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Contrast media injection being suitable for MR arthrography

An arthrography and injection technology, applied in the medical field, can solve the problems of poor body tolerance and high incidence of toxic and side reactions, and achieve the effects of small toxic and side reactions, low incidence of side reactions, and clear image display.

Inactive Publication Date: 2017-02-01
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The property of ionic developer is stable and the contrast is good, but the solution is hypertonic, the incidence of side effects of poisoning is high, and the tolerance of the body is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Perform shoulder arthrography:

[0026] 57 hospitalized patients with recurrent shoulder dislocation or subluxation, 42 males and 15 females; aged 13 to 63 years, with an average of 26 years. Left 34 cases, right 23 cases, 52 cases of anterior dislocation, 5 cases of posterior dislocation.

[0027] The joint contrast agent injection is prepared from the following raw materials: 0.25ml of gadopentetate meglumine, 5ml of iohexol, 5ml of lidocaine and 5ml of normal saline, and the injection dosage is 10-12ml. The standard anterior approach was adopted for the shoulder arthrodesis, and the contrast medium injection was injected into the joint cavity with a No. 7 lumbar puncture needle under the guidance of CT. During CT-guided injection, the patient was in the supine position, the upper limbs were slightly internally rotated, the scanning plane was perpendicular to the humeral shaft, the scanning slice thickness was 2 mm, and the images were acquired through soft tissue wi...

Embodiment 2

[0031] Hip arthrography:

[0032] 20 patients with hip pain, a total of 21 hip joints, 9 males (10 hips), 11 females (11 hips); average age 31.4 years old. All cases were excluded femoral head necrosis, tumor history.

[0033] The joint contrast agent injection is prepared from the following raw materials: 0.25ml of gadopentetate meglumine, 5ml of iohexol, 5ml of lidocaine and 10ml of normal saline, and the injection dosage is 15ml. The hip is in flexion and abduction, and the needle is positioned under the adductor tendon and muscle sheath. Under the guidance of CT, the puncture needle was inserted into the hip joint or the anterior superior iliac spine at an angle of 45 degrees, and the contrast agent was injected after confirming that it entered the joint cavity. During CT-guided injection, the patient is placed in the supine position, and left-right symmetry is kept as far as possible. The thickness of the scanning slice is 1-2 mm, and the scanning is performed separatel...

Embodiment 3

[0037] Wrist arthrography:

[0038] Wrist and forearm trauma left 193 cases with wrist weakness. Among them, there were 91 males and 102 females; the youngest age was 21 years old, the oldest age was 87 years old, and the average age was 51 years old.

[0039] The joint contrast agent injection is prepared from the following raw materials: 0.05ml of gadopentetate meglumine, 1.25ml of iohexol, and 1.25ml of lidocaine. The injection dosage is 1.5ml. Under CT guidance, the hip joint was in flexion and abduction, and the puncture needle was located under the adductor tendon and muscle sheath. Insert the needle through the space between the distal edge of the radius on the back of the wrist and the edge of the proximal row of carpal bones. During CT-guided injection, a 64-slice spiral CT scanner was used to scan the original volume, with a tube voltage of 120-140kv and a tube current of 130-200mA.

[0040] During MR examination, the patient’s position is the same as that of CT, ...

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Abstract

The invention belongs to the medical field and particularly relates to a contrast media injection being suitable for MR arthrography. The injection is prepared from the following raw materials: 0.05-0.25 ml of gadopentetate dimeglumine, 1.25-5 ml of iohexol, 1.25-5 ml of lidocaine and 0-10 ml of physiological saline. The injection has following advantages: 1) under guidance of X ray or CT, the injection, when being injected into articular cavity for performing the MR inspection to the arthrosis that needs to inspect, can be used for development under both X-ray and MR inspection, wherein according to different inspection positions, only does corresponding proportion adjustment need to carry out, thus greatly simplifying operation procedure of medical staffs; 2) the injection has low permeability, low toxic and side effects, high bio-safety, low toxicity on nervous system, low generation rate of side reactions, and good body tolerance; and 3) the injection can generate high-intensive magnetic resonance signal and increase signal intensity of magnetic resonance imaging, so that an image can be displayed clearly.

Description

technical field [0001] The invention belongs to the medical field and relates to a joint contrast agent, in particular to a contrast agent injection suitable for MR arthrography. Background technique [0002] Interventional radiology is a marginal subject that developed rapidly in the late 1970s. Under the guidance of medical imaging equipment, it is based on imaging diagnostics and clinical diagnostics, combined with the principles of clinical therapeutics, and uses catheters, guide wires and other equipment to diagnose and treat various diseases. [0003] Contrast agents, also known as contrast agents or contrast agents, are the imaging basis of imaging medicine and are mainly used for the display of blood vessels and body cavities. Imaging medicine mainly includes X-rays, X-ray computed tomography (CT), magnetic resonance imaging (MR), ultrasound, etc. Due to different detection principles, the requirements for contrast agents are also different, resulting in a variety o...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/04
CPCA61K49/0002A61K49/0438A61K49/18
Inventor 于华龙徐文坚张传玉郝大鹏
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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