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Preparation and use of injectable isopropyl acrylamide tripolymer as thrombus material and its use

A technology of isopropylacrylamide terpolymer and n-propylacrylamide, which is applied in the field of vascular embolization materials and can solve the problems of unfavorable injection and high concentration

Inactive Publication Date: 2005-10-12
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is worth mentioning that Poloxamers 407 forms a gel at a high concentration (>16%), which is not conducive to injection

Method used

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  • Preparation and use of injectable isopropyl acrylamide tripolymer as thrombus material and its use
  • Preparation and use of injectable isopropyl acrylamide tripolymer as thrombus material and its use
  • Preparation and use of injectable isopropyl acrylamide tripolymer as thrombus material and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 65.86 ml of n-propylamine after water removal was dissolved in 160 ml of tetrahydrofuran, and 32.47 ml of acryloyl chloride was added dropwise under magnetic stirring in an ice-water bath. After the reaction is complete, remove the generated amine salt by vacuum filtration, and remove tetrahydrofuran by rotary evaporation to obtain liquid n-propylacrylamide (NPAAm).

[0027] Dissolve 1.8106g of isopropylacrylamide, 1.8106g of n-propylacrylamide and 0.1065ml of vinylpyrrolidone in 80ml of deionized water; pass nitrogen gas for 30min under magnetic stirring, add 0.0268g of potassium persulfate and 0.0149g of tetramethylethylenediamine ml; the temperature was controlled in a water bath at 20°C, and the reaction was carried out under nitrogen protection for 8 hours. After the reaction, the mixed solution was put into a dialysis bag for purification (molecular weight cut-off 5000), and the water was changed every 12 hours. After 5 days of dialysis, freeze-dried to obtain PNI...

Embodiment 2

[0035] The synthesis of monomer n-propylacrylamide is the same as in Example 1.

[0036] Dissolve 0.9053g of isopropylacrylamide, 1.3579g of n-propylacrylamide and 0.0532ml of vinylpyrrolidone in 46ml of deionized water; pass nitrogen gas for 30min under magnetic stirring, add potassium persulfate 0.0166g and tetramethylethylenediamine 0.0092 ml; the temperature was controlled in a water bath at 20°C, and the reaction was carried out under nitrogen protection for 8 hours. After the reaction, the mixed solution was put into a dialysis bag for purification (molecular weight cut-off 5000), and the water was changed every 12 hours. After 5 days of dialysis, freeze-dried to obtain PNINAVP of 16:24:1.

[0037] Proton NMR spectrum detection: an appropriate amount of sample is dissolved in deuterated water (D 2 O) in, record on NMR spectrometer Varian UNITY plus 400 1 H-NMR spectrum, such as figure 2 shown.

[0038] DSC detection: Weigh a certain amount of copolymer to prepare a ...

Embodiment 3

[0044] The synthesis of monomer n-propylacrylamide is the same as in Example 1.

[0045] Dissolve 0.9053g of isopropylacrylamide, 0.4526g of n-propylacrylamide and 0.0532ml of vinylpyrrolidone in 28ml of deionized water; pass nitrogen gas for 30min under magnetic stirring, add potassium persulfate 0.0101g and tetramethylethylenediamine 0.0056 ml; the temperature was controlled in a water bath at 20°C, and the reaction was carried out under nitrogen protection for 8 hours. After the reaction, the mixed solution was put into a dialysis bag for purification (molecular weight cut-off 5000), and the water was changed every 12 hours. After 5 days of dialysis, freeze-dried to obtain PNINAVP of 16:8:1.

[0046] Proton NMR spectrum detection: an appropriate amount of sample is dissolved in deuterated water (D 2 O) in, record on NMR spectrometer Varian UNITY plus 400 1 H-NMR spectrum, such as figure 2 shown.

[0047] DSC detection: Weigh a certain amount of copolymer to prepare a s...

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Abstract

An injection of three-element isopropyl acrylamide material used as the vascular blocking material for treating the deformity of human cerebral artery and vein is prepared through reacting between propencyl chloride and n-propylamine to obtain propyl propenoyl chloride, synthesizing PNINAVP from ammonium persulfate and tetramethyl ethyldiamine in water, and dissolving iohexol in the solution of PNINAVP.

Description

technical field [0001] The invention relates to the preparation and application of an injectable isopropylacrylamide terpolymer thrombus material, which belongs to the blood vessel embolization material technology in the field of biomedical engineering. Background technique [0002] Cerebral arteriovenous malformations (arteriovenous malformations, AVM) is a disease of the central nervous system that mainly occurs in adolescents. Hypoperfusion, hypoperfusion, high venous pressure, lesion malformation blood vessel rupture and bleeding, blood stealing, etc. cause cerebral ischemia and delayed sexual dysfunction in patients, and even life-threatening. Common symptoms are cerebral hemorrhage and epilepsy. The incidence rate of cerebral arteriovenous malformation is 0.01-0.5%, and most AVM patients will develop it before the age of 40. It is one of the main diseases that cause death and disability in adolescents. [0003] Cerebral arteriovenous ma...

Claims

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Application Information

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IPC IPC(8): A61B17/12A61K31/787A61L17/10A61P43/00
Inventor 刘文广李晓卫叶桂香姚康德
Owner TIANJIN UNIV
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