Medicinal composition for preventing and controlling pebrine and application of medicinal composition

Abstract

The invention relates to a medicinal composition for preventing and controlling pebrine and application of the medicinal composition. The composition contains albendazole, florfenicol and trisodium phosphate. A parasite killing mechanism of albendazole is used for metabolizing the medicinal composition in host silkworms to form an internal environment of the medicinal composition to disable the survival and breeding of microsporidia parasites in the host silkworms, so that good prevention and control effects on the pebrine are achieved; the wide antibacterial spectrum of the florfenicol is combined, so that bacterial gastrointestinal diseases caused by various gram positive bacteria and bacterial septicemia caused by gram negative bacteria in the silkworms can be effectively controlled, and the probability of potential bacterial diseases probably caused by the addition of an albendazole solution can be reduced; in addition, the trisodium phosphate has solubilization helping and synergistic effects, so that the release of the albendazole and the florfenicol can be accelerated to reach target concentration, and control effects are improved. When the silkworms are fed with the medicinal composition, the food intake and albendazole absorption rate of the silkworms can be increased, so that the effects of preventing and controlling the pebrine and bacterial diseases of the silkworms only by virtue of low-concentration albendazole can be achieved, and the medication cost is lowered.

Description

technical field [0001] The invention relates to the technical field of prevention and treatment of silkworm microparticle disease, in particular to a pharmaceutical composition for preventing and treatment of silkworm microparticle disease and an application thereof. Background technique [0002] Microsporidia ( Microsporidia ) is a type of obligate intracellular parasitic unicellular eukaryotes, and the microsporidia of silkworms caused by the infection of No. The survey found that the proportion of the original silkworm species being eliminated due to infection with microsporidia exceeding the national legal standard (referred to as "super poison") has a relatively obvious trend of increasing year by year. In general, for every 10,000 pieces of original species produced, nearly 1,000 pieces have to be eliminated due to the detection of particulate disease, and the remaining 50% of the qualified and non-toxic qualified, the direct economic loss reached tens of millions of ...

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Problems solved by technology

After being metabolized into sulfoxides or sulfones in the body, it can inhibit the absorption of glucose by parasites, resulting in the depletion of glycogen in the parasites, or inhibit the fumarate reductase system, hinder the production of ATP, and make the parasites unable to survive and reproduce

Yang Qiong et al disclosed that albendazole has a relatively ideal control effect on silkworm microparticulate disease in "Research I. Drug Screening of Bombyx mori Microparticle Disease Therapeutic Drugs" published by Guangdong Sericulture, but Yang Qiong etc. only disclosed 500mg / L The therapeutic effect of albendazole on silkworm microparticle disease is 95.8%, and the infection rate is 4.12%.

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