent.

The present invention discloses a stocking method for porcupines, and is characterized in that the stocking method comprises the steps of building a physical part, selecting a food part and selecting a feeding method. The physical part comprises a courtyard enclosed by bounding walls, the courtyard is built on an open space, and the area of the courtyard is greater than 400 square meters; the courtyard is square or circular; the bounding walls are 1.3 meters high off the ground; the bounding walls are 0.5 meters deep into the ground; the middle of the courtyard is provided with a plurality of hog houses, and a distance from an edge of each hog house to the nearest bounding wall is at least 4 meters; each hog house is built on a platform which is at least 1.2 meters high off the ground; each hog house is square or circular, and the area of each hog house is no less than 4 square meters; and no more than 3 porcupines are stocked in each hog house. Environmental conditions and food systems in the cultivation system are mutually cooperated to generate a disease control system and a disposition control system, the environmental conditions, the disease control system, the disposition control system and the food systems in the cultivation system are mutually configured, acted and balanced, behaviors and internal balance of the porcupines are remoulded, and immunity, behaviors, disposition and spleen and stomach of the porcupines are well controlled.

The invention discloses an ingredient for conditioning porcupines. The ingredient is composed of the following components in parts by weight: 5-6 parts of oyster shell, 30-40 parts of mung beans, 3-4 parts of lotus seed kernel, 4-5 parts of radix rehmanniae, 0.5-1 part of coptis chinensis, 3-5 parts of the root of straight ladybell, 1-2 parts of abrus herb, 10-12 parts of wax gourd, 4-5 parts of lily, 0.1-0.2 part of scaphium scaphigerum, 2-3 parts of cortex lycii radicis, 2-3 parts of longhairy antenoron herb, 4-5 parts of selfheal, 3-5 parts of radix ophiopogonis, 2-3 parts of polygonatum odoratum, 3-4 parts of lalang grass rhizome, 2-3 parts of cyrtomium fortunei, 5-7 parts of Chinese yam, 2-4 parts of polygala root, 1-2 parts of cremanthodium reniforme, 1-2 parts of herba artemisiae adamsii and 2-3 parts of soroseris gillii. The ingredient disclosed by the invention has balanced nutrition, and in addition, the food cooperates with the Chinese herbal medicines to regulate internal balance of the porcupines, so that the external behaviors of the porcupines are influenced to reduce anxious, irritable, wild and violent behaviors of the porcupines in a breeding process. Diarrhea, parasite and other diseases or symptoms are reduced further. The invention further discloses a preparation method for the ingredient.

The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

The present invention relates to methods for treating cancer through combination therapy with a TRP channel antagonist and standard-of-care cancer agents.

The present invention discloses a breeding method for porcupines, and is characterized in that the stocking method comprises a physical part, a food part and a feeding method. The physical part comprises a courtyard enclosed by bounding walls, the courtyard is built on an open space, and the area of the courtyard is greater than 400 square meters; the courtyard is square or circular; the bounding walls are 1.3 meters high off the ground; the bounding walls are 0.5 meters deep into the ground; the middle of the courtyard is provided with a plurality of hog houses, and a distance from an edge of each hog house to the nearest bounding wall is at least 4 meters; each hog house is built on a platform which is at least 1.2 meters high off the ground; each hog house is square or circular, and the area of each hog house is no less than 4 square meters; and no more than 3 porcupines are bred in each hog house. Environmental conditions and food systems in the breeding system are mutually cooperated to generate a disease control system and a disposition control system, the environmental conditions, the disease control system, the disposition control system and the food systems in the breeding system are mutually configured, acted and balanced, behaviors and internal balance of the porcupines are remoulded, and immunity, behaviors, disposition and spleen and stomach of the porcupines are well controlled.

The invention discloses a porcupine nursing system which comprises a physical part, a food part, a feeding method and a temperature control method, wherein A, the physical part comprises a yard defined by walls, the yard is built outdoors, and a channel in which circulating warm air can be introduced is formed in a pig house; hay is arranged on the floors of the pig house; B, the food part comprises food I and food II; C, the feeding method comprises the following steps: feeding a porcupine once in the morning and at nightfall respectively; D, the temperature control method comprises the following steps: introducing the warm air into the pig house to increase the air temperature to be 18-22 DEG C when the air temperature is lower than 15 DEG C. According to the breeding system, by the environmental conditions, the food, the feeding method and the temperature control method, the influence of winter on breeding is avoided, and normal breeding incomes can be guaranteed.

