Prevention, Prophylactic and Therapeutic Treatment of Autoimmune Diseases Including Multiple Sclerosis Using Novel Small Molecules and Compositions Thereof

Abstract

The present invention relates to the prevention, prophylactic and therapeutic treatment of autoimmune diseases including but not limited to multiple sclerosis by administering novel small molecules to a subject in need thereof.

Description

TECHNICAL FIELD[0001]The present invention relates to novel small molecules for prevention, prophylactic and treatment of autoimmune diseases, such as multiple sclerosis among others.BACKGROUND[0002]Multiple sclerosis (MS) is a chronic immune mediated and g-degenerative disease directed against central nervous system antigens. MS is a potentially disabling disease in which the immune system causes de-myelinization of the sheaths of nerve fibers, disrupting the signaling ability of parts of the nervous system. MS causes permanent neurological damage and has no apparent cure. Current available treatments of MS focus on reducing the frequency of relapses and prolong recovery period. There is a need for effective treatment or ideally for prevention of multiple sclerosis.SUMMARY OF THE INVENTION[0003]Provided are two novel compounds for the treatment, prophylactic and for prevention of autoimmune diseases, in particular MS.[0004]In one embodiment of the present disclosure is provided the...

AI Technical Summary

Benefits of technology

[0033]Transdermal patches have the added advantage of providing controlled delivery of the compound to the body. Such dosage forms can be made by dissolving or dispersing an extract in the proper medium. Absorption enhancers can also be used to increase the flux of the extract or dispersing the extract in a polymer matrix or gel.

[0040]The term “treatment” is used conventionally, e.g., the management or care of a subject for the purpose of combating, alleviating, reducing, relieving, improving, etc., one or more of the symptoms associated with MS. Administering effective amounts of the compound can treat one or more aspects of MS, including, but not limited to, reducing demyelination; causing re-myelination; reducing disease progression; stabilizing the disease; prolonging patent survival; enhancing patient's quality of life; reducing adverse symptoms associated with MS; and reducing the frequency, severity, intensity, and / or duration of any of the aforementioned aspects.

[0044]The combined use of the compounds may reduce the required dosage for any individual component because the onset and duration of effect of the different components may be complementary. In such combination therapies, the different active agents may be delivered together or separately, and simultaneously or at different times within the day.

Problems solved by technology

MS is a potentially disabling disease in which the immune system causes de-myelinization of the sheaths of nerve fibers, disrupting the signaling ability of parts of the nervous system.

MS causes permanent neurological damage and has no apparent cure.

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