44 results about "Bacterial septicemia" patented technology

The invention relates to a special compound feed for sturgeon, and a preparation method thereof. The special compound feed is prepared from the following materials according to weight percent: 28%-40% of bean pulp, 20%-25% of wheat middling, 25%-35% of fish meal, 7%-9% of fish oil, 6%-7% of shrimp powder, 0.2%-0.4% of salt, 0.1%-0.3% of bilineurine, and 0.9%-1.5% of special sturgeon feed additives, wherein the sum of the weight percent of the materials is 100%. By adopting the special compound feed for the sturgeon disclosed by the invention, the economic benefits of artificial breeding of the sturgeon can be obviously improved, the diseases, especially bacterial septicemia, a bacterial hemorrhagic disease and bacterial enteritis, in the artificial breeding process of the sturgeon can be obviously reduced, the survival ratio of the sturgeon is improved by 13%-16%, the growth of the sturgeon promoted, and the quality of the sturgeon can be improved. As the raw materials of the feed are cheap, the production and use costs of the special compound feed are relatively low and are saved.

The invention relates to a fishery Chinese and western compound medicine composition as well as a premix compound, batch mixture and application thereof and discloses a fishery Chinese and western compound medicine composition. The fishery Chinese and western compound medicine composition comprises the following components, namely, rheum officinale, golden cypress, scutellaria baicalensis, coptis chinensis, radix bupleuri, liquorice, gypsum and enrofloxacin. The fishery Chinese and western compound medicine composition has remarkable curative effects and takes quick effects on common bacterial diseases, such as bacterial septicemia, gill rot and red skin disease of aquatic livestock. The fishery Chinese and western compound medicine composition is stable in quality, convenient to use and low in cost, has the advantages of small toxic and side effects, efficient broad-spectrum, safety, environmental friendliness and the like and can be used for effectively ensuring the health and safety of the aquaculture animals.

The invention discloses a preparation method of microcapsule vaccines capable of resisting the infection of aeromonas hydrophila, relating to the field of the preparation of antibacterial vaccines and solving the problems of time and labor wasting and difficult in large-scale popularization during the practical operations of cultivating fish and the like with immunotherapy by means of vaccine injection. The preparation method of the microcapsule vaccines capable of resisting the infection of the aeromonas hydrophila comprises the following steps of: (1) the preparation of aeromonas hydrophila suspension: inoculating the aeromonas hydrophila to prepare the aeromonas hydrophila suspension with the effective viable bacteria content of 1010 per ml, inactivating the aeromonas hydrophila suspension with formalin, and storing the suspension; and (2) the preparation of the microcapsule vaccines of the aeromonas hydrophila: uniformly mixing the aeromonas hydrophila suspension prepared in the step (1) and a 5% sodium alginate solution in the proportion of 1:1 in a vortex oscillator, and performing spraying and drying treatment on the mixture to obtain microcapsule particles. The method can be used for preparing the microcapsule vaccines for preventing and treating bacterial septicemia of sturgeon, particularly acipenser baeri.

The invention discloses application of LECT2 protein and LECT2 protein variant in pharmacy, and particularly relates to application LECT2 protein and LECT2 protein variant in preparation of medicines for improving the phagocytosis of macrophage and/or preventing and treating bacterial septicemia. The LECT2 protein variant is a modification product of the LECT2 protein sequence, and is obtained by changing, replacing, substituting, inserting or losing one or more amino acids in the code sequence; at least 60% of the amino acid sequence of the LECT2 protein variant is the same as the amino acid sequence of the LECT2 protein; the LECT2 protein and LECT2 protein variant can induce the activity change of the macrophage to improve the phagocytosis of macrophage, and thus the septicemia caused by bacteria invasion can be prevented and treated; and the curate rate of a mice bacterial septicemia model can exceed 40%.

