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Prevention, Prophylactic and Therapeutic Treatment of Autoimmune Diseases Including Multiple Sclerosis Using Novel Small Molecules and Compositions Thereof

a technology of autoimmune diseases and small molecules, applied in the field of new small molecules for the prevention, prophylactic and treatment of autoimmune diseases, can solve the problems of permanent neurological damage, no apparent cure, and disruption of the signaling ability of parts of the nervous system, so as to prevent the development of the disease, prevent demyelination, and significant therapeutic effects

Inactive Publication Date: 2022-06-16
UNIV OF SHARJAH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent is about using transdermal patches to treat certain symptoms of multiple sclerosis (MS). These patches can be made by dissolving or dispersing a compound in a suitable medium, and may also contain absorption enhancers to increase the uptake of the compound. The patches can be applied to the skin to deliver the compound to the body in a controlled manner. By using these patches, it is believed that the compound can help reduce demyelination, cause re-myelination, and slow down the progression of MS. Combination therapies with different compounds can be used, and may provide a more effective treatment for relapsing-remitting MS. Overall, this patent describes a novel way to treat various aspects of MS using transdermal patches.

Problems solved by technology

MS is a potentially disabling disease in which the immune system causes de-myelinization of the sheaths of nerve fibers, disrupting the signaling ability of parts of the nervous system.
MS causes permanent neurological damage and has no apparent cure.

Method used

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  • Prevention, Prophylactic and Therapeutic Treatment of Autoimmune Diseases Including Multiple Sclerosis Using Novel Small Molecules and Compositions Thereof
  • Prevention, Prophylactic and Therapeutic Treatment of Autoimmune Diseases Including Multiple Sclerosis Using Novel Small Molecules and Compositions Thereof
  • Prevention, Prophylactic and Therapeutic Treatment of Autoimmune Diseases Including Multiple Sclerosis Using Novel Small Molecules and Compositions Thereof

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Embodiment Construction

[0077]Prevention, Prophylactic or Therapeutic Treatment of MS using Novel Small Molecules

[0078]Experimental Parameters

[0079]A study was conducted using novel compounds SIMR-1281 and SIMR-1707 as disease modifying therapies for multiple sclerosis (MS) using experimental autoimmune encephalomyelitis (EAE) model. The above compounds were utilized as preventive, prophylactic or therapeutic drugs for MS. The evaluation of the effects of SIMR-1281 and SIMR-1707 was done through measuring the EAE clinical scores, body weight changes, and examining the histological features of the EAE untreated mice and comparing them to the treated mice. As a control, was used Rituximab (RTX), which has been used as an off-label drug for MS patients and EAE mice [2-12]. The results show a significant reduction in the clinical score severity and clinical features in the mice treated with SIM-1281 and SIMR-1707 compounds.

[0080]Experimental Procedures

[0081]The basic experimental approaches to test the efficac...

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Abstract

The present invention relates to the prevention, prophylactic and therapeutic treatment of autoimmune diseases including but not limited to multiple sclerosis by administering novel small molecules to a subject in need thereof.

Description

TECHNICAL FIELD[0001]The present invention relates to novel small molecules for prevention, prophylactic and treatment of autoimmune diseases, such as multiple sclerosis among others.BACKGROUND[0002]Multiple sclerosis (MS) is a chronic immune mediated and g-degenerative disease directed against central nervous system antigens. MS is a potentially disabling disease in which the immune system causes de-myelinization of the sheaths of nerve fibers, disrupting the signaling ability of parts of the nervous system. MS causes permanent neurological damage and has no apparent cure. Current available treatments of MS focus on reducing the frequency of relapses and prolong recovery period. There is a need for effective treatment or ideally for prevention of multiple sclerosis.SUMMARY OF THE INVENTION[0003]Provided are two novel compounds for the treatment, prophylactic and for prevention of autoimmune diseases, in particular MS.[0004]In one embodiment of the present disclosure is provided the...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D513/14C07D498/14A61P25/28
CPCC07D513/14A61P25/28C07D498/14
Inventor MAGHAZACHI, AZZAM A.AL-TEL, TALEBDHAIBAN, SARAHAL-AIN, MENAMOUSAAD ELEMAM, NOHAVUNNAM, SRINIVASULU
Owner UNIV OF SHARJAH
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