Methods for treating arthritic conditions in dogs

A technology for osteoarthritis and joints, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, active ingredients of phosphorus compounds, etc., and can solve the problems of analgesics alleviating discomfort and not treating the primary disease.

Inactive Publication Date: 2007-05-16
MERCK & CO INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Analgesics relieve discomfort but do not treat the underlying condition

Method used

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  • Methods for treating arthritic conditions in dogs

Examples

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Embodiment

[0088] The following examples further describe and demonstrate embodiments within the scope of the present invention. The examples are given for the purpose of illustration only and are not to be construed as limiting the invention, since many changes can be made thereto without departing from the spirit and scope of the invention.

[0089] Tablet Composition

[0090] Tablets are prepared using standard mixing and forming techniques as described in US Patent No. 5,358,941, Bechard et al., issued October 25, 1994, which is hereby incorporated by reference in its entirety.

[0091] Tablets based on active alendronic acid containing about 6.5 mg of monosodium alendronate trihydrate were prepared using the following relative weights of ingredients.

[0092] Element

[0093] The resulting tablet can be used for administration according to the method of the present invention for inhibiting, ie treating or reducing the risk of, osteoarthritis associated with hip dyspl...

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Abstract

The present invention relates to a method for eliciting a disease modifying effect on an arthritic condition in a hip or stifle of a canine which comprises administering to the canine a therapeutically effective amount of a bisphosphonate. The present invention also relates to method for eliciting a disease modifying effect on hip dysplasia or stifle instability, the pain associated with hip dysplasia or stifle instability, joint swelling, shallowing of the acetabulum, narrowing of the joint space, subchondral bone sclerosis, preventing osteophyte formation and preventing joint destruction in a canine which comprises administering to the canine a therapeutically effective amount of a bisphosphonate.

Description

Background of the invention [0001] Osteoarthritis (OA) is a degenerative joint disease characterized by pain, cartilage loss, and joint stiffness. It is a common disease affecting dogs of all ages, but is most prevalent in older animals. It can be a primary condition, which is the result of general wear and tear, or a secondary condition, which is the result of an injury, infection, non-union fracture, or developmental abnormality. [0002] Developmental hip disease is a developmental disorder in dogs in which a deformity between the femoral head and the acetabulum creates joint instability that allows excessive movement of the femoral head. This is a common condition in dogs, especially in large breeds. The exact cause is not known, but there is a genetic component. Although the disease may be genetic, the expression of the defect is largely influenced by factors such as nutrition, growth rate, obesity and exercise. [0003] Initially, hip dysplasia was observed as a loss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61K31/19
CPCA61K31/675A61K31/19A61K31/66A61K31/445A61P19/02A61P43/00
Inventor D·汤森P·汉森
Owner MERCK & CO INC
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