The invention discloses a use of aeromonas hydrophila phage AH10-Phage-QY01 in preparation of medicines for treating or preventing and controlling bacterial diseases in aquaculture, and belongs to thetechnical field of prevention and control of bacterial diseases in aquaculture. The phage AH10-Phage-QY01 is preserved in China Center for Type Culture Collection and has the preservation number of CCTCC NO:M2019109. The invention also includes a use of the phage AH10-Phage-QY01 in preparation of medicines for bacterial septicemia caused by aeromonas hydrophila. The phage AH10-Phage-QY01 can be used alone or in combination with antibiotics. The universality of the phage and high specificity to host bacteria are used, the aeromonas hydrophila phage AH10-Phage-QY01 is screened for the first time from natural environment for pathogenic bacteria, and is used for inhibiting and cracking the pathogenic bacteria, treating or preventing and controlling bacterial septicemia and other bacterial fish diseases caused by the pathogenic bacteria.

The invention relates to a compound traditional Chinese medicine preparation for preventing and treating bacterial septicemia of fishes. The compound traditional Chinese medicine preparation is prepared from the following components: unprepared rehmannia roots, honeysuckles, fructus forsythiae, herba violae, figwort roots, rhubarbs, baikal skullcap roots and liquorice roots. The compound traditional Chinese medicine is prepared by the following steps: weighing the components in parts by weight, adding the components into a smasher respectively, smashing the components, sieving, mixing, and sieving. When in use, the compound traditional Chinese medicine is mixed with a feeder according to a certain proportion, and then a powdery bonding agent is added into the mixture of the compound traditional Chinese medicine and the feeder to form a medicinal bait. The medicinal bait needs to be aired before being fed to fishes. After the fishes are fed by the medicinal bait continuously for a period of time, the disease of the fishes can be controlled gradually, the appetite of the fishes can return to be normal, and the observation on the dissected fish shows that the upper jaw, lower jaw, oral cavity, branchial mantle, eyes and abdomen of the fish return to be normal, the color of the back of the fish becomes normal. The fishes fed by the preparation can grow well, no medicine is left, and side and toxic effects do not exist.

The invention discloses a sturgeon-source aeromonas hydrophila and an application thereof. The collection number of the sturgeon-source aeromonas hydrophila is CCTCC NO:M 2016555. Inactivated vaccine prepared with the sturgeon-source aeromonas hydrophila can prevent sturgeon bacterial septicemia. The quantity of the aeromonas hydrophila HZ8 (Aeromonas HydrophilaHZ8) in the inactivated vaccine is larger than or equal to 1.0*10<8> CFU/ml. The screened sturgeon-source aeromonas hydrophila has the high pathogenicity, the inactivated vaccine prepared with the sturgeon-source aeromonas hydrophila can prevent sturgeon bacterial septicemia, and the sturgeon-source aeromonas hydrophila has good market popularization prospects.

The invention relates to a construction method of a grass carp anti-bacterial septicemia strain. The construction method comprises the following steps: a) selecting parent fishes, applying PIT (Point In Time) electronic tags to the parent fishes, when the parent fishes are mature in sexual glands, injecting hormone to accelerate maturation, performing natural fertilization, hatching fertilized ova to be baby fishes, cultivating fingerlings, and cultivating one-year-old fishes and two-year-old fishes in the same pool; b) respectively using pathogenic bacteria to infect offspring artificially in the baby fish phase and the 2-year-old fish phase, observing for 19-23 days after infection, and taking the residual individuals as a disease-resistant colony; c) adopting a paternity test method to perform progeny test on the obtained disease-resistant colony, selecting the parent fishes with strong disease resistance from the parent fishes, and in the second year, matching and propagating the parent fishes with strong disease resistance, and constructing the grass carp anti-bacterial septicemia strain. The construction method disclosed by the invention avoids the environment effect, can ensure that the obtained disease-resistant parent through screening is the real one with excellent heredity, ensures that the cultivated disease-resistant strain is of good disease-resistant performance; meanwhile, the method is easier to operate, and suitable for large-scale breeding for disease resistance.

