33 results about "Acetohydroxamic acid" patented technology

The invention discloses a method for measuring nano-gold mimetic peroxidase based urease and an inhibitor thereof. The method is characterized by comprising the following steps: coupling a urease catalysis urea reaction system with a nano-gold mimetic peroxidase-hydrogen peroxide-3,3',5,5'-tetramethylbenzidine dihydrochloride catalytic chromogenic reaction system, and combining with the changes of solution colors and ultraviolet absorption spectrum characteristics to directly measure the content of urease and the inhibitor thereof, wherein in a range of 1.8-90U / L, A450 and the urease concentration have a linear relationship, and the limit of detection is 1.8U / L; and by virtue of software fitting, IC50 of obtained acetohydroxamic acid of the urease inhibitor is 0.05mmoL / L. The method disclosed by the invention is simple and convenient to operate and high in sensitivity, and can be applied to the measurement of the content of urease and the inhibitor thereof in environment and life science systems as an analysis method.

This invention discloses a sustained-release nitrogen fertilizer containing secondary and trace elements. The sustained-release nitrogen fertilizer is composed of: urea 10-96 parts, ammonium sulfate 0.1-78.8 parts, attapulgite powder 0-8 parts, ammonium chloride 0.1-78.8 parts, magnesium sulfate 0.05-2.0 parts, borax 0.01-1 part, copper sulfate 0.01-0.2 part, manganese sulfate 0.01-0.6 part, ferrous sulfate 0.01-1 part, zinc sulfate 0.01-1 part, acetohydroxamic acid 0.01-0.02 part, composite amino acids 0.01-1 part, and dicyandiamide 0.01-0.2 part. The sustained-release nitrogen fertilizer is prepared by: mixing the above components, adding into a disc granulator, spraying an appropriate amount of water, granulating and drying. The sustained-release nitrogen fertilizer has such advantages as long effective period and high effective utilization rate (above 45%). Crops applied with the sustained-release nitrogen fertilizer have such advantages as high stress resistance and high yield.

During the preparation of acetohydroxamic acid, hydroxylamine chloride and methyl acetate are first mixed in a reactor, and solid alkali catalyst to neutralize hydrochloric acid carried by hdyroxylamine chloride and alcohol in the same volume as methyl acetate as solvent are then added, so that a synthetic reaction is effected to produce acetohydroxamic acid. The artificially prepared acetohydroxamic acid has a purity has high as 80% and may be re-compounded into 5% product suitable for use as feed additive. The product may find its wide use in stockbreeding, agriculture, medicine and environment protection.

The invention relates to a compound deodorant for livestock and poultry houses, and belongs to the technical field of livestock and poultry breeding management. An adopted technical scheme of the compound deodorant for the livestock and poultry houses comprises the following ingredients in mass percentage: 60-73% of acetohydroxamic acid, 2-8% of microbial bacterium dry-powder, 20-32% of tea residues and 4-10% of mineral powder. The compound deodorant for the livestock and poultry houses has the following beneficial effects: (1), the compound deodorant provided by the invention is simple, scientific and rational in formula, and has multiple coordination functions of regulating internal environment of digestive tracts of the livestock and the poultry, improving feed utilization rate as well as enhancing immunity of the livestock and the poultry; and the compound deodorant solves odor pollution problems of the farms in a highly effective way; and (2), the compound deodorant is simple in preparation method, low in cost and convenient to use; thus, economic benefits of the breeding industry are improved by the compound deodorant.

The invention relates to a medicinal composition for preventing and treating canine / feline magnesium ammonium phosphate stones, and a preparation method thereof. The composition is prepared by evenlymixing the following effective components in ratio by weight or unit: 13 to 39 grams of lysimachia nummularia and lygodium japonicum granules, 0.3 gram of acetohydroxamic acid and 4,000 IU of vitaminA. The medicinal composition for preventing and treating canine / feline magnesium ammonium phosphate stones is added as a unit for each kilogram of canine / feline feed. In the invention, lysimachia nummularia promotes urination and treats stranguria, while lygodium japonicum clears heat, promotes urination, treats stranguria and relieves pain, and both the lysimachia nummularia and the lygodium japonicum can increase the frequency of ureteral peristalsis, raise the pressure in ureteral upper-section cavities and play a significant role in promoting urination and eliminating stones; meanwhile, the agent utilizes the characteristic of inhibiting urease activity through acetohydroxamic acid to reduce the ammonia concentration and pH of urine and prevent the formation of infectious urinary stones or inhibit the growth thereof; and the vitamin A is utilized to maintain the integrity of urinary-tract epithelium so as to realize the activity of crystallization inhibitors and inhibit crystallization. The agent jointly uses medicaments from different angles to eliminate the inducing factors of stones and plays a definite role in preventing magnesium ammonium phosphate stones.

