Visual absolute ethyl alcohol-iopromide composite hardening injection as well as preparation method and application thereof
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A technology of iopromide and anhydrous ethanol, applied in the field of medicine, can solve the problems of increased side effects or risks, complicated steps, long time, etc., and achieves the effects of reducing treatment risks and complications, and simple preparation
Pending Publication Date: 2021-11-26
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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The traditional DSA-guided sclerotherapy technique is divided into two steps. Firstly, a contrast agent (iopromide injection) is injected after puncture to fill the lesion, and the location and size of the lesion are determined, and then the non-developing sclerosing agent (absolute ethanol) is injected into the lesion cavity. Gap replaces the original contrast medium. Contrast and treatment are carried out in two steps. The steps are relatively cumbersome and take a long time. Ethanol sclerosing agent does not develop under DSA. Big
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[0036] The second aspect of the present invention provides a method for preparing a visual anhydrous ethanol-iopromide composite sclerosing injection, the preparation method comprising the following steps:
[0037] Mix iopromide powder with an appropriate amount of absolute ethanol, stir to disperse evenly, and obtain iopromide-absolute ethanol suspension; then add absolute ethanol to constant volume, so that the volume of ethanol at 15°C for the prepared composite hardening injection The score is 99.5%.
[0038] In some preferred embodiments of the present invention, the preparation method also includes adding a medical suspending agent to the iopromide-dehydrated alcohol suspension; the medical suspending agent is selected from Tween-80, Span-85 , Pluronic F-68, one or more of carboxymethylcellulose, sodium alginate, polyvinylpyrrolidone, gelatin, mannitol, sorbitol, aluminum monostearate, silicone oil; Suspending agent can improve the stability of suspension.
[0039] In ...
Embodiment 1
[0047] A visualized absolute ethanol-iopromide composite sclerosing injection, including absolute ethanol, iopromide and Tween-80, at 15°C, the content of each component is 1ml, 0.2g, 0.5mg respectively.
[0048] A preparation method for visualized absolute ethanol-iopromide composite sclerosing injection, comprising the following steps:
[0049] 1) Disperse 0.2 g of iopromide powder in 0.5 mL of dehydrated ethanol, shake to obtain iopromide-dehydrated ethanol suspension;
[0050] 2) Add 0.5 mg Tween 80 to the suspension, oscillate and disperse it evenly to obtain a suspension;
[0051] 3) Finally, absolute ethanol was added to the suspension to dilute to 1 mL to obtain a composite sclerosis injection, and the mass fraction of ethanol in the composite sclerosis injection at 15° C. was 99.5%.
[0052] Clinical application
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Abstract
The invention provides a visual absolute ethyl alcohol-iopromide composite hardening injection. The visual absolute ethyl alcohol-iopromide composite hardening injection comprises absolute ethyl alcohol and iopromide, and the volume fraction of ethyl alcohol in the composite hardening injection is 99.5% at the temperature of 15 DEG C. The invention also provides a preparation method of the visual absolute ethyl alcohol-iopromide composite hardening injection. The method comprises the following steps: mixing iopromide powder with a proper amount of absolute ethyl alcohol, and stirring to uniformly disperse to obtain an iopromide-absolute ethyl alcohol suspension; and adding absolute ethyl alcohol to fix the volume, so that the volume fraction of the ethyl alcohol of the prepared composite hardening injection at 15 DEG C is 99.5%. According to the composite hardening injection, the flow direction of the absolute ethyl alcohol is dynamically monitored in the embolism hardening process, accurate and visual treatment is achieved, the treatment risk and complications are reduced, and the X-ray radiation resistance of the composite preparation can be adjusted by adjusting the content of iopromide added into the absolute ethyl alcohol according to specific treatment requirements.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a visual anhydrous ethanol-iopromide composite sclerosing injection and its preparation method and application. Background technique [0002] Venous malformation is a relatively common congenital venous dysplasia disease, the incidence rate is 1 in 1,000, and there is no obvious gender difference. It can affect all parts of the body, and the most common parts are the mouth, airway and head and neck. Severe venous malformations involve multiple tissues and organs, which can lead to a variety of disabling and fatal complications, such as head and neck venous malformations leading to obvious deformities, masticatory disorders, respiratory obstruction and other functional disorders; venous malformations involving limbs and joints are often It can lead to severe swelling, pain, joint stiffness, limb dysfunction, and even disability. Some patients may be life-threatening due to LIC o...
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