The invention relates to a medicinal composition for preventing and controlling pebrine and application of the medicinal composition. The composition contains albendazole, florfenicol and trisodium phosphate. A parasite killing mechanism of albendazole is used for metabolizing the medicinal composition in host silkworms to form an internal environment of the medicinal composition to disable the survival and breeding of microsporidia parasites in the host silkworms, so that good prevention and control effects on the pebrine are achieved; the wide antibacterial spectrum of the florfenicol is combined, so that bacterial gastrointestinal diseases caused by various gram positive bacteria and bacterial septicemia caused by gram negative bacteria in the silkworms can be effectively controlled, and the probability of potential bacterial diseases probably caused by the addition of an albendazole solution can be reduced; in addition, the trisodium phosphate has solubilization helping and synergistic effects, so that the release of the albendazole and the florfenicol can be accelerated to reach target concentration, and control effects are improved. When the silkworms are fed with the medicinal composition, the food intake and albendazole absorption rate of the silkworms can be increased, so that the effects of preventing and controlling the pebrine and bacterial diseases of the silkworms only by virtue of low-concentration albendazole can be achieved, and the medication cost is lowered.

The invention discloses an egg yolk antibody microcapsule feed additive for resisting carassius auratus gibelio bacterial septicemia. The additive consists of three kinds of raw materials, namely, egg yolk antibody freeze-dried powder for resisting the carassius auratus gibelio bacterial septicemia, astragalus powder and beta-cyclodextrin, wherein the egg yolk antibody freeze-dried powder for resisting the carassius auratus gibelio bacterial septicemia is mainly used for lowering the infection rate of carassius auratus gibelio by three kinds of mesophilic aeromonas or preventing carassius auratus gibelio from being infected by the three kinds of mesophilic aeromonas; the astragalus powder is used for enhancing the immunity of the carassius auratus gibelio; the beta-cyclodextrin is mainly used for realizing embedding and slow release of the egg yolk antibody freeze-dried powder. When the microcapsule feed additive and a commercially available carassius auratus gibelio compound feed are fed together according to a certain proportion, diseases caused by three kinds of pathogenic mesophilic aeromonas can be prevented and treated during cultivation of the carassius auratus gibelio, the yield of the carassius auratus gibelio is increased, and the economical benefit of carassius auratus gibelio cultivation is increased remarkably. The problem of bacterial septicemia in current carassius auratus gibelio production is solved.

The invention discloses a grass carp bacterial septicemia and red skin disease bigeminy propolis inactivated vaccine.The grass carp bacterial septicemia and red skin disease bigeminy propolis inactivated vaccine is prepared from an aeromonas hydrophila culture inactivating solution, a pseudomonas aeruginosa culture inactivating solution, normal saline and a propolis ethyl alcohol soaking solution.The invention further provides a factory-like preparing method for the grass carp bacterial septicemia and red skin disease bigeminy propolis inactivated vaccine.The factory-like preparing method comprises the steps that the aeromonas hydrophila culture inactivating solution, the pseudomonas aeruginosa culture inactivating solution, the normal saline and the propolis ethyl alcohol soaking solution are mixed evenly at the proportion of 12:10:76.4:1.6 and stirred, sterile filling is carried out, and the grass carp bacterial septicemia and red skin disease bigeminy propolis inactivated vaccine finished product is obtained.According to the grass carp bacterial septicemia and red skin disease bigeminy propolis inactivated vaccine and the factory-like preparing method, the defect that a grass carp single inactivated vaccine is only used for one kind of grass carp pathogenic bacteria is overcome, the bigeminy vaccine is provided to reach the effect of simultaneously defending two kinds of pathogenic bacteria of grass carps through one-time immunization, and the vaccine is convenient to apply through injection and soaking.

The invention discloses an application of chitosan in preparing drugs for preventing and curing bacterial septicemia of silkworm. The drug can obviously reduce the risk of infection of the bacterial septicemia of silkworm and has obvious curative effect. The adoption of the drug for preventing and curing bacterial septicemia of silkworm is easy to operate and has lower cost; and more importantly, the preventing and curing links can not generate any threat to the health of workers working for preventing and curing.