The invention discloses a fattening pig feed additive prepared from the following raw materials in parts by weight: 10-20 parts of astragalus polysaccharide; 5-10 parts of fucoidan; 3-6 parts of tea saponin; 1-3 parts of acetohydroxamic acid; 3-6 parts of tangerine peel; 5-10 parts of chamomile; 6-12 parts of fried atractylodes; 0.1-0.5 parts of beta-complex detoxifying enzyme; and 3-5 parts of 5-nitroguaiacol sodium salt. The fattening pig feed additive has the effects of strengthening spleen and appetizing, expelling evil spirits and solidifying roots, the ratio is reasonable, the cost is low, the effect is good, and the weight increase effect is significant, the feed addictive improves the production performance, increases economic benefits, and can also improve the body's immunity.

The invention relates to a feed additive for producing selenium-rich beef. The feed additive is characterized by being prepared from the following substances in parts by weight: 15-25 parts of 30% enveloped mercaptamine, 8-12 parts of dihydropyridine, 130-150 parts of cardamine violifolia, 110-130 parts of honeysuckle, 90-110 parts of roots of Chinese pulsatilla, 70-90 parts of medicated leaven, 70-90 parts of malt, 70-90 parts of semen raphanin, 70-90 parts of fructus aurantii, 70-90 parts of fructus quisqualis, 30-50 parts of acetohydroxamic acid, 50-60 parts of commercially available selenium yeast which contains 2000mg / kg of selenium, 50-60 parts of commercially available bacillus subtillis and 50-70 parts of medical stones. The feed additive for producing selenium-rich beef has the advantages of preventing various diseases of cattle, providing safe, nutritious and healthy food for the citizens, being the best food and way for selenium supplementation of the citizens, and having important practical significance.

The invention relates to a preparation method of a special biological selenium-rich nutrition solution for plants, wherein the components of the formula comprises (by weight): 0.3-1.3% of cystine, 0.5-1.5% of a methionine-copper complex, 0.7-1.7% of Clostridium butyricum, 1-2% of a common yam rhizome extract, 1.2-2.1% of an amino acid-iron complex, 1.3-2.2% of a Sterculia lychnophora Hance extraction liquid, 1.9-2.9% of folic acid, 2.5-3.5% of Saccharomyces cerevisiae, 2.9-3.9% of a Fritillaria ussuriensis Maxim extract, 2.3-3.3% of acetohydroxamic acid, 2.7-3.7% of sorbitol, 2.8-3.8% of a fructus momordicae extract, 1.1-2.1% of Bifidobacterium bifidum, 0.5-1.5% of Trisodium hydrogen diphosphate, 0.1-1% of Glycerol, 0.8-1.8% of a Cassia nomame extract, 0.2-1% of Avocado oil, 0.9-1.9% of Macrocystis pyrifera powder, 2.7-3.7% of probiotics, 1.7-2.7% of yeast selenium, and 71.9-52.4% of water. According to the present invention, the special biological selenium-rich nutrition solution canwell supplement nutrition elements required in plant growth, strengthening and enlarge seedlings, promote the robust growth of plants, enhance the stress resistance, the cold resistance and the disease resistance of plants, achieve the strong stems and the green leaves of plants, fundamentally reduce the occurrence of diseases, balance the plant nutrition, ensure the healthy growth of plants, andprolong the flowering period of plants.

