The invention discloses a medicine for preventing fowl plague, which is prepared by the following raw materials according to the weight portion: 5-15 of peach kernel, 3-10 of safflower, 5-15 of red paeonia, 5-15 of cortex moutan, 5-15 of trihosanthes root, 10-20 of ordate houttuynia, 5-15 of balloon flower, 5-15 of almond, 5-15 of liquorice, 5-15 of burdock, 10-20 of chrysanthemum, 10-20 of mulberry leaf, 5-15 of peppermint, 5-15 of radix bupleuri, 10-30 of dyers woad leaf, 10-30 of dandelion, 10-30 of radix isatidis, 10-30 of honeysuckle, 10-30 of forsythia, 5-15 of alisma orientale, 5-15 of betelnut and 5-15 of radix sileris. The invention has reasonable medicine formulation, low cost and remarkable treatment effect, and is easy to largely popularize and use.