The invention discloses a feed additive for controlling the hemorragic disease of grass carp. The feed additive is prepared from, by weight, 1-10 parts of pine needle meal, 3-18 parts of humifuse euphorbia herb, 3-15 parts of radix angelica sinensis, 3-18 parts of Chinese tallow tree, 1-15 parts of honeysuckle flower, 5-30 parts of allicin, 1-15 parts of folium syringae, 1-12 parts of semen pharbitidis, 3-18 parts of table salt, 1-12 parts of rhizoma atractylodis, 3-18 parts of hawthorn fruit and 0.2-10 parts of malt. The feed additive can prevent and treat the hemorragic disease of freshwater aquaculture grass carp, and has remarkable treatment and prevention effects on viral hemorrhagic disease, bacterial septicemia, hemolytic ascitic disease and hemorrhagic ascites syndromes caused by parechovirus and underjaw, oral cavity, branchial gland, gill rot, anus redness and swelling and red skin disease caused by yersinia ruckeri.

The invention relates to a disease-resistant Chinese herbal medicine and egg yolk antibody compound additive for siniperca chuatsi. The additive consists of egg yolk antibodies for resisting bacterialsepticemia of the siniperca chuatsi, lixivium of 3 Chinese herbal medicines and beta-cyclodextrin, wherein the egg yolk antibodies for resisting bacterial septicemia of the siniperca chuatsi are mainly used for reducing the possibility that the siniperca chuatsi is infected with high-pathogenicity aeromonas hydrophila or enabling the siniperca chuatsi to be prevented from being infected with thehigh-pathogenicity aeromonas hydrophila; in the lixivium of 3 Chinese herbal medicines, rheum officinale can restrain or destroy pathogenetic aeromonas hydrophila and has the effect of reducing the possibility that the siniperca chuatsi is infected with high-pathogenicity aeromonas hydrophila or enabling the siniperca chuatsi to be prevented from being infected with the high-pathogenicity aeromonas hydrophila, glossy privet fruits have the effect of enhancing immunity, and licorice root has the effect of removing toxicity; and the beta-cyclodextrin is mainly used for enabling a mixture of theegg yolk antibodies and the Chinese herbal medicine lixivium to have the effects of adhesion and slow release. The disease-resistant Chinese herbal medicine and egg yolk antibody compound additive disclosed by the invention can prevent and treat septicaemia caused by the pathogenetic aeromonas hydrophila during breeding of the siniperca chuatsi, the breeding yield of the siniperca chuatsi can be increased, and the breeding economic benefits of the siniperca chuatsi can be markedly increased. The problem that the bacterial septicemia is easy to generate during the breeding and producing courseof the siniperca chuatsi at present can be solved.

The invention discloses a novel medicament for treating bacterial septicemia of freshwater fish. The novel medicament comprises the following components in parts by weight: 30-60 parts of gentamicin sulfate for oral administration, 1-3 parts of vitamin E, 0.2-0.4 part of vitamin C, 0.3-0.6 part of glycine, 0.2-0.4 part of tyrosine, 1-3 parts of enrofloxacin, and 300-600 parts of water. Compared with the prior art, the novel medicament has the beneficial effects of excellent usage effect, simple preparation technology, low cost and the like.

The invention provides an SNP marker associated with bacterial septicemia of schizothorax prenanti and application of the SNP marker. A nucleotide sequence of the SNP marker is shown in SEQ ID NO. 1; a 779th base of the sequence from 5' terminus is C or T. At an SNP site of the invention, the probability that the schizothorax prenanti having genotype CT is infected with bacterial septicemia is significantly higher than that of homozygous CC type individuals. Therefore, whether the schizothorax prenanti is easily infected with bacterial septicemia can be determined effectively by detecting the SNP of the schizothorax prenanti. The CT genotype individuals are knocked out in breeding of parents; and the marker of the invention is used for auxiliary breeding to accelerate a cultivation process of excellent disease-resistant varieties of the schizothorax prenanti.