The invention discloses a preparation technology of acetohydroxamic acid, which comprises the following steps: hydroxylamine hydrochloride is dissolved into water; caustic soda liquid is added to neutralize hydrochloric acid in the hydroxylamine hydrochloride so as to dissociate hydroxylamine; acetamide and a catalyst of 4-dimethylamino pyridine are added for carrying out synthetic reaction to obtain acetohydroxamic acid aqueous solution; the aqueous solution is dried through vacuum concentration to obtain acetohydroxamic acid crystal with the mass percentage of above 80%; and the aqueous solution can be also directly compounded with light calcium carbonate and then dried to obtain a product applicable to a feed additive, and the product has wide use in the fields of animal husbandry, agriculture and the like. The invention has the advantages that reaction can be carried out with water as a reaction medium under the conditions of room temperature and normal pressure; the conversion rate reaches above 95%; the production cost is low; and industrial production is easily carried out.

The invention provides a buffalo calf lick brick and a preparation method thereof, and belongs to the field of feeds. The buffalo calf lick brick is prepared from the following raw materials in partsby weight: 200 to 400 parts of hydroxymethyl cellulose, 250 to 450 parts of bentonite, 2800 to 3200 parts of feed salt, 400 to 500 parts of urea, 100 to 130 parts of anhydrous calcium hydrophosphate,120 to 150 parts of mineral additives, 400 to 600 parts of composite vitamins, 0.2 to 1 part of acetohydroxamic acid, 1 to 3 parts of lactoferrin, 1 to 5 parts of rumen bypass protein, 1 to 5 parts ofalgal polysaccharide, 1 to 5 parts of yeast cell wall polysaccharide and 20 to 50 parts of plant extracts. The buffalo calf lick block is rich in nutrition and capable of maintaining electrolyte balance of calf bodies, preventing and treating mineral nutrient deficiency, promoting growth, improving feed conversion, improving resistance and preventing and treating ticks.

The invention relates to a medicinal health agent for preventing and treating canine / feline magnesium ammonium phosphate stones, which is characterized in that the agent is prepared by evenly mixing the following effective components in ratio by weight or unit: 100 to 500 mg of acetohydroxamic acid, 1,000 to 4,000 mg of methenamine and 4,000 IU of vitamin A. The medicinal health agent for preventing and treating canine / feline magnesium ammonium phosphate stones is added as a unit for each kilogram of canine / feline feed. The agent utilizes the characteristic of inhibiting urease activity through acetohydroxamic acid to reduce the ammonia concentration and pH of urine and prevent the formation of infectious urinary stones or inhibit the growth thereof, utilizes the methenamine to kill pathogens and maintain urine acidity so as to destroy the conditions of crystal formation, and utilizes the vitamin A to maintain the integrity of urinary-tract epithelium so as to realize the activity of crystallization inhibitors and inhibit crystallization. The agent is reasonable in compatibility, jointly uses medicaments from different angles to eliminate the inducing factors of stones, and plays adefinite role in preventing magnesium ammonium phosphate stones after the agent is added to canine / feline diets. The agent has the advantages of simple preparation, remarkable effects and wide application range.

The invention relates to a synthetic method for acetohydroxamic acid. The method synthesizes the acetohydroxamic acid with hydroxylamine sulfate and ethyl acetate as raw materials and with an ethanol solution of sodium ethoxide as a catalyst. Compared with a traditional synthetic method (e.g., using sodium hydroxide as the catalyst), the synthetic method provided by the invention has the advantages of simple and convenient process, easily-available raw materials which are bulk chemical materials, low cost, high yield and facilitation to industrial popularization.

The invention discloses a naproxen copper complex with a function of inhibiting the urease activity and a preparing method thereof, and belongs to the technical field of complex synthesis and medicinal chemistry. According to the naproxen copper complex, naproxen and 1,3-propane diamine serve as ligands, a copper ion serves as a center ion, and through a solvent evaporation method, a mononuclear-structure naproxen copper complex is prepared. The naproxen copper complex has the good biological activity, it discovers after detection that IC50 values of the naproxen copper complex and positive control medicine acetohydroxamic acid (N-glycolamide) are 1.69 micromole / L and 6.26 micromole / L respectively with respect to urease inhibition, it indicates that an effect of the complex for inhibitingthe urease activity is better than an effect of acetohydroxamic acid, the inhibition ratio of the complex for the urease activity is 72.6%, and the naproxen copper complex is a good urease inhibitor.

