Canine distemper and parvovirus disease bivalent inactivated vaccine for dogs and preparation method of canine distemper and parvovirus disease bivalent inactivated vaccine

Abstract

The invention discloses a canine distemper and parvovirus disease bivalent inactivated vaccine for dogs and a preparation method of the canine distemper and parvovirus disease bivalent inactivated vaccine, and relates to a vaccine preparation method. The effective components of the vaccine comprise an inactivated canine distemper virus CDV-LG strain and an inactivated canine parvovirus CPV-W strain, and safety tests show that no adverse reaction occurs when the bivalent inactivated vaccine is used for inoculating dogs; and efficacy tests show that within 6 months after single-dose vaccination,the dogs can be prevented from being attacked by virulent viruses for canine distemper and parvovirus disease examination, and the dogs can be protected. The bivalent inactivated vaccine adopts a canine distemper virus and canine parvovirus inactivation process, can be used for preventing canine distemper and canine parvovirus disease at the same time, realizes prevention of two diseases by one injection, and has wide application prospects.

Description

technical field [0001] The invention relates to a vaccine preparation method, in particular to a dual inactivated vaccine for canine distemper and parvovirus disease and a preparation method thereof. Background technique [0002] Canine distemper is an acute, febrile, highly contagious infectious disease caused by canine distemper virus belonging to the genus Morbillivirus in the Paramyxoviridae family. Other pneumonia, gastroenteritis, and occasional neurological symptoms are prone to secondary mixed infection and secondary infection of other bacteria and viruses, and the mortality rate can be as high as 80%. Virus-carrying animals are the most dangerous source of infection. Viruses are excreted through eye and nasal secretions, saliva, urine, and feces, and are mainly transmitted through the digestive tract and respiratory tract. In recent years, with my country's military dogs, police dogs, experimental dogs and pets With the substantial increase in the amount of dog bree...

AI Technical Summary

Problems solved by technology

The high infection rate and fatality rate of canine parvovirus have caused huge losses to the dog industry and the breeding of commercial animals

[0004] At present, most of the dual vaccines for canine distemper and canine parvovirus are attenuated live vaccines. On the one hand, live vaccines have the risk of spreading the virus; It may be affected by it. In practical applications, it is difficult to grasp the timing of immunization with live vaccines for puppies before and after weaning. When the maternal antibody is at a high level, the immune effect of the live vaccine will be greatly reduced. At a low level of immunity, potential infection may have occurred before immunization; compared with live vaccines, the immunity of inactivated vaccines is less affected by maternal antibodies. Therefore, it is safe, effective, long-lasting, and easy to store and transport. Canine distemper and parvovirus dual-inactivated vaccine for dogs is an effective method to control canine distemper and parvovirus disease in puppies. It is an urgent need of the industry and the market to realize "one shot to prevent two diseases" and has a broad market prospect