The invention discloses a novel method for preventing bacterial septicemia in freshwater fishes. The method includes the technical steps of 1, performing periodic sterilization around a fishpond, and timely treating diseases on discovery; 2, removing and deeply burying the fishes dead of disease; 3, splashing quick lime, bleaching powder or chlorine dioxide to the fishpond for sterilization every 5-10 days; 4, starting an aerator and injecting fresh water; 5, adding vitamin C, which helps increase disease resistance of the fishes, into feed according to the standard 100g/mu; 6, regulating water quality for the fishpond every 1-2 weeks so as to keep good cleanliness.

The invention discloses a medicine for treating bacterial septicemia and enteritis of fishes and a preparation method of the medicine. The medicine is prepared from the following raw materials in parts by weight: 100 to 150 parts of radix isatidis, 100 to 150 parts of radix et rhizoma rhei, 50 to 125 parts of rhizoma coptidis, 75 to 100 parts of fructus forsythia, 50 to 100 parts of cortex phellodendri, 50 to 100 parts of radix scutellariae, 50 to 100 parts of liquorice root, 25 to 75 parts of herba andrographitis, 50 to 75 parts of radix scrophulariae and 50 to 75 parts of honeysuckle flower.The traditional Chinese medicine provided by the invention is prepared through the following steps: weighing all components according to the weight; adding the components into a pulverizing machine respectively and pulverizing; sieving and mixing to obtain a finished product. The preparation method is simple and low in cost; the medicine can be used for preventing and treating the bacterial septicemia and the enteritis of the fishes, has the effects of treating both principal and secondary aspects of diseases, is safe and has no toxic and side effects, no drug resistance and no residues in bodies.

The invention discloses a Chinese herbal medicine compound preparation for prevention of crucian bacterial septicemia, and the Chinese herbal medicine compound preparation comprises the following Chinese herbal medicine raw materials: by weight, 18-22% of artemisia capillaris, 18-22% of euphorbia humifusa, rhubarb, 18-22% of rheum officinale, 8-12% of scutellaria baicalensis, 8-12% of bighead atractylodes rhizome, 8-12% of radix codonopsis and 8-12% of radix isatidis. Clinical fish disease prevention and control trials and safety evaluation show that the Chinese herbal medicine compound preparation is safe and effective to the crucian bacterial septicemia.

The invention relates to a 1% pre-mixture for preventing and controlling fish bacterial septicemia. The 1% pre-mixture comprises the following components: bentonite, fine wheat bran powder, iron, copper, zinc, manganese, potassium iodide, sodium selenite, vitamin A, vitamin D3, vitamin E, vitamin K3, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, niacin, biotin, folic acid, calcium pantothenate, inositol, oxytetracycline, flavoring agent, sweetening agent and traditional Chinese medicine powder. The ratio of raw materials is improved, so that the content of various microelements and vitamins is more balanced; the traditional Chinese medicine powder for preventing and controlling bacterial septicemia is added, so that the bacterial septicemia of fish can be effectively prevented and controlled; a preparation method for the 1% pre-mixture for preventing and controlling fish bacterial septicemia provided by the invention is easy for standardizing the process, is suitable forlarge-scale production and has significance in promoting enterprise product competitiveness and promoting the enterprise technology innovation and technical progress.

The invention belongs to the technical field of aquatic feed, and particularly relates to feed for preventing and curing silver carp bacterial septicemia. The feed is prepared from the following raw materials in parts by weight: 66 to 70 parts of wheat bran, 82 to 86 parts of peanut meal, 43 to 45 parts of duck intestines, 11 to 12 parts of goose egg shell, 18 to 20 parts of fresh wax gourd flesh, 28 to 30 parts of fresh sweet potato leaf, 8.3 to 8.7 parts of cricket powder, 0.33 to 0.35 part of decumbent corydalis tuber extract, 0.22 to 0.24 part of horse chestnut extract, 2.1 to 2.3 parts of traditional Chinese medicine additive and 3.1 to 3.3 parts of linseed oil. The feed is good in palatability, the absorption and transformation efficiency is high, the daily gain of silver carp is increased by 45.20 to 47.61 percent, an effect of treating both symptoms and root causes is achieved by two functions of enhancing the organism immunity of the silver carp and repairing injury, drug resistance cannot be generated, and a remarkable preventing and curing effect on the bacterial septicemia is achieved.