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Pharmaceutical composition with thrombus prevention effect and preparation method and application thereof

A technology of composition and medicine, applied in the field of pharmaceutical composition with antithrombotic effect and its preparation and application, to achieve the effects of preventing process safety, improving life quality, and preventing blood hypercoagulability

Active Publication Date: 2020-05-19
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have found that up to 75% of tumor patients have PICC-related thrombosis, but only 4% of patients with PICC-related thrombosis diagnosed by B-ultrasound have clinical symptoms

Method used

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  • Pharmaceutical composition with thrombus prevention effect and preparation method and application thereof
  • Pharmaceutical composition with thrombus prevention effect and preparation method and application thereof
  • Pharmaceutical composition with thrombus prevention effect and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 The preparation of the local external application preparation of the pharmaceutical composition of the present invention

[0020] Prescription: Glauber's salt 60g, rhubarb 60g, arborvitae leaves 60g, cork 30g, mint 30g, Eupatorium 30g, borneol 5g, cassia twig 15g.

[0021] Preparation: Weigh the medicinal material according to the prescription, grind it into powder, store it for later use, add 1 part of water and 1 part of honey, stir evenly, and prepare it for immediate use.

Embodiment 2

[0022] Embodiment 2 The preparation of the local external application preparation of the pharmaceutical composition of the present invention

[0023] Prescription: Glauber's salt 42g, rhubarb 42g, arborvitae leaves 42g, cork 21g, mint 21g, Eupatorium 21g, borneol 4.5g, cassia twig 10.5g.

[0024] Preparation: Weigh the medicinal material according to the prescription, grind it into powder, store it for later use, add 1 part of water and 1 part of honey, stir evenly, and prepare it for immediate use.

Embodiment 3

[0025] Embodiment 3 The preparation of the local external application preparation of the pharmaceutical composition of the present invention

[0026] Prescription: Glauber's salt 78g, rhubarb 78g, arborvitae leaves 78g, cork 39g, mint 39g, eupatorium 39g, borneol 6.5g, cassia twig 19.5g.

[0027] Preparation: Weigh the medicinal material according to the prescription, grind it into powder, store it for later use, add 1 part of water and 1 part of honey, stir evenly, and prepare it for immediate use.

[0028] The beneficial effects of the present invention are illustrated below through clinical experiments.

[0029] 1 Materials and methods

[0030] 1.1 General information

[0031] A total of 130 patients with malignant tumors requiring PICC catheterization in the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from January 2017 to January 2018 were selected. According to the odd and even numbers of hospitalization numbers, they were randomly divided ...

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Abstract

The invention relates to a pharmaceutical composition with a thrombus prevention effect. The composition is prepared from the following traditional Chinese medicines in parts by weight: 42-78 parts ofmirabilite, 42-78 parts of rheum officinale, 42-78 parts of cacumen biotae, 21-39 parts of cortex phellodendri, 21-39 parts of mint, 21-39 parts of herba lycopi, 4.5-6.5 parts of borneol and 10.5-19.5 parts of cassia twigs. Through local external application, the composition can obviously reduce thrombus occurrence rate caused by PICC catheterization; the occurrence rate of related symptoms of the PICC catheterization, such as local swelling and pain and bleeding, is also obviously reduced; and thrombus related indexes, such as D dimer and FIB, are obviously reduced compared with those of a control group. The pharmaceutical composition disclosed by the invention has an obvious effect in the aspect of preventing thrombosis, can prevent and treat the hypercoagulable state of blood, conformsto the concept that the thrombus caused by the PICC catheterization depends on prevention, is safe, convenient and economical in prevention process, brings more benefits to patients, and improves thelife quality of tumor chemotherapy patients.

Description

technical field [0001] The invention relates to a pharmaceutical composition with the effect of preventing thrombosis, its preparation method and application. Background technique [0002] Blood in patients with malignant tumors is often in a hypercoagulable state, accompanied by abnormal coagulation mechanisms, such as increased fibrin degradation products and thrombocytosis, especially in patients with metastatic cancer. PICC catheter placement is an essential part of malignancy treatment, especially chemotherapy. However, central venous catheterization increases the incidence of thrombosis, which is related to vessel wall damage during catheterization, stimulation by disinfectants, mechanical stimulation of vascular endothelial cells by long-term catheterization, influence of vascular endothelium on catheter materials, and intravascular catheter placement. The impact of infusion on blood return, decreased limb movement after catheterization, limited limb movement during ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P7/02A61K31/045A61K33/04
CPCA61K33/04A61K36/708A61K36/14A61K36/756A61K36/534A61K36/53A61K31/045A61K36/54A61P7/02A61K2300/00
Inventor 吴茂林杨淑艳钱琳黄梅蓉邓婧唐欣
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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