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Traditional Chinese medicinal preparation for treating primary thrombocytopenia

A technology of traditional Chinese medicine preparations and platelets, applied in the field of medicine, can solve the problems of insufficient, vulnerable, bleeding, infection, etc.

Inactive Publication Date: 2011-05-18
天津金世制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the malignant proliferation of tumor cells, it inhibits the production of red blood cells and platelets to stop bleeding, and there is not even enough normal white blood cells to fight infection, so it is easy to be injured, bleeding, and infected

Method used

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  • Traditional Chinese medicinal preparation for treating primary thrombocytopenia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Cinnamon-free 10 parts, Atractylodes macrocephala 30 parts, Radix Astragali 30 parts, Codonopsis 15 parts, Salvia miltiorrhiza 15 parts, Rhizoma Chuanxiong 15 parts, Ganoderma lucidum 10 parts, (heating or percolation) 2 times, combined 2 extracts, and recovered ethanol under reduced pressure to obtain The crude extract and the dregs were discarded. The crude extract is adjusted to pH 7-8 with 5% NaOH solution to obtain an alkaline liquid, which is extracted with chloroform (or petroleum ether). Separate the solvent layer, discard it, adjust the pH of the water layer to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify the precipitate for later use. After drying, 30g (C) is obtained, and the solution is extracted with chloroform (or petroleum ether). The layers were separated, the water layer was concentrated to obtain 86g, and the solvent layer was concentrated to obtain an extract, which was dried to obtain 40g of (D), which was uniformly mixed with the aci...

Embodiment 2

[0039] Mix 30 parts of Atractylodes macrocephala, 30 parts of Radix Astragali, 15 parts of Codonopsis pilosula, 15 parts of Salvia miltiorrhiza, 15 parts of Rhizoma Chuanxiong, and 10 parts of Ganoderma lucidum, extract twice with 18 times the amount of 50% ethanol, combine the two extracts, recover ethanol under reduced pressure, and obtain a crude extract The medicine residue was discarded. Adjust the pH of the crude extract to 7-8 with 5% NaOH solution to obtain an alkaline liquid, filter, discard the precipitate, adjust the pH of the supernatant to 2-4 with 5% sulfuric acid, place it, centrifuge, and acidify Standby, after drying, 34g was obtained. The solution was extracted with ethyl acetate (or n-butanol), separated into layers, the water layer was discarded, and the solvent layer was concentrated to obtain the extract, which was dried to obtain 45g, and mixed with the acidic precipitate to obtain a mixture of 79g. Mix the extract and 10 parts of cinnamon evenly, add 20...

Embodiment 3

[0041] 80 parts of cinnamon-free, 50 parts of Astragalus, 50 parts of Codonopsis, 50 parts of Danshen, 50 parts of Chuanxiong, 30 parts of Ganoderma lucidum, mixed with 18 times the amount of 1% sodium hydroxide (or sodium carbonate) solution to extract twice, combined 2 The secondary extract was concentrated under reduced pressure to obtain a crude extract, and the dregs were discarded. The crude extract was applied to a silica gel column, eluted with chloroform (or ethyl acetate, methanol), and each fraction was collected for qualitative identification with magnesium powder-hydrochloric acid. The positive fractions were combined and concentrated under reduced pressure to obtain 30 g of the mixture. Mix the extract with 10 parts of decinnamon evenly, add No. 2 capsules to make capsules.

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Abstract

The invention discloses a traditional Chinese medicinal preparation for treating primary thrombocytopenia, which is prepared from the following raw material medicaments in part by weight: 10 to 50 parts of cassia bark, 30 to 50 parts of large-headed atractylodes rhizome, 30 to 50 parts of astragalus, 15 to 50 parts of szechwon tangshen root, 15 to 50 parts of root of red-rooted salvia, 15 to 50 parts of szechuan lovage rhizome and 10 to 30 parts of glossy ganoderma. The traditional Chinese medicinal preparation has the obvious curative effect on leukemia, has a certain curative effect on lung cancer, myeloma multiplex, nasopharyngeal darcinoma and the like and particularly has the good short-term curative effect on primary thrombocytopenic purpura, and has 86 percent of remission rate and low toxic and side effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine preparation for treating idiopathic thrombocytopenic purpura. Background technique [0002] Leukemia is a malignant disease of hematopoietic tissue, also known as "blood cancer". It is characterized by the unlimited proliferation of a large number of anucleated cells in the bone marrow and other hematopoietic tissues, and enters the peripheral blood, and the core of normal blood cells is obviously absorbed. This disease ranks first among malignant diseases in young people. Sexual negative tissue hyperplasia, and many factors such as food mineral radioactivity, poisoning (benzene, etc.) or drug variation, genetic quality, etc. may be pathogenic cofactors. According to the degree of immaturity of leukemia cells and the natural course of leukemia, it is divided into two categories: acute and chronic. [0003] Leukemia is a malignant tumor of the hem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/54A61P7/00A61P35/02
Inventor 宋富智
Owner 天津金世制药有限公司
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