The invention relates to a preparation capable of reducing concentration of ammonia gas in a livestock housing and a preparing method of the preparation. The preparation comprises components in percentage by weight as follows: 3%-10% of yucca schidigera extracts, 2%-10% of acetohydroxamic acid, 1%-5% of isobutyric acid, 1%-5% of origanum oil, 5%-15% of calcium superphosphate and the balance of montmorillonite. The preparation is scientific in formula, efficient, safe, environment-friendly, low in cost and simple to prepare. The preparation reduces ammonia gas by restraining and killing putrefying bacteria and restraining urease activity and can absorb ammonia gas in the livestock housing. The concentration of ammonia gas in the livestock housing can be greatly reduced by using the preparation.

The present invention belongs to the technical field of feeds and particularly relates to a low defecation nitrogen environment protection type special feed for fattening pigs. The special feed comprises a Bangji S-AALN functional package and the Bangji S-AALN functional package comprises the following components of threonine, methionine, tryptophan, valine, insoluble fibers, acetohydroxamic acid,modified zeolite and tributyrin. The feed comprises the following ingredients of corns, bran, rice bran meal, corn germ meal, soybean oil, 70% lysine, high temperature resistant phytase, compound vitamins, compound trace elements, the Bangji S-AALN functional package, etc. By using a combination of the amino acids to replace a part of common protein raw materials, the feed provides micropowder type insoluble fibers not damaging intestinal tracts, reduces concentrations of toxic amines and nitrogen in feces in the intestinal tracts, improves an intestinal health condition of the pigs in the fattening period and is reasonable in nutrition. Each of the ingredients has a joint function. The environment protection type special feed balances supply and demand of the amino acids, reduces the toxic amines and is low in defecation nitrogen in the fattening period, reduces a feed-to-meat ratio of the pigs and improves economic efficiencies.

The invention discloses an industrialization method for synthesizing O-chloropropene hydroxylamine by virtue of a one-pot method and a catalyst utilized in the industrialization method. The industrialization method comprises the following steps: adding acetic ester, hydroxylammonium salt and a catalyst A into a reaction kettle, adding alkali metal hydroxide, and stirring to react at 0-50 DEG C for 0-10 hours so as to generate acetohydroxamic acid; continuing to add a catalyst B and dichloropropene into reaction liquid to generate etherification reaction at 20-80 DEG C for 0-20 hours, so as to obtain N-acetyl-O-chloropropene hydroxylamine; and continuing to add protonic acid to generate acidification at 20-100 DEG C for 0-10 hours, so as to prepare O-chloropropene hydroxylammonium salt, and finally carrying out neutralization, extraction and desolvation, so as to obtain dissociative O-chloropropene hydroxylamine. The product content is higher than 99%, and the total yield is over 90%. An intermediate can be utilized for preparing high-content cyclohexenone herbicides by virtue of further reaction, is applicable to large-scale industrial production, low in cost and high in product purity and yield, and the operation is easy.

This invention provides that Ropinirole (4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one) possess potent urease inhibitory potential (in vitro) with 97.3% inhibition and IC50=11.7+0.46 μM, when compared to the standard inhibitors i.e. acetohydroxamic acid (IC50=41.5+1.50 μM), and thiourea (IC50=21.0+0.50 μM).

The invention relates to a feed additive for producing selenium-rich beef. The feed additive is characterized by being prepared by mixing the following substances in parts by weight: 15-25 parts of 30% coated cysteamine hydrochloride, 8-12 parts of dihydropyridine, 130-150 parts of cardamine violifolia, 110-130 parts of flos lonicerae, 90-110 parts of stevia rebaudiana, 70-90 parts of rhizoma gynurae, 70-90 parts of fructus hordei germinatus, 7-9 parts of laifeng crossostephium leaf extract, 70-90 parts of fructus aurantii, 70-90 parts of fructus quisqualis, 30-50 parts of acetohydroxamic acid, 50-60 parts of commercially available selenium yeast containing 2,000mg / kg of selenium, 50-60 parts of commercially available bacillus subtilis and 50-70 parts of medical stone. The feed additive for producing the selenium-rich beef can prevent various diseases of cattle and provide safe and nutritional healthy food for citizens, and is optimal food and way for selenium supplement of the whole people, thereby having an important practical significance.

