Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease

a technology of senescence cells and senescence, which is applied in the field of detection and treatment of cancer, age-related diseases, tobacco-related diseases, etc., can solve the problems of cellular senescence, increased cancer incidence and severity, and questionable whether replicative senescence actually contributes to aging or age-related symptoms in vivo, so as to reduce the size of tumors or the number, slow or prevent the growth of cancer cells, and stabilize the effect of cancer
US20150151001A1Inactive Publication Date: 2015-06-04UNITY BIOTECHNOLOGY INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNITY BIOTECHNOLOGY INC
Publication Date
2015-06-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of their use for imaging senescent cells in vivo and for treating or preventing cancer, age-related disease, tobacco-related disease, or other diseases and disorders related to or caused by cellular senescence in a mammal. The methods include administering one or more of the agents of the invention to a mammal, e.g., a human. The agents, which specifically bind to senescent cells, can be labeled with a radioactive label or a therapeutic label, e.g., a cytotoxic agent.
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Description

STATEMENT REGARDING SEQUENCE LISTING

[0001] The Sequence Listing associated with this application is provided in text format in lieu of a paper copy, and is hereby incorporated by reference into the specification. The name of the text file containing the Sequence Listing is 200201—401D1_SEQUENCE_LISTING.txt. The text file is 70.5 KB, was created on Nov. 29, 2014, and is being submitted electronically via EFS-Web.FIELD OF THE INVENTION

[0002] This invention relates to compositions and methods for the detection and treatment of cancer, age-related diseases, tobacco-related diseases, and other diseases and disorders related to or caused by cellular senescence.BACKGROUND OF THE INVENTION

[0003] The definition of cellular senescence has undergone some revision since the phenomenon was described by Leonard Hayflick as cessation of replication of cultured human cells after a finite number of population doublings (Hayflick et al., Exp. Cell Res. 37:585-621, 1961). Senescent cells remain metabolic...

Claims

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