The invention discloses a heath pig feed, comprising the following components in parts by weight: 45-50 parts of corn, 18-20 parts of wheat bran, 10-15 parts of sorghum rice, 20-22 parts of bean cake, 1-1.5 parts of bone meal, 3-3.5 parts of fish meal, 2-2.5 parts of salt, 5-6 parts of oyster shell, 0.1 part of cyrtomium fortune, 0.3-0.5 part of Chinese yam, 0.2 part of poria cocos, 0.2 part of hawthorn, 0.1 part of sea-buckthorn, 0.1 part of radix isatidis, 0.2 part of abrus cantoniensis hance, 0.1 part of sophora fruit, 0.2 part of lophatherum gracile, 0.1 part of witloof, 0.1 part of hot pepper stem, 0.2 part of kapok, 0.1 part of gynostemma pentaphylla, 0.1 part of pinellia ternate, 0.1 part of phellodendron chinense, 0.1 part of pomegranate bark, 0.2-0.5 part of muskmelon pedicel, 0.2-0.25 part of medulla stachyuri, 0.1-0.2 part of saussurea japonica and 0.1-0.2 part of cremanthodium reniforme. The feed disclosed by the invention is beneficial to normal growth and development of pigs, is capable of ensuring a good immune system, enhancing the resistance on diseases, keeping a good appetite state, reducing symptoms, ensuring normal growth and weight gain, and reducing use of hormone or antibiotic on animals, and is an environmental protection feed, and the fed pork is natural, and does not contain antibiotic or residue hormone.

The invention discloses a porcupine feeding food which is characterized by including a NO.1 food and a NO.2 food; the NO.1 food is composed of the following components in parts by weight: 20-25 parts of pumpkin, 10-15 parts of sweet potato, 5-10 parts of leaf lettuce, 35-40 parts of corn, 16-20 parts of wheat bran, 10-15 parts of sorghum rice, 10-15 parts of soybean, 1-1.5 parts of bone meal, 2-2.5 parts of table salt, and 5-6 parts of oyster shell. The NO.2 food is composed of the following components in parts by weight: 30-40 parts of corn, 20-30 parts of wheat, 20-30 parts of Chinese cabbage, 10-15 parts of radish, 30-40 parts of pumpkin, and 5-10 parts of peanut. The porcupine feeding food is beneficial for pig normal growth and development, ensures a good immune system, enhances the resistance to diseases, maintains a good appetite state, reduces adverse symptoms, ensures normal growth and weight gaining, can reduce the use of hormones or antibiotics on animals, is capable of strengthening spleen and benefiting stomach, and provides an ideal system. The porcupine feeding food can also reduce all kinds of diseases or symptoms such as diarrhea and parasites. The invention also provides a feeding method.

The present invention relates to the prevention, prophylactic and therapeutic treatment of autoimmune diseases including but not limited to multiple sclerosis by administering novel small molecules to a subject in need thereof.

The invention relates to a pharmaceutical composition with a thrombus prevention effect. The composition is prepared from the following traditional Chinese medicines in parts by weight: 42-78 parts ofmirabilite, 42-78 parts of rheum officinale, 42-78 parts of cacumen biotae, 21-39 parts of cortex phellodendri, 21-39 parts of mint, 21-39 parts of herba lycopi, 4.5-6.5 parts of borneol and 10.5-19.5 parts of cassia twigs. Through local external application, the composition can obviously reduce thrombus occurrence rate caused by PICC catheterization; the occurrence rate of related symptoms of the PICC catheterization, such as local swelling and pain and bleeding, is also obviously reduced; and thrombus related indexes, such as D dimer and FIB, are obviously reduced compared with those of a control group. The pharmaceutical composition disclosed by the invention has an obvious effect in the aspect of preventing thrombosis, can prevent and treat the hypercoagulable state of blood, conformsto the concept that the thrombus caused by the PICC catheterization depends on prevention, is safe, convenient and economical in prevention process, brings more benefits to patients, and improves thelife quality of tumor chemotherapy patients.