The invention relates to the technical field of feeds, and especially relates to a premix capable of preventing urinary tract calculus of fattening sheep in shed. The premix capable of preventing urinary tract calculus of fattening sheep in shed is prepared from the following raw materials in parts by weight: 40-58 parts of calcium carbonate, 1-1.45 parts of an enteric coated acidifier, 1.2-1.7 parts of acetohydroxamic acid, 3.5-4.9 parts of calcium hydrogen phosphate, 0.1-0.13 part of a sweetener, 0.5-0.65 part of betaine hydrochloride, 18-26 parts of sodium chloride, 10-14 parts of rice huskpowder, 1.8-2.6 parts of amino acid, 5.5-7 parts of compound trace elements, and 2.3-3.2 parts of multivitamins. A preparation method of the premix comprises the following steps: step one, weighing the raw materials of the premix according to weight ratio; and step two, mixing the weighed raw materials of the premix, and carrying out uniform stirring. The premix capable of preventing urinary tract calculus of fattening sheep in shed provided by the invention is rational in feed formula match, as well as rich and balanced in nutrients; so that, the premix is capable of effectively preventing occurrence of imbalance of calcium and phosphorus, imbalance of urine pH value, irregular exfoliation of urothelial cells, metabolic disorder of nutrients and urinary tract calculus of fattening sheepin shed.

The invention relates to a selenium-enriched beef additive. The selenium-enriched beef additive is prepared from following substances in parts by weight by mixing: 15-25 parts of 30% coated cysteamine hydrochloride, 8-12 parts of dihydropyridine, 130-150 parts of Cardamine violifolia, 110-130 parts of honeysuckle, 90-110 parts of stevia rebaudiana, 70-90 parts of Gynura japonica, 70-90 parts of malt, 70-90 parts of Laifeng Dendranthema indicum, 70-90 parts of Fructus aurantii, 70-90 parts of rangoon creeper fruit 30-50 parts of acetohydroxamic acid, 50-60 parts of commercially available selenium yeast containing 2,000 mg / kg of selenium, 50-60 parts of commercially available Bacillus subtillis and 50-70 parts of medical stone. The selenium-enriched beef additive can prevent various bovine diseases, is safe and provides nutritious healthy food for citizens, is used for providing the optimal food and path for selenium supplement of the whole people and has great practical significance.

The invention relates to the field of animal husbandry additive preparation, in particular to a synthesis method of a urease inhibitor acetohydroxamic acid. The method comprises the following steps: reacting hydroxylamine hydrochloride with ethyl acetate in an alkaline solvent system, and performing extraction by using an organic solvent after the reaction is finished, with the chemical equation being CH3COOC2H5 + NH2OH.HCl -> CH3CONHOH. The synthesis method can realize industrial mass production of the acetohydroxamic acid, and can ensure a high yield and high purity of the acetohydroxamic acid. The solvents used in the production process can be recycled, and the preparation method is green and economical.

The invention provides a compound premix feed for cattle and sheep. The compound premix feed for cattle and sheep is prepared from microbial compound bacteria, acetohydroxamic acid and compound enzyme, the acetohydroxamic acid can reduce the discharge of urine nitrogen and improve the utilization rate of crude proteins, and the acetohydroxamic acid not only can improve the utilization rate of ureaand the feed and reduce the cost, but also can avoid ammonia poisoning or ammonia stress, so that cattle and sheep can keep physiological balance and grow healthily and strongly; cellulase, xylanase,beta-glucanase, protease and the like contained in the premix feed are helpful for cattle and sheep to absorb cellulose, proteins and other nutrient substances in the feed, so that the digestibilityof the feed is improved; and bacillus and Saccharomyces cerevisiae contained in the compound premix feed for the cattle and the sheep can generate various nutritional and growth-promoting components including vitamins, amino acids, organic acids, various digestive enzymes and the like in cattle and sheep bodies.

