Medicinal composition for preventing and controlling pebrine and application of medicinal composition

A technology of silkworm microparticles and compositions, applied in applications, biocides, animal repellents, etc., can solve problems such as hindering ATP production, parasites cannot survive and reproduce, and glycogen depletion, so as to increase food intake and reduce The cost of medication and the effect of broad antibacterial spectrum

Active Publication Date: 2014-06-04
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After being metabolized into sulfoxides or sulfones in the body, it can inhibit the absorption of glucose by parasites, resulting in the depletion of glycogen in the parasites, or inhibit the fumarate reductase system, hinder the production of ATP, and make the parasites unable to survive and reproduce
Yang Qiong et al disclosed that albendazole has a relatively ideal control effect on silkworm microparticulate disease in "Research I. Drug Screening of Bombyx mori Microparticle Disease Therapeutic Drugs" published by Guangdong Sericulture, but Yang Qiong etc. only disclosed 500mg / L The therapeutic effect of albendazole on silkworm microparticle disease is 95.8%, and the infection rate is 4.12%.

Method used

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  • Medicinal composition for preventing and controlling pebrine and application of medicinal composition
  • Medicinal composition for preventing and controlling pebrine and application of medicinal composition
  • Medicinal composition for preventing and controlling pebrine and application of medicinal composition

Examples

Experimental program
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Effect test

Embodiment 1

[0025] A pharmaceutical composition, comprising the following components: 300 mg / L albendazole, 200 μg / L florfenicol and 300 mg / L trisodium phosphate.

[0026] The preparation method of the drug: add 3 g of albendazole, 2 mg of florfenicol and 3 g of trisodium phosphate into 10 L of cold boiled water, and mix thoroughly to obtain the drug. Alternatively, after fully mixing 3g of albendazole, 2mg of florfenicol and 3g of trisodium phosphate, add a small amount of cold boiled water, grind thoroughly, add the remaining amount of cold boiled water, and mix well to obtain the drug.

Embodiment 2

[0028] A pharmaceutical composition, comprising the following components: 100 mg / L albendazole, 100 μg / L florfenicol and 100 mg / L trisodium phosphate.

[0029] The preparation method of the drug: add 1 g of albendazole, 1 mg of florfenicol and 1 g of trisodium phosphate into 10 L of cold boiled water, and mix thoroughly to obtain the drug. Alternatively, after fully mixing 1 g of albendazole, 1 mg of florfenicol and 1 g of trisodium phosphate, add a small amount of cold boiled water, grind thoroughly, add the remaining amount of cold boiled water, and mix well to obtain the drug.

Embodiment 3

[0031] A pharmaceutical composition, comprising the following components: 400 mg / L albendazole, 50 μg / L florfenicol and 400 mg / L trisodium phosphate.

[0032] The preparation method of the drug: add 4 g of albendazole, 0.5 mg of florfenicol and 4 g of trisodium phosphate into 10 L of cold boiled water, and mix thoroughly to obtain the drug. Alternatively, after fully mixing 4g of albendazole, 0.5mg of florfenicol and 4g of trisodium phosphate, add a small amount of cold boiled water, grind thoroughly, add the remaining amount of cold boiled water, and mix well to obtain the drug.

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PUM

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Abstract

The invention relates to a medicinal composition for preventing and controlling pebrine and application of the medicinal composition. The composition contains albendazole, florfenicol and trisodium phosphate. A parasite killing mechanism of albendazole is used for metabolizing the medicinal composition in host silkworms to form an internal environment of the medicinal composition to disable the survival and breeding of microsporidia parasites in the host silkworms, so that good prevention and control effects on the pebrine are achieved; the wide antibacterial spectrum of the florfenicol is combined, so that bacterial gastrointestinal diseases caused by various gram positive bacteria and bacterial septicemia caused by gram negative bacteria in the silkworms can be effectively controlled, and the probability of potential bacterial diseases probably caused by the addition of an albendazole solution can be reduced; in addition, the trisodium phosphate has solubilization helping and synergistic effects, so that the release of the albendazole and the florfenicol can be accelerated to reach target concentration, and control effects are improved. When the silkworms are fed with the medicinal composition, the food intake and albendazole absorption rate of the silkworms can be increased, so that the effects of preventing and controlling the pebrine and bacterial diseases of the silkworms only by virtue of low-concentration albendazole can be achieved, and the medication cost is lowered.

Description

technical field [0001] The invention relates to the technical field of prevention and treatment of silkworm microparticle disease, in particular to a pharmaceutical composition for preventing and treatment of silkworm microparticle disease and an application thereof. Background technique [0002] Microsporidia ( Microsporidia ) is a type of obligate intracellular parasitic unicellular eukaryotes, and the microsporidia of silkworms caused by the infection of No. The survey found that the proportion of the original silkworm species being eliminated due to infection with microsporidia exceeding the national legal standard (referred to as "super poison") has a relatively obvious trend of increasing year by year. In general, for every 10,000 pieces of original species produced, nearly 1,000 pieces have to be eliminated due to the detection of particulate disease, and the remaining 50% of the qualified and non-toxic qualified, the direct economic loss reached tens of millions of ...

Claims

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Application Information

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IPC IPC(8): A01N59/26A01P1/00A01P3/00A01P5/00A01N47/18A01N41/10
Inventor 刘吉平
Owner SOUTH CHINA AGRI UNIV
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