30results about How to "High purity product" patented technology

The invention relates to a preparation method of hexaphenoxycyclotriphosphazene, in particular to a preparation method of high purity hexaphenoxycyclotriphosphazene, belonging to the technical field of the synthesis of organic compounds with nitrogen and phosphorus and the method contains the reaction process of hexachlorocyclotriphosphazene and sodium phenate substantially. The invention is characterized in that the reaction conditions are as follows: the catalyst is PEG-500-1000, the reaction temperature is 60-140 DEG C, the reaction time is 10-42h, the chlorinity of the target material is less than 500ppm at end point and the reaction solvent is chlorobenzene; concentrative crystallization method is used for purifying, the purity of hexaphenoxycyclotriphosphazene is not less than 99%. The preparation method of the invention has the advantage that the yield is as high as 95%, the type of the used solvent is less, the catalyst can be recycled to use, the consumption of the catalyst is low, the method is simple and is applicable to industrialized production and the purity of the product is high.

The invention relates to the field of medicine synthesis, and discloses a method for synthesizing ganirelix acetate. The method comprises the following steps: carrying out esterification reaction on D-alanine with a protecting group coupled to an N end, and amino resin with a protecting group coupled to amino under the action of a contracting reagent and an activating reagent to obtain peptide resin 1; carrying out gradual extending coupling on other protected amino acids under the action of the contracting reagent and the activating reagent from the peptide resin 1 according to the order from a C end of a ganirelix acetate amino acid sequence to the N end, thus obtaining corresponding peptide resin after extending coupling each time; finally obtaining ganirelix acetate resin, carrying out acidolysis to obtain a ganirelix acetate crude product; and purifying the ganirelix acetate crude product to obtain a ganirelix acetate pure product. According to the method disclosed by the invention, an appropriate synthetic scheme is selected; Ac-D-Nal is selected as the finally synthesized raw material; the whole synthesis process is optimized; an appropriate acidolysis liquid and amino resin are selected to be synthesized; the purity of the ganirelix acetate is improved; and the ganirelix acetate is relatively high in total yield, and is free of harm to any environment.

The invention provides a sulfuryl fluoride preparation method using sulfuryl chloride as a raw material by two-stage fluorination reaction, the sulfuryl fluoride preparation method has the advantages of simple technology and equipment, easy enlarging production, high product purity and the like, and prepared sulfuryl fluoride can be used as a fumigant to replace methyl bromide.

The invention provides a manganese-zinc ferrite magnetic material with uniform particle size, regular particle morphology, and good dispersion. The material is a self-assembled submicron-level rod assembled by octahedral units, and has a structural formula of MnxZn1-xFe2O4, wherein x is no smaller than 0 and no greater than 1. In a reactant, a molar ratio of the elements are that (Mn+Zn) / Fe=1:2. Reaction medium mass / reactant total mass=0-6:1. The invention also provides a process for preparing the material. In the reaction process of the method, molten salt exists among produced manganese-zinc ferrite particles, such that particle agglomeration can be prevented. With the method provided by the invention, stoichiometric ratio of the components can be precisely controlled. The method also has the advantages of simple process, high-purity product, controllable particle morphology, no need of mechanical ball milling, no doping, narrow particle size distribution, wide raw material source, and the like.

The invention relates to the field of medicine synthesis, and discloses a method for synthesizing teriparatide. The method comprises the following steps: performing esterification reaction between Phe coupled with a protecting group at an N end and HMP Linker resin under the action of a coupling reagent and an activating reagent to obtain peptide resin 1; and performing one-by-one extension coupling on the rest protective amino acids under the reaction of a condensation reagent and an activating reagent according to a sequence from a C end to the N end of a teriparatide amino acid sequence to obtain corresponding peptide resin after each extension coupling and finally obtain teriparatide resin, performing acid hydrolysis to obtain a teriparatide crude product, and purifying the teriparatide crude product into acetate so as to obtain a teriparatide pure product. According to the method disclosed by the invention, a suitable synthesis scheme is selected, the HMP Linker resin is used as carrier resin, the whole synthesis process is optimized, a high-purity product is obtained, the total yield of the teriparatide is improved, and the method is harmless to any environment.