The invention relates to a growing and fattening pig feed additive as well as a preparation method and application thereof, and belongs to the field of feed. The additive comprises the following raw materials: a composite detoxifying agent, an enzyme preparation, camphor tree seed powder, plant essential oil, tea saponin, acetohydroxamic acid, activated carbon and a carrier. The additive can promote the growth of growing and fattening pigs and increase the feed intake and the feed conversion efficiency, and also can adjust the immune function of livestock and poultry, adjust the intestinal microecological balance and enhance the disease resistance; and in addition, the additive can reduce the discharge quantity of nitrogen and phosphorus and dissipating quantity of ammonia gas in excrementof the growing the fattening pigs, and reduce pollution to the environment by the excrement. During preparation, the raw materials are mixed according to the proportion, the operation is simple and rapid and the condition controllability is high. After the additive is added into growing and fattening pig feed, the quality of the growing and fattening pigs can be improved, digestion and absorptionof nutritional materials by the growing and fattening pigs are promoted, the nutrient utilization rate is increased and discharge of manure of a pig field is reduced.

The invention discloses application of farnesene in preparation of a plant-derived urease inhibitor, and belongs to the technical field of urease inhibitors. The compound can effectively inhibit the activity of concanavalin urease and soil urease, and the effect of the compound can be equivalent to that of a commercial urease inhibitor acetohydroxamic acid. The urease inhibiting substance provided by the invention is derived from plants, has the characteristic of'green 'of a natural product, is high in biological safety, simple and stable in chemical structure and remarkable in urease inhibiting effect, can solve the problems of high toxicity, easiness in degradation and poor stability of a conventional chemically synthesized urease inhibitor, and has a wide application prospect. Meanwhile, a new thought is provided for creating a biological and ecological technology for efficiently inhibiting rapid hydrolysis of farmland urea and improving the utilization rate of urea nitrogen fertilizer, and good application value and development prospects are achieved.

A spent fuel reprocessing method contacts an aqueous solution containing Technetium(V) and uranyl with an acidic solution comprising hydroxylamine hydrochloride or acetohydroxamic acid to reduce Tc(V) to Tc(II, and then extracts the uranyl with an organic phase, leaving technetium(II) in aqueous solution.

This invention discloses a sustained-release nitrogen fertilizer containing secondary and trace elements. The sustained-release nitrogen fertilizer is composed of: urea 10-96 parts, ammonium sulfate 0.1-78.8 parts, attapulgite powder 0-8 parts, ammonium chloride 0.1-78.8 parts, magnesium sulfate 0.05-2.0 parts, borax 0.01-1 part, copper sulfate 0.01-0.2 part, manganese sulfate 0.01-0.6 part, ferrous sulfate 0.01-1 part, zinc sulfate 0.01-1 part, acetohydroxamic acid 0.01-0.02 part, composite amino acids 0.01-1 part, and dicyandiamide 0.01-0.2 part. The sustained-release nitrogen fertilizer is prepared by: mixing the above components, adding into a disc granulator, spraying an appropriate amount of water, granulating and drying. The sustained-release nitrogen fertilizer has such advantages as long effective period and high effective utilization rate (above 45%). Crops applied with the sustained-release nitrogen fertilizer have such advantages as high stress resistance and high yield.

This invention provides that (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid (captopril) possess potent in vitro urease inhibitory potential with 95.00% inhibition and IC50=16.6±1.52 μM, when compared to the standard inhibitor i.e. acetohydroxamic acid (IC50=41.5±1.50 μM).

The invention discloses an industrialization method for synthesizing O-chloropropene hydroxylamine by virtue of a one-pot method and a catalyst utilized in the industrialization method. The industrialization method comprises the following steps: adding acetic ester, hydroxylammonium salt and a catalyst A into a reaction kettle, adding alkali metal hydroxide, and stirring to react at 0-50 DEG C for 0-10 hours so as to generate acetohydroxamic acid; continuing to add a catalyst B and dichloropropene into reaction liquid to generate etherification reaction at 20-80 DEG C for 0-20 hours, so as to obtain N-acetyl-O-chloropropene hydroxylamine; and continuing to add protonic acid to generate acidification at 20-100 DEG C for 0-10 hours, so as to prepare O-chloropropene hydroxylammonium salt, and finally carrying out neutralization, extraction and desolvation, so as to obtain dissociative O-chloropropene hydroxylamine. The product content is higher than 99%, and the total yield is over 90%. An intermediate can be utilized for preparing high-content cyclohexenone herbicides by virtue of further reaction, is applicable to large-scale industrial production, low in cost and high in product purity and yield, and the operation is easy.