Provided is a production method for an iodine compound in which iodine is reacted with a substrate in the presence of a porous material having a pore diameter of 500 nm or less or in the presence of the above porous material and an oxidizing agent and a production process for high purity 5-iodo-2-methylbenzoic acid comprising an iodination reaction step carried out by the above-mentioned, a crystal precipitation and separation step in which a product is precipitated by adding water or cooling and then separated and a purification step in which crystal separated is recrystallized using an organic solvent. According to the production method for an iodine compound described above, iodine can be introduced into various substrates at a high selectivity. Since expensive metals and specific reagents do not have to be used, it can readily be carried out in an industrially scale, and the product having a high purity can be obtained. Further, the process comprising the iodination reaction, separation and purification steps described above makes it possible to readily obtain at a high yield, 5-iodo-2-methylbenzoic acid having a high purity which is useful in uses for functional chemical products such as medicines. The process of the present invention comprising iodination reaction, separation and purification steps is characterized by that it is simple in terms of a procedure and that the purification load is smaller, and it is very advantageous in industrially carrying out.

A method and related apparatus for confirming whether a kill laser successfully destroys an undesired population of cells includes introducing fluorescent dye into cells, exciting the cells with a detection laser or a light emitting diode to cause the cell to fluoresce for a first time, measuring the amount of fluorescence in the cells with a detector capable of emitting a detection pulse, classifying the cells via embedded processing as undesired or desired cells based on the amount of fluorescence, firing a kill beam with a kill laser at any undesired cells, measuring the amount of fluorescence in the cells a second time to determine whether a fluorescent event was generated from the kill beam striking the cells, and providing feedback to an operator of the kill laser as to whether any fluorescent events were generated from the kill beam striking the cells.

A purification method in which, from a specific polyoxyalkylene derivative having a molecular weight of 8,800 to 100,000, an impurity differing in the number of hydroxyl groups is separated, the method including steps (A), (B), (C), and (D). Step (A): a step in which an aprotic organic solvent is used in an amount at least 5 times by weight the amount of the polyoxyalkylene derivative to dissolve the polyoxyalkylene derivative therein and give a solution; step (B): a step in which an adsorbent comprising an oxide containing at least one of aluminum and silicon is added to the solution in an amount 0.5 to 5 times by weight the amount of the polyoxyalkylene derivative to thereby yield a slurry; step (C): a step in which the slurry is stirred at 25° C. or higher; step (D): a step in which the polyoxyalkylene derivative is recovered from the slurry.

The invention discloses an immobilized ionic-liquid catalyst. A preparing method of the immobilized ionic-liquid catalyst includes the following steps that 1, ionic liquid, absolute ethyl alcohol and tetraethyl orthosilicate are stirred at the constant temperature of 40 DEG C to 70 DEG C till the ionic liquid is dissolved, and the solution is clarified; then a hydrochloric acid solution is added, the mixture is continuously stirred for 1 h to 3 h to be stood and aged for 12 h to 24 h, and a primary product of the mesoporous-silica immobilized ionic-liquid catalyst is obtained; 2, the primary product of the mesoporous-silica immobilized ionic-liquid catalyst is subjected to vacuum drying for 3 h to 6 h at the temperature of 80 DEG C to 100 DEG C, and the mesoporous-silica immobilized ionic-liquid catalyst is obtained. The invention further discloses an application of the catalyst to synthesizing ester lubricating oil. According to the immobilized ionic-liquid catalyst and the application thereof to synthesizing the ester lubricating oil, the catalyst is simple in the synthesizing method and high in catalyst activity, and the process of industrial applications of the catalyst